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48 results on '"Oscar Fernandez-Capetillo"'

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1. Supraphysiological protection from replication stress does not extend mammalian lifespan

2. Distinct roles for PARP-1 and PARP-2 in c-Myc-driven B-cell lymphoma in mice

3. USP7 limits CDK1 activity throughout the cell cycle

4. ATR expands embryonic stem cell fate potential in response to replication stress

5. A Chemical Screen Identifies Compounds Capable of Selecting for Haploidy in Mammalian Cells

6. POLD3 Is Haploinsufficient for DNA Replication in Mice

7. ERF deletion rescues RAS deficiency in mouse embryonic stem cells

8. Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice

9. A p53-dependent response limits the viability of mammalian haploid cells

10. Fos-dependent induction of Chk1 protects osteoblasts from replication stress

11. Efficacy of ATR inhibitors as single agents in Ewing sarcoma

12. Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

13. An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation

14. Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR

15. Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

16. A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations

17. Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8

18. Nuclear phosphoinositide 3-kinase β controls double-strand break DNA repair

19. Cdk2 suppresses cellular senescence induced by the c-myc oncogene

20. Overall Cdk activity modulates the DNA damage response in mammalian cells

21. ATR signaling can drive cells into senescence in the absence of DNA breaks

22. The (elusive) role of the SMC5/6 complex

23. Global chromatin compaction limits the strength of the DNA damage response

24. Replication fork stability confers chemoresistance in BRCA-deficient cells

25. Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

26. Specific Association of Mouse MDC1/NFBD1 with NBS1 at Sites of DNA-Damage

27. Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

28. H2AX Is Required for Chromatin Remodeling and Inactivation of Sex Chromosomes in Male Mouse Meiosis

29. Modeling the Study of DNA Damage Responses in Mice

30. Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells

31. Genomic Instability in Mice Lacking Histone H2AX

32. The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity

33. A synthetic lethal interaction between APC/C and topoisomerase poisons uncovered by proteomic screens

34. p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia

35. Cyclin-dependent kinase inhibitor p21 controls adult neural stem cell expansion by regulating Sox2 gene expression

36. Lac operator repeats generate a traceable fragile site in mammalian cells

37. BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair

38. Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer syndrome

39. ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase

40. Intrauterine programming of ageing

41. A mouse model of the ATR-Seckel Syndrome reveals that replicative stress during embryogenesis limits mammalian lifespan

42. Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression

43. Silencing of unsynapsed meiotic chromosomes in the mouse

44. Phosphorylation of histone H2B at DNA double-strand breaks

45. H2AX regulates meiotic telomere clustering

46. Focusing on Foci: H2AX and the Recruitment of DNA-Damage Response Factors

47. H2AX Haploinsufficiency Modifies Genomic Stability and Tumor Susceptibility

48. PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors

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