1. Morphological Changes in Tissue When Using Polypropylene Implants with Adsorbed Multipotent Stromal Cells in Experiment.
- Author
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Maiborodin IV, Mikheeva TV, Sheplev BV, Yarin GY, Onoprienko NV, and Maiborodina VI
- Subjects
- Animals, Rats, Male, Adsorption, Prostheses and Implants, Mesenchymal Stem Cell Transplantation methods, Subcutaneous Tissue pathology, Rats, Wistar, Bone Marrow Cells cytology, Polypropylenes chemistry, Mesenchymal Stem Cells cytology
- Abstract
The subcutaneous tissue of rats after implantation of polypropylene materials with adsorbed bone marrow-derived mesenchymal multipotent stromal cells (MMSCs) was studied using light microscopy. Inflammation in response to implantation was mild, and the foreign material was encapsulated into a thin strip of dense fibrous connective tissue with multinucleated macrophages. By 1 year after introduction of the monofilament and 6 and 12 months after implantation of the mesh product, some threads were deformed, broken, and had sharp edges. Small fragments of foreign material appeared in the adjacent tissues surrounded by their own relatively thick acellular capsule. As a result of preliminary adsorption of MMSCs on polypropylene, the thickness of the connective tissue capsule decreased, its vascularization increased, and the severity of inflammatory infiltration decreased. However, all effects of MMSCs adsorption in rats were transient and disappeared within 1 week., (© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2024
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