7 results on '"Stolte, Ineke G."'
Search Results
2. Motives of Dutch men who have sex with men for daily and intermittent HIV pre-exposure prophylaxis usage and preferences for implementation
- Author
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Bil, Janneke P., van der Veldt, Wendy M., Prins, Maria, Stolte, Ineke G., and Davidovich, Udi
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Adult ,Male ,Motivation ,Sexually Transmitted Diseases ,Observational Study ,HIV ,men who have sex with men ,HIV Infections ,Middle Aged ,Patient Acceptance of Health Care ,Condoms ,Sexual and Gender Minorities ,sexual behavior ,Sexual Partners ,Humans ,Pre-Exposure Prophylaxis ,Homosexuality, Male ,prevention of sexual transmission ,Qualitative Research ,Research Article ,Netherlands - Abstract
Although PrEP is not yet registered in Europe, including the Netherlands, its approval and implementation are expected in the near future. To inform future pre-exposure prophylaxis (PrEP) implementation, this study aimed to gain insight into motives and preferences for daily or intermittent PrEP use among Dutch HIV-negative men having sex with men (MSM). Between February and December 2013, semistructured interviews were conducted until data saturation was reached (N = 20). Interviews were analyzed using the Grounded Theory approach. Motives for (not) using daily PrEP were based on beliefs about PrEP efficacy and side effects, preferences for other prevention strategies, self-perceived HIV risk, self-perceived efficacy of PrEP adherence, beliefs about possible benefits (e.g., anxiety reduction, sex life improvement), and barriers of PrEP use (e.g., costs, monitoring procedures). The perceived benefits of intermittent versus daily PrEP use were the lower costs and side effects and the lower threshold to decision to start using intermittent PrEP. Barriers of intermittent PrEP versus daily PrEP use were the perceived need to plan their sex life and adhere to multiple prevention strategies. Although some perceived PrEP as a condom substitute, others were likely to combine PrEP and condoms for sexually transmitted infections (STI) prevention and increased HIV protection. Participants preferred PrEP service locations to have specialized knowledge of HIV, antiretroviral therapy, sexual behavior, STIs, patients’ medical background, be easily approachable, be able to perform PrEP follow-up monitoring, and provide support. To maximize the public health impact of PrEP, ensuring high uptake among MSM at highest risk is important. Therefore, targeted information about PrEP efficacy and side effects need to be developed, barriers for accessing PrEP services should be minimized, and perceived self-efficacy to use PrEP should be addressed and improved. To prevent increases in STIs, condom use should be monitored and PrEP should be integrated into routine STI screening and counseling.
- Published
- 2016
3. Development and validation of a risk score to assist screening for acute HIV-1 infection among men who have sex with men.
- Author
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Dijkstra, Maartje, de Bree, Godelieve J., Stolte, Ineke G., Davidovich, Udi, Sanders, Eduard J., Prins, Maria, van der Loeff, Maarten F. Schim, and Schim van der Loeff, Maarten F
- Subjects
HIV infection transmission ,MEN who have sex with men ,MEDICAL screening ,COHORT analysis ,LOGISTIC regression analysis ,DISEASES ,DIAGNOSIS of HIV infections ,COMPARATIVE studies ,GONORRHEA ,HIV ,HOMOSEXUALITY ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,RESEARCH funding ,RISK assessment ,HUMAN sexuality ,EVALUATION research ,SEXUAL partners - Abstract
Background: Early treatment of acute HIV-1 infection (AHI) is beneficial for patients and could reduce onward transmission. However, guidelines on whom to test for AHI with HIV-1 RNA testing are lacking.Methods: A risk score for possible AHI based on literature and expert opinion - including symptoms associated with AHI and early HIV-1 - was evaluated using data from the Amsterdam Cohort Studies among men who have sex with men (MSM). Subsequently, we optimized the risk score by constructing two multivariable logistic regression models: one including only symptoms and one combining symptoms with known risk factors for HIV-1 seroconversion, using generalized estimating equations. Several risk scores were generated from these models and the optimal risk score was validated using data from the Multicenter AIDS Cohort Study.Results: Using data from 1562 MSM with 175 HIV-1 seroconversion visits and 17,271 seronegative visits in the Amsterdam Cohort Studies, the optimal risk score included four symptoms (oral thrush, fever, lymphadenopathy, weight loss) and three risk factors (self-reported gonorrhea, receptive condomless anal intercourse, more than five sexual partners, all in the preceding six months) and yielded an AUC of 0.82. Sensitivity was 76.3% and specificity 76.3%. Validation in the Multicenter AIDS Cohort Study resulted in an AUC of 0.78, sensitivity of 56.2% and specificity of 88.8%.Conclusions: The optimal risk score had good overall performance in the Amsterdam Cohort Studies and performed comparable (but showed lower sensitivity) in the validation study. Screening for AHI with four symptoms and three risk factors would increase the efficiency of AHI testing and potentially enhance early diagnosis and immediate treatment. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
4. High awareness of hepatitis C virus (HCV) but limited knowledge of HCV complications among HIV-positive and HIV-negative men who have sex with men.
- Author
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Lambers, Femke A.E., Prins, Maria, Davidovich, Udi, and Stolte, Ineke G.
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CHI-squared test ,CONFIDENCE intervals ,EPIDEMIOLOGY ,FISHER exact test ,GAY men ,HEPATITIS C ,LONGITUDINAL method ,PROBABILITY theory ,QUESTIONNAIRES ,RESEARCH funding ,RISK-taking behavior ,HUMAN sexuality ,TIME series analysis ,U-statistics ,DATA analysis ,HIV seroconversion ,HEALTH literacy ,HIV seronegativity ,DISEASE complications - Abstract
Hepatitis C virus (HCV) has emerged as a sexually transmitted infection among HIV-positive men who have sex with men (MSM) in high-income countries. Little is reported about HCV awareness among MSM, although this is essential for developing targeted prevention strategies. We, therefore, studied HCV awareness and knowledge among HIV-positive and HIV-negative MSM from the Amsterdam Cohort Studies (ACS). During two visits, 1 year apart and starting in October 2007, MSM from the ACS answered questions regarding HCV awareness, knowledge of HCV transmission (7 items), complications (8 items) and sexual risk behaviour. We examined the percentage of HCV awareness and correctly answered knowledge items, and whether awareness and knowledge improved significantly over time. Using logistic regression, we studied whether HIV status and sexual risk behaviour were associated with awareness. Seventy percent (312/444) of HIV-negative and 80% (74/92) of HIV-positive MSM reported to have ever heard of HCV on the first visit. Overall, awareness increased with 9% between the first and second visit (p< 0.001). In multivariate analysis the association of group sex with HCV awareness was borderline significant (OR 1.49, 95% CI 0.97–2.30). Compared with knowledge of transmission routes, knowledge of complications appeared to be limited. In the ACS, awareness of HCV is high, particularly among those reporting group sex, an important risk factor for HCV transmission. The majority of participants had good knowledge of transmission routes, but limited knowledge of complications of chronic HCV infection. HCV prevention messages could be strengthened, therefore, by further addressing the complications of HCV infection. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
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5. Low Bone Mineral Density, Regardless of HIV Status, in Men Who Have Sex With Men.
- Author
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Grijsen, Marlous L., Vrouenraets, Saskia M. E., Wit, Ferdinand W. N. M., Stolte, Ineke G., Prins, Maria, Lips, Paul, Reiss, Peter, and Prins, Jan M.
- Subjects
BONE density ,HIV infections ,MEN who have sex with men ,LUMBAR vertebrae ,MULTIVARIATE analysis ,DISEASES - Abstract
A high prevalence of low bone mineral density (BMD) has been reported among men with primary or chronic human immunodeficiency virus (HIV) infection. To gain further insight into the contribution of HIV infection, we compared the BMD of 41 men who have sex with men (MSM) with primary HIV infection, 106 MSM with chronic HIV infection, and a control group of 30 MSM without HIV infection. Low BMD, defined as a z score of ≥2.0 SDs below the mean at the lumbar spine or hip, was highly prevalent in all 3 groups. In the multivariate analyses, HIV infection was not associated with BMD, suggesting that low BMD previously reported in HIV-infected MSM may predate HIV acquisition. [ABSTRACT FROM PUBLISHER]
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- 2013
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6. Correction to: Development and validation of a risk score to assist screening for acute HIV-1 infection among men who have sex with men.
- Author
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Dijkstra, Maartje, de Bree, Godelieve J, Stolte, Ineke G, Davidovich, Udi, Sanders, Eduard J, Prins, Maria, and Schim van der Loeff, Maarten F
- Subjects
HIV infections ,MEN who have sex with men - Abstract
A correction to the article "Development and Validation of a Risk Score to Assist Screening for Acute HIV-1 Infection Among Men Who Have Sex With Men" which appeared in the previous issue is presented.
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- 2017
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7. Is Serosorting Effective in Reducing the Risk of HIV Infection Among Men Who Have Sex With Men With Casual Sex Partners?
- Author
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van den Boom, Wijnand, Konings, Roos, Davidovich, Udi, Sandfort, Theo, Prins, Maria, and Stolte, Ineke G.
- Abstract
We investigated the prevalence and protective value of serosorting [ie, establishing HIV concordance in advance to practice unprotected anal intercourse (UAI)] with casual partners (CP) among HIV-negative men who have sex with men (MSM) using longitudinal data from 2007 to 2011.Men of the Amsterdam Cohort Studies were tested biannually for HIV-1 antibodies and filled in questionnaires about sexual behavior in the preceding 6 months. HIV incidence was examined among men who practiced UAI, UAI with serosorting, or consistent condom use, using Poisson regression.Of 445 MSM with CPs, 31 seroconverted for HIV during a total follow-up of 1107 person-years. Overall observed HIV incidence rate was 2.8/100 person-years. Consistent condom use was reported in 64%, UAI in 25%, and UAI with serosorting in 11% of the 2137 follow-up visits. MSM who practiced serosorting were less likely to seroconvert [adjusted incidence rate ratio (aIRR) = 0.46; 95% confidence interval (CI): 0.13 to 1.59] than MSM who had UAI, but more likely to seroconvert than MSM who consistently used condoms (aIRR = 1.32; 95% CI: 0.37 to 4.62), although differences in both directions were not statistically significant. MSM who consistently used condoms were less likely to seroconvert than MSM who had UAI (aIRR = 0.37; 95% CI: 0.18 to 0.77).The protective effect for serosorting we found was not statistically significant. Consistent condom use was found to be most protective against HIV infection. Larger studies are needed to demonstrate whether serosorting with CPs offers sufficient protection against HIV infection, and if not, why it fails to do so. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
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