Search

Your search keyword '"Adela Chirita-Emandi"' showing total 4 results
Start Over Author "Adela Chirita-Emandi" Topic metabolic syndrome
4 results on '"Adela Chirita-Emandi"'

1. Use of a Micronutrient Cocktail to Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Adults with Obesity: A Randomized, Double-Blinded Pilot Clinical Trial

Author

Iulia Teodora Perva, Iulia Elena Simina, Renata Bende, Alexandru Cătălin Motofelea, Adela Chirita Emandi, Nicoleta Andreescu, Alexandra Sima, Adrian Vlad, Ioan Sporea, Cristian Zimbru, Paul Calin Tutac, Maria Puiu, and Mihai Dinu Niculescu

Subjects
5-MTHF, betaine, choline, omega-3 fatty acids, vitamin B12, metabolic syndrome, Medicine (General), R5-920
Abstract

Background and Objectives: The goal of this study was to assess the impact of supplementation with a combination of nutrients on metabolic-dysfunction-associated steatotic liver disease (MASLD)-related liver parameters, and other parameters related to metabolic syndrome in adults with obesity. These measurements included anthropometric and lipid profiling, and FibroScan technology (controlled attenuation parameter (CAP) and transient elastography (TE) values). Materials and Methods: A double-blind, placebo-controlled pilot clinical trial was conducted over a three-month treatment period. Adults with metabolic syndrome and obesity were allocated to receive either a cocktail of nutrients with defined daily dosages (5-MTHF, betaine, alpha-linolenic acid, eicosapentaenoic acid, choline bitartrate, docosahexaenoic acid, and vitamin B12) or a placebo. The participants were evaluated at the start and the end of the three-month treatment period. Results: A total of 155 participants entered the study, comprising 84 in the treatment group and 71 in the placebo group. The administration of the nutritional supplement resulted in a notable reduction in both CAP and TE scores when compared to the placebo group. The treatment group exhibited a mean reduction in CAP of 4% (p < 0.05) and a mean reduction in TE of 7.8% (p < 0.05), indicative of a decline in liver fat content and fibrosis. Conclusions: The supplementation over a period of three months led to a significant amelioration of liver fibrosis and steatosis parameters in adults with metabolic syndrome and obesity. These findings suggest that this supplementation regimen could be a beneficial adjunct therapy for improving liver health in adults with obesity-induced MASLD.

Published
2024
Full Text
View/download PDF

2. CHDH-PNPLA3 Gene–Gene Interactions Predict Insulin Resistance in Children with Obesity

Author

Corina Paul, Nicoleta Andreescu, Costela Lacrimioara Serban, Iulian Velea, Paul Tutac, Alexandra Mihailescu, Diana-Andreea Tiugan, Adela Chirita-Emandi, Cristian G. Zimbru, Maria Puiu, Mihai D. Niculescu, and Vlad Serafim

Subjects
Pharmacology, medicine.medical_specialty, business.industry, Fatty liver, 030209 endocrinology & metabolism, Single-nucleotide polymorphism, 030204 cardiovascular system & hematology, medicine.disease, Obesity, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Insulin resistance, Endocrinology, Gene interaction, chemistry, Internal medicine, Internal Medicine, medicine, Homeostatic model assessment, Choline, Metabolic syndrome, business
Abstract

Introduction Insulin resistance plays a major role in metabolic syndrome and is recognized as the most common risk factor for non-alcoholic fatty liver disease (NAFLD). Identifying predictors for insulin resistance could optimize screening and prevention. Purpose To evaluate the contribution of multiple single nucleotide polymorphisms across genes related to NAFLD and choline metabolism, in predicting insulin resistance in children with obesity. Methods One hundred fifty-three children with obesity (73 girls), aged 7-18 years, were evaluated within the NutriGen Study (ClinicalTrials.gov-NCT02837367). Insulin resistance was defined by Homeostatic Model Assessment for insulin-resistance cut-offs that accommodated pubertal and gender differences. Anthropometric, metabolic, intake-related variables, and 55 single nucleotide polymorphisms related to NAFLD and choline metabolism were evaluated. Gene-gene interaction effects were assessed using Multiple Data Reduction Software. Results Sixty percent (93/153) of participants showed insulin resistance (58.7% of boys, 63% of girls). Children with insulin resistance presented significantly higher values for standardized body mass index, triglycerides, transaminases and plasma choline when compared to those without insulin resistance. Out of 52 single nucleotide polymorphisms analysed, the interaction between genotypes CHDH(rs12676) and PNPLA3(rs738409) predicted insulin resistance. The model presented a 6/10 cross-validation consistency and 0.58 testing accuracy. Plasma choline levels and alanine aminotransferase modulated the gene interaction effect, significantly improving the model. Conclusion The interaction between genotypes in CHDH and PNPLA3 genes, modulated by choline and alanine aminotransferase levels, predicted insulin-resistance status in children with obesity. If replicated in larger cohorts, these findings could help identify metabolic risk in children with obesity.

Published
2020

3. No clinical utility of common polymorphisms in IGF1, IRS1, GCKR, PPARG, GCK1 and KCTD1 genes previously associated with insulin resistance in overweight children from Romania and Moldova

Author

Chiril Boiciuc, Paul Tutac, Maria Puiu, Adela Chirita-Emandi, Nicoleta Andreescu, Victoria Sacara, Corina Paul, Iulian Velea, Natalia Usurelu, Agneta Maria Pusztai, Lorina Vudu, Diana Munteanu, and Victoria Hlistun

Subjects
Male, Pediatric Obesity, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, Type 2 diabetes, Protein Serine-Threonine Kinases, 030204 cardiovascular system & hematology, Overweight, Polymorphism, Single Nucleotide, Body Mass Index, Germinal Center Kinases, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Insulin resistance, Internal medicine, Diabetes mellitus, medicine, Humans, Obesity, Insulin-Like Growth Factor I, Child, Adaptor Proteins, Signal Transducing, Romania, business.industry, Insulin, Moldova, Prognosis, medicine.disease, PPAR gamma, Repressor Proteins, Case-Control Studies, Child, Preschool, Pediatrics, Perinatology and Child Health, Insulin Receptor Substrate Proteins, Homeostatic model assessment, Female, Insulin Resistance, medicine.symptom, Metabolic syndrome, business, Co-Repressor Proteins, Biomarkers, Follow-Up Studies
Abstract

Background Previous genome-wide association studies (GWAS) identified IGF1, IRS1, GCKR, PPARG, GCK1 and KCTD1 as candidate genes for insulin resistance and type 2 diabetes (T2D). We investigated the associations of these previously reported common variants in these genes with insulin resistance in overweight children from Romania and Moldova. Methods Six single nucleotide polymorphisms (SNPs), IGF1 (rs35767), IRS1 (rs2943634), GCKR (rs780094), PPARG (rs1801282), GCK1 (rs1799884) and KCTD15 (rs29941), were genotyped in 100 overweight children along with clinical and metabolic parameters. Homeostatic model assessment of insulin resistance (HOMA-IR) above 3.4 (defining insulin resistance) was used as the outcome. Results Children differed in insulin resistance status despite having similar body mass index (BMI) standard deviation scores (SDS) (World Health Organization, [WHO] reference). The identified predictors for altered insulin metabolism were higher cholesterol levels, higher diastolic blood pressure and higher waist-to-hip-ratio (as a marker for increased abdominal fat). None of the SNPs showed significant association with increase in the risk for insulin resistance in children (p range=0.478–0.724; odds ratio [OR] range=1.924–4.842); however, the risk allele in GCKR (rs780094, p=0.06, OR=6.871) demonstrated near statistical significance. Conclusions The interrogated risk alleles did not show any significant association with insulin resistance in children in our cohort; however, the GCKR (rs780094) might be a viable candidate in larger cohorts. The lack of replication of the proposed association may point to differences in linkage disequilibrium or effect modifiers across studies.

Published
2019

4. The Role of Acanthosis Nigricans in Identifying Clinical and Metabolic Features of the Metabolic Syndrome in Obese Children.

Author

Corina, Duncescu, Monica, Mărăzan, Adela, Chirita-Emandi, Teodora, Craioveanu, Camelia, Dăescu, Sabău, I., and Ioana, Micle

Subjects
*ACANTHOSIS nigricans, *PIGMENTATION disorders, *METABOLIC syndrome, *INSULIN resistance, *CHILDHOOD obesity, *GLUCOSE metabolism, *BODY mass index, *BLOOD testing
Abstract

Background: Acanthosis nigricans (AN) is a dermatologic marker of hyperinsulinemia and has been linked with metabolic syndrome in adults. In children, the relationship between AN and different components of the metabolic syndrome has received mixed research results. We investigated whether the clinical and metabolic profile of obese children with AN was different from those without AN. Material and methods: We studied retrospectively the observation charts of children who were evaluated in our clinic for obesity and/or anomalies of glucose metabolism from January 1st 2005 to December 31st 2009. The study population consisted of 52 children. The analyzed data included: age, sex, body mass index (BMI), the presence or absence of AN, systolic and diastolic blood pressure, the results of the oral glucose tolerance test, triglycerides and high-density lipoprotein (HDL) cholesterol levels, baseline insulin, the homeostatic model assessment: insulin resistance (HOMA-IR), glicated hemoglobin. We divided our study population into two groups according to the presence or absence of AN. We used One-Way ANOVA to evaluate the clinical and metabolic differences between the two study groups. Results: We found significant differences between the two groups for BMI, systolic and diastolic blood pressure, triglycerides, HDL cholesterol, baseline insulin and HOMA-IR. Conclusions: Our study shows that AN seems to be linked with most of the features of the metabolic syndrome in children. The relationship of AN and anomalies of glucose metabolism need further testing. [ABSTRACT FROM AUTHOR]

Published
2011

Catalog

Books, media, physical & digital resources
See catalog results