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Metronidazole (MNZ) is an extensively used antibiotic against bacterial infections for humans and farm animals. Prevention of antibiotics discharge is essential to prevent adverse environmental and health impacts. A member of metal-organic frameworks, zeolite imidazole framework-67 with cobalt sulfate precursor (ZIF-67-SO 4 ) and exceptional physio-chemical properties was prepared via room temperature precipitation to adsorb MNZ. The study framework was designed by Box-Behnken Design to evaluate the effect of pH, ZIF-67-SO 4 dose, and contact time on adsorption efficiency. The polynomial model fitted the adsorption system indicated the optimal condition for 97% MNZ removal occurs at pH = 7, adsorbent dosage = 1 g/L, and mixing time = 60 min. The model also revealed that the removal increased with contact time and decreased at strong pH. Equilibrium and kinetic study also indicated the adsorption of MNZ followed the intra-particle diffusion model and the Langmuir isotherm model with a qmax = 63.03 mg/g. The insignificant loss in removal efficacy in use-reuse adsorption cycles reflected the practical viability of ZIF-67-SO 4 ., (© 2023. Springer Nature Limited.)