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As the global population ages, bone diseases have become increasingly prevalent in clinical settings. These conditions often involve detrimental factors such as infection, inflammation, and oxidative stress that disrupt bone homeostasis. Addressing these disorders requires exogenous strategies to regulate the osteogenic microenvironment (OME). The exogenous regulation of OME can be divided into four processes: induction, modulation, protection, and support, each serving a specific purpose. To this end, metal-organic frameworks (MOFs) are an emerging focus in nanomedicine, which show tremendous potential due to their superior delivery capability. MOFs play numerous roles in OME regulation such as metal ion donors, drug carriers, nanozymes, and photosensitizers, which have been extensively explored in recent studies. This review presents a comprehensive introduction to the exogenous regulation of OME by MOF-based nanomaterials. By discussing various functional MOF composites, this work aims to inspire and guide the creation of sophisticated and efficient nanomaterials for bone disease management., (© 2024 Wiley‐VCH GmbH.)

The use of nanoscale metal-organic frameworks (MOFs) as drug delivery vehicles has attracted considerable attention in tumor therapy. In this study, novel biocompatible MOF-based nanocarriers were used as part of a facile and reproducible strategy for precision cancer theranostics. Both diagnostic (Mn 2+ ) and therapeutic compounds (doxorubicin, DOX) were incorporated into the multifunctional MOF-based nanocarriers, which exhibited high colloidal stability and promoted T 1 -weighted proton relaxivity and low-pH-activated drug release. The obtained MOF-based nanocarriers exhibited significantly high cellular uptake and efficient intracellular drug delivery into cancer cells, which resulted in high apoptosis and cytotoxicity, in addition to effectively inhibiting the migration of 4T1 breast cancer cells. Moreover, the MOF-based nanocarriers could intensively deliver diagnostic and therapeutic agents to tumors to enable precise visualization of the nanocarrier accumulation and accurate tumor positioning, diagnosis, and imaging-guided therapy using magnetic resonance imaging (MRI). In addition, the functional MOF-based nanocarriers exhibited effective ablation of the primary breast cancer, as well as significant inhibition of lung metastasis with a high survival rate. Therefore, the developed nanocarriers represent a viable platform for cancer theranostics., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier Inc. All rights reserved.)

Developing high efficiency and durability catalysts for the electrocatalytic oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) is fundamental to achieve the large‐scale commercial application of fuel cells and metal‐air batteries. Herein, a series of Co−N doped bi‐functional hierarchical porous electrocatalysts were synthesized using polyvinyl pyrrolidone (PVP) as soft template to assist the Zn/Co bimetal Zeolitic Imidazolate Framework (BMZIF) to form micro‐/mesoporous carbon nanospheres via a convenient one‐step solution synthesis method, followed by pyrolysis to form carbon nanospheres catalysts. The as‐prepared Co/N co‐doped carbon exhibits outstanding performances in the ORR and OER due to the formed hierarchical pores architecture and the high surface area. The catalyst displays superior ORR performance with a high half‐wave potential of 0.89 V, and a remarkable long‐term stability in 0.1 M KOH. In addition, the electrocatalyst elicits a low voltage of 1.72 V under the current density of 10 mA cm−2. Moreover, the zinc‐air battery fabricated with P‐CNCo‐3 delivers a power density of 175.1 mW cm−2, a high specific capacity of 791 mAh g−1 and an energy density of 976 Wh kg−1 at 20 mA cm−2. [ABSTRACT FROM AUTHOR]

Development of noble metal-free catalysts with great electrocatalytic performance and stability is of importance for electrochemical energy conversion and storage devices. Herein, we reported the synthesis of trifunctional catalysts with three-dimension (3D) hierarchically porous nitrogen-doped carbon framework with Ni-Co dual metal-involving and carbon nanotubes growth derived from nickel metal-organic framework. The as-synthesized catalyst exhibited better oxygen reduction reaction performance under both neutral and basic conditions compared with commercial Pt/C catalysts. Under basic electrolyte, the oxygen evolution reaction performance of the synthesized catalyst was comparable to that of commercial IrO 2 catalysts and reasonable hydrogen evolution activity was achieved compared with reported non-noble metal-based catalysts. The assembled microbial fuel cell using the as-prepared material as the air electrode exhibited a maximum power density of 1971.2 mW m−2 and could steadily operate for more than 250 h of feed period. Furthermore, the Zn-air battery fabricated with the obtained catalyst showed excellent power density and rechargeability, which were superior to that of a Zn-air battery using Pt/C/IrO 2 as the air electrode. We anticipate that the results described here can provide a new idea for design of multifunctional electrocatalysts for energy conversion and storage devices. [ABSTRACT FROM AUTHOR]