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OBJECTIVE: To systematically review the efficacy of Yixuesheng capsules in the treatment of irondeficiency anemia (IDA), so as to provide ideas for clinical medication. METHODS: The Cochrane Library, PubMed, Embase, CNKI, Wangfang Data and VIP databases were retrieved to collect randomized controlled trials (RCT) of Yixuesheng capsules in the treatment of IDA. The retrieval time was from the establishment of the data base to Nov. 2023. The tools for literature quality and Meta-analysis were Cochrane System Evaluator Manual and RevMan 5. 4 statistical software. RESULTS: Totally 13 RCTs were enrolled, including 1 295 patients. Meta-analysis showed that compared with simply supplement of iron, the combination of Yixuesheng capsules and iron supplements can improve the total effective rate (RR =1. 23, 95%CI =1. 17-1. 29, P<0. 000 01), hemoglobin (MD = 14. 85, 95%CI = 12. 65-17. 05, P<0. 000 01), erythrocyte (MD = 0. 77, 95%CI = 0. 41-1. 14, P<0. 000 1), mean erythrocyte volume (MD =6. 07, 95%CI =1. 75-10. 39, P = 0. 006), mean corpuscular hemoglobin (MD = 3. 62, 95%CI = 3. 14-4. 11, P< 0. 000 01), serum iron (MD = 3. 95, 95%CI = 2. 51-5. 38, P<0. 000 01) and serum ferritin (MD = 16. 49, 95%CI = 9. 00-23. 97, P < 0. 000 1) after treatment, the differences were statistically significant. However, there was no significant advantage in increasing the level of transferrin receptor after treatment (MD = -5. 42, 95%CI = -13. 51- 2. 67, P =0. 19) and reducing the incidence of adverse drug reactions (RR = 0. 69, 95%CI = 0. 42-1. 12, P = 0. 14). CONCLUSIONS: The combination of Yixuesheng capsules and iron supplements has certain advantages in the treatment of IDA, yet more high-level and large-scale RCT is needed to provide data support. [ABSTRACT FROM AUTHOR]

Objective To systematically evaluate the diagnostic value of metagenomic next-generation sequencing(mNGS) for detecting pulmonary infection. Methods PubMed, Embase, Web of Science, the Cochrane Library, CNKI, WanFang, VIP databases were searched for studies according to the criteria of inclusion and exclusion, enrolling literature recorded from database establishment to May 30,2022. Statistical analysis was performed by Meta-Discl. 4, RevMan5. 3 and STATA15.0 software. Results A total of 12 relevant studies were enrolled, including 1 154 patients. The results of meta-analysis showed that the pooled sensitivity was 0.82(95% CI 0.79-0.84, 189.1%), and the pooled specificity was 0.73 (95% CI 0.68 0.78, I² = 85.4%). The heterogeneity in sensitivity and specificity between studies was significant. The area under the curve (AUC) of the total subject operating characteristic curve (SROC) was 0.850, and the Q index was 0. 782. Conclusion The diagnostic performance of mNGS in the clinical application of lung infections is acceptable. [ABSTRACT FROM AUTHOR]

Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OBJECTIVE: To systematically evaluate the efficacy and safety of Fuyang granules combined with antihistamines in the treatment of chronic urticaria (CU). METHODS: PubMed, the Cochrane Library, EMBase, W anfang data base, CNKI and CBM database were retrieved to collect the randomized controlled trial ( RCT) of Fuyang granules combined with antihistamines in the treatment of CU ( the study group was given Fuyang granules combined with antihistamines, while the control group received antihistamines). The retrieval time was from the establishment of the database to May 2021. Meta-analysis was performed by using RevMan 5. 4 software after selection of literature, extraction of information and evaluation of risk of bias in the included literature by two researchers. RESULTS : Totally 10 RCT were collected, including 873 patients( 451 patients in the study group and 422 patients in the control group) . Meta-analysis showed that the total effective rate( OR= 4. 31, 95%CI = 2. 78-6. 68, P

Objective To evaluate the efficacy of Liuwei Dihuang pill on the treatment of postmenopausal osteoporosis(PMOP).Methods CNKI,CBM,VIP,WanFang,PubMed,Embase,and Cochrane library were systematically retrieved and the included studies were evaluated for the method ological quality. Meta-analysis was used with Review Manager 5. 3 software for data analysis. A total of 12 literatures and 14 studies were included. Results Meta-analysis showed that Liuwei Dihuang pill +conventional treatment regimen was effective in the treatment of postmenopausal osteoporosis[OR= 1. 22,95%CI(1. 13-1. 32),P<0. 00001]. The pain reduction was better[MD =-0. 50,95% CI(-0. 77-0. 22),P = 0. 0004]. The improvement effect on hip bone mineral density was better than that of conventional Western medicine group [MD = 0. 55,95% CI(0. 26-0. 84),P =0. 0002]. However,the improvement of lumbar vertebra density [MD = 0. 05,95% CI(0. 03 ～ 0. 07),P< 0. 0001]by using Liuwei Dihuang pill alone or combined with a single routine intervention was better than that of conventional Western medicine.Liuwei Dihuang pill alone had certain clinical advantages in improving radial bone mineral density [MD = 0. 02,95% CI(0. 02-0. 003),P< 0. 00001],ulna bone mineral density [MD = 0. 02,95% CI(0. 01-0. 03),P < 0. 0001]. Conclusion Liuwei Dihuang pill is effective in improving bone mineral density of the hip,the lumbar vertebra,the ulna,and the radius. It improves theefficacy and relieves the pain of PMOP. However,there is insufficient evidence to improve femoral neck density,which may be affected by various factors. At the same time,Liuwei Dihuang pill has an enhanced effect in combination with conventional treatment. Whether the combination of multiple drugs is effective remains to be studied. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)