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13 results on '"Lohaus F"'

1. Interobserver agreement on definition of the target volume in stereotactic radiotherapy for pancreatic adenocarcinoma using different imaging modalities

Author

Gkika, E., Kostyszyn, D., Fechter, T., Moustakis, C., Ernst, F., Boda-Heggemann, J., Sarria, G., Dieckmann, K., Dobiasch, S., Duma, M.N., Eberle, F., Kroeger, K., Häussler, B., Izaguirre, V., Jazmati, Danny, Lautenschläger, S., Lohaus, F., Mantel, F., Menzel, J., Pachmann, S., Pavic, M., Radlanski, K., Riesterer, O., Gerum, S., Röder, F., Willner, J., Barczyk, S., Imhoff, D., Blanck, O., Wittig, A., Guckenberger, M., Grosu, Anca-L., and Brunner, T.B.

Subjects
Medizin
Abstract

Purpose: The aim of this study was to evaluate interobserver agreement (IOA) on target volume definition for pancreatic cancer (PACA) within the Radiosurgery and Stereotactic Radiotherapy Working Group of the German Society of Radiation Oncology (DEGRO) and to identify the influence of imaging modalities on the definition of the target volumes. Methods: Two cases of locally advanced PACA and one local recurrence were selected from a large SBRT database. Delineation was based on either a planning 4D CT with or without (w/wo) IV contrast, w/wo PET/CT, and w/wo diagnostic MRI. Novel compared to other studies, a combination of four metrics was used to integrate several aspects of target volume segmentation: the Dice coefficient (DSC), the Hausdorff distance (HD), the probabilistic distance (PBD), and the volumetric similarity (VS). Results: For all three GTVs, the median DSC was 0.75 (range 0.17–0.95), the median HD 15 (range 3.22–67.11) mm, the median PBD 0.33 (range 0.06–4.86), and the median VS was 0.88 (range 0.31–1). For ITVs and PTVs the results were similar. When comparing the imaging modalities for delineation, the best agreement for the GTV was achieved using PET/CT, and for the ITV and PTV using 4D PET/CT, in treatment position with abdominal compression. Conclusion: Overall, there was good GTV agreement (DSC). Combined metrics appeared to allow a more valid detection of interobserver variation. For SBRT, either 4D PET/CT or 3D PET/CT in treatment position with abdominal compression leads to better agreement and should be considered as a very useful imaging modality for the definition of treatment volumes in pancreatic SBRT. Contouring does not appear to be the weakest link in the treatment planning chain of SBRT for PACA. in press

Published
2023

5. The PD-1/PD-L1 axis and human papilloma virus in patients with head and neck cancer after adjuvant chemoradiotherapy: A multicentre study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG)

Author

Balermpas, P., Rödel, F., Krause, M., Linge, A., Lohaus, F., Baumann, M., Tinhofer, I., Budach, V., Sak, A., Stuschke, M., Gkika, E., Grosu, A.-L., Abdollahi, A., Debus, J., Stangl, S., Ganswindt, U., Belka, C., Pigorsch, S., Multhoff, G., Combs, S. E., Welz, S., Zips, D., Lim, S. Y., Rödel, C., and Fokas, E.

Subjects
Male, HPV, Papillomavirus Infections, Programmed Cell Death 1 Receptor, Medizin, CD8, Chemoradiotherapy, Adjuvant, Middle Aged, Prognosis, PD-1/PD-L1, B7-H1 Antigen, SCCHN, chemoradiotherapy, Survival Rate, Head and Neck Neoplasms, Biomarkers, Tumor, Carcinoma, Squamous Cell, Humans, Female, Neoplasm Grading, prognostic, Papillomaviridae, Follow-Up Studies, Neoplasm Staging
Abstract

We examined the prognostic role of PD-1+ and CD8+ tumor infiltrating lymphocytes (TILs), and PD-L1+ cells in patients with squamous cell carcinoma of the head and neck (SCCHN) treated with surgery and postoperative chemoradiotherapy (CRT). FFPE samples from 161 patients were immunohistochemically stained for PD-1, CD8 and PD-L1. The immune marker expression was correlated with clinicopathologic characteristics, and overall survival (OS), local progression-free survival (LPFS) and distant metastases free-survival (DMFS), also in the context of HPV16 DNA/p16 status. The median follow-up was 48 months (range: 4-100). The 2-year-OS was 84.1% for the entire cohort. High PD-1 and PD-L1 expression were more common in patients with positive HPV16 DNA (p

Published
2017

6. Impact of tumour hypoxia and cancer stem cells on loco-regional control after primary radiochemotherapy in locally advanced HNSCC : results of a multicentre biomarker study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG)

Author

Linge, A., Lohaus, F., Loeck, S., Gudziol, V., Nowak, A., Neubeck, C., Tinhofer, I., Budach, V., Sak, A., Stuschke, M., Balermpas, P., Roedel, C., Avlar, M., Grosu, A. -L, Abdollahi, A., Debus, J., Bayer, C., Belka, C., Pigorsch, S., Combs, S. E., Moennich, D., Zips, D., Baretton, G. B., Frank Buchholz, Baumann, M., and Krause, M.

Subjects
Medizin
Published
2016

7. Identification of epigenetic prognosticators of adjuvant radiochemotherapy in HPV-negative squamous cell carcinomas of the head and neck (SCCHN) via genome-wide methylation analysis : A multicenter biomarker study of the German Cancer Consortium Radiation

Author

Debus, J., Schwager, C., Warta, R., Tawk, B., Hauswald, H., Wirkner, U., Lohaus, F., Linge, A., Tinhofer, I., Gkikac, E., Balermpas, P., Avlar, M., Bayer, C., Pigorsch, S., Moennich, D., Grosu, A. -. L., Zips, D., Krause, M., Combs, S. E., Roedel, C., Budach, V., Belka, C., Stuschke, Martin, Weichert, W., Baumann, M., Dyckhoff, G., Herold-Mende, C., Abdollahi, A., and DKTK-ROG

Subjects
Medizin
Published
2015

8. Einfluss von Tumorvolumen und p16 Status auf die lokoregionäre Kontrolle von Kopf-Hals-Tumoren nach primärer Radiochemotherapie : Ergebnisse einer multizentrischen Biomarker-Studie des Deutschen Konsortiums für Translationale Krebsforschung (DKTK-ROG)

Author

Lohaus, F., Linge, A., von Neubeck, Cläre, Loeck, S., Tinhofer-Keilholz, I., Budach, V., Gkika, E., Stuschke, Martin, Balermpas, P., Roedel, C., Avlar, M., Grosu, A. -. L., Abdollahi, A., Debus, J., Bayer, C., Belka, C., Pigorsch, S., Combs, S. E., Moennich, D., Zips, D., Haase, R., Baretton, G. B., Baumann, M., Krause, M., and DKTK-ROG

Subjects
Medizin
Published
2015

9. Einzelnukleotid Polymorphismen in Reparaturproteinen sind prognoserelevant für des Überleben von Kopf-Hals- Tumorpatienten nach postoperativer Radiochemotherapie mit Cisplatin (DKTK-ROG)

Author

Stuschke, Martin, Sak, Ali, Abu Jawad, Jehad, Bachmann, H. S., Tinhofer, I., Budach, V., Baumann, M., Krause, M., Lohaus, F., Linge, A., Gkika, E., Balermpas, P., Roedel, C., Avlar, M., Grosu, A. L., Abdollahi, A., Debus, J., Bayer, C., Belka, C., Pigorsch, S., Combs, S. E., Moennich, D., Zips, D., Lang, Stephan, and Klein-Hitpaß, Ludger

Subjects
Medizin
Published
2015

10. Next-generation sequencing of locally advanced squamous cell carcinomas of the head and neck (LASCCHN) for assessment of mutational patterns and their interference with outcome after adjuvant chemoradiation : Results from a multicenter biomarker study of t

Author

Tinhofer, I., Budach, V., Linge, A., Lohaus, F., Gkika, E., Stuschke, Martin, Balermpas, P., Rodel, C., Avlar, M., Grosu, A. L., Abdollahi, A., Debus, J., Belka, C., Pigorsch, S., Combs, S. E., Monnich, D., Zips, D., Weichert, W., Krause, M., Baumann, M., and DKTK-ROG

Subjects
Medizin
Published
2015

11. Cytotoxic Lymphocytes infiltrating tumor correlated with better Prognosis in HPV-Status-associated Patterns in Patients receiving chemotherapy adjuvant radio with Head and Neck Squamous

Author

Balermpas, P., Rodel, F., Krause, M., Linge, A., Lohaus, F., Baumann, M., Tinhofer, I., Budach, V., Gkika, E., Stuschke, Martin, Avlar, M., Grosu, A. L., Abdollahi, A., Debus, J., Bayer, C., Belka, C., Pigorsch, S., Multhoff, G., Combs, S. E., Monnich, D., Zips, D., and Rodel, C.

Subjects
Medizin
Published
2015

12. Mutational patterns of HPV+ and HPV- squamous cell carcinomas of the head and neck (SCCHN) and their interference with outcome after adjuvant chemoradiation: A multicenter biomarker study of the German Cancer Consortium Radiation Oncology Group

Author

Tinhofer, I., Budach, V., Linge, A., Lohaus, F., Gkika, E., Stuschke, Martin, Balermpas, P., Rodel, C., Avlar, M., Grosu, A., Abdollahi, A., Debus, J., Belka, C., Pigorsch, S., Combs, S. E., Monnich, D., Zips, D., Weichert, W., Krause, M., Baumann, M., and DKTK-ROG

Subjects
Oncology, Cancer Research, medicine.medical_specialty, business.industry, medicine.medical_treatment, Treatment outcome, Cell, Medizin, Cancer, medicine.disease, stomatognathic diseases, medicine.anatomical_structure, Internal medicine, Radiation oncology, medicine, Biomarker (medicine), Head and neck, business, Adjuvant
Abstract

6006 Background: The genetic landscape of SCCHN is currently being unravelled, but the role of distinct mutations for treatment outcome remains largely unknown. We compared mutational patterns of H...

Published
2015

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