1. Megestrol Acetate Induces Declarative Memory Changes and Cortisol Suppression in Healthy Volunteers.
- Author
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Mason BL, Ivleva EI, Van Enkevort E, Nakamura A, and Brown ES
- Subjects
- Adult, Appetite Stimulants administration & dosage, Appetite Stimulants adverse effects, Cognition drug effects, Cross-Over Studies, Drug Monitoring, Female, Healthy Volunteers, Humans, Male, Phenytoin administration & dosage, Phenytoin adverse effects, Receptors, Progesterone agonists, Treatment Outcome, Hydrocortisone blood, Megestrol Acetate administration & dosage, Megestrol Acetate adverse effects, Memory drug effects
- Abstract
Background: The effects of the glucocorticoid and progesterone receptor agonist megestrol on declarative memory, and the ability of phenytoin to block these effects, were assessed., Methods: Healthy volunteers received each medication combination (placebo and megestrol, phenytoin and megestrol, and placebo and placebo) using a randomized, crossover design. The Rey Auditory Verbal Learning Test assessed declarative memory., Results: Megestrol was associated with a significant reduction in declarative memory (p = 0.0008), which was attenuated by phenytoin, and was associated with significant cortisol suppression compared to placebo (p < 0.001)., Conclusion: Changes in memory and cortisol suppression were found in healthy volunteers given megestrol., (© 2018 S. Karger AG, Basel.)
- Published
- 2018
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