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Two new platinum(IV) complexes (1, trifluoperazinehydrochloride-aquapentachloridoplatinate(IV) and2, chlorpromazine-chlorpromazinehydrochloridepentachloridoplatinate(IV)) were synthesized in the reaction of K2[PtCl6] with trifluoperazine dihydrochloride (TF·2HCl) or chlorpromazine hydrochloride (CP·HCl). The complexes were characterized by elemental analysis, molar conductivity measurement, and spectral (IR,1H,13C, 2D1H–13C heteronuclear correlation spectra,195Pt NMR, and MS) methods. Outer-coordination sphere was proposed for1; while in2, the ligand was coordinated to the metal. The complexes exhibit antibacterial effect on strains ofBacillus subtilis,Bacillus cereus,Bacillus pumilus, and methicillin-resistantStaphylococcias Gram-positive bacteria and anEscherichia colias Gram-negative bacteria, as well as the reference strains. [ABSTRACT FROM PUBLISHER]

The thermal decomposition of [RuCl(η- p-cymene)] ( 1) and its biologically active N-alkylphenothiazine compounds of composition L[RuCl(η- p-cymene)] where L = CPH ( 2), TFH·HCl ( 3), and TRH ( 4) (chlorpromazine hydrochloride, CP·HCl; trifluoperazine dihydrochloride, TF·2HCl; and thioridazine hydrochloride, TR·HCl, respectively) has been studied. The crystal and molecular structure of compound 3 was determined earlier by single crystal X-ray diffraction analysis. The thermal data were collected by simultaneous TG/DSC measurements. For evolved gas detection, the qualitative reaction of chlorides with AgNO in an acidic solution was applied. The measurements were carried out in the temperature range to 700 °C in nitrogen atmosphere. Compounds of L[RuCl(η- p-cymene)] crystallize with water or water/2-propanole. On the basis of thermal data, the trend in the solvent bonding energies was assessed. [ABSTRACT FROM AUTHOR]

Abstract: Three new ruthenium(II) complexes 1–3 containing N-alkylphenothiazine molecules were synthesized by reaction of [RuCl2(η6-p-cymene)]2 with chlorpromazine hydrochloride (1), trifluoperazine dihydrochloride (2) or thioridazine hydrochloride (3). The compounds of the general formula L[RuCl3(η6-p-cymene)] were characterized by elemental analysis and spectroscopic methods (FT-IR, UV–Vis, 1H and 13C NMR). Complex 2 was structurally characterized by single crystal X-ray diffraction. In vitro cytotoxic activity of complexes 1–3 were assayed in four human carcinoma cell lines MCF-7, MDA-MB-453 (breast carcinoma), SW-480 (colon carcinoma) and IM9 (myeloma multiple cells). The highest cytotoxicity (12.1 ≤ IC50 ≤ 17.3 μM) and induced a total (SW-480) or almost total cell death (MCF-7, MDA-MB-453) at 25 μM in 48 h of treatment were observed for complex 2. The influence of three different doses (0.4, 4.5 and 90.4 μM/kg bw) of complex 2 on activities of antioxidants enzymes (superoxide dismutase (SOD) and catalase (CAT)) and lactate dehydrogenase (LDH) were investigated under physiological conditions. The effects on nitrite production () and level of erythrocytes malondialdehyde (MDA) in rats blood were evaluated, too. [Copyright &y& Elsevier]

Abstract: Three new complexes of the general formula L[RuCl3(DMSO)3] (1–3), where L = chlorpromazine hydrochloride, trifluoroperazine dihydrochloride or thioridazine hydrochloride, were prepared and characterized by elemental analysis and spectroscopic methods (FT-IR, UV–Vis, 1H NMR and 13C NMR). In addition, the crystal structure of the complex 2 containing trifluoroperazine dihydrochloride was solved by single crystal X-ray diffraction. The complex crystallizes in the monoclinic system, space group P21/n, with a = 10.4935(7) Å, b = 18.6836(12) Å, c = 19.9250(13) Å, β = 98.448(2)°, V = 3864.0(4) Å3. The structure was refined to the agreement factors of R = 4.79%, R w = 11.23%. The effect of three different doses (0.4, 4.5 and 90.4 μM/kg bw) of complex 2 on superoxide dismutase (SOD) and catalase (CAT) activity was investigated under physiological conditions. Influence on nitrite production (NO2 −) and the level of erythrocytes malondialdehyde (MDA) in rats blood was also evaluated. Complex 2 did not affect the CAT enzyme activity in vivo and did not cause the hydroxyl radicals production. In the 0.4 and 4.5 μM/kg bw doses it showed almost the same or lower SOD activity and nitrite levels, while the dose of 90.4 μM/kg bw significantly increased these parameters. Finally, the cytotoxicity of complexes were assayed in four human carcinoma cell lines MCF-7, MDA-MB-453 (breast carcinoma), SW-480 (colon adenocarcinoma) and IM9 (myeloma multiple cells). Antiproliferative activity in vitro with low IC50 during 48 h of treatment was observed. [ABSTRACT FROM AUTHOR]