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Abstract: Objective: To evaluate the anti-inflammatory and analgesic activities of methanolic leaf extract of Indigofera cassioides (I. cassioides) (MEIC) using various animal models. Methods: Anti-inflammatory and analgesic activities of MEIC was assessed by using different animal models. Anti-inflammatory activity of the extract was evaluated by using carrageenan-induced rat paw edema and cotton pellet granuloma method. Anti-nociceptive activity of the extract was evaluated for its central and peripheral pharmacological actions by using Eddy's hot plate method and acetic acid-induced writhing respectively. The study was carried out using dose of 200 & 400 mg/kg orally. Aceclofenac, aspirin and pentazocine was used as standard drugs to evaluate anti-inflammatory and analgesic activities, respectively. Results: Treatment with MEIC significantly (P<0.001) decrease the paw volume and weight of cotton pellet in the tested models. It also exhibit potent analgesic activity on chemical and thermal induced pain in mice. MEIC exhibit potent and dose dependent anti-inflammatory and analgesic activities in all the tested animal models. Conclusions: All the results obtained revealed that the extract MEIC showed potent anti-inflammatory and anti-nociceptive activity against all the tested models and the results obtained were comparable with the standards used. The activity of the extract may be due to the presence of terpenoids, flavonoids and other phytochemicals. [Copyright &y& Elsevier]

The article reports on the evaluation of the antitumor activity of the methanol extract of Phyllanthus polyphyllus (MPP) against an Ehrlich ascites carcinoma tumor model. The activity was assessed using survival time, hematological studies, lipid peroxidation, antioxidant enzymes, solid tumor mass and short-term in-vitro cytotoxicity. The oral administration of MPP increased the survival time and reduced the solid tumor volume.