1. Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy
- Author
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Željka Večerić-Haler, Nika Kojc, Matjaž Sever, Samo Zver, Urban Švajger, Primož Poženel, Katrina Hartman, Tereza Urdih, Gregor Mlinšek, Manca Oblak, Andreja Aleš Rigler, Alojz Ihan, Jadranka Buturović Ponikvar, Philip P. Halloran, and Miha Arnol
- Subjects
mesenchymal stem cell ,kidney graft ,kidney transplant ,kidney graft failure ,autologous stem cell ,stem cell transplant ,Medicine (General) ,R5-920 - Abstract
Mesenchymal stem cells (MSCs) have attracted great interest in the field of kidney transplantation due to their immunomodulatory and reparative properties. In registered clinical trials, MSCs have been used before, at the time of, or early after transplantation and have been reported to be well-tolerated with no serious safety concerns. No results are available on the use of MSCs in the late post-transplant period. Here, we present a case report of a severe systemic complication mimicking capillary leak syndrome with ultimate kidney transplant failure after autologous transplantation of MSCs used as rescue treatment of late antibody-mediated kidney allograft rejection.
- Published
- 2021
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