1. 2-Hydroxysorangiadenosine: Structure and Biosynthesis of a Myxobacterial Sesquiterpene–Nucleoside.
- Author
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Okoth, Dorothy A., Hug, Joachim J., Garcia, Ronald, Spröer, Cathrin, Overmann, Jörg, and Müller, Rolf
- Subjects
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ANTINEOPLASTIC antibiotics , *BIOSYNTHESIS , *NATURAL products , *NUCLEOSIDE synthesis , *MYXOBACTERALES , *METABOLOMICS , *METABOLITES - Abstract
Myxobacteria represent an under-investigated source for biologically active natural products featuring intriguing structural moieties with potential applications, e.g., in the pharmaceutical industry. Sorangiadenosine and the here-discovered 2-hydroxysorangiadenosine are myxobacterial sesquiterpene–nucleosides with an unusual structural moiety, a bicyclic eudesmane-type sesquiterpene. As the biosynthesis of these rare terpene–nucleoside hybrid natural products remains elusive, we investigated secondary metabolomes and genomes of several 2-hydroxysorangiadenosine-producing myxobacteria. We report the isolation and full structure elucidation of 2-hydroxysorangiadenosine and its cytotoxic and antibiotic activities and propose a biosynthetic pathway in the myxobacterium Vitiosangium cumulatum MCy10943T. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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