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Uvod: Ulaskom Republike Hrvatske u Europsku uniju povećao se udio migracija medicinskih sestara. Cilj: Istraživanja bio je utvrditi postoje li razlike u motivaciji odlazaka medicinskih sestara s obzirom na regiju Hrvatske u kojoj pohađaju školu. Metode: U istraživanju je sudjelovalo 165 učenika, polaznika Srednje medicinske škole u Pakracu i Srednje medicinske škole Vinogradska u Zagrebu. Rezultati: U istraživanju je sudjelovalo značajno više ispitanica (N=112) od ispitanika (N=52) (p, Introduction: Since Croatia entered the European Union, the portion of nurses' migration has increased. Aim: The aim of the research is to determine if there are any differences regarding the motivation of the nurses' departures regarding the region of the Republic of Croatia in which they attend their schools. Materials and Methods: In this research 165 examinees who attend medical high schools have participated. Results: Significantly higher number are female examinees (N=112) compared to male examinees (N=52) (p< 0,001). Examinees attend High school Pakrac (N=83) and High school Vinogradska (N=82). Significant majority achieves very good grades, regarding the school achievement scale. It turned out that examinees from High school Pakrac feel more satisfied with their professional career choice than the examinees from High school Vinogradska (p=0,001). On the other hand, examinees from High school Vinogradska have more positive attitude when it comes to moving abroad (p=0,001). They also consider that they will find a job more easily, compared to the opinion of High school Pakrac examinees. Results also show that the examinees from High school Vinogradska consider as more important reason for possible leaving the Republic of Croatia, significantly stronger feeling of hopelessness in the society, than the examinees from High school Pakrac see it (p=0,026). There are also the need for assertion (p=0,014), the feeling of discouraging environment (p=0,004), as well as the perception that their children in the future will have a better life if they were raised abroad (p=0,033). Conclusion: Motives for leaving significantly differ between the nurses from High school Pakrac and nurses from High school Vinogradska, which can be explained due to regional differences, as well as social and economic differences.