1. Methemoglobinemia and hemolytic anemia after rasburicase administration in a child with leukemia.
- Author
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Bauters T, Mondelaers V, Robays H, De Wilde H, Benoit Y, and De Moerloose B
- Subjects
- Child, Gout Suppressants adverse effects, Gout Suppressants therapeutic use, Humans, Male, Pancreatitis chemically induced, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy, Urate Oxidase therapeutic use, Anemia, Hemolytic chemically induced, Methemoglobinemia chemically induced, Urate Oxidase adverse effects
- Abstract
Case: We report a case of simultaneous methemoglobinemia and hemolytic anemia, probably related to the use of rasburicase, in a child starting treatment for acute lymphoblastic leukemia (ALL). In addition, the patient developed symptoms of pancreatitis. All complications resolved after 3 days of supportive therapy., Conclusion: Although usually well tolerated in pediatrics, physicians prescribing rasburicase should be aware of these possible life-threatening adverse reactions.
- Published
- 2013
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