1. Radiotherapy for Melanoma with Perineural Invasion: University of Florida Experience.
- Author
-
Zhu S and Mendenhall WM
- Subjects
- Adult, Aged, Aged, 80 and over, Disease Progression, Disease-Free Survival, Female, Florida, Humans, Male, Melanoma mortality, Melanoma secondary, Middle Aged, Neoplasm Invasiveness, Neoplasm Recurrence, Local, Peripheral Nerves pathology, Radiotherapy, Adjuvant, Retrospective Studies, Skin Neoplasms mortality, Skin Neoplasms pathology, Time Factors, Treatment Outcome, Melanoma drug therapy, Peripheral Nerves radiation effects, Skin Neoplasms radiotherapy, Universities
- Abstract
Purpose: Outcomes after adjuvant radiotherapy for cutaneous melanoma with perineural invasion (PNI)., Methods: Seven patients (5 cutaneous, 2 recurrent nerve lesions) received radiotherapy., Results: At a median 4.5 years: Two patients did not recur; no local failures occurred. Three patients who omitted nodal irradiation developed regional failures (2 out-of-field, 1 in-field). Three patients developed distant metastases. Four died with disease (median, 3.6 years); 1 died from intercurrent disease (13.0 years). Two are alive without disease (6.8 and 11.6 years). No patient experienced grade ≥3 toxicity., Conclusions: Postoperative radiotherapy can reduce local recurrences; primary radiotherapy for unresectable disease is recommended.
- Published
- 2018
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