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Background. Research is crucial to the development of society. The literature on the challenges for scientific development highlights that chronic stress in researchers can affect their academic production and their physical and mental health. Although some literature reports the consequences of stress in the academic field, most studies are carried out on students, and there is very little knowledge on the characteristics of stress because of simultaneous academic, occupational, and socio-personal demands. Objective. To analyze and contrast the methodological components and main results of stress-related studies on researchers. Method. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guide was used to analyze current evidence in the literature. Full-text scientific papers from the period 2008-2019 were included in both English and Spanish, on subjects engaged in research and teaching. The databases used were Scopus, Ebsco, Dialnet, and Web of Science. Results. One hundred and eighty records were obtained, but only four met the criteria for the qualitative evaluation. Discussion and conclusion. Stress is present in the 20% of subjects associated with psychological (lack of control, emotional fatigue, overload, multi-tasking) and institutional variables (evaluation system demands, tenure track, lack of scientific recognition). The studies emphasize aspects that predispose and precipitate stress but do not highlight psychological aspects of the stressful experience. [ABSTRACT FROM AUTHOR]