1. Syk expression in non-small-cell lung cancer and its relation with angiogenesis.
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Peng Chuanliang, Zhao Yunpeng, Hao Yingtao, Sun Qifeng, Zhao Xiaogang, Cong Bo, Chuanliang, Peng, Yunpeng, Zhao, Yingtao, Hao, Qifeng, Sun, Xiaogang, Zhao, and Bo, Cong
- Subjects
NON-small-cell lung carcinoma ,NEOVASCULARIZATION ,MESSENGER RNA ,PROTEIN-tyrosine kinases ,REVERSE transcriptase polymerase chain reaction ,DIAGNOSIS ,ANTIGEN analysis ,LUNG cancer ,LUNG tumors ,TUMOR classification ,PATHOLOGIC neovascularization - Abstract
Objective: To study the expression of spleentyrosine kinase (Syk) gene in non--small--cell lung cancer and the relationship between Syk mRNA and microvessel density (MVD) in the tumor cells.Materials and Methods: The expression of Syk gene in 70 cases of lung tumor tissues, adjacent tissues, and normal lung tissues were examined with reverse transcription polymerase chain reaction (RT--PCR). The expression of MVD was examined with immunohistochemical streptavidin--biotin complex (SABC). The relation between them was analyzed.Results: Syk mRNA expression rates were 5.7, 95.7, and 100% in tumor, adjacent lung cells, and normal lung cells, respectively. The expression rate in tumor cells was significantly lower compared with those in normal lung tissue and adjacent lung tissue (P < 0.05), expression rate among different pathologic types, differentiation and clinical stages did not reveal any statistically significant differences (P > 0.05). The positive rate of CD34 in tumor was higher than that in adjacent tissues and normal lung tissues. The expression of Syk mRNA and MVD were negatively correlated.Conclusions: The lack of Syk mRNA expression in lung cancer play an important role in angiogenesis. [ABSTRACT FROM AUTHOR]- Published
- 2016
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