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The widespread distribution of micro(nano)plastics (MNPs) and bisphenols (BPs) in the environment inevitably resulted in their multifaceted interactions and associated detrimental effects being largely uncharted yet. Hence, this review summarized available studies highlighting the environmental occurrence, sorption mechanisms, and eco-toxicological effects of MNPs and BPs. The existing data indicated that the environmental concentrations of the adsorbed bisphenol A (BPA) and bisphenol S (BPS) on MNPs were 9.52–4961 ng/g and 1.89–118 ng/g of plastic particles, respectively, while bisphenol F (BPF) was below the detection limit. Hydrophobic interaction force was predominantly observed as the main factor in maintaining the adsorption of MNPs and BPA/S, whereas electrostatic repulsion between MNPs and BPF inhibited the adsorption of BPF onto plastic particles. Moreover, co-exposure to MNPs and BPs posed immune responses, neurotoxicity, reproductive inhibition and even survival impairment in test organisms. This review implied that it would facilitate the evaluation of the ecological safety and environmental risks of MNPs and BPs as well as contribute to theoretical guidance for their pollution prevention and control. To better understanding the associated toxicological mechanisms, there is an urgent need to assess the combined toxicological effects of MNPs and BPs. [Display omitted] • Hydrophobic interaction forces primarily maintain the adsorption of BPs on MNPs. • BPA alternatives are not environmentally friendly, they exhibit toxic impacts. • MNPs increased the reproductive toxicity of BPA to the test organisms. • Toxicogenetic mechanisms of MNPs and BPs and the factors affecting them are further required to clarify. [ABSTRACT FROM AUTHOR]