1. Assessment of possible biomedical applications of green synthesized TiO 2 NPs-an in-vitro approach.
- Author
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Anh Nga NT, Fathima H A, and Alahmadi TA
- Subjects
- Antifungal Agents, Antioxidants, Aspergillus, Cell Line, Nanoparticles, Metal Nanoparticles chemistry
- Abstract
Biomedical applications for various types of nanoparticles are emerging on a daily basis. Hence this research was performed to evaluate the antifungal (Aspergillus sp., Alternaria sp., Trichophyton sp., Candida sp., and Penicillium sp.), cytotoxicity (MCF10A cell lines), and antioxidant (DPPH) potential of Coleus aromaticus mediated and pre-characterized TiO
2 NPs were studied with respective standard methodology. Interestingly, the TiO2 NPs exhibited significant antifungal activity on pathogenic fungal strains like Alternaria sp., Aspergillus sp. (31 ± 1.4), Penicillium sp. (31 ± 1.9) Trichophyton sp. (27 ± 2.1), and Candida sp. (26 ± 2.3) at high concentration (250 μg mL-1 ). However, the considerable levels of zone of inhibitions on fungal pathogens were recorded at 100 μg mL-1 of TiO2 NPs as well as it was considerably greater than positive control. It also demonstrated dose based anti-inflammatory and antidiabetic activities. The plant-mediated TiO2 NPs demonstrated a maximum DPPH scavenging efficiency of 91% at a dosage of 250 μg mL-1 , comparable to the positive control's 94%. Furthermore, TiO2 NPs at 100 μg mL-1 concentration did not cause cytotoxicity in MCF10A cell lines. At higher concentrations (250 μg mL-1 ), the nanoparticles showed the lowest cytotoxicity (17%). These findings suggest that C. aromaticus-mediated TiO2 NPs have significant biomedical applications. However, in-vivo studies are needed to learn more about their (C. aromaticus-mediated TiO2 NPs) potential biomedical applications., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)- Published
- 2024
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