1. Trifecta versus perimount bioprosthesis for surgical aortic valve replacement; systematic review and meta‐analysis
- Author
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Shinichi Fukuhara, Toshiki Kuno, Hisato Takagi, and Yujiro Yokoyama
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Prosthesis Design ,law.invention ,Bioprosthetic valve ,Randomized controlled trial ,Aortic valve replacement ,law ,Humans ,Medicine ,In patient ,Retrospective Studies ,Bioprosthesis ,Heart Valve Prosthesis Implantation ,business.industry ,Hazard ratio ,Aortic Valve Stenosis ,medicine.disease ,Confidence interval ,Surgery ,Aortic Valve ,Heart Valve Prosthesis ,Meta-analysis ,Observational study ,Cardiology and Cardiovascular Medicine ,business - Abstract
OBJECTIVE Recent studies suggested higher rates of early structural valve degeneration or reintervention for the Trifecta valve compared to other valves. Thus, we conducted a systematic review and meta-analysis comparing the outcomes of the Trifecta valve and the Perimount valves in patients who underwent a surgical aortic valve replacement (SAVR). METHODS All randomized control trials and observational studies which investigated the outcomes of the Trifecta valve and Perimount valves were identified with PubMed and EMBASE. The endpoints were the rates of reintervention and all-cause mortality. Hazard ratios (HRs) for reintervention and all-cause mortality were combined with the random-effects model. RESULTS Our search identified 6 eligible observational studies which enrolled a total of 11,135 patients who underwent SAVR with either the Trifecta valve (n = 4932) or Perimount (n = 6203). Pooled analyses demonstrated that the reintervention rates were significantly higher with the Trifecta valve compared with Perimount valves (HR [95% confidence interval {CI}] = 3.16 [1.83-5.46]; p
- Published
- 2021