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1. Hematological changes in human lymphotropic-T virus type 1 carriers

Author

Jairo Falcão Ribeiro, Akim Felipe Santos Nobre, Louise Canto Ferreira Covre, Maria de Nazaré do Socorro de Almeida Viana, Ingrid Christiane Silva, Leonardo Miranda dos Santos, Edna Aoba Ishikawa, Carlos Araújo da Costa, and Maísa Silva de Sousa

Subjects
HTLV-1, hematological changes, ATL, epidemiology, Amazon, Microbiology, QR1-502
Abstract

The human T-lymphotropic virus type 1 (HTLV-1), isolated in 1980, causes T-cell leukemia/lymphoma in adulthood, a type of lymphoproliferative disease, and chronic HTLV-1-associated myelopathy, a disease that causes paralysis of the lower limbs, which occur in about 5% of cases in this viral infection. This study aimed to establish the hematological profile of patients with HTLV-1 infection in Belém do Pará, describing the hematological parameters under study, estimating the frequency of lymphocytic atypical, and associating the hematological profile with diseases and symptoms. Hematologic data from 202 individuals were analyzed, including 87 HTLV-1 infected individuals and 115 non-HTLV-1 infected individuals as a control group, composed, at a great part, of relatives of the infected. The seroprevalence of HTLV-1 infection was observed in 71.3% of female individuals, with predominance in the group older than 50 years (44.8%). The analysis of hematological parameters showed a significant difference in the counts of the segmented cells (p = 0.0303) and eosinophils (p = 0.0092) in HTLV-1 carriers. Lymphocytic atypical was a finding present only in HTLV-1 carriers (p = 0.0001). There was no high frequency in the leukocyte counts of those infected by HTLV-1 not among them concerning a significant increase or decrease. It is concluded that HTLV-1 infection is prominent in women over 50 years old. The hematological profile of those infected shows a reduction of segmented cells, an increase of eosinophils, and the presence of atypical lymphocytes. The hematological profile of the HTLV-1 carrier should always be evaluated to identify early some diseases associated with the infection.

Published
2022
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2. High prevalence of sexual Chlamydia trachomatis infection in young women from Maraj? Island, in the Brazilian Amazon

Author

Stephen F. Ferrari, Ricardo Ishak, Mihoko Yamamoto Tsutsumi, Jessica Fernanda Galdino Oliveira, Danielle Murici Brasiliense, Maísa Silva de Sousa, Leonardo Miranda dos Santos, Josinaide Quaresma Trindade, Hellen Thais Fuzii, Edna Aoba Yassui Ishikawa, Edivaldo Costa Sousa Júnior, and Maria Renata Mendonça dos Santos Vieira

Subjects
0301 basic medicine, Artificial Gene Amplification and Extension, Chlamydia trachomatis, Pathology and Laboratory Medicine, medicine.disease_cause, Polymerase Chain Reaction, Geographical locations, Chlamydia Infection, Risk Factors, Epidemiology, Medicine and Health Sciences, Prevalence, Chlamydia, Young adult, Data Management, Reproductive health, Islands, Multidisciplinary, Geography, Amazon rainforest, Database and informatics methods, Sequence analysis, Phylogenetic Analysis, Middle Aged, Bacterial Pathogens, Phylogenetics, Comportamento Sexual, Phylogeography, Infectious Diseases, Reproductive Health, Biogeography, Medical Microbiology, symbols, Medicine, Female, Pathogens, medicine.symptom, Brazil, Research Article, Adult, Doen?as Bacterianas Sexualmente Transmiss?veis, Computer and Information Sciences, medicine.medical_specialty, Adolescent, Bioinformatics, Sexual Behavior, Science, 030106 microbiology, Sexually Transmitted Diseases, Research and Analysis Methods, Microbiology, Asymptomatic, Young Adult, 03 medical and health sciences, symbols.namesake, Assist?ncia ? Sa?de, Genetics, medicine, Humans, Evolutionary Systematics, Poisson regression, Molecular Biology Techniques, Microbial Pathogens, Molecular Biology, DNA sequence analysis, Taxonomy, Aged, Chlamydia trachomatis / patogenicidade, Evolutionary Biology, Bacteria, Population Biology, business.industry, Ecology and Environmental Sciences, Organisms, Biology and Life Sciences, South America, Chlamydia Infections, medicine.disease, Infec??es por Chlamydia / virologia, Nested Polymerase Chain Reaction, Infec??es por Chlamydia, Earth Sciences, People and places, business, Arquip?lago do Maraj? (PA), Population Genetics, Demography
Abstract

The present study was fully supported by grants from the Fundac??o Amazo?nia Paraense de Amparo a Pesquisa (FAPESPA ? ICAAF 014/2012) and Ministe?rio da Sau?de do Brasil (MS). Universidade Federal do Par?. N?cleo de Medicina Tropical. Laborat?rio de Biologia Molecular e Celular. Bel?m, PA, Brasil / Universidade Federal do Par?. Programa de P?s-gradua??o em Doen?as Tropicais. Bel?m, PA, Brasil. Universidade Federal do Par?. N?cleo de Medicina Tropical. Laborat?rio de Biologia Molecular e Celular. Bel?m, PA, Brasil / Universidade Federal do Par?. Programa de P?s-gradua??o em An?lises Cl?nicas. Bel?m, PA, Brasil. Universidade Federal do Par?. Instituto de Ci?ncias Biol?gicas. Laborat?rio de Citopatologia. Bel?m, PA, Brasil. Universidade Federal do Par?. Instituto de Ci?ncias Biol?gicas. Laborat?rio de Citopatologia. Bel?m, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Universidade Federal do Sergipe. Departamento de Ecologia. S?o Crist?v?o, SE, Brasil. Universidade Federal do Par?. Programa de P?s-gradua??o em An?lises Cl?nicas. Bel?m, PA, Brasil / Universidade Federal do Par?. Instituto de Ci?ncias Biol?gicas. Laborat?rio de Citopatologia. Bel?m, PA, Brasil. Universidade Federal do Par?. N?cleo de Medicina Tropical. Laborat?rio de Imunopatologia. Bel?m, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Universidade Federal do Par?. N?cleo de Medicina Tropical. Laborat?rio de Biologia Molecular e Celular. Bel?m, PA, Brasil. Universidade Federal do Par?. Instituto de Ci?ncias Biol?gicas. Laborat?rio de Virologia. Bel?m, PA, Brasil. Universidade Federal do Par?. N?cleo de Medicina Tropical. Laborat?rio de Biologia Molecular e Celular. Bel?m, PA, Brasil. BACKGROUND: Chlamydia trachomatis is the most prevalent bacterial sexually transmitted infection (STI) in the world. Approximately 80% of infected women are asymptomatic, although this infection can lead to serious complications in the female reproductive tract. Few data on Chlamydia infection are available in rural Amazonian communities. OBJECTIVES: To evaluate the prevalence of sexual C. trachomatis infection in women from Maraj? Archipelago communities in the Amazon region of Brazil and to identify associated factors and genotypes. METHODS: We utilized amplification of the ompA gene by nested PCR. Positive samples were genotyped by sequencing. Study participants completed a questionnaire on social, epidemiological, and reproductive health variables. A Poisson regression was used to evaluate the degree of association of these variables with the infection. RESULTS: The sexual infection by C. trachomatis was observed in 4% (16/393) of the subjects, and was more often found in women aged ?25 (14.3%; 95% CI = 2.83-35.47; p

Published
2018

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