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1. Multiplexed genotyping of ABC transporter polymorphisms with the Bioplex suspension array.

Author

Seok Hwee Koo, Tan Ching Ong, Kok Ting Chong, Guat Lay Lee, Caroline, Fook Tim Chew, and Jon Deoon Lee, Edmund

Subjects
GENETIC polymorphisms, CHROMOSOME polymorphism, MEDICAL genetics, MEDICAL sciences, PHENOTYPES, BIOTECHNOLOGY
Abstract

The article discusses a study on the development of a consolidated bead-based genotyping platform, the Bioplex suspension array for simultaneous detection of multiple single nucleotide polymorphisms (SNPs) of the ATP-binding cassette transporters. It cites the influence of genetic polymorphisms on therapeutic response and risk of disease pathologies. The study concluded that the suspension array thus proves to be a reliable, cost-effective and high-throughput technological platform for genotyping.

Published
2008
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