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Pancreatic carcinoma (PC) easily invades the peripancreatic arteries, which is the main reason for the poor prognosis. This meta-analysis aimed to investigate the perioperative outcomes and long-term survival of pancreatectomy combined with arterial resection (AR) in PC patients with arterial infiltration. We searched the Medline, EMbase, and Cochrane Library and used the Review Manager 5.3. A total of 11 studies were reviewed, including 1829 patients who underwent pancreatectomy or palliative therapies, of whom 205 received AR. The results showed that AR was associated with a longer operation time (MD = 87.05, P < 0.00001), higher blood loss (MD = 422.73, P < 0.00001), and an increased risk for overall complication (OR = 2.10, P < 0.0001), postpancreatectomy hemorrhage (PPH) (OR = 3.32, P = 0.003), and reoperation (OR = 2.38, P = 0.001). The occurrence of postoperative pancreatic fistula (POPF) (OR = 1.66, P = 0.05), delayed gastric emptying (DGE) (OR = 2.15, P = 0.13), and perioperative mortality (OR = 1.94, P = 0.06) seemed higher in AR group. Pancreatectomy with AR showed a better survival at 1 year (OR = 1.55, P = 0.05), 3 years (OR = 1.78, P = 0.04), and 5 years (OR = 3.24, P = 0.03). Therefore, we concluded that pancreatectomy with AR could be conducted under the comprehensive consideration of patients' conditions, and it may be especially beneficial for those who have the probability to achieve R0 resection. [ABSTRACT FROM AUTHOR]

Background: Cholangiocarcinoma (CCA) is the second most common fatal primary hepatobiliary malignant carcinoma, characterized by early invasion and extremely poor outcomes. It is therefore necessary to identify a novel biomarker to better diagnose CAA and predict its prognosis. Recently, emerging evidence has revealed that some lncRNAs play an important role in the tumorigenesis and progression of CAA. In order to support this search for novel diagnostic and prognostic biomarkers for CAA, we conducted a meta-analysis to analyze the published association between lncRNA expression and its clinical value in CAA. Methods: Eligible studies were pooled and analyzed according to our inclusion and exclusion criteria after a comprehensive literature search. Stata 14.0 software was used to analyze the data from relevant studies and to construct a forest plot. Different effect sizes were selected for the meta-analysis. Results: In total, 24 publications were included in this meta-analysis. After review of their full-text, 16 articles studied the association between lncRNAs and clinicopathological characteristics, 2 discussing diagnosis and 16 discussing prognosis. Our results showed that overexpression of CCAT1 was significantly correlated with tumor stage (I + II vs III + IV) (OR, 4.99; 95% CI 2.77–8.99; P<0.001) and lymph node metastasis in CCA (OR, 4.75; 95% CI 2.65–8.52; P<0.001). Furthermore, elevated CCAT lncRNA family expression predicted a shorter overall survival (HR, 2.09; 95% CI 1.17–3.00; P<0.001), especially CCAT2. Upregulation of CCAT2 was also obviously associated with tumor stage in CCA (OR, 5.29; 95% CI 2.64–10.58; P=0.001). Conclusion: This is the first meta-analysis to assess the relationship between expression of lncRNAs and the clinical values of patients with CCA. lncRNAs can function as potential molecular biomarkers of the clinicopathology and prognosis of CCA. [ABSTRACT FROM AUTHOR]

Background: ACYP2 gene may be involved in the process of telomere shortening which may be involved in the liver cancer. So, this research was to examine whether the ACYP2 gene polymorphism has impact on the risk of liver cancer in Chinese population. Methods: Two hundred and fifty cirrhosis patients and 248 liver cancer patients were selected. Unconditional logistic regression was to calculate the odds ratio (OR) and 95% confidence intervals (CIs). Analyze the relationship between ACYP2 gene polymorphism and tumor using meta‐analysis. Analyze the expression of ACYP2 gene in liver cancer and its influence on the prognosis of liver cancer by databases (Ualcan, GTEX and Kaplan–Meier plotter). Results: In the allele model, ACYP2 rs843720 was protection against the occurrence of cirrhosis developed into liver cancer (OR = 0.76, 95% CI: 0.58–0.99, p = 0.04). Rs1682111 and rs843720 play a protective role in the additive model (rs1682111: OR = 0.69, 95% CI: 0.52–0.93, p = 0.01; rs843720: OR = 0.73, 95% CI: 0.54–0.98, p = 0.04).While rs843645 G allele increased the risk of cirrhosis developed into liver cancer under the additive model (OR = 1.42, 95% CI: 1.02–2.00, p = 0.04).The haplotype analysis detected that "ATATCGCC" decreased the risk of cirrhosis developed into liver cancer (OR = 0.69, 95% CI: 0.51–0.92, 95% CI: p = 0.013); however, "TGAGCGTC" increased the risk of cirrhosis developed into liver cancer (OR = 1.48, 95% CI: 1.04–2.10, p = 0.027). Meta‐analysis shown that ACYP2 rs1682111 was associated with the risk of cancer (OR = 0.90, 95% CI: 0.78–1.05, p = 0.02). ACYP2 gene high expression was found to be associated with better OS for all liver patients. Conclusion: Based on this research, we surmised that ACYP2 gene may be involved in the occurrence of liver cancer in Chinese populations. [ABSTRACT FROM AUTHOR]