1. Seasonal variation in dysplastic naevi.
- Author
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Welsch M, Marszalek R, Young M, Zhu J, Clarke L, and Helm K
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Biomarkers, Tumor metabolism, Child, Child, Preschool, Cohort Studies, Dysplastic Nevus Syndrome metabolism, Female, Humans, Immunohistochemistry, MART-1 Antigen metabolism, Male, Melanocytes metabolism, Melanoma-Specific Antigens metabolism, Middle Aged, Multivariate Analysis, Young Adult, gp100 Melanoma Antigen, Dysplastic Nevus Syndrome pathology, Melanocytes pathology, Seasons, Ultraviolet Rays adverse effects
- Abstract
There is a relationship between sunlight and the development of melanocytic neoplasms. Because the incidence and excision of melanocytic neoplasms varies according to season, we sought to determine if dysplasia and/or intraepidermal melanocytic expression differed in a cohort of dysplastic naevi (DN) removed in January compared with a similar cohort removed in August. The DN were graded based on the degree of dysplasia, and the number of intraepidermal melanocytes were counted after immunohistochemical staining with HMB-45 and Melan-A. There was no seasonal difference in the grading of the dysplastic naevi in either season (P = 0.08). Comparing 85 cases from August and 86 from January, there was a larger number of Melan-A-positive melanocytes in the August samples (P < 0.02), and a larger number of HMB-45-positive melanocytes in January (P < 0.01). This difference may be related to seasonal variations such as exposure to ultraviolet light exposure; however, there was no difference between the two groups in the degree of atypia seen., (© The Author(s). CED © 2012 British Association of Dermatologists.)
- Published
- 2012
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