22 results on '"Ya-Hui Yang"'
Search Results
2. A Randomized Controlled Trial on the Role of Enthusiasm About Exergames: Players' Perceptions of Exercise
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T.C.E. Cheng, May Kuen Wong, Huynh Van Nguyen, Hsin Ying Chiu, Ya-Hui Yang, Han Chung Huang, and Ching-I Teng
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Adult ,Male ,medicine.medical_specialty ,Health (social science) ,Psychometrics ,media_common.quotation_subject ,Happiness ,Taiwan ,law.invention ,Randomized controlled trial ,law ,Perception ,medicine ,Humans ,Exercise ,media_common ,Analysis of Variance ,Enthusiasm ,Relaxation (psychology) ,Rehabilitation ,ComputingMilieux_PERSONALCOMPUTING ,Public Health, Environmental and Occupational Health ,Computer Science Applications ,Video Games ,Physical therapy ,Female ,Patient Participation ,Psychology - Abstract
Objective: Exergames are popular technology applications that encourage individuals to engage in exercise and create positive moods for players. However, little is known as to whether play...
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- 2019
3. Developing Strategy of Clinical Practice Guidelines for Post-intensive Care Syndrome: A Systematic Review of 14 Practice Guidelines and 10 Consensus Statements
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Bao Fu, Rujun Hu, Xi-Ying Zhang, Ying Wang, Fang Zhang, Xiao-Tian Zheng, Min He, Chen-Qiong Wang, Ya-Hui Yang, Qian-Ling Xiang, Lan Luo, and Zhixia Jiang
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Clinical Practice ,medicine.medical_specialty ,business.industry ,medicine ,Intensive care medicine ,business ,Post-intensive care syndrome - Abstract
BackgroundPost-intensive care syndrome (PICS) seriously affects the quality of life of patients and their caregivers. This study systematically evaluates PICS related guidelines and consensuses to provide methodological and strategic guidance for the development and improvement of these guidelines and consensus.MethodsAn Internet search of PICS specific or related guidelines and consensus statements was conducted among academic databases and the websites. The AGREE II was used to evaluate their methodological quality. The themes and contents were evaluated based on the definition of PICS and the “patient-clinical problem-intervention-target” framework.ResultsWe included fourteen guidelines and 10 expert consensuses. The mean AGREE II score for scope and purpose was 86.89% ± 16.12%/ 79.47% ± 11.80%, 55.86% ± 29.17%/16.72% ± 16.39% for stakeholder involvement, 76.35% ± 15.82% /36.09% ±26.05% for rigor of development, 88.03% ± 15.55%/58.84% ± 28.94% for clarity of presentation, 61.79% ± 23.16/32.95% ± 20.91% for applicability, and 66.67% ± 37.96% /28.79% ± 36.54% for editorial independence in Guidelines/Consensus. Most only described a single or series of clinical related issues of PICS; only applicable for critically ill patients with clinical problems of ICUAW, pain, sleep disruption, agitation, and delirium. The interventions included risk assessment, monitoring/diagnosis, prevention, treatment, safety criteria, and home care of one or more symptoms of PICS.ConclusionsOur results suggested that development and improvement of guidelines/consensus should focus on refining the methodology, strengthening quality control, and improving presentation clarity, editorial independence, and applicability. The results may provide new idea for a future guidelines and consensus statements.
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- 2020
4. Intrathoracic infusion therapy of thymic peptides and chemical irritants for malignant pleural effusion: a meta-analysis of 24 randomized controlled trials
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Xing-Sheng Yao, Zheng Xiao, Teng-Yang Fan, Ji-Hong Feng, You-Shu Shen, Xiao-Tian Zheng, Ya-Hui Yang, Yuan-Xiu He, Xiao-Fan Chen, Shu-Guang Li, Cheng-Qiong Wang, Xue Xiao, and Min He
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medicine.medical_specialty ,business.industry ,medicine.disease ,Gastroenterology ,law.invention ,Text mining ,Infusion therapy ,Randomized controlled trial ,law ,Internal medicine ,Meta-analysis ,Medicine ,Malignant pleural effusion ,business ,Chemical irritants - Abstract
Background: To further determine the clinical efficacy and survival of intrathoracic infusion with TPs and chemical irritants and their therapeutic threshold and optimal control regimen to achieve a desired response in malignant pleural effusion (MPE). Methods: We collected all randomized controlled trials (RCTs) of TPs with chemical irritants from Chinese and English databases (from inception until September 2019), and performed a new meta-analysis following the PRISMA guidelines. We measured their bias risk, summarized data using meta-analysis, and evidence quality using the Grades of Recommendation Assessment, Development and Evaluation approach. Results: We collected 24 trials involving three TPs and platinum and 1,592 patients. Most trials had unclear bias risk. TPs with platinum significantly improved complete response [4.02 (3.12 to 5.18)] and quality of life [3.64 (2.34 to 5.66)], the 0.5-year overall survival (OS) rate [5.75 (3.02 to 10.92)], and 1-year OS rate [5.29, (1.71 to 16.36)], and reduced the treatment failure, myelosuppression, and gastrointestinal toxicity. For patients with moderate to large volume of pleural effusion, KPS score ≥50 to 60, or AST ≥3 months, the thymosin (200–300mg/time), thymopentin (2mg/time) or thymosin alpha 1 (3.2mg/time) with cisplatin (30–40mg/m 2 ), carboplatin (400mg/m 2 ), or oxaliplatin (100mg/m 2 ) are possible regimens for achieving a desired success, and low failure. Most results were robust and moderate quality. Conclusion: The moderate evidence suggests that the TPs with platinum is beneficial to the patient with MPE, and provides evidence for the therapeutic threshold and possible regimens that may achieve a desired success and reduce the failure.
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- 2020
5. Motor Vehicle Accident Risk after Methadone Use: A Population-Based Study
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Chun-Hung Richard Lin, Peng-Wei Wang, Trong-Neng Wu, Yue Leon Guo, Jui-Hsiu Tsai, Pei-Shan Ho, Hung-Yi Chuang, and Ya-Hui Yang
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Methadone maintenance ,medicine.medical_specialty ,education.field_of_study ,business.industry ,Proportional hazards model ,Incidence (epidemiology) ,Population ,Hazard ratio ,Retrospective cohort study ,mental disorders ,Emergency medicine ,medicine ,business ,education ,Cohort study ,Methadone ,medicine.drug - Abstract
Background: Opioid dependence, a major global public health concern, can be alleviated through methadone maintenance treatment (MMT). However, MMT possibly increases motor vehicle accident risk. The aim of this study was to determine motor vehicle accident risk in MMT users. Methods: We performed preliminary estimation of motor vehicle accident incidence rates in Taiwan. In this population-based retrospective cohort study with frequency-matched controls, adult opiate users receiving MMT and not receiving MMT (control) were identified at a 1:2 ratio by linking data from several nationwide administrative registry databases. All individuals were followed for motor vehicle accident events. Data were adjusted for potential covariates and assessed using Kaplan–Meier and Cox proportional hazard model analyses. Findings: From 2009 to 2016, the crude incidence rate of motor vehicle accidents was the lowest in the general adult population, followed by that in adult opiate users, and it was the highest in adults receiving MMT. Among opiate users, motor vehicle accident incidence rates were significantly higher in those receiving MMT than in those not receiving MMT (adjusted hazard ratio [aHR] 2.75, 95% CI 1.87–4.04; p
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- 2020
6. Long-acting injectable paliperidone palmitate in a haemodialysis patient with schizophrenia
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Chun-Liong Tung, Tsung-Huang Tsai, Chia-Shun Lee, Jui-Hsiu Tsai, Kuang-Peng Chen, Jia-Hong Lin, and Ya-Hui Yang
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Paliperidone Palmitate ,medicine.medical_specialty ,business.industry ,Schizophrenia (object-oriented programming) ,General Medicine ,Hospitalization ,Psychiatry and Mental health ,Long acting ,Renal Dialysis ,Delayed-Action Preparations ,Internal medicine ,Schizophrenia ,medicine ,Humans ,business ,Antipsychotic Agents - Published
- 2020
7. Intrathoracic infusion therapy with Lentinan and chemical irritants for malignant pleural effusion: a systematic review and meta-analysis of 65 randomized controlled trials
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Shan-Shan Hu, Xing-Xia Zou, Qing-Yong Cai, Ji-Hong Feng, Xiao-Tian Zheng, Ya-Hui Yang, Li-Jing Shan, Xiao-Fan Chen, Xue Xiao, Yuan Jiang, Cheng-Qiong Wang, Yu-Hong Tang, Wei-hong Xu, Jia-Mei Zhou, and Zheng Xiao
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medicine.medical_specialty ,Lentinan ,Pharmaceutical Science ,law.invention ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Infusion therapy ,Randomized controlled trial ,law ,Internal medicine ,Drug Discovery ,Medicine ,Malignant pleural effusion ,030304 developmental biology ,Pharmacology ,0303 health sciences ,business.industry ,medicine.disease ,Confidence interval ,Regimen ,Complementary and alternative medicine ,chemistry ,030220 oncology & carcinogenesis ,Meta-analysis ,Relative risk ,Molecular Medicine ,business - Abstract
Aderivative of Shiitake mushrooms, Lentinan is used to control malignant pleural effusion (MPE) through intrathoracic infusion.To determine the clinical response, survival and safety of Lentinan plus chemical irritants, and the optimal combinations with chemical irritants, indication, threshold and optimal regimen for achieving the desired responses.We performed a new systematic review and meta-analysis following the PRISMA guidelines.We collected all randomized controlled trials (RCTs) regarding Lentinan plus chemical irritants from Chinese and English electronic databases (from inception until March 2019). We evaluated their bias risk, synthesized data using meta-analysis, and summarized evidence quality following the Grades of Recommendation Assessment, Development and Evaluation approach.We included 65 RCTs involving 4,080 patients and nine chemical irritants. Most trials had unclear bias risk. Lentinan with cisplatin significantly improved complete response [Risk ratio (RR) = 1.68, 95% confidence intervals (CI) (1.51 to 1.87), p0.00001, Fig.3a] and quality of life [RR = 1.51 95% CI (1.41 to 1.62), p0.00001, Fig.4], and decreased the risk of treatment failure, myelosuppression, gastrointestinal reaction, and chest pain. For patients with moderate to large volume of the pleural effusion, primary treatment, KPS score ≥ 50-60, or anticipated survival time ≥ 3months, Lentinan (3-4 mg/time, once a week for three to four times) withcisplatin (30-40 mg/mThe results suggest that Lentinan with chemical irritants, especially cisplatin is beneficial to the patient with MPE, and provide evidence for the indication, threshold, and optimal regimen that may achieve success and decrease failure.
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- 2019
8. Determinants of cerebral white matter changes in patients with stroke
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Meng-Ni Wu, Ping-Song Chou, Y.-H. Lin, Chiao-Yun Chen, Ya-Hui Yang, Ruey-Tay Lin, and Chiou-Lian Lai
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medicine.medical_specialty ,education.field_of_study ,medicine.diagnostic_test ,Cerebral white matter ,business.industry ,Population ,Leukoaraiosis ,Magnetic resonance imaging ,Odds ratio ,Logistic regression ,medicine.disease ,Confidence interval ,Internal medicine ,Internal Medicine ,medicine ,Physical therapy ,education ,business ,Stroke - Abstract
Background/Aim Cerebral white matter changes (WMC) are commonly observed in magnetic resonance imaging (MRI) scans of elderly people. Information about the prevalence of WMC is limited, and little is known about site-specific risk factors for the subcortical and periventricular regions in patients with ischaemic stroke. The study aims to analyse the prevalence and severity of WMC and investigate the risk factors of periventricular WMC (PVWMC) and deep WMC (DWMC) separately in patients with ischaemic stroke. Methods The data were collected between January and December 2013 from a medical centre in southern Taiwan. Every patient underwent a cerebral MRI scan, and WMC was separately rated as PVWMC and DWMC by using the modified Fazekas scale. Results In total, 527 patients who had experienced ischaemic stroke were included. The mean age of the patients was 67.0 ± 12.5 years (range: 31–94) and 62% of them were men. The mean age was significantly different among the four grades of severity in both the PVWMC (P < 0.001) and DWMC (P < 0.001) groups after adjustments for sex and vascular risk factors. Hypertension was independently correlated with severity of DWMC (P = 0.032) but not with PVWMC (P = 0.222). In multiple logistic regressions model, hypertension was a significant independent indicator of DWMC (odds ratio = 4.30; 95% confidence interval = 1.70–10.89). Conclusion Our results suggest a region-specific pathogenesis of cerebral white matter in Asian patients with ischaemic stroke that may differ from those in the general population.
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- 2015
9. Impact of Playing Exergames on Mood States: A Randomized Controlled Trial
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May-Kuen Wong, Ching-I Teng, Hsin-Ying Chiu, Han-Chung Huang, and Ya-Hui Yang
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Adult ,Male ,medicine.medical_specialty ,Psychotherapist ,Social Psychology ,media_common.quotation_subject ,Happiness ,Physical Exertion ,Poison control ,050109 social psychology ,Suicide prevention ,Occupational safety and health ,law.invention ,Young Adult ,Randomized controlled trial ,law ,Injury prevention ,medicine ,Humans ,0501 psychology and cognitive sciences ,Exercise ,Applied Psychology ,media_common ,Analysis of Variance ,Communication ,05 social sciences ,050301 education ,Repeated measures design ,General Medicine ,Computer Science Applications ,Human-Computer Interaction ,Affect ,Mood ,Video Games ,Physical therapy ,Female ,Psychology ,0503 education - Abstract
To examine how playing exergames impacts the mood states of university students and staff, and whether such an impact depends on gender and players' previous exercise time. This study was designed as a randomized controlled trial. It enrolled 337 participants and randomly assigned them to an intervention group (n = 168) or a control group (n = 167). A 2-week exergame program was designed for the participants in the intervention group. They were required to play exergames for 30 consecutive minutes each week for 2 weeks and respond to the items measuring vigor, happiness, and perceived stress. All measures were administered before and after the study. Repeated measures analysis of variances were conducted. Playing exergames enhanced vigor and happiness for participants in the intervention group. This group exhibited more positive change in vigor and happiness than the control group. This effect of playing exergames was not moderated by gender, age, occupation (student or staff), or previous exercise time. Playing exergames may induce positive mood states among university students and staff.
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- 2017
10. Influence of Socioeconomic Status on the Association between Prenatal Periodontal Care and Preterm Low Birthweight Delivery: A Population-Based Case-Control Study
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Ya-Hui Yang, Chung Yi Li, Vivian Chia-Rong Hsieh, Trong-Neng Wu, and Saou-Hsing Liou
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Periodontitis ,Pediatrics ,medicine.medical_specialty ,business.industry ,Case-control study ,Population based ,medicine.disease ,Gestational period ,Gingivitis ,National health insurance ,Environmental health ,medicine ,Household income ,medicine.symptom ,business ,Socioeconomic status - Abstract
We report the effect of in-pregnancy periodontal care intensity on the risk of preterm low birthweight (PLBW) births, and the role of household income in this association. Only a few studies have examined the role of socioeconomic status (SES) in the relationship between prenatal periodontal care and risk of PLBW delivery under universal health care. This study adopted a population-based, case-control study using medical claims data in Taiwan. Mothers of PLBW and non-PLBW babies with livebirth deliveries between 2001 and 2005 (cases, n=20430 and controls, n=81573, respectively) were identified using the National Health Insurance Research Database (NHIRD) and matched. Periodontal disease and disease-specific (gingivitis and periodontitis) dental service utilization was calculated during gestational period and analyzed for its association with risk for PLBW delivery. Household income as proxy for SES was tested for modification effect. Prevalence of periodontitis and gingivitis was significantly higher
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- 2014
11. Air pollution and hospital admissions for chronic obstructive pulmonary disease: are their potentially sensitive groups?
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Chun-Yuh Yang, Trong-Neng Wu, Saou-Hsing Liou, Shang-Shyue Tsai, and Ya-Hui Yang
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COPD ,medicine.medical_specialty ,business.industry ,Air pollution ,Pulmonary disease ,General Medicine ,medicine.disease ,medicine.disease_cause ,respiratory tract diseases ,Pneumonia ,Relative risk ,Heart failure ,Diabetes mellitus ,Emergency medicine ,medicine ,Risk factor ,business - Abstract
Recent studies showed that air pollution is a risk factor for hospitalization for chronic obstructive pulmonary disease (COPD). However, there is limited evidence to suggest which subpopulations are at higher risk from air pollution. This study was undertaken to examine the modifying effect of specific secondary diagnosis (including hypertension, diabetes, pneumonia, congestive heart failure) on the relationship between hospital admissions for COPD and ambient air pollutants concentrations. Hospital admissions for COPD and ambient air pollution data for Taipei were obtained for the period from 1999-2009. The relative risk of hospital admissions for COPD was estimated using a case-crossover approach. None of the secondary diagnosis we examined showed much evidence of effect modification.
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- 2012
12. Air Pollution and Hospital Admissions for Myocardial Infarction: Are There Potentially Sensitive Groups?
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Pei-Shih Chen, Shang-Shyue Tsai, Saou-Hsing Liou, Ya-Hui Yang, Chun-Yuh Yang, Trong-Neng Wu, and Fung-Chang Sung
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Male ,medicine.medical_specialty ,Health, Toxicology and Mutagenesis ,Respiratory Tract Diseases ,Myocardial Infarction ,Taiwan ,Air pollution ,Toxicology ,medicine.disease_cause ,Effect Modifier, Epidemiologic ,Diabetes Complications ,Patient Admission ,Risk Factors ,Air Pollution ,Internal medicine ,Diabetes mellitus ,Odds Ratio ,medicine ,Humans ,Poisson Distribution ,Myocardial infarction ,Risk factor ,Aged ,Aged, 80 and over ,Air Pollutants ,business.industry ,Case-control study ,Environmental Exposure ,Odds ratio ,Middle Aged ,medicine.disease ,Logistic Models ,Cardiovascular Diseases ,Case-Control Studies ,Heart failure ,Relative risk ,Cardiology ,Female ,business - Abstract
Recent studies showed that air pollution is a risk factor for hospitalization for myocardial infarction (MI). However, there is limited evidence to suggest which subpopulations are at higher risk for MI arising from air pollution. This study was undertaken to examine the modifying effects of specific secondary cardiovascular diagnosis (including hypertension, diabetes, congestive heart failure, and arrhythmias) on the relationship between hospital admissions for MI and exposure to ambient air pollutants. Hospital admissions for MI and ambient air pollution data for Taipei were obtained for the period 1999-2009. The relative risk of hospital admissions for MI was estimated using a case-crossover approach. None of the secondary diagnosis examined showed significant evidence of effect modification. It would appear that the correlation between air pollutant exposure and MI occurrence is not affected by predisposing factors present in other cardiovascular diseases.
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- 2012
13. A follow-up comparison of blood lead levels between foreign and native workers of battery manufacturing in Taiwan
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Fung-Chang Sung, Chun-Yuh Yang, Hung-Yi Chuang, Trong-Neng Wu, Wen-Chia Cheng, Ya-Hui Yang, and Chiu-Ying Chen
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Adult ,Gerontology ,medicine.medical_specialty ,Environmental Engineering ,Foreign worker ,media_common.quotation_subject ,Health Behavior ,Immigration ,Taiwan ,Air Pollutants, Occupational ,Occupational medicine ,Chemical exposure ,Electric Power Supplies ,Asian People ,Personal hygiene ,Occupational Exposure ,Environmental health ,parasitic diseases ,Humans ,Environmental Chemistry ,Medicine ,Waste Management and Disposal ,Occupational Health ,Drink alcohol ,media_common ,business.industry ,Pollution ,Lead ,Cohort ,Health education ,business ,Environmental Monitoring - Abstract
Foreign workers employed in industries in Taiwan have been found at elevated risk of injuries. Less well known is whether the elevated risk persists in chemical exposure such as lead exposure at battery manufacturing. A cohort of 70 Thai workers and 55 native workers employed at a battery plant were followed up, after an education of job safety, from 2000 until 2002. This study compared the change of blood lead levels (BLLs) between these two groups of workers. With informed consent, BLLs were measured annually for participants and compared. The average baseline BLLs were approximately at similarly high levels between Thai workers and native workers with means +/- standard deviations of 36.9 +/- 16.4 and 36.2 +/- 12.4 microg/dl, respectively (p = 0.79). At the end of 2002, the average concentration was higher in Thai workers than in native workers. Using mixed models, Thai workers had an average of 5.95 microg/dl increase in BLLs over native workers during the 3-year study. Further measurements revealed that the average BLL for workers in the assembly department was 3.57 +/- 1.83 microg/dl in excess, compared with workers in the plate engineering department. Thai workers were more likely to drink alcohol but less likely to wear gloves at work and wash hands before meals. The BLL disparities between Thai workers and native workers can partly be explained by differences in risk-taking behaviors. Higher BLLs in Thai workers suggest the need of language appropriate health education to improve their personal hygiene. Workplace smoking ceasing program may be needed both in Thai and native workers.
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- 2008
14. Use of HLA-B*58:01 genotyping to prevent allopurinol induced severe cutaneous adverse reactions in Taiwan: national prospective cohort study
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Chun Lin Huang, Ya-Hui Yang, Chia-Li Yu, Kuang Hui Yu, Chung-Ming Huang, Chen-Yang Shen, Pi-Jung Hsiao, Tai-Ming Ko, Chia Tse Weng, Yuan-Tsong Chen, Song Chou Hsieh, Hsueh Wei Yen, Shih Yang Chen, Yi-Ming Chen, Mei-Chuan Kuo, Jer-Chia Tsai, Ming Ta Michael Lee, Der-Yuan Chen, Jeng-Hsien Yen, Chang-Youh Tsai, Chrong-Reen Wang, Hung Ting Liao, C.W. Wang, Yi-Chun Chou, Shue Fen Luo, Teh Ling Liou, Meng Yu Weng, Tsan Teng Ou, Chih Shung Wong, Chen Ching Wu, Chih Sheng Chu, Jer-Yuarn Wu, Kuo Shu Chen, Guang Dar Yin, Chia Shuo Chang, Kai Hung Cheng, Jia Jung Lee, Pei Chen, Wen Ter Lai, Chen Hung Chen, Hui Ping Chuang, Wen Chan Tsai, Ming Fei Liu, Shih Yuan Hung, Chien Hsiun Chen, and Tsung-Hsien Lin
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Male ,medicine.medical_specialty ,Heterozygote ,Genotype ,Allopurinol ,Taiwan ,Scars ,Gout Suppressants ,Internal medicine ,medicine ,Humans ,Genetic Testing ,Prospective Studies ,Prospective cohort study ,Genotyping ,business.industry ,Incidence (epidemiology) ,Pruritus ,Research ,General Medicine ,Exanthema ,Middle Aged ,Rash ,HLA-B ,Confidence interval ,Surgery ,HLA-B Antigens ,Chronic Disease ,Female ,Drug Eruptions ,medicine.symptom ,business ,medicine.drug - Abstract
Objective To evaluate the use of prospective screening for the HLA-B*58:01 allele to identify Taiwanese individuals at risk of severe cutaneous adverse reactions (SCARs) induced by allopurinol treatment. Design National prospective cohort study. Setting 15 medical centres in different regions of Taiwan, from July 2009 to August 2014. Participants 2926 people who had an indication for allopurinol treatment but had not taken allopurinol previously. Participants were excluded if they had undergone a bone marrow transplant, were not of Han Chinese descent, and had a history of allopurinol induced hypersensitivity. DNA purified from 2910 participants’ peripheral blood was used to assess the presence of HLA-B*58:01. Main outcome measures Incidence of allopurinol induced SCARs with and without screening. Results Participants who tested positive for HLA-B*58:01 (19.6%, n=571) were advised to avoid allopurinol, and were referred to an alternate drug treatment or advised to continue with their prestudy treatment. Participants who tested negative (80.4%, n=2339) were given allopurinol. Participants were interviewed once a week for two months to monitor symptoms. The historical incidence of allopurinol induced SCARs, estimated by the National Health Insurance research database of Taiwan, was used for comparison. Mild, transient rash without blisters developed in 97 (3%) participants during follow-up. None of the participants was admitted to hospital owing to adverse drug reactions. SCARs did not develop in any of the participants receiving allopurinol who screened negative for HLA-B*58:01. By contrast, seven cases of SCARs were expected, based on the estimated historical incidence of allopurinol induced SCARs nationwide (0.30% per year, 95% confidence interval 0.28% to 0.31%; P=0.0026; two side one sample binomial test). Conclusions Prospective screening of the HLA-B*58:01 allele, coupled with an alternative drug treatment for carriers, significantly decreased the incidence of allopurinol induced SCARs in Taiwanese medical centres.
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- 2015
15. Relationship between Hyperuricemia and Lipid Profiles in US Adults
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Chung-Ching Wang, Tao-Chun Peng, Ya-Hui Yang, Yaw-Wen Chang, Tung-Wei Kao, James Yi-Hsin Chan, and Wei-Liang Chen
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Adult ,Male ,medicine.medical_specialty ,Apolipoprotein B ,Article Subject ,lcsh:Medicine ,Hyperuricemia ,General Biochemistry, Genetics and Molecular Biology ,chemistry.chemical_compound ,Internal medicine ,medicine ,Humans ,Triglycerides ,Apolipoproteins B ,Apolipoprotein A-I ,General Immunology and Microbiology ,biology ,business.industry ,Cholesterol ,Cholesterol, HDL ,lcsh:R ,nutritional and metabolic diseases ,General Medicine ,medicine.disease ,Lipids ,United States ,Confidence interval ,Uric Acid ,Endocrinology ,chemistry ,biology.protein ,Uric acid ,Female ,lipids (amino acids, peptides, and proteins) ,Metabolic syndrome ,business ,Dyslipidemia ,Research Article ,Lipoprotein - Abstract
Background. Although the link between hyperuricemia and metabolic syndrome had been recognized, the association of the dyslipidemia among individuals with hyperuricemia remains not comprehensively assessed.Methods. Using NHANES III study, we examined the relation between serum lipid profiles and different serum uric acid levels, including serum total cholesterol, LDL cholesterol, triglycerides, HDL cholesterol, apolipoprotein-B, lipoprotein (a), apolipoprotein AI, ratio of triglycerides to HDL cholesterol, and ratio of apolipoprotein-B to AI.Results. After adjusting for potential confounders, average differences (95% confidence interval) comparing the top to the bottom (reference) serum uric acid were 0.29 (0.19, 0.39) mmol/L for total cholesterol, 0.33 (0.26, 0.41) mmol/L for triglycerides, 0.14 (0.01, 0.27) mmol/L for LDL cholesterol, −0.08 (−0.11, −0.05) mmol/L for HDL, and 0.09 (0.05, 0.12) g/L for serum apolipoprotein-B. Notably, ratios of triglycerides to HDL cholesterol and apolipoprotein-B to AI were also linearly associated with uric acid levels (Pfor trend < 0.001).Conclusions. This study suggested that serum LDL cholesterol, triglycerides, total cholesterol, apolipoprotein-B levels, ratio of triglycerides to HDL cholesterol, and ratio of apolipoprotein-B to AI are strongly associated with serum uric acid levels, whereas serum HDL cholesterol levels are significantly inversely associated. In the clinical practice, the more comprehensive strategic management to deal with dyslipidemia and hyperuricemia deserves further investigation.
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- 2015
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16. Mortality among shipbreaking workers in Taiwan--a retrospective cohort study from 1985 to 2008
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Jin Huei Hsu, Wei-Te Wu, Chung Yi Li, Yu Jen Lin, Huei Sheng Shiue, Chun-Yuh Yang, Yao Hua Lu, Trong-Neng Wu, Ya-Hui Yang, and Saou-Hsing Liou
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Adult ,Male ,medicine.medical_specialty ,Lung Neoplasms ,Asbestosis ,Population ,Taiwan ,medicine.disease_cause ,Risk Assessment ,Asbestos ,Cohort Studies ,Young Adult ,Age Distribution ,Environmental health ,Cause of Death ,Occupational Exposure ,otorhinolaryngologic diseases ,medicine ,Confidence Intervals ,Humans ,Industry ,Sex Distribution ,Lung cancer ,education ,Cause of death ,Retrospective Studies ,education.field_of_study ,business.industry ,Incidence (epidemiology) ,Incidence ,technology, industry, and agriculture ,Public Health, Environmental and Occupational Health ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Survival Analysis ,respiratory tract diseases ,Surgery ,Occupational Diseases ,Female ,business ,Cohort study - Abstract
Background Shipbreaking workers are typically exposed to a wide range of hazardous chemicals. However, long-term follow-up studies of their mortality patterns are lacking. This study examined mortality among shipbreaking workers over a 24-year follow-up period. Methods A total of 4,962 shipbreaking workers were recruited from the database of the Kaohsiung Shipbreaking Workers Union. The data were then linked to the Taiwan National Death Registry from 1985 to 2008. The mortality ratios—standardized for age and calendar years—(SMRs) for various causes of deaths were calculated with reference to the general population of Taiwan. Results Among men workers, a statistically significant increased SMR was observed for all causes (SMR = 1.28), all cancers (SMR = 1.26; particularly noteworthy for lesions of oral and nasopharyngeal: SMR 2.03, liver: SMR 4.63, and lung: SMR 1.36), cirrhosis of the liver (SMR = 1.32), and accidents (SMR = 1.91). A statistically significant increase in mortality was observed for respiratory system cancer (SMR = 1.87) and lung cancer (SMR = 1.91) among workers with a longer duration of employment (≥7 years). The result also showed that among shipbreaking workers who were still alive, two people had mesothelioma and 10 people have asbestosis. Conclusions Those employed in shipbreaking industries experienced an increase in mortality from all causes. The increased SMR for lung cancer was probably related to asbestos, metals, and welding fume exposure. Am. J. Ind. Med. 56:701–708, 2013. © 2012 Wiley Periodicals, Inc.
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- 2012
17. USING THE NATIONAL HEALTH INSURANCE RESEARCH DATABASE TO ANALYZE THE RISK OF OCCUPATIONAL INJURIES/ DISEASES IN REGISTERED NURSES
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Trong-Neng Wu, Ya-Hui Yang, and Saou-Hsing Liou
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medicine.medical_specialty ,National health insurance ,business.industry ,Family medicine ,medicine ,General Earth and Planetary Sciences ,Injuries diseases ,Database research ,business ,General Environmental Science - Published
- 2011
18. Incidence of needlestick and other sharp object injuries in newly graduated nurses
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Trong-Neng Wu, Chao Ling Wang, Chun-Yuh Yang, Saou-Hsing Liou, Ya-Hui Yang, and Shyh Jong Wu
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medicine.medical_specialty ,Epidemiology ,business.industry ,Incidence ,Health Policy ,Incidence (epidemiology) ,Taiwan ,Public Health, Environmental and Occupational Health ,MEDLINE ,Nurses ,Object (computer science) ,Occupational Diseases ,Young Adult ,Infectious Diseases ,Family medicine ,Humans ,Medicine ,Female ,Young adult ,Needlestick Injuries ,business - Published
- 2013
19. Increased blood lead concentration during menstruation in teen female students
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Saou-Hsing Liou, Chin-Ching Wu, Chun-Yuh Yang, Fung-Chang Sung, Ya-Hui Yang, and Trong-Neng Wu
- Subjects
Gerontology ,medicine.medical_specialty ,Environmental Engineering ,Adolescent ,media_common.quotation_subject ,Paired difference test ,Menstruation ,Epidemiology ,Environmental Chemistry ,Medicine ,Humans ,Girl ,Lead (electronics) ,Students ,Waste Management and Disposal ,Menstrual cycle ,media_common ,biology ,medicine.diagnostic_test ,business.industry ,Obstetrics ,Environmental Exposure ,biology.organism_classification ,Pollution ,Lead ,Tasa ,Blood lead level ,Female ,business ,Environmental Monitoring - Abstract
Among many studies on the health effects associated with lead burden in human, none has addressed for menstrual cycle. Studies have reported that blood lead levels (BLLs) may increase as estrogen levels decrease. We conducted a study to test whether the BLLs vary during the menstrual cycle. The subjects were 138 teen girls recruited at a junior nursing college. Blood specimens were collected in non-menses days in September 2003 (baseline BLLs) and during days of the menses in December 2003 (between 72nd and 96th hours of the period for follow-up measures). The paired test for differences of BLLs was used to compare between these two measures. There were no significant differences in baseline characteristics between students who had participated in both the baseline and follow-up studies and students who had participated only in baseline study. The average BLLs measured during the menses was 0.20 microg/dL higher than that measured at the baseline study (p0.01). This finding suggests that the average BLL was 7.6% increased at the menses among these teen girl students. In the future, the time to collect blood samples for measuring lead for women should be standardized.
- Published
- 2007
20. Local Augmented Angiotensinogen Secreted from Apoptotic Vascular Endothelial Cells Is a Vital Mediator of Vascular Remodelling
- Author
-
Chih-Sheng Chu, Shyh-Jong Wu, Ya-Hui Yang, Shih-Chuan Shih, Mei-Chuan Kuo, Marie-Josée Hébert, Ya-Ju Hsieh, and Mathilde Soulez
- Subjects
medicine.medical_specialty ,Intimal hyperplasia ,Vascular smooth muscle ,MAP Kinase Signaling System ,Myocytes, Smooth Muscle ,Angiotensinogen ,lcsh:Medicine ,Angiotensin-Converting Enzyme Inhibitors ,Apoptosis ,Peptidyl-Dipeptidase A ,Vascular Remodeling ,Biology ,Muscle, Smooth, Vascular ,Umbilical vein ,Cell Line ,Vascular remodelling in the embryo ,Mice ,Lisinopril ,Internal medicine ,Renin–angiotensin system ,Human Umbilical Vein Endothelial Cells ,medicine ,Animals ,Humans ,lcsh:Science ,Mitogen-Activated Protein Kinase 1 ,Mitogen-Activated Protein Kinase 3 ,Multidisciplinary ,Angiotensin II ,lcsh:R ,medicine.disease ,Rats ,Losartan ,Endocrinology ,ACE inhibitor ,cardiovascular system ,lcsh:Q ,Research Article ,medicine.drug - Abstract
Vascular remodelling is a critical vasculopathy found in atheromatous diseases and allograft failures. The local renin angiotensin system (RAS) has been implicated in vascular remodelling. However, the mechanisms by which the augmented local RAS is associated with the initial event of endothelial cell apoptosis in injured vasculature remain undefined. We induced the apoptosis of human umbilical vein endothelial cells (HUVECs) and vascular smooth muscle cells (VSMCs) through serum starvation (SS). After the cells were subjected to SS, we found that the mRNA expression of angiotensinogen (AGT) was increased by >3-fold in HUVECs and by approximately 2.5-fold in VSMCs. In addition, the expression of angiotensin-converting enzyme (ACE) mRNA was increased in VSMCs but decreased to 50% in HUVECs during the same apoptotic process. Increases in the expression of AGT protein and angiotensin II (Ang II) were found in a serum-free medium conditioned by HUVECs (SSC). The increased Ang II was suppressed using lisinopril (an ACE inhibitor) treatment. Moreover, the activation of ERK1/2 induced by the SSC in VSMCs was also suppressed by losartan. In conclusion, we first demonstrated that the augmented AGT released from apoptotic endothelial cells acts as a vital progenitor of Ang II to accelerate vascular remodelling, and we suggest that blocking local augmented Ang II might be an effective strategy for restraining intimal hyperplasia.
- Published
- 2015
21. Relationship between Lung Function and Metabolic Syndrome
- Author
-
Ya-Hui Yang, Chung-Ching Wang, Tao-Chun Peng, Wei-Liang Chen, Li-Wei Wu, Yaw-Wen Chang, Ying-Jen Chen, James Yi-Hsin Chan, and Tung-Wei Kao
- Subjects
Male ,Vital capacity ,Pulmonology ,Physiology ,Vital Capacity ,lcsh:Medicine ,Body Mass Index ,Pulmonary function testing ,Endocrinology ,Forced Expiratory Volume ,Medicine and Health Sciences ,lcsh:Science ,Lung ,Abdominal obesity ,Metabolic Syndrome ,education.field_of_study ,Multidisciplinary ,respiratory system ,Nutrition Surveys ,Respiratory Function Tests ,Obesity, Abdominal ,Hypertension ,Respiratory Physiological Phenomena ,Female ,medicine.symptom ,Research Article ,Adult ,medicine.medical_specialty ,National Health and Nutrition Examination Survey ,Population ,FEV1/FVC ratio ,Diabetes mellitus ,Internal medicine ,medicine ,Humans ,education ,Triglycerides ,business.industry ,lcsh:R ,Cholesterol, HDL ,Biology and Life Sciences ,medicine.disease ,United States ,respiratory tract diseases ,Health Care ,Cross-Sectional Studies ,Diabetes Mellitus, Type 2 ,Metabolic Disorders ,lcsh:Q ,Metabolic syndrome ,business - Abstract
Although the link between impaired lung function and cardiovascular events and type 2 diabetes mellitus has been recognized, the association between impaired lung function and metabolic syndrome has not been comprehensively assessed in the United States (U.S.) population. The aim of our study was to explore the association between impaired lung function and metabolic syndrome in a nationally representative sample of men and women. This cross-sectional population-based study included 8602 participants aged 20-65 years in the Third National Health and Nutrition Examination Survey (NHANES III). We examined the relationship between the different features of metabolic syndrome and lung function, including forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1). After adjusting for potential confounders such as age, body mass index, inflammatory factors, medical condition, and smoking status, participants with more components of metabolic syndrome had lower predicted values of FVC and FEV1 (p for trend
- Published
- 2014
22. Mortality Among Ship-breaking Workers—-A Retrospective Cohort Study
- Author
-
Yu-Jen Lin, Trong-Neng Wu, WT Wu, Jiin-Chyr Hsu, Yu Jen Lin, Yang Yh, Chun-Yuh Yang, Chun Yuh Yang, Wei-Te Wu, Jin-Huei Hsu, and Ya-Hui Yang
- Subjects
Pediatrics ,medicine.medical_specialty ,Ship breaking ,Epidemiology ,business.industry ,Medicine ,Retrospective cohort study ,Prospective cohort study ,business ,Cohort study - Published
- 2011
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