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Dyslipidemia is one of the leading causes of various cardiovascular and central nervous system disorders. Death from cardio-vascular disorders accounted for 36.3% of the 2.4 million deaths world-wide. Recognition that dyslipidemia is a risk factor has led to the development of drugs that modify cholesterol level. The intensity of therapy should be sufficient to achieve 30-40% reduction in LDL - C without side effects and low cost. The prescription order is an important therapeutic transaction between the prescriber and the patient. It has been well accepted that inadequate and irrational prescriptions could lead to serious consequences. The study was carried out by observing and analyzing data of 100 consecutive patients admitted in ICU and receiving lipid lowering agents for a period of eighteen months. From the study it is found that statins are the cornerstone of pharmacotherapy of dyslipidemias. At the same time the importance of dietary manipulations can't be ignored in management of dyslipidemias. Statins are relatively safe drugs however a few significant adverse reactions such as myalgia were also encountered during the course of the study.

CONTEXT: Pain is an unpleasant sensation localized to a part of body. It is a subjective experience, hard to define quantitatively. Chronic pain is an affliction of millions of patients and is associated with comorbidities such as depression and anxiety. Current standard of care for pain management includes Non-steroidal anti-inflammatory drugs (NSAIDs) like Ibuprofen and Opioid analgesics such as Pentazocine. NSAIDs are effective analgesics and are very frequently used as over- the-counter (OTC) medication. Opioids are the most potent analgesics and provide a rapid and sustained pain relief. Adjuvant analgesics include anti-depressants, anti-convulsants etc. Fluoxetine is a Selective Serotonin Reuptake Inhibitor (SSRI) used mainly as an anti-depressant. Previous studies on the efficacy of Fluoxetine for pain management have imparted us with conflicting data. Hence this present study was carried out with a view to elucidate its analgesic action and to compare it with standard drugs like Ibuprofen and Pentazocine. AIMS: The present study was conducted with the following objectives in mind: 1) To evaluate analgesic activity of Fluoxetine. 2) To compare analgesic activity of Fluoxetine with Ibuprofen and Pentazocine. METHODS AND MATERIALS: Materials: Adult albino rats, Eddy's Hot-plate, Tuberculin syringe. Drugs: Ibuprofen, Pentazocine and Fluoxetine. The study was carried out from 1st to 9th August, 2011 at the Department of Pharmacology, MR Medical College, Gulbarga. RESULTS AND CONCLUSION: Though Fluoxetine has significant analgesic properties as demonstrated by our study, but when compared with standard analgesics like Ibuprofen and Pentazocine, it is found lacking. From the present study it is apparent that Fluoxetine has significantly high activity in central-analgesic model i.e. Hot-plate method.

Sodium Valproate is a branched chain aliphatic carboxylic acid with broad- spectrum anti-seizure activity effective in the treatment of absence, myoclonic, partial, and tonic-clonic seizures. The most common side effects are transient gastrointestinal symptoms, including anorexia, nausea, and vomiting. Liver injury may follow the inhalation, ingestion, or parenteral administration of a number of pharmacologic and chemical agents. The risk is greatest for children under two years of age and for those taking multiple medications. A rare complication in adults is a fulminant hepatitis that is frequently fatal. We would like to report a case of Sodium Valproate induced hepatitis in an elderly male who presented with dark urine, fever, generalized weakness and other symptoms suggestive of drug