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Your search keyword '"Thornton, Christine"' showing total 2 results
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2 results on '"Thornton, Christine"'

1. THE DISEASE OF THE NZB MOUSE.

Author

Barnes, R. D., Tuffrey, Maureen, Kingman, Jean, Thornton, Christine, and Turner, M. W.

Subjects
AUTOIMMUNE diseases, AUTOIMMUNITY, GERM cells, OVUM, MICE, IMMUNOLOGY
Abstract

It has previously been proposed that the autoimmune disease of the inbred NZB mouse is due to an age-related failure of a normal autoimmune control mechanism. Ovum fusion-derived tetraparental NZB : CFW chimaeras have been used to investigate this hypothesis since it was anticipated that the autoimmune control process present in the CEW would inhibit the development of the classic progressive autoimmune NZB diseases This view is supported since although certain chiniaeras developed positive direct Coombs' test (DCT) reactions, evidence suggests that the NZB disease has been inhibited and furthermore. It appears that these reactions reflect graft-versus-host (g-v-h) activity in the chimaeras. [ABSTRACT FROM AUTHOR]

Published
1972

2. The disease of the NZB mouse. I. Examination of ovum fusion-derived tetraparental NZB:CFW chimaeras

Author

Barnes, R. D., Tuffrey, Maureen, Kingman, Jean, Thornton, Christine, and Turner, M. W.

Subjects
Immunodiffusion, Lymphoma, Fluorescent Antibody Technique, Mice, Inbred Strains, Thymus Gland, Cross Reactions, Kidney, Antibodies, Autoimmune Diseases, Cell Fusion, Graft vs Host Reaction, Mice, Histocompatibility Antigens, Animals, Lung, Ovum, Mice, Inbred NZB, Mosaicism, Articles, Immunoglobulin M, Liver, Antibodies, Antinuclear, Female, Lymph Nodes, Lymphoma, Large B-Cell, Diffuse, Spleen
Abstract

It has previously been proposed that the autoimmune disease of the inbred NZB mouse is due to an age-related failure of a normal autoimmune control mechanism. Ovum fusion-derived tetraparental NZB: CFW chimaeras have been used to investigate this hypothesis since it was anticipated that the autoimmune control process present in the CFW would inhibit the development of the classic progressive autoimmune NZB disease. This view is supported since although certain chimaeras developed positive direct Coombs' test (DCT) reactions, evidence suggests that the NZB disease has been inhibited and furthermore it appears that these reactions reflect graft-versus-host (g-v-h) activity in the chimaeras.

Published
1972

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