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Clip‐off Chemistry is a synthetic strategy that our group previously developed to obtain new molecules and materials through selective cleavage of bonds. Herein, we report recent work to expand Clip‐off Chemistry by introducing into it a retrosynthetic analysis step that, based on virtual extension of the products through cleavable bonds, enables one to define the required precursor materials. As proof‐of‐concept, we have validated our new approach by synthesising and characterising four aldehyde‐functionalised Rh(II)‐based complexes: a homoleptic cluster; a cis‐disubstituted paddlewheel cluster; a macrocycle; and a crown. [ABSTRACT FROM AUTHOR]

Bond breaking is an essential process in chemical transformations and the ability of researchers to strategically dictate which bonds in a given system will be broken translates to greater synthetic control. Here, we report extending the concept of selective bond breaking to reticular materials in a new synthetic approach that we call Clip‐off Chemistry. We show that bond‐breaking in these structures can be controlled at the molecular level; is periodic, quantitative, and selective; is effective in reactions performed in either solid or liquid phases; and can occur in a single‐crystal‐to‐single‐crystal fashion involving the entire bulk precursor sample. We validate Clip‐off Chemistry by synthesizing two topologically distinct 3D metal‐organic frameworks (MOFs) from two reported 3D MOFs, and a metal‐organic macrocycle from metal‐organic polyhedra (MOP). Clip‐off Chemistry opens the door to the programmed disassembly of reticular materials and thus to the design and synthesis of new molecules and materials. [ABSTRACT FROM AUTHOR]

This document, published in the journal Angewandte Chemie, discusses various research articles in the field of chemistry. One article explores the use of bond scission as a synthetic tool to design new molecules and materials, showcasing the synthesis of Rh(II)-based architectures through the disassembly of metal-organic polyhedra. Another article focuses on the incorporation of Pd nanoparticles into MOFs for high selectivity in CO esterification. Additionally, there is a report on the use of sulfonium salt reagents for introducing deuterated alkyl groups in drug discovery, and a study on adaptive catalysts that can switch selectivity in hydrogenation reactions. Lastly, the document mentions a research article on the photophysics of [Ru(bpy)3]2+, highlighting the importance of rate-determining states in understanding its behavior. [Extracted from the article]

This article discusses various research articles published in the journal Angewandte Chemie International Edition. One research article by Jorge Albalad, Inhar Imaz, Daniel Maspoch, et al. explores the use of bond scission as a synthetic tool to design new molecules and materials. They demonstrate this concept by obtaining unprecedented Rh(II)-based architectures through the disassembly of metal-organic polyhedra. Another research article by Weijie Yang, Hai-Long Jiang, et al. focuses on incorporating Pd nanoparticles into MOFs for high selectivity in CO esterification. Yoshinari Sawama, et al. report on sulfonium salt reagents for introducing deuterated alkyl groups in drug discovery, while Alexis Bordet, Walter Leitner, et al. discuss the adaptivity of a catalyst in the hydrogenation of heteroaromatics. Lastly, Leticia González, et al. investigate the photophysics of [Ru(bpy)3]2+ and propose a kinetic model for its behavior. [Extracted from the article]

This chemistry is first used to synthesize two 3D metal-organic frameworks (MOFs) and a metal-organic macrocycle from precursor reticular materials. This chemistry is first used to synthesize two 3D metal-organic frameworks (MOFs) and a metal-organic macrocycle from precursor reticular materials. Cover Picture: Clip-off Chemistry: Synthesis by Programmed Disassembly of Reticular Materials (Angew. [Extracted from the article]