19 results on '"Li, Jue"'
Search Results
2. Optimal duration of Vitamin K antagonists anticoagulant therapy after venous thromboembolism: a systematic review and network meta-analysis of randomized controlled trials
- Author
-
Wang, Wei, Su, Yang, Wu, Chunyan, Sun, Yuxi, Dai, Neng, Chen, Wei, Zhang, Jie, Xu, Yawei, Brindis, Ralph G, Xu, Dachun, and Li, Jue
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Research ,Prevention ,Clinical Trials and Supportive Activities ,Hematology ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Cardiovascular ,Adult ,Aged ,Aged ,80 and over ,Anticoagulants ,Drug Administration Schedule ,Hemorrhage ,Humans ,Middle Aged ,Randomized Controlled Trials as Topic ,Recurrence ,Risk Assessment ,Risk Factors ,Time Factors ,Treatment Outcome ,Venous Thromboembolism ,Vitamin K ,Young Adult ,Meta-analysis ,Venous thromboembolism ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology - Abstract
BACKGROUND:The optimal duration of oral anticoagulant therapy for patients with venous thromboembolism (VTE) remains highly uncertain in clinical practice. It is essential to accurately assess the effect of anticoagulant therapy in reducing recurrent VTE against the risk of inducing major bleeding. METHODS:Randomized controlled trials were identified by searching PubMed, Web of Science, Embase, and the Cochrane library, reporting rates of recurrent VTE and major bleeding in patients taking Vitamin K Antagonists (VKA) with VTE and comparing different durations. RESULTS:Eleven RCTs with 3109 participants utilizing varied durations were included in the meta-analysis. Longer VKA therapy was associated with significantly lower rates of VTE recurrence compared with shorter duration of VKA therapy (OR 0.75, 95%CI 0.57-0.99), with significant difference noted in major bleeding risk (OR 2.31, 95%CI 1.17-4.56). During anticoagulation duration, patients treated by 6-month VKA had higher risk of major bleeding compared with 3-month VKA regimen (OR 33.45, 95%CI 2.00-559.67). CONCLUSIONS:Regimen longer than 6 months did not show statistical elevation of major bleeding risk. VKA treatment strongly reduces the risk of recurrent VTE during anticoagulation therapy. The absolute risk of recurrent VTE declines over time while the risk for major bleeding after 6 months' treatment did not demonstrate a continuous significant increase with extended duration of VKA therapy.
- Published
- 2020
3. Prehypertension A Meta-Analysis of the Epidemiology, Risk Factors, and Predictors of Progression
- Author
-
Guo, Xiaofan, Zou, Liling, Zhang, Xingang, Li, Jue, Zheng, Liqiang, Sun, Zhaoqing, Hu, Jian, Wong, Nathan D., and Sun, Yingxian
- Subjects
Adult ,blood glucose/analysis ,blood pressure ,body mass index ,cholesterol ,HDL/blood ,cholesterol ,LDL/blood ,cross-sectional studies ,disease susceptibility ,hypertension/diagnosis/epidemiology/etiology/prevention & control ,longitudinal studies ,meta-analysis ,obesity ,prehypertension/epidemiology/etiology/prevention & control ,prevalence ,risk factors ,triglycerides/blood ,waist circumference - Abstract
We investigated the prevalence and risk factors of prehypertension, as well as the predictors of progression from prehypertension to hypertension. To do this, we performed a systematic review and meta-analysis of cross-sectional and longitudinal studies, after unrestricted searches of PubMed and The Cochrane Library through September 2010. In addition, we reviewed references, major textbooks, and review articles. Pooled prevalence, standardized mean differences, and odds ratios were estimated by using a random-effects model.Twenty-six articles met our inclusion criteria; these included 20 cross-sectional and 6 longitudinal studies, with a total sample of 250,741 individuals. The overall pooled prevalence of prehypertension was 36%. The pooled prevalence among males was higher than that among females (40% vs 33%). The pooled standardized mean difference for body mass index was 1.37 (95% confidence interval [CI], 1.20–1.55); for total cholesterol, 8.08 (95% CI, 6.71–9.46); for low-density-lipoprotein cholesterol, 5.14 (95% CI, 3.09–7.18); and for fasting plasma glucose, 4.23 (95% CI, 3.28–5.18); all of which showed more significant results in females. The pooled odds ratio was 1.13 (95% CI, 0.93–1.37) for smoking and 0.98 (95% CI, 0.69–1.39) for drinking. In addition, factors such as older age at baseline, male sex, Mongolian race, and being overweight or obese were predictors of progression to hypertension, according to descriptive analysis.The prevalence of prehypertension was relatively high, especially for males. There were many modifiable risk factors associated with prehypertension, to which healthcare providers should pay more attention.
- Published
- 2011
4. Prognostic value of TGF-β in lung cancer: systematic review and meta-analysis
- Author
-
Li, Jue, Shen, Cheng, Wang, Xin, Lai, Yutian, Zhou, Kun, Li, Pengfei, Liu, Lunxu, and Che, Guowei
- Published
- 2019
- Full Text
- View/download PDF
5. Comparison of the short‐ and long‐term prognosis of early‐onset colorectal cancer compared with later‐onset colorectal cancer: A systematic review and meta‐analysis.
- Author
-
Jin, Taojun, Li, Xinxing, Ji, Jianmei, Li, Jue, Yin, Xiaomao, Xu, Kai, Wang, Wenqiang, Zhang, Wei, Xu, Xiaowen, Hu, Zhiqian, and Gong, Biao
- Abstract
Background and Aims: The annual incidence of early‐onset colorectal cancer (EOCRC) is increasing at an alarming rate. The prognosis of EOCRC remains controversial, and whether the early onset is a risk factor for colorectal cancer remains unclear. Methods: We searched four electronic bibliographic databases from database inception to April 25, 2022 for studies that included both early‐ and later‐onset patients and performed a prognostic analysis. Random‐effects models were used to summarize the prognostic information extracted by the investigators, including overall survival (OS), cancer‐special survival (CSS), and disease‐free survival (DFS). Network meta‐analysis (NMA) was used to compare patients' long‐term prognoses in different age subgroups. Results: After 694 reports were screened, 13 studies were included in the final analysis, with a total of 448,781 CRC cases. In the meta‐analysis of the 5‐year OS, EOCRC had a better prognosis compared to LOCRC (hazard ratio [HR] 0.87, 95% confidence interval [CI], 0.74–0.99; relative risk [RR] 0.83, 95% CI, 0.78–0.89). No difference in prognosis was found between the two groups in terms of 5‐year CSS (RR 0.99, 95% CI, 0.93–1.05), 5‐year DFS (RR 0.90, 95% CI, 0.74–1.09), and short‐term OS. In the NMA, patients aged <30 years had the worst outcome (surface under the cumulative ranking curve [SUCRA], 15.8%) in 5‐year OS; consistent results were observed in the analysis of 5‐year CSS (<30 years, SUCRA 4.5%), but the difference was not statistically significant. Conclusion: Although patients with early‐onset CRC had better OS than those with later‐onset CRC, there was no difference in the CSS. Meanwhile, the trend for survival was worse in younger patients, especially in those ages 18–29 years. Thus, more attention should be paid to early diagnosis and treatment of EOCRC. Systematic Review and Meta‐Analysis Registration: The systematic review and Meta‐analysis protocol was registered with PROSPERO (registration number CRD42022334697). [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
6. The Influence of Overminus Lens Therapy on Control of Intermittent Exotropia: A Meta-Analysis of Randomized Clinical Trials.
- Author
-
Song, Desheng, Li, Jue, Qian, Jing, Lou, Bin, and Chen, Zhijun
- Abstract
Intermittent exotropia (IXT) is the most common type of strabismus, overminus lens (OML) therapy is frequently prescribed to treat IXT.Background: The purpose of this study was to compare the effectiveness of OML and observation in the treatment of IXT.Objectives: An exhaustive search of the literature in PubMed, Embase, Web of Science, and Cochrane Library databases was performed until July 2022. No language restrictions were used. The literature was rigorously screened according to eligibility criteria. Weighted mean differences and 95% confidence intervals (CIs) were calculated.Method: A total of 4 articles with 561 participants were included in this meta-analysis. Our pooled results showed that OML demonstrated superior outcomes compared with observation, with greater decreases in distance and near exodeviation control (MD = −1.08, 95% CI: −1.96 to −0.20,Results: p = 0.02; MD, −0.64, 95% CI: −1.15 to −0.13,p < 0.001). Patients who received OML therapy had a greater decrease in the deviation at both distance and near (MD = −4.00, 95% CI: −7.03 to −0.98,p < 0.001; MD = −4.79, 95% CI: −6.29 to −3.30,p < 0.001). There was no statistical difference between the two groups in terms of post-treatment proximal stereopsis (MD, 0.00, 95% CI: −0.08 to 0.08,p = 1.00). The present meta-analysis indicated that OML therapy was effective in improving the control and decreasing exodeviation angle of IXT. However, it seemed not to be effective in improving the level of near stereopsis. [ABSTRACT FROM AUTHOR]Conclusions: - Published
- 2023
- Full Text
- View/download PDF
7. Association Between Pre-hypertension and Cardiovascular Outcomes: A Systematic Review and Meta-analysis of Prospective Studies
- Author
-
Guo, Xiaofan, Zhang, Xiaoyu, Guo, Liang, Li, Zhao, Zheng, Liqiang, Yu, Shasha, Yang, Hongmei, Zhou, Xinghu, Zhang, Xingang, Sun, Zhaoqing, Li, Jue, and Sun, Yingxian
- Published
- 2013
- Full Text
- View/download PDF
8. The prognostic value of pretreatment Glasgow Prognostic Score in patients with esophageal cancer: a meta-analysis
- Author
-
Wang, Yan, Li, Pengfei, Li, Jue, Lai, Yutian, Zhou, Kun, Wang, Xin, and Che, Guowei
- Subjects
meta-analysis ,Review ,esophageal cancer ,survival ,Glasgow Prognostic Score - Abstract
Objectives To examine the predictive role of Glasgow Prognostic Score (GPS) on long-term survival in esophageal cancer. Method Comprehensive searches of electronic databases were performed to identify potential studies that evaluated the prognostic value of pretreatment GPS in esophageal cancer patients. We combined the hazard ratios (HRs) with 95% confidence intervals (CIs) to assess the association of GPS with overall survival (OS), disease-free survival (DFS) and cancer-specific survival (CSS). Results A total of 21 studies including 6115 patients were analyzed. Compared with patients with GPS 0, patients with elevated GPS had poorer OS (HR =2.12, 95% CI: 1.83–2.45, P
- Published
- 2019
9. Efficacy and safety of Qishen Yiqi dripping pills as a complementary treatment for Heart Failure
- Author
-
Guan, Hui, Dai, Guohua, Ren, Lili, Gao, Wulin, Fu, Haoran, Zhao, Zepeng, Liu, Xin, and Li, Jue
- Subjects
Heart Failure ,complementary treatment ,qishen yiqi dripping pills ,Patient Readmission ,meta-analysis ,Treatment Outcome ,Meta-Analysis as Topic ,Research Design ,Cause of Death ,Study Protocol Systematic Review ,Humans ,Research Article ,Drugs, Chinese Herbal ,Randomized Controlled Trials as Topic ,Systematic Reviews as Topic - Abstract
Background: Heart failure (HF) has become a serious global public health issue due to its high incidence, high mortality and extremely low quality of life. According to several clinical trials, Qishen Yiqi Dripping pills (QSYQ) combined with routine western medicine treatment can further enhance the curative effect of HF patients. However, most of the trials are small in sample size and poor in quality, which can only provide limited evidence-based medicine. The existing systematic reviews of efficacy and safety has provided evidence for the clinical application of QSYQ to a certain extent, but there are still 3 major defects. Here, we will perform a systematic review and meta-analysis that include the randomized clinical trial (RCT) of CACT-IHF, apply meta-regression and subgroup analysis to cope with multiple confounding factors, and add the clinical efficacy standards of TCM, all-cause death and readmission rates as reliable efficacy evaluation indicators. The purpose of this study was to rigorously evaluate the clinical efficacy and safety of QSYQ in the complementary treatment of HF with a well-designed systematic review and meta-analysis. Methods: Following the strict search strategy, 9 databases will be searched to ensure a comprehensive search. We search the database from the establishment until November 30, 2020. This study will include RCTs of QSYQ in HF patients’ complementary treatment. Two searchers will independently draft and carry out the search strategy, and the third member will further complete it. Two members independently screen literature, extract data and cross-check, and solve different opinions through discussion or negotiation with the third member. The risk bias will be evaluated based on Cochrane tool of risk of bias. Meta-regression and subgroup analysis are used to check and deal with the heterogeneity. The data analysis will be conducted by the statistical software Stata 16.0. Results: The results of this research will be delivered in a peer-reviewed journal. Conclusion: This study expects to provide credible and scientific evidence for the efficacy and safety of QSYQ in HF's complementary treatment, and at the same time provide a convenient and effective choice for decision-makers and patients. Protocol registration number: INPLASY 2020120106. Ethical approval: Since this study is on the basis of published or registered RCTs, ethical approval and informed consent of patients are not required.
- Published
- 2021
10. Robot‐assisted thoracic surgery versus video‐assisted thoracic surgery for treatment of patients with thymoma: A systematic review and meta‐analysis.
- Author
-
Shen, Cheng, Li, Jialong, Li, Jue, and Che, Guowei
- Subjects
ONLINE information services ,LENGTH of stay in hospitals ,THYMOMA ,META-analysis ,MEDICAL databases ,INFORMATION storage & retrieval systems ,MEDICAL information storage & retrieval systems ,SURGICAL robots ,THORACIC surgery ,SYSTEMATIC reviews ,SURGICAL complications ,CANCER patients ,VIDEO-assisted thoracic surgery ,MEDLINE ,DATA analysis software ,MEDICAL drainage - Abstract
Background: Surgical resection of the thymus is indicated in the presence of primary thymic diseases such as thymoma. Video‐assisted thoracoscopic surgery (VATS) and robot‐assisted thoracic surgery (RATS) offer a minimally invasive approach to thymectomy. However, there is no clear conclusion whether RATS can achieve an equal or even better surgical effect when compared with VATS in treatment of thymoma. We performed this meta‐analysis to explore and compare the outcomes of RATS versus VATS for thymectomy in patients with thymoma. Methods: PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure (CNKI), Medline, and Web of Science databases were searched for full‐text literature citations. The quality of the articles was evaluated using the Newcastle–Ottawa Scale and the data analyzed using Review Manager 5.3 software. Fixed or random effect models were applied according to heterogeneity. Subgroup analysis was conducted. Results: A total of 11 studies with 1418 patients, of whom 688 patients were in the RATS group and 730 in the VATS group, were involved in the analysis. Compared with VATS, RATS was associated with less blood loss in operation, lower volume of drainage, fewer postoperative pleural drainage days, shorter postoperative hospital stay, and fewer postoperative complications. There was no significant difference in operative time and patients with or without myasthenia gravis between the two groups. Conclusions: RATS has more advantages over VATS, indicating that RATS is better than VATS in terms of postoperative recovery. We look forward to more large‐sample, high‐quality randomized controlled studies published in the future. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
11. Prognostic Value of Pretreatment Albumin to Globulin Ratio in Lung Cancer: A Meta-Analysis.
- Author
-
Li, Jue, Wang, Yan, Wu, Yanming, Li, Jialong, and Che, Guowei
- Subjects
- *
GLOBULINS , *INFORMATION storage & retrieval systems , *MEDICAL databases , *MEDICAL information storage & retrieval systems , *LUNG tumors , *MEDLINE , *META-analysis , *ONLINE information services , *SYSTEMATIC reviews , *ALBUMINS - Abstract
Objective: To explore the predictive role of pretreatment albumin to globulin ratio (AGR) for prognosis in lung cancer. Methods: A comprehensive literature retrieval was performed in the PubMed, Cochrane Library, Web of Science and EMBASE databases up to May 20, 2019. The pooled hazard ratio (HR) and 95% confidence interval (CI) were applied to assess the correlation of pretreatment AGR with overall survival (OS) and disease-free survival (DFS). Sensitivity analysis was performed to assess the stability of results. Bess's funnel plot and Egger's test were conducted to detect potential publication bias. Results: Eight articles involving 3496 patients were included in our meta-analysis and all studies were from Asian countries. The results demonstrated that a low pretreatment AGR was significantly associated with poor OS (HR = 1.88, 95% CI: 1.49–2.38, P<0.001) and DFS (HR = 2.09, 95% CI: 1.56–2.81, P<0.001) and sensitivity analysis indicated the stability of above results. Publication bias test showed that there were two potentially unpublished articles, but they did not have a significant influence on the results of our meta-analysis. Conclusion: Our study manifested that pretreatment AGR was a reliable predictor for survival and it may contribute to the risk evaluation and therapy strategy formulation of lung cancer patients. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
12. Clinical Significance of PIK3CA Gene in Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis.
- Author
-
Wang, Yi, Wang, Yan, Li, Jialong, Li, Jue, and Che, Guowei
- Subjects
LUNG cancer prognosis ,GENE expression ,MEDICAL information storage & retrieval systems ,MEDLINE ,META-analysis ,GENETIC mutation ,ONLINE information services ,TRANSFERASES ,SYSTEMATIC reviews - Abstract
Aim. To explore the clinicopathological and prognostic role of PIK3CA gene mutation and expression in non-small-cell lung cancer (NSCLC) patients. Methods. A systematic and comprehensive literature search was conducted through EMBASE (via OVID), Web of Science, and PubMed. Relative risks (RRs) and hazard ratios (HRs) with 95% confidence intervals (CIs) were combined to evaluate the relationship of the PIK3CA gene with clinicopathological parameters and the survival of NSCLC patients, respectively. Results. A total of 13 studies involving 3908 patients were analyzed in our study. Only lymph node metastasis status had an association with PIK3CA mutation (RR = 2.823 ; 95% CI: 1.128-7.065; P = 0.029). The results indicated that PICK3CA mutation was related with overall survival (OS) (HR = 1.55 ; 95% CI: 1.13-2.13; P = 0.007), progression-free survival (PFS) (HR = 1.48 ; 95% CI: 1.06-2.08; P = 0.023), and cancer-specific survival (CSS) (HR = 2.63 ; 95% CI: 1.00-6.92; P = 0.005). Furthermore, PIK3CA high expression was more prevalent in NSCLC patients with smoking history (RR = 2.42 ; 95% CI: 1.04-5.61; P = 0.040). However, no significant relation between PIK3CA expression and OS was found (HR = 0.80 ; 95% CI: 0.58-1.12; P = 0.193). Conclusion. PIK3CA mutation may affect lymph node metastasis and serve as a promising prognostic factor, and smoking may be related with PIK3CA high expression in NSCLC patients. However, more well-designed prospective researches are needed to verify the abovementioned findings. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
13. Prognostic value of pre-treatment red blood cell distribution width in lung cancer: a meta-analysis.
- Author
-
Wang, Yan, Zhou, Yaojie, Zhou, Kun, Li, Jue, and Che, Guowei
- Subjects
ERYTHROCYTES ,LUNG cancer ,META-analysis ,CANCER prognosis ,PROGRESSION-free survival ,FORECASTING - Abstract
Objective: In recent years, increasing studies found that pre-treatment red blood cell distribution width (RDW) could predict clinical outcomes in various cancers. However, the prognostic value of pre-treatment RDW in lung cancer was inconsistent. Therefore, we performed a meta-analysis to determine prognostic value of pre-treatment RDW in lung cancer. Methods: We performed a search in PubMed, The Cochrane Library, EMBASE (via OVID), Web of Science, CNKI, Wanfang, VIP, SinoMed databases, then we identified all records up to February 15, 2019. Outcomes of interest were overall survival (OS) and disease-free survival (DFS). Hazard ratios (HRs) and corresponding 95% confidence intervals (95% CIs) were calculated to assess the relevance of pre-treatment RDW to OS in lung cancer. Results: We included ten articles in total. Pooled results revealed that elevated pre-treatment RDW was significantly associated with poor OS (HR = 1.55, 95% CI: 1.26–1.92, p < 0.001) and DFS (HR = 1.53, 95% Cl: 1.15–2.05; p = 0.004) in lung cancer. Further subgroup analysis manifested that lung cancer patients with elevated pre-treatment RDW had worse prognosis. Conclusions: A higher value of pre-treatment RDW indicated worse survival of patients with lung cancer. RDW may serve as a reliable and economical marker for prediction of lung cancer prognosis. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
14. Effect of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on cardiovascular events in patients with heart failure: a meta-analysis of randomized controlled trials.
- Author
-
Chenhui Tai, Tianyi Gan, Liling Zou, Yuxi Sun, Yi Zhang, Wei Chen, Jue Li, Jian Zhang, Yawei Xu, Huihe Lu, Dachun Xu, Tai, Chenhui, Gan, Tianyi, Zou, Liling, Sun, Yuxi, Zhang, Yi, Chen, Wei, Li, Jue, Zhang, Jian, and Xu, Yawei
- Subjects
ANGIOTENSINS ,HEART failure ,ENZYME inhibitors ,LEFT heart ventricle ,MYOCARDIAL infarction ,ACE inhibitors ,ANGIOTENSIN receptors ,CARDIOVASCULAR diseases ,CLINICAL trials ,COMPARATIVE studies ,RESEARCH methodology ,MEDICAL cooperation ,META-analysis ,RESEARCH ,EVALUATION research ,TREATMENT effectiveness ,THERAPEUTICS - Abstract
Background: Heart failure (HF) remains a significant cause of morbidity and mortality. Multiple trials over the past several years have examined the effects of both angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) in the treatment of left ventricular dysfunction, both acutely after myocardial infarction and in chronic heart failure. Yet, there is still confusion regarding the relative efficacy of rennin-angiotensin-aldosterone system (RAAS) inhibition. Our study was conducted to assess efficacy of ACEIs and ARBs in reducing all-cause and cardiovascular mortality in heart failure patients.Methods: We included randomized clinical trials compared ACEIs and ARBs treatment (any dose or type) with placebo treatment, no treatment, or other anti-HF drugs treatment, reporting cardiovascular or total mortality with an observation period of at least 12 months. Data sources included Pubmed, EMBASE, the Cochrane Central Register of Controlled Trials. Dichotomous outcome data from individual trials were analyzed using the risk ratio measure and its 95%CI with random-effects/ fixed-effects models. We performed meta-regression analyses to identify sources of heterogeneity. All-cause mortality and CV mortality were thought to be the main outcomes.Results: A total of 47,662 subjects were included with a mean/median follow-up ranged from 12 weeks to 4.5 years. Of all 38 studies, 32 compared ACEIs with control therapy (included 13 arms that compared ACEIs with placebo, 10 arms in which the comparator was active treatment and 9 arms that compared ACEIs with ARBs), and six studies compared ARBs with placebo. ACEIs treatment in patients with HF reduced all-cause mortality to 11% (risk ratio (RR): 0.89, 95% confidence interval (CI): 0.83-0.96, p = 0.001) and the corresponding value for cardiovascular mortality was 14% (RR: 0.86, 95% CI: 0.78-0.94, p = 0.001). However, ARBs had no beneficial effect on reducing all-cause and cardiovascular mortality. In head-to-head analysis, ACEIs was not superior to ARBs for all-cause mortality and cardiovascular deaths.Conclusions: In HF patients, ACEIs, but not ARBs reduced all-cause mortality and cardiovascular deaths. Thus, ACEIs should be considered as first-line therapy to limit excess mortality and morbidity in this population. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
15. Does Drug-Eluting Bead Transcatheter Arterial Chemoembolization Improve the Management of Patients with Hepatocellular Carcinoma? A Meta-Analysis.
- Author
-
Han, Shilong, Zhang, Xiaoping, Zou, Liling, Lu, Chenhui, Zhang, Jun, Li, Jue, and Li, Maoquan
- Subjects
LIVER cancer patients ,DRUG-eluting stents ,CANCER chemotherapy ,ANTINEOPLASTIC agents ,LIVER cancer ,GASTROINTESTINAL tumors - Abstract
Background: Drug eluting beads (DEB) are relatively new embolic agents that allow sustained release of chemotherapeutic agents in a localized fashion to the tumor. This technique is associated with reduced systemic side effects relative to systemic chemotherapy and an increase in the dose of antineoplastic agent delivered to the lesion. The meta-analysis was undertaken to assess the effectiveness of DEB-transcatheter arterial chemoembolization (TACE) in the management of hepatocellular cancer. Methods: We searched the Web of Science, PubMed, EBSCO, EMBASE, the Wiley Library and Google Scholar for studies on DEB-TACE in the management of hepatocellular cancer from 1979 to April 2013. The risk of bias was assessed using RevMan 5·1. Random and fixed-effects meta-analytical models were used where indicated, and between-study heterogeneity was assessed. Disease control, complications and severe complications were recorded. Results: Five studies met the selection criteria, three RCTs and two case-control studies, published from 2010 to 2012, included 217 patients in the DEB-TACE group and 237 in the conventional-TACE group. There was no significance over disease control (OR 2.27, 95% CI 0.78–6.63) with moderate between-study heterogeneity (χ
2 = 6.83, degrees of freedom [df] = 3; p<0.08; I2 = 56%). Complications in both groups were assessed and no significant difference was observed (χ2 = 6.34, degrees of freedom [df] = 4; p<0.18; I2 = 37%). Severe complications were also assessed and no significant difference was observed (χ2 = 6.47, degrees of freedom [df] = 4; p<0.17; I2 = 38%). No publication bias relating to the above outcomes was detected by funnel plot. DEB-TACE benefited disease control without an increase in complications and severe complications. [ABSTRACT FROM AUTHOR]- Published
- 2014
- Full Text
- View/download PDF
16. Prehypertension Is Not Associated with All-Cause Mortality: A Systematic Review and Meta-Analysis of Prospective Studies.
- Author
-
Guo, Xiaofan, Zhang, Xiaoyu, Zheng, Liqiang, Guo, Liang, Li, Zhao, Yu, Shasha, Yang, Hongmei, Zhou, Xinghu, Zou, Lu, Zhang, Xingang, Sun, Zhaoqing, Li, Jue, and Sun, Yingxian
- Subjects
PREHYPERTENSION ,CAUSES of death ,CARDIOVASCULAR diseases ,EPIDEMIOLOGY ,CONFIDENCE intervals ,PREVENTIVE medicine ,HEALTH policy ,META-analysis - Abstract
Objectives: Quantitative associations between prehypertension or its two separate blood pressure (BP) ranges and cardiovascular disease (CVD) or all-cause mortality have not been reliably documented. In this study, we performed a comprehensive systematic review and meta-analysis to assess these relationships from prospective cohort studies. Methods: We conducted a comprehensive search of PubMed (1966-June 2012) and the Cochrane Library (1988-June 2012) without language restrictions. This was supplemented by review of the references in the included studies and relevant reviews identified in the search. Prospective studies were included if they reported multivariate-adjusted relative risks (RRs) and corresponding 95% confidence intervals (CIs) of CVD or all-cause mortality with respect to prehypertension or its two BP ranges (low range: 120–129/80–84 mmHg; high range: 130–139/85–89 mmHg) at baseline. Pooled RRs were estimated using a random-effects model or a fixed-effects model depending on the between-study heterogeneity. Results: Thirteen studies met our inclusion criteria, with 870,678 participants. Prehypertension was not associated with an increased risk of all-cause mortality either in the whole prehypertension group (RR: 1.03; 95% CI: 0.91 to 1.15, P = 0.667) or in its two separate BP ranges (low-range: RR: 0.91; 95% CI: 0.81 to 1.02, P = 0.107; high range: RR: 1.00; 95% CI: 0.95 to 1.06, P = 0.951). Prehypertension was significantly associated with a greater risk of CVD mortality (RR: 1.32; 95% CI: 1.16 to 1.50, P<0.001). When analyzed separately by two BP ranges, only high range prehypertension was related to an increased risk of CVD mortality (low-range: RR: 1.10; 95% CI: 0.92 to 1.30, P = 0.287; high range: RR: 1.26; 95% CI: 1.13 to 1.41, P<0.001). Conclusions: From the best available prospective data, prehypertension was not associated with all-cause mortality. More high quality cohort studies stratified by BP range are needed. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
17. GW28-e0594 Comparison of control fasting plasma glucose of exercise-only versus exercise-diet among a pre-diabetic population: A meta-analysis.
- Author
-
Zheng, Liang, Lan, Qin, Li, Jue, Liu, Zhongmin, and Fan, Huimin
- Subjects
- *
BLOOD plasma , *BLOOD sugar , *EXERCISE , *META-analysis , *CLINICAL trials - Published
- 2017
- Full Text
- View/download PDF
18. GW26-e1839 Efficacy of exercise-only versus exercise-diet in the prevention of type 2 diabetes among pre-diabetic population: A meta-analysis.
- Author
-
Zheng, Liang, Wang, Guanghua, Li, Jue, Persuitte, Gioia, Ma, Yunsheng, Liu, Zhongmin, and Fan, Huimin
- Subjects
- *
TYPE 2 diabetes prevention , *EXERCISE physiology , *PREDIABETIC state , *META-analysis , *CARDIAC research , *MEDICAL publishing - Published
- 2015
- Full Text
- View/download PDF
19. Epidemiological evidence for the link between sleep duration and high blood pressure: A systematic review and meta-analysis
- Author
-
Guo, Xiaofan, Zheng, Liqiang, Wang, Jun, Zhang, Xiaoyu, Zhang, Xingang, Li, Jue, and Sun, Yingxian
- Subjects
- *
EPIDEMIOLOGY , *HEALTH , *SLEEP , *BLOOD pressure , *HYPERTENSION , *SYSTEMATIC reviews , *META-analysis - Abstract
Abstract: Objectives: We aim to assess if the relationship between short or long sleep duration and hypertension is present among adults from epidemiological evidence and to investigate the relationship quantitatively. Methods: We performed a comprehensive search of cross-sectional and longitudinal studies using PubMed and the Cochrane Library through February 2012. Our search was supplemented by reviewing reference lists of original and relevant reviews. After the related data were extracted by two investigators independently, pooled odds ratios (ORs) or relative risks (RRs) were estimated using a random-effects model or a fixed-effects model. Publication bias was evaluated, while sensitivity and meta-regression analyses were performed. Results: Twenty-four adult studies met our inclusion criteria, with ages ranging from 18 to 106years. Twenty-one studies involving 225,858 subjects were included in the meta-analysis. The pooled results from the cross-sectional studies showed that short sleep duration was associated with a greater risk for hypertension (OR, 1.21; 95% confidence interval [CI], 1.09–1.34; P <0.001), and long sleep duration also increased the risk for hypertension (OR, 1.11; 95% CI, 1.04–1.18; P =0.003). There was no evidence of publication bias. Pooled analysis from the longitudinal studies indicated a significant association between short sleep duration and hypertension (RR, 1.23; 95% CI, 1.06–1.42; P =0.005), but an insignificant relationship between long sleep duration and hypertension (RR, 1.02; 95% CI, 0.91–1.14; P =0.732). The effects of sleep duration differed by gender, location of the population, and definitions of short or long sleep duration. Meta regression analysis including seven variables did not find the sources of heterogeneity. Conclusions: Among adults, a U-shaped relationship between habitual sleep duration and hypertension was found at the cross-sectional level. Short sleep duration was associated with a higher risk for hypertension even longitudinally. We must pay more attention to this lifestyle factor. [Copyright &y& Elsevier]
- Published
- 2013
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.