1. Activation of histamine H
- Author
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Gong-Hao, He, Jia-Qi, Ding, Xin, Zhang, Wen-Mang, Xu, Xiao-Qian, Lin, Mei-Jin, Huang, Ju, Feng, Ping, Wang, and Wen-Ke, Cai
- Subjects
Adult ,Aged, 80 and over ,Male ,MAP Kinase Signaling System ,Middle Aged ,Models, Biological ,Xenograft Model Antitumor Assays ,Disease Models, Animal ,Mice ,Cell Movement ,Case-Control Studies ,Cell Line, Tumor ,Animals ,Humans ,Female ,Esophageal Squamous Cell Carcinoma ,Neoplasm Grading ,Neoplasm Metastasis ,Energy Metabolism ,Aged ,Cell Proliferation ,Neoplasm Staging ,Receptors, Histamine H4 ,Signal Transduction - Abstract
Although dysregulation of histamine HThe function of H4R in ESCC and the underlying mechanisms were investigated. H4R expression was correlated with ESCC cell differentiation and patients' survival. Both metabolism (ACSS2) and non-metabolism (MAPK)-related pathways were involved. This study provided new insight into the relationship between H4R and ESCC. H4R may be a novel potential therapeutic target for ESCC.
- Published
- 2018