603 results on '"Totsuka A"'
Search Results
2. Japanese Man with HCV Genotype 4 Infection and Cirrhosis Who Was Successfully Treated by the Combination of Glecaprevir and Pibrentasvir
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Reina Sasaki, Tomotaka Ishii, Yoichiro Yamana, Shunichi Matsuoka, Hiroaki Okamoto, Ryota Masuzaki, Hiroshi Takahashi, Mariko Kumagawa, Hiroshi Ohnishi, Naoki Matsumoto, Tatsuo Kanda, Kazushige Nirei, Mai Totsuka, Masayuki Honda, Shini Kanezawa, Hiroaki Yamagami, Mitsuhiko Moriyama, Tomohiro Kaneko, and Taku Mizutani
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Adult ,Liver Cirrhosis ,Male ,medicine.medical_specialty ,Pyrrolidines ,Cirrhosis ,Genotype ,Hepatitis C virus ,Case Report ,HCV genotype 4 ,Hepacivirus ,030204 cardiovascular system & hematology ,medicine.disease_cause ,Antiviral Agents ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Combined treatment ,Japan ,Quinoxalines ,Internal medicine ,Internal Medicine ,Humans ,Medicine ,Aged ,DAA ,transfusion ,Sulfonamides ,business.industry ,cirrhosis ,virus diseases ,General Medicine ,Glecaprevir ,Hepatitis C, Chronic ,medicine.disease ,digestive system diseases ,Pibrentasvir ,Drug Combinations ,Virologic response ,Benzimidazoles ,Drug Therapy, Combination ,030211 gastroenterology & hepatology ,business - Abstract
A 74-year-old man with a history of transfusion at 35 years old in Egypt was referred to our hospital. He was infected with hepatitis C virus (HCV) genotype 4 (GT4), which is a rare HCV GT in Japan, and was also diagnosed with hepatic compensated cirrhosis. We safely treated the patient for 12 weeks with the combination of glecaprevir and pibrentasvir, and a sustained virologic response (SVR) was achieved. This is the first report of HCV GT4 infection in a treatment-naïve Japanese patient with cirrhosis in whom SVR was achieved with the combination treatment of glecaprevir and pibrentasvir.
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- 2021
3. Mortality and risk factors on admission in toxic epidermal necrolysis: A cohort study of 59 patients
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Tomoya Watanabe, Yukie Yamaguchi, Hideyuki Ishikawa, Yumiko Yamane, Yusuke Saigusa, Hirofumi Go, Kazuko Nakamura, Naoko Takamura, Michiko Aihara, Michiru Totsuka, Takeshi Kambara, Setsuko Matsukura, Yuko Watanabe, and Shunsuke Takaki
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Adult ,Male ,lcsh:Immunologic diseases. Allergy ,0301 basic medicine ,medicine.medical_specialty ,Adolescent ,SCORTEN ,Malignancy ,Logistic regression ,Severity of Illness Index ,Cohort Studies ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Adrenal Cortex Hormones ,Risk Factors ,Internal medicine ,Humans ,Immunology and Allergy ,Medicine ,Modified scoring model ,Mortality ,Child ,Blood urea nitrogen ,Aged ,Aged, 80 and over ,Body surface area ,Receiver operating characteristic ,business.industry ,Mortality rate ,Anti-Inflammatory Agents, Non-Steroidal ,Toxic epidermal necrolysis ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Anti-Bacterial Agents ,030104 developmental biology ,030228 respiratory system ,Child, Preschool ,Stevens-Johnson Syndrome ,Anticonvulsants ,Female ,lcsh:RC581-607 ,business ,Cohort study - Abstract
Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening disorders characterized by widespread epidermal necrosis of the skin and mucosa. The severity-of-illness scoring system for TEN (SCORTEN) was widely used since 2000 as a standard prognostic tool consisting of seven clinical values. Methods: To evaluate the prognosis using current treatments and risk factors for mortality, we retrospectively analyzed 59 cases of TEN, including SJS/TEN overlap treated in two university hospitals from January 2000 to March 2020. Results: The mortality rate of TEN was 13.6% (8/59). All patients treated with high-dose steroid administration in combination with plasma exchange and/or immunoglobulin therapy recovered. Logistic regression analysis showed nine clinical composite scores, namely: heart rate (≧120 bpm), malignancy present, percentage of body surface area with epidermal detachment (>10%), blood urea nitrogen (>28 mg/dL), serum bicarbonate level (252 mg/dL), age (≧71 years), the interval between disease onset and treatment initiation at the specialty hospital (≧8 days), and respiratory disorder within 48 h after admission. The receiver operating characteristic curves confirmed a high potential for predicting the prognosis of TEN. Conclusions: Recent developments in treatment strategies have contributed to the improved prognosis of TEN patients. A modified severity scoring model composed of nine scores may be helpful in the prediction of TEN prognosis in recent patients. Further large-scale studies are needed to confirm mortality findings to improve prognostication in patients with TEN.
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- 2021
4. Impending Blindness by Obstructive Hydrocephalus Intractable to Endoscopic Third Ventriculostomy: Case Report
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Muneyoshi Yasuda, Akihiro Miyasaki, Takeaki Totsuka, Yohei Maruga, Makoto Negoro, Nobuo Shirasaka, Yoshihito Hasegawa, Kazuhito Takeuchi, Keisuke Ito, and Mikiko Funai
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Endoscopic third ventriculostomy ,Obstructive hydrocephalus ,Magnetic resonance imaging ,Chiasmatic cistern ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Lumbar ,Cerebrospinal fluid ,Edema ,030221 ophthalmology & optometry ,medicine ,medicine.symptom ,Papilledema ,business ,030217 neurology & neurosurgery - Abstract
Endoscopic third ventriculostomy (ETV) has been accepted for obstructive hydrocephalus (OH). We herein present a case of OH and optic nerve sheath edema (ONSE). Although ETV was successful, ONSE worsened. Discussion is focused on the relationship among intracranial hypertension (IH), ETV, and ONSE. The patient was a 19-year-old woman with complaints of headache and emesis. Papilledema was prominent. Radiological examination showed OH as an aqueductal tumor. Endoscopic tumorectomy and ETV were accomplished. Although headache and emesis disappeared, papilledema persisted. On the 4th day, the patient lost light perception. On magnetic resonance imaging, the third ventricular stroma and aqueduct were patent. Nevertheless, ONSE was prominent. After lumbar drainage, her vision was restored. Finally, ventriculoperitoneal shunting was performed, following which ONSE disappeared. IH is not always accompanied by ONSE. However, once it occurs, it may act separately from IH, and ETV may even exacerbate ONSE due to alteration of cerebrospinal fluid (CSF) flow into the chiasmatic cistern. In the optic nerve sheath, CSF pressure is not easily transmitted across different areas; this should explain the dissociation between ONSE and other symptoms of IH. Furthermore, we suggest that ONSE and acute optic dysfunction should be considered an independent crisis as “hydronervus opticus.”
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- 2021
5. Correlation Between Metamorphopsia Caused by Macular Diseases and Ocular Dominance
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Yuko Ishikawa, Nobuyoshi Totsuka, Etsuko Totsuka, Ayumi Watanabe, and Emi Yoshida
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Correlation ,medicine.medical_specialty ,business.industry ,Ophthalmology ,medicine ,Metamorphopsia ,medicine.symptom ,business ,Ocular dominance - Published
- 2019
6. Apararenone in patients with diabetic nephropathy: results of a randomized, double-blind, placebo-controlled phase 2 dose–response study and open-label extension study
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Ryuji Terata, Takashi Wada, Masaya Inagaki, Miki Gotou, Toru Yoshinari, Gaia Hashimoto, and Naoko Totsuka
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Adult ,Male ,Nephrology ,medicine.medical_specialty ,Physiology ,Apararenone ,Urology ,Renal function ,Diabetic nephropathy ,Urine ,Placebo ,Creatine ,Mineralocorticoid receptor antagonists ,Young Adult ,chemistry.chemical_compound ,Double-Blind Method ,Physiology (medical) ,Internal medicine ,Oxazines ,medicine ,Albuminuria ,Humans ,Diabetic Nephropathies ,Diabetic kidney disease ,Adverse effect ,Aged ,Sulfonamides ,Dose-Response Relationship, Drug ,business.industry ,Incidence (epidemiology) ,Middle Aged ,medicine.disease ,Fibrosis ,chemistry ,Creatinine ,Female ,Original Article ,Dose-finding study ,business ,Glomerular Filtration Rate - Abstract
Background We investigated the efficacy and safety of apararenone (MT-3995), a non-steroidal compound with mineralocorticoid receptor agonist activity, in patients with stage 2 diabetic nephropathy (DN). Methods The study had two parts: a dose–response, parallel-group, randomized, double-blind, placebo-controlled, multicenter, phase 2, 24-week study and an open-label, uncontrolled, 28-week extension study. Primary and secondary endpoints were the 24-week percent change from baseline in urine albumin to creatine ratio (UACR) and 24- and 52-week UACR remission rates. Safety parameters were changes from baseline in estimated glomerular filtration rate (eGFR) and serum potassium at 24 and 52 weeks, and incidences of adverse events (AEs) and adverse drug reactions (ADRs). Results In the dose–response period, 73 patients received placebo and 73, 74, and 73 received apararenone 2.5 mg, 5 mg, and 10 mg, respectively. As a percentage of baseline, mean UACR decreased to 62.9%, 50.8%, and 46.5% in the 2.5 mg, 5 mg, and 10 mg apararenone groups, respectively, at week 24 (placebo: 113.7% at week 24; all P Conclusion The UACR-lowering effect of apararenone administered once daily for 24 weeks in patients with stage 2 DN was confirmed, and the 52-week administration was safe and tolerable. Clinical trial registration NCT02517320 (dose–response study) and NCT02676401 (extension study)
- Published
- 2020
7. New Evaluation Method for Bone Formation around a Fully Hydroxyapatite-Coated Stem Using Digital Tomosynthesis: A Retrospective Cross-Sectional Study
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Hajime Mishima, Sho Totsuka, Tomofumi Nishino, Ryunosuke Watanabe, and Masashi Yamazaki
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musculoskeletal diseases ,fully hydroxyapatite-coated stem ,surrounding bone formation ,medicine.medical_specialty ,Medicine (General) ,digital tomosynthesis ,business.industry ,Radiography ,Clinical Biochemistry ,Tomosynthesis ,Article ,R5-920 ,Plain radiography ,Evaluation methods ,Orthopedic surgery ,medicine ,Bone formation ,Implant ,business ,Nuclear medicine ,POLARSTEM ,Total hip arthroplasty - Abstract
Digital tomosynthesis (DTS) is a new imaging technique derived from radiography, and its usefulness has been gradually reported in the field of orthopedic diagnosis in recent years. A fully hydroxyapatite (HA)-coated stem, which is used for total hip arthroplasty (THA), is a type of cementless stem that has been widely used recently and reported to have good results. However, stem loosening on plain radiographs is difficult to determine in some cases due to cancellous condensation around the stem. In this retrospective cross-sectional study, we compared the results of plain radiography versus DTS to evaluate the imaging findings after THA using a fully HA-coated stem. Twenty joints each in the 3 y and 1 y postoperative groups underwent plain radiography and DTS. On DTS, bone formation around the stem was confirmed in all cases, however, this formation was not reproducible on plain radiography, and there were cases in which the reaction could not be confirmed or cases with cancellous condensation resembling reactive lines. This reaction was not reproducible on plain radiographs, and in some cases, the reaction could not be confirmed, or there were cases with cancellous condensation that resembled reactive lines. Therefore, DTS was useful in the diagnosis of bone formation around the implant.
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- 2021
8. Cases Showing Crossed Monovision After Cataract Surgery
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Emi Yoshida, Ayumi Watanabe, Yuko Ishikawa, Nobuyoshi Totsuka, and Etsuko Totsuka
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medicine.medical_specialty ,business.industry ,Medicine ,After cataract ,business ,Surgery - Published
- 2018
9. Efficacy and safety of apararenone (MT-3995) in patients with nonalcoholic steatohepatitis: A randomized controlled study
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Michiie Sakamoto, Naoko Totsuka, Hiromitsu Kumada, Masaya Inagaki, Gaia Hashimoto, Kenichi Harada, and Takeshi Okanoue
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medicine.medical_specialty ,Randomization ,Hepatology ,biology ,business.industry ,Phases of clinical research ,Placebo ,medicine.disease ,Gastroenterology ,law.invention ,Infectious Diseases ,Randomized controlled trial ,Tolerability ,Alanine transaminase ,law ,Fibrosis ,Internal medicine ,Nonalcoholic fatty liver disease ,biology.protein ,Medicine ,business - Abstract
Aim To evaluate the efficacy, safety, and tolerability of apararenone 10 mg/day in patients with nonalcoholic steatohepatitis (NASH). Methods In this multicenter, randomized, double-blind, placebo-controlled phase II study, patients received apararenone 10 mg or placebo once daily for 72 weeks. The primary efficacy end-point was percent change in serum alanine aminotransferase (ALT) from baseline to 24 weeks after randomization. Secondary efficacy end-points included changes in liver fibrosis markers. Adverse drug reactions (ADRs) and serum potassium levels were evaluated. Results Forty-eight patients were randomly assigned to treatment (placebo, 23; apararenone, 25). The percent change in ALT at 24 weeks was -3.0% and -13.7% with placebo and apararenone, respectively (p = 0.308). The apararenone group showed greater reductions from baseline in fibrosis markers (type IV collagen 7S and procollagen-3 N-terminal peptide) and noninvasive tests of fibrosis (enhanced liver fibrosis score and Fibrosis-4 index) at all time points versus placebo. The percentage of patients with improvement of 1 point or more in fibrosis stage/without nonalcoholic fatty liver disease activity score worsening was 41.7% with apararenone and 26.1% with placebo (p = 0.203). Adverse drug reactions were reported in three (13.0%) and three (12.5%) patients in the placebo and apararenone groups, respectively. Serum potassium levels increased in the apararenone group during the study and decreased to near baseline after the end of treatment. Conclusions In patients with NASH, apararenone 10 mg/day for 72 weeks was effective in decreasing ALT levels, improved multiple potential fibrosis markers, and was safe and well tolerated. Pathological findings showed anti-inflammatory and antifibrotic effects of apararenone.
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- 2021
10. Long-term outcomes of anterior chest wall arteriovenous graft with polyurethane
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Hajime Nakamura, Hiromu Rachi, Megumi Shimasaki, Kei Yamada, Akashi Togawa, Akira Takanohasi, Satoko Uyama, Yuichi Totsuka, Seiko Takanohashi, Kazuaki Shirota, and Kimitoshi Shiratori
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medicine.medical_specialty ,business.industry ,Anterior chest wall ,Polyurethanes ,Graft Occlusion, Vascular ,Surgery ,Blood Vessel Prosthesis ,Blood Vessel Prosthesis Implantation ,Arteriovenous Shunt, Surgical ,Nephrology ,Renal Dialysis ,Long term outcomes ,medicine ,Humans ,business ,Thoracic Wall ,Polytetrafluoroethylene ,Vascular Patency - Abstract
Background: Anterior chest wall arteriovenous graft (ACWAVG) is one option for haemodialysis patients when vessels of the upper extremities become exhausted. We report here the long-term outcomes of ACWAVG with polyurethane. Methods: From April 2005 to October 2015, nine ACWAVGs with polyurethane grafts were created. We observed patients until April 2019 and evaluated graft patency, interval from operation to first cannulation, and numbers of interventions and complications. Results: Primary patency rate and secondary patency rate of 6, 12 and 24 months were 55.3%, 33.3%, 33.3% and 77.8%, 55.6%, 55.6% respectively. Mean interval from operation to first cannulation was 3 days. Infection rate and kinking formation rate were slightly higher than previous reports of ACWAVGs with expanded polytetrafluoroethylene (ePTFE). However, one patient was able to keep using a single graft for 166 months with multiple interventions. Conclusions: Slight disadvantage are seen with patency rate and complication rate in polyurethane ACWAVG compare to ePTFE. However, when early cannulation is required, polyurethane is worth to consider for creating ACWAVG.
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- 2021
11. Exercise-Induced Acute Kidney Injury in a Police Officer with Hereditary Renal Hypouricemia
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Yoshio Shimizu, Kazuaki Hara, Yasuhiko Tomino, Yusuke Suzuki, Shusaku Nitta, Ayako Totsuka, Maiko Akira, Yoko Hayashi, and Keiichi Wakabayashi
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medicine.medical_specialty ,030232 urology & nephrology ,Renal function ,Case Report ,030204 cardiovascular system & hematology ,lcsh:RC870-923 ,urologic and male genital diseases ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,RENAL HYPOURICEMIA ,Hypouricemia ,Exercise ,Low serum uric acid ,business.industry ,Serum uric acid ,Hereditary renal hypouricemia ,Acute kidney injury ,lcsh:Diseases of the genitourinary system. Urology ,medicine.disease ,Police officer ,Occupational training ,Nephrology ,business ,Anaerobic exercise - Abstract
Hereditary renal hypouricemia is characterized by hypouricemia with hyper-uric acid clearance due to a defect in renal tubular transport. Patients with hereditary renal hypouricemia have a higher risk of exercise-induced acute kidney injury (EAKI) and reduced kidney function. Although the best preventive measure is avoiding exercise, there are many kinds of jobs that require occupational exercise. A 27-year-old male police officer suffered from stage 3 AKI after performing a 20-m multistage shuttle run test. His mother had previously been diagnosed as having renal hypouricemia at another facility. The patient had reported having hypouricemia during a health check at a previous police station, but his serum uric acid concentration was within the normal range at our hospital. After treatment, he recovered from EAKI and exhibited low serum uric acid and hyper-uric acid clearance. Since the patient desired to continue his career requiring strenuous exercise, it was difficult to establish a preventive plan against the recurrence of EAKI. Patients with hereditary renal hypouricemia who must undergo strenuous occupational anaerobic exercise are at higher risk of developing EAKI than other workers. The risks of EAKI among patients with hypouricemia should be considered when undergoing physical occupational training.
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- 2019
12. Multifocal origin of occupational cholangiocarcinoma revealed by comparison of multilesion mutational profiles
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Hitoshi Nakagama, Yukari Totsuka, Shigeru Marubashi, Atsushi Ochiai, Masahiko Watanabe, Katsuya Tsuchihara, Sachiyo Mimaki, Shoji Nakamori, Shogo Tanaka, Tatsuhiro Shibata, Shigekazu Takemura, Shoji Kubo, Riu Yamashita, Hiroshi Haeno, and Masahiko Kinoshita
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Adult ,Male ,0301 basic medicine ,Cancer Research ,Pathology ,medicine.medical_specialty ,Mutation rate ,Carcinogenesis ,Somatic cell ,Disease ,medicine.disease_cause ,Cholangiocarcinoma ,03 medical and health sciences ,0302 clinical medicine ,Occupational Exposure ,Exome Sequencing ,Humans ,Medicine ,Exome ,Aged ,Mutation ,Invasive carcinoma ,business.industry ,Bile duct ,General Medicine ,Middle Aged ,030104 developmental biology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Printing ,Female ,Bile Ducts ,Neoplasm Recurrence, Local ,business - Abstract
Recently identified occupational cholangiocarcinoma among printing workers is characterized by chronic bile duct injuries and precancerous or early cancerous lesions at multiple sites of the bile ducts. These observations suggested the potential multifocal carcinogenesis of the disease. We performed whole-exome analysis of multiple lesions, including the invasive carcinomas and precancerous lesions of four occupational cholangiocarcinoma cases. A much higher mutation burden was observed in both the invasive carcinomas (mean 76.3/Mb) and precancerous lesions (mean 71.8/Mb) than in non-occupational cholangiocarcinomas (mean 1.6/Mb). Most somatic mutations identified in 11 of 16 lesions did not overlap with each other. In contrast, a unique trinucleotide mutational signature of GpCpY to GpTpY was shared among the lesions. These results suggest that most of these lesions are multiclonal in origin and that common mutagenic processes, which may be induced by exposure to haloalkanes or their metabolites, generated somatic mutations at different sites of the bile ducts. A similarly high mutation rate had already been identified in the precancerous lesions, implying an increased potential for carcinogenesis throughout the biliary tree. These genomic features support the importance of ongoing close follow-up of the patients as a group at high risk of recurrence.
- Published
- 2019
13. Quantitative analysis of mutagenicity and carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in F344 gpt delta transgenic rats
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Anna Kakehashi, Hideki Wanibuchi, Takashi Yamaguchi, Michiharu Matsumoto, Masaki Fujioka, Yukari Totsuka, Min Gi, Shoji Fukushima, and Kenichi Masumura
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Male ,medicine.medical_specialty ,Carcinogenicity Tests ,Health, Toxicology and Mutagenesis ,Mutant ,010501 environmental sciences ,Toxicology ,01 natural sciences ,03 medical and health sciences ,chemistry.chemical_compound ,In vivo ,Internal medicine ,Genetics ,medicine ,Animals ,Humans ,Transversion ,Genetics (clinical) ,Carcinogen ,030304 developmental biology ,0105 earth and related environmental sciences ,0303 health sciences ,Mutation Spectra ,Dose-Response Relationship, Drug ,Mutagenicity Tests ,Chemistry ,発がん性 ,Glutathione ,Immunohistochemistry ,Rats, Inbred F344 ,Rats ,Dose–response relationship ,Endocrinology ,Liver ,Mutagenesis ,変異原性 ,Carcinogens ,Quinolines ,Rats, Transgenic ,Quantitative analysis (chemistry) ,Mutagens - Abstract
Quantitative analysis of the mutagenicity and carcinogenicity of the low doses of genotoxic carcinogens present in food is of pressing concern. The purpose of the present study was to determine the mutagenicity and carcinogenicity of low doses of the dietary genotoxic carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ). Male F344 gpt delta transgenic rats were fed diets supplemented with 0, 0.1, 1, 10 or 100 ppm IQ for 4 weeks. The frequencies of gpt transgene mutations in the liver were significantly increased in the 10 and 100 ppm groups. In addition, the mutation spectra was altered in the 1, 10 and 100 ppm groups: frequencies of G:C to T:A transversion were significantly increased in groups administered 1, 10 and 100 ppm IQ in a dose-dependent manner, and the frequencies of G:C to A:T transitions, A:T to T:A transversions and A:T to C:G transversions were significantly increased in the 100 ppm group. Increased frequencies of single base pair deletions and Spi− mutants in the liver, and an increase in glutathione S-transferase placental form (GST-P)-positive foci, a preneoplastic lesion of the liver in rats, was also observed in the 100 ppm group. In contrast, neither mutations nor mutation spectra or GST-P-positive foci were statistically altered by administration of IQ at 0.1 ppm. We estimated the point of departure for the mutagenicity and carcinogenicity of IQ using the no-observed-effect level approach and the Benchmark dose approach to characterise the dose–response relationship of low doses of IQ. Our findings demonstrate the existence of no effect levels of IQ for both in vivo mutagenicity and hepatocarcinogenicity. The findings of the present study will facilitate an understanding of the carcinogenic effects of low doses of IQ and help to determine a margin of exposure that may be useful for practical human risk assessment.
- Published
- 2019
14. Case of severe bullous erythema including intertrigo‐like eruptions with angioedema induced by pegylated liposomal doxorubicin
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Mayumi Hagiwara, Hideyuki Ishikawa, Yuko Watanabe, Chika Asai, Naoko Takamura, Michiko Aihara, Saki Takahashi, and Michiru Totsuka
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medicine.medical_specialty ,Intertrigo ,Stage IIIC Ovarian Cancer ,Anthracycline ,Erythema ,Prednisolone ,Administration, Oral ,Dermatology ,Polyethylene Glycols ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Blister ,0302 clinical medicine ,Humans ,Medicine ,Doxorubicin ,Angioedema ,skin and connective tissue diseases ,Skin ,Ovarian Neoplasms ,Antibiotics, Antineoplastic ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Axilla ,Treatment Outcome ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Female ,lipids (amino acids, peptides, and proteins) ,Drug Eruptions ,medicine.symptom ,business ,Ovarian cancer ,medicine.drug - Abstract
Pegylated liposomal doxorubicin (PLD) is an anthracycline anticancer agent used in ovarian cancer and a form of doxorubicin enclosed in pegylated liposomes. There are only a few reports on intertrigo-like eruptions caused by PLD. We describe the first case of severe bullous erythema, including intertrigo-like eruptions with angioedema, induced by PLD in Japan. We present the case of a 53-year-old woman who was diagnosed with stage IIIC ovarian cancer. After receiving three cycles of PLD, the patient developed swelling of the upper lip and painful erythema with blisters and erosions on the axilla, upper back, flank and wrists. The patient was diagnosed with angioedema and severe skin lesions, including intertrigo-like eruptions induced by PLD. Although treatment with oral prednisolone and topical steroids was effective against these eruptions, the administration of PLD was discontinued because of its ineffectiveness against the primary disease. Several risk factors, such as obesity, perspiration and racial differences, may contribute toward a severe manifestation such as that seen in our patient. Moreover, our case was the first accompanied by angioedema. The mechanism of coexistence of intertrigo-like eruptions and angioedema is not clear; further studies are required to clarify the pathological mechanism of intertrigo-like eruptions.
- Published
- 2019
15. Corneal Refractive Power at the Age of 3 in Children With a History of Retinopathy of Prematurity
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Nobuyuki Shoji, Satoru Totsuka, Hitoshi Ishikawa, Aya Saito, and Tetsuya Ikeda
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medicine.medical_specialty ,business.industry ,Ophthalmology ,Medicine ,Optical power ,Retinopathy of prematurity ,business ,medicine.disease - Published
- 2019
16. A Patient with Cervical Vertebral Arteriovenous Fistula Which Manifested as Radiculopathy: A Case Complicated by Neurofibromatosis Type 1
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Tomoya Ohishi, Shusuke Matsui, Hisaya Hiramatsu, Mika Kamiya, Takeaki Totsuka, and Hiroki Nanba
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medicine.medical_specialty ,business.industry ,medicine ,Arteriovenous fistula ,Neurology (clinical) ,Radiology ,Neurofibromatosis ,Cardiology and Cardiovascular Medicine ,business ,medicine.disease - Published
- 2019
17. Improvement of Adherence with Occlu-Pad Therapy for Pediatric Patients with Amblyopia
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Satoru Totsuka, Nobuyuki Shoji, Hitoshi Ishikawa, and Tomoya Handa
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Male ,medicine.medical_specialty ,Visual acuity ,Article Subject ,genetic structures ,Treatment outcome ,Visual Acuity ,lcsh:Medicine ,Amblyopia ,Eye ,General Biochemistry, Genetics and Molecular Biology ,Anisometropia ,03 medical and health sciences ,0302 clinical medicine ,Ophthalmology ,Humans ,Medicine ,Strabismic amblyopia ,In patient ,030212 general & internal medicine ,Child ,General Immunology and Microbiology ,business.industry ,lcsh:R ,Significant difference ,General Medicine ,Training methods ,Bandages ,eye diseases ,Eyeglasses ,Treatment Outcome ,Child, Preschool ,Clinical Study ,030221 ophthalmology & optometry ,Female ,medicine.symptom ,business - Abstract
We aimed to examine visual acuity improvement effect and adherence in amblyopia training using tablet type vision training equipment (Occlu-pad). The subjects were 138 patients with amblyopia (average age of 5.5 ± 1.6 years old); their amblyopic visual acuity at the start of training was logMAR 0.15 to 1.3. Occlu-pad is a device that processes images such that amblyopic eyes can only view the image as it passes through polarized glasses; this is achieved by peeling off the polarizing film layer in the liquid crystal display of an iPad (Apple). Amblyopia training comprised either the instructional training with Occlu-pad or the eye patch (Patching) as a family training, after wearing perfectly corrected glasses. Visual acuity improvement following amblyopia training by Occlu-pad and Patching was significantly different after 6 months in patients with anisometropic amblyopia (p
- Published
- 2018
18. A pediatric case of Stevens-Johnson syndrome with acute liver failure, resulting in liver transplantation
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Yuko Watanabe, Satoru Saito, Masato Yoneda, Michiko Aihara, Michiru Totsuka, Yasushi Honda, Naoko Takamura, Takafumi Kumamoto, Tomoya Watanabe, and Shoji Yamanaka
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medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Dermatology ,Human leukocyte antigen ,Liver transplantation ,Gastroenterology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Mucositis ,Humans ,Child ,Acetaminophen ,Skin ,business.industry ,Liver failure ,General Medicine ,Liver Failure, Acute ,medicine.disease ,Toxic epidermal necrolysis ,Liver Transplantation ,stomatognathic diseases ,030220 oncology & carcinogenesis ,Stevens-Johnson Syndrome ,Female ,Liver dysfunction ,Complication ,business ,medicine.drug - Abstract
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are fatal adverse skin reactions characterized by high fever, epidermal detachment, and mucositis. It is well known that SJS/TEN occasionally affects various organs, leading to permanent damage and death in some patients. Although acute liver dysfunction is a relatively common complication of SJS/TEN, severe acute liver dysfunction requiring liver transplantation is rare. We present the case of a 14-year-old girl with SJS complicated by severe and rapidly progressive liver dysfunction, specifically, acute liver failure (ALF) requiring liver transplantation. A lymphocyte transformation test showed positive results for acetaminophen and cefdinir. Furthermore, human leukocyte antigen (HLA) genotyping revealed the presence of the HLA-A*02:06 genotype, which is reported to be strongly associated with acetaminophen-related SJS/TEN with severe ocular complications. These results suggested that our patient may have presented with acetaminophen-induced SJS complicated by ALF, but no ocular complications. This is the first report of a pediatric patient with SJS who required liver transplantation. In rare instances, severe liver dysfunction requiring liver transplantation should be considered as a possible complication of SJS/TEN.
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- 2021
19. Complex Modulating Effects of Dietary Calcium Intake on Obese Mice
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Kosuke Tashiro, Michihiro Mutoh, Masahito Hagio, Maiko Takahashi, Gen Fujii, Takahiro Hamoya, Takumi Narita, Masami Komiya, and Yukari Totsuka
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Cancer Research ,medicine.medical_specialty ,Normal diet ,medicine.medical_treatment ,chemistry.chemical_element ,Mice, Obese ,Calcium ,General Biochemistry, Genetics and Molecular Biology ,chemistry.chemical_compound ,Mice ,Internal medicine ,medicine ,Animals ,Microbiome ,Obesity ,Dietary calcium ,Feces ,Pharmacology ,business.industry ,Insulin ,Deoxycholic acid ,Body Weight ,medicine.disease ,Diet ,Calcium, Dietary ,Mice, Inbred C57BL ,Endocrinology ,chemistry ,business ,Research Article - Abstract
Background/Aim: Οverweight and obesity are risk factors for chronic diseases. Dietary calcium has been reported to exert anti-obesity effects. However, the complex modulating effects of calcium intake on obese mice have not been clarified. Materials and Methods: The effects of calcium intake on body weight/visceral fat mass were examined in the obese mouse model, KK-A(y). Results: Body weight gain decreased in mice fed a diet containing 0.4 to 3.2% calcium at the age of 11 and 13 weeks, but not at 12 weeks after normalization for food intake. Calcium intake also decreased serum insulin levels and increased the amount of feces excreted. Fecal deoxycholate levels were lower in the high-calcium group than in the normal diet control group. Furthermore, the ratio of the deoxycholate-producing microbiome in feces decreased. Conclusion: Dietary calcium has anti-obesity effects in obese KK-A(y) mice. Inhibition of insulin production and an increased amount of feces excreted with calcium intake may affect body weight.
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- 2021
20. U.S.-Japan cooperative medical sciences program: 22nd International Conference on Emerging Infectious Diseases in the Pacific Rim
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Leilani Paitoonpong, F. Gray Handley, Eun Chung Park, Kumiko Yoshimatsu, Opass Putcharoen, Watsamon Jantarabenjakul, Gompol Suwanpimolkul, Masahiko Noda, Marie Ricciardone, Takuya Yamamoto, Meng Ling Moi, Ichiro Kurane, Patrick J. Brennan, Marissa Tan, Kristina T. Lu, Diane E. Griffin, Wei Li, Asuka Nanbo, Miwa Sonoda, David McDonald, Yukari Totsuka, K. Gayle Bernabe, and Allan Hildesheim
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medicine.medical_specialty ,Pacific Rim ,business.industry ,Public health ,virus diseases ,Biology ,medicine.disease ,medicine.disease_cause ,Dengue fever ,Acquired immunodeficiency syndrome (AIDS) ,Family medicine ,Virology ,Pandemic ,medicine ,Global health ,Rabies ,Chikungunya ,business - Abstract
This review summarizes the presentations given at the 22nd International conference on Emerging Infectious Diseases in the Pacific Rim. The purpose of this annual meeting is to foster international collaborations and address important public health issues in the Asia-Pacific region. This meeting was held in Bangkok in February 2020 and focused on emerging virus infections. Unexpectedly, the SARS-CoV-2 pandemic was in the initial stages leading to a special session on COVID-19 in addition to talks on dengue, influenza, hepatitis, AIDS, Zika, chikungunya, rabies, cervical cancer and nasopharyngeal carcinoma.
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- 2021
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21. Effectiveness of a Japanese multi-professional cooperative osteoporosis liaison service at a private hospital for decreasing secondary fractures in osteoporosis patients with fragility fractures
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Yasumasa Yoshino, Toshiro Kubo, Kazumi Sakamoto, Hikaru Ohama, Rie Fujioka, Shinya Tanaka, Saori Kobayashi, Sachiko Ishimine, Kanae Kuwagaki, Hideki Tobita, Hiroaki Totsuka, and Yuka Ichiba
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0301 basic medicine ,Male ,medicine.medical_specialty ,Osteoporosis ,030209 endocrinology & metabolism ,Hospitals, Private ,03 medical and health sciences ,0302 clinical medicine ,Fragility ,Japan ,Internal medicine ,Multi professional ,medicine ,Secondary Prevention ,Humans ,Orthopedics and Sports Medicine ,In patient ,Medical prescription ,Aged ,Aged, 80 and over ,Hip fracture ,Bone Density Conservation Agents ,business.industry ,medicine.disease ,Orthopedic surgery ,Life circumstances ,Female ,030101 anatomy & morphology ,business ,Osteoporotic Fractures - Abstract
A fracture liaison service (FLS) was established in England to support patients with fragility fractures, and it was introduced in Japan as the osteoporosis liaison service (OLS). The study aim was to determine if the Japanese OLS/FLS prevents secondary fractures in patients with fragility fractures and assess the value of the OLS/FLS. Our OLS/FLS evaluated the status of osteoporosis in patients and their life circumstances. Additionally, it introduced osteoporosis therapies during the patients’ hospitalization period and then continued periodical examinations and prescription of drug after discharge. This study was conducted in consecutive patients: 400 were assigned to the non-OLS group and 406 to the OLS group. The mean age of the patients was 81.7 ± 9.7 years in the non-OLS group (154 patients with vertebral fractures and 246 with hip fractures; 100 males, 300 females) and 82.4 ± 9.3 years in the OLS group (245 patients with hip fractures and 161 with vertebral fractures; 101 males, 305 females). During hospitalization, 74.9% of the OLS group patients started medications and 63.9% of patients continued after discharge, while 35.8% and 53.5% of non-OLS group. The incidence rate of secondary fractures was 89.8/1000 person-years in the non-OLS group, and 55.2/1000 person-years in the OLS group. The multivariate Cox hazards test showed that secondary fractures after vertebral or hip fractures increased with age, and the risk was 0.58-fold in patients in the OLS group. OLS was effective in reducing secondary fractures in patients with osteoporosis with fragility fractures.
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- 2020
22. Aortic stiffness and central hemodynamics in treatment-naïve HIV infection: a cross-sectional study
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Monserrat Alvarez-Zavala, Diego Castañeda-Zaragoza, Karina Sánchez-Reyes, Pedro Martínez-Ayala, Rodolfo I. Cabrera-Silva, Guillermo Alanis-Sánchez, David Cardona-Müller, Sylvia E Totsuka-Sutto, Jaime Andrade-Villanueva, Carlos G Ramos-Becerra, Moisés Ramos-Solano, Ernesto Germán Cardona-Muñoz, and Luz A. González-Hernández
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Adult ,Male ,Mean arterial pressure ,medicine.medical_specialty ,lcsh:Diseases of the circulatory (Cardiovascular) system ,Manometry ,Arteriosclerosis ,Blood Pressure ,HIV Infections ,030204 cardiovascular system & hematology ,Risk Assessment ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Vascular Stiffness ,Internal medicine ,Heart rate ,medicine ,Prevalence ,Humans ,Pulse wave velocity ,Mexico ,030304 developmental biology ,0303 health sciences ,business.industry ,Central pulse pressure ,Hemodynamics ,Chronic inflammation ,medicine.disease ,HIV infection ,Cardiovascular risk ,Arterial stiffness ,Pulse pressure ,Blood pressure ,Cross-Sectional Studies ,lcsh:RC666-701 ,Cardiovascular Diseases ,Heart Disease Risk Factors ,Carotid-Femoral Pulse Wave Velocity ,Case-Control Studies ,Cardiology ,Aortic stiffness ,Female ,Cardiology and Cardiovascular Medicine ,business ,Viral load ,Research Article - Abstract
Background Human immunodeficiency virus (HIV) infection is associated with a greater risk of cardiovascular disease (CVD). HIV infection causes a chronic inflammatory state and increases oxidative stress which can cause endothelial dysfunction and arterial stiffness. Aortic stiffness measured by carotid femoral-pulse wave velocity (cfPWV) and central hemodynamics are independent cardiovascular risk factors and have the prognostic ability for CVD. We assessed cfPWV and central hemodynamics in young individuals with recent HIV infection diagnosis and without antiretroviral therapy. We hypothesized that individuals living with HIV would present greater cfPWV and central hemodynamics (central systolic blood pressure and pulse pressure) compared to uninfected controls. Methods We recruited 51 treatment-naïve individuals living with HIV (HIV(+)) without previous CVD and 51 age- and sex-matched controls (HIV negative (−)). We evaluated traditional CVD risk factors including metabolic profile, blood pressure (BP), smoking, HIV viral load, and CD4+ T-cells count. Arterial stiffness and central hemodynamics were evaluated by cfPWV, central systolic BP, and central pulse pressure (cPP) via applanation tonometry. Results HIV(+) individuals presented a greater prevalence of smoking, reduced high-density lipoprotein cholesterol, and body mass index. 65.9% of HIV(+) individuals exhibited lymphocyte CD4+ T-cells count p Conclusion In the early stages of infection, non-treated HIV individuals present a greater prevalence of traditional CVD risk factors, arterial stiffness, and normal or in some cases central hemodynamics.
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- 2020
23. Simple prediction model for homologous recombination deficiency in breast cancers in adolescents and young adults
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Yoko Shimada, Yae Kanai, Maki Tanioka, Mineko Ushiama, Takashi Kohno, Hirohiko Totsuka, Kenji Tamura, Masayuki Yoshida, Teruhiko Yoshida, Kouya Shiraishi, Tomoko Watanabe, Eri Arai, and Takayuki Honda
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0301 basic medicine ,Oncology ,Cancer Research ,Loss of Heterozygosity ,medicine.disease_cause ,Logistic regression ,Germline ,Cohort Studies ,0302 clinical medicine ,Japan ,Risk Factors ,Breast ,Young adult ,Homologous Recombination ,Mastectomy ,Mutation ,BRCA1 Protein ,Phenotype ,Europe ,030220 oncology & carcinogenesis ,Cohort ,PARP inhibitor ,Female ,Adult ,medicine.medical_specialty ,Adolescent ,Antineoplastic Agents ,Breast Neoplasms ,Poly(ADP-ribose) Polymerase Inhibitors ,03 medical and health sciences ,Young Adult ,Breast cancer ,Predictive Value of Tests ,Internal medicine ,Exome Sequencing ,medicine ,Biomarkers, Tumor ,Humans ,Genetic Testing ,Germ-Line Mutation ,BRCA2 Protein ,Models, Genetic ,business.industry ,medicine.disease ,United States ,030104 developmental biology ,Drug Resistance, Neoplasm ,Tumor Suppressor Protein p53 ,business - Abstract
Homologous recombination deficiency (HRD), which influences the efficacy of PARP inhibitor- and platinum agent-based therapies, is a prevalent phenotype of breast cancer in adolescents and young adults (AYAs; 15–39 years old). However, HRD score, indicating HRD status, is not routinely assessed in the breast oncology clinic, particularly in patients without germline BRCA1/2 mutations. Hence, we sought to develop a model for determining HRD status based on genetic and clinicopathological factors. Subjects were our own cohort of 46 Japanese AYA breast cancer patients and two existing breast cancer cohorts of US and European patients. Models for prediction of the HRD-high phenotype, defined as HRD score ≥ 42, were constructed by logistic regression analysis, using as explanatory variables genetic and clinicopathological factors assessable in the clinical setting. In all three cohorts, the HRD-high phenotype was associated with germline BRCA1/2 mutation, somatic TP53 mutation, triple-negative subtype, and higher tumor grade. A model based on these four factors, developed using the US cohort, was validated in the Japanese and European AYA cases: area under the receiver operating characteristic curve [AUC] was 0.90 and 0.96, respectively. A model based on three factors excluding germline BRCA1/2 mutation also yielded high-predictive power in cases from these two cohorts without germline BRCA1/2 mutations: AUC was 0.92 and 0.90, respectively. The HRD-high phenotype of AYA breast cancer patients can be deduced from genomic and pathological factors that are routinely examined in the oncology clinic, irrespective of germline BRCA1/2 mutations.
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- 2020
24. P47 Hypertension Prevalence in Health Sciences Students of the University of Guadalajara
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Claudia Yanette Galan Ruiz, Brandon Giovany Illescas Vidrio, Carlos Gerardo Ramos Becerra, Fernando Grover Páez, David Cardona Müller, Sylvia Elena Totsuka Sutto, and Ernesto Germán Cardona Muñoz
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medicine.medical_specialty ,RC581-951 ,business.industry ,Hypertension prevalence ,Family medicine ,RC666-701 ,Medicine ,Specialties of internal medicine ,Diseases of the circulatory (Cardiovascular) system ,General Medicine ,business ,Biomedical sciences - Abstract
Hypertension (HTN) is considered within the first 9 preventable causes of death in Mexico [1]. In order to estimate HTN prevalence in students a blood pressure (BP) measuring campaign was performed at the University of Guadalajara. Methods: BP was measured in morning shift students, none with known chronic diseases. Before the measurement a survey was made to identify the cardiovascular risk factors, BP was measured in 3 occasions with an automatized sphygmomanometer (OMRON HEM907XL), according to the recommendations and protocol of international guidelines [2]. The average of the measurements were used to classify the subjects in normotensive (
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- 2020
25. Serum Neuropeptide Y Levels Are Associated with TNF-α Levels and Disease Activity in Rheumatoid Arthritis
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Ana Miriam Saldaña-Cruz, Betsabe Contreras-Haro, N. S. Fajardo-Robledo, Cesar Arturo Nava-Valdivia, Edsaul Emilio Perez-Guerrero, Edy David Rubio-Arellano, Javier Alejandro Aceves-Aceves, Melissa Ramirez-Villafaña, Norma Alejandra Rodriguez-Jimenez, Laura Gonzalez-Lopez, Maria O. Carrillo-Escalante, David Cardona-Müller, Miguel Huerta, Jorge I. Gamez-Nava, Mario Salazar-Páramo, Sylvia E Totsuka-Sutto, and Ernesto Germán Cardona-Muñoz
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medicine.medical_specialty ,Article Subject ,Immunology ,Arthritis ,Proinflammatory cytokine ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,mental disorders ,medicine ,Immunology and Allergy ,Interleukin 6 ,030304 developmental biology ,0303 health sciences ,biology ,business.industry ,Leptin ,General Medicine ,RC581-607 ,medicine.disease ,Neuropeptide Y receptor ,humanities ,Endocrinology ,Rheumatoid arthritis ,biology.protein ,030211 gastroenterology & hepatology ,Tumor necrosis factor alpha ,Antibody ,Immunologic diseases. Allergy ,business - Abstract
Background. Neuropeptide Y (NPY) is a sympathetic neurotransmitter with effects on the regulation of inflammatory cells. The role of NPY on autoimmune inflammatory diseases such as rheumatoid arthritis (RA) is not completely understood. Therefore, we evaluate if NPY levels are markers of disease activity in RA and if there is a correlation between NPY levels and tumor necrosis factor-alpha (TNF-α), leptin, and interleukin 6 (IL-6) levels. Methods. Cross-sectional design, including 108 women with RA. We assessed disease activity by DAS28-ESR (considering active disease a score of ≥2.6). Serum NPY levels and anti-CCP2 antibody, TNF-α, IL-6, and leptin levels were quantified (ELISA). Results. Sixty-eight RA had an active disease (RA-active), and 40 were in remission (RA-remission). RA-active patients had higher NPY levels vs. RA-remission (22.8±13.6 vs. 17.8±10.3; p=0.04). NPY levels correlated with increased TNF-α levels (r=0.32, p=0.001). Leptin or IL-6 did not correlate with NPY levels. In the logistic regression analysis, NPY increased the risk of disease activity (OR: 1.04, 95% CI 1.006-1.09, and p=0.03). Conclusion. Higher NPY levels are an independent marker of disease activity in RA. This study encourages the quantification of NPY levels as a surrogate marker for RA-active. Future studies evaluating the role of NPY levels interacting with other proinflammatory cytokines are required.
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- 2020
26. Penetrating Traumatic Injury to the Trachea Inflicted with a Knife
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Yorihisa Imanishi, Marie Shimanuki, Nana Nakahara, Yoichiro Sato, and Daisuke Totsuka
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medicine.medical_specialty ,Traumatic injury ,Otorhinolaryngology ,business.industry ,medicine ,Tracheal injury ,Stab wound ,medicine.disease ,business ,Penetrating trauma ,Surgery - Published
- 2018
27. Estimated Stearoyl-CoA-desaturase (SCD)-1 and Elongase of Very Long Chain Fatty Acids (Elovl) 6 Activities From Serum Fatty Acids Are Reciprocally Associated with Visceral Fat Area in Type 2 Diabetic Patients
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Hiroaki Suzuki, Hitoshi Shimano, Kumiko Totsuka-Mizuma, Motohiro Sekiya, Shigeru Yatoh, Takashi Matsuzaka, and Ommega Internationals
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medicine.medical_specialty ,Stearoyl-CoA Desaturase ,Elongase ,Endocrinology ,Chemistry ,Internal medicine ,medicine ,Very long chain ,Visceral fat - Published
- 2018
28. Pretreatment monocyte counts and neutrophil counts predict the risk for febrile neutropenia in patients undergoing TPF chemotherapy for head and neck squamous cell carcinoma
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Koshiro Miura, Satoko Yoshida, Yasutomo Araki, Yoichiro Sato, Takehiro Tominaga, Kosuke Uno, Yasuo Sato, Daisuke Totsuka, Yusuke Ogawa, Nana Nakahara, Junko Nagayama, Keiko Soma, Ayako Endo, Marie Shimanuki, Seiji Shigetomi, Yorihisa Imanishi, Yuichi Ikari, Emiri Sato, Takuya Tomioka, Kaoru Ogawa, Hiroyuki Ozawa, and Sena Iguchi
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0301 basic medicine ,medicine.medical_specialty ,TPF ,Neutropenia ,head and neck squamous cell carcinoma ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,business.industry ,neutrophil count ,medicine.disease ,monocyte count ,Head and neck squamous-cell carcinoma ,Chemotherapy regimen ,Regimen ,030104 developmental biology ,febrile neutropenia ,Oncology ,Docetaxel ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Absolute neutrophil count ,business ,Febrile neutropenia ,medicine.drug ,Research Paper - Abstract
// Marie Shimanuki 1 , Yorihisa Imanishi 1 , Yoichiro Sato 1 , Nana Nakahara 1 , Daisuke Totsuka 1 , Emiri Sato 1 , Sena Iguchi 1 , Yasuo Sato 2 , Keiko Soma 3 , Yasutomo Araki 1 , Seiji Shigetomi 4 , Satoko Yoshida 5 , Kosuke Uno 6 , Yusuke Ogawa 7 , Takehiro Tominaga 5 , Yuichi Ikari 5 , Junko Nagayama 4 , Ayako Endo 8 , Koshiro Miura 9 , Takuya Tomioka 10 , Hiroyuki Ozawa 5 and Kaoru Ogawa 5 1 Department of Otorhinolaryngology–Head and Neck Surgery, Kawasaki Municipal Kawasaki Hospital, Kawasaki, Kanagawa, Japan 2 Department of Otorhinolaryngology, Kyosai Tachikawa Hospital, Tachikawa, Tokyo, Japan 3 Department of Otorhinolaryngology, Matsumoto Dental University, Matsumoto, Nagano, Japan 4 Department of Otorhinolaryngology, Yokohama Municipal Citizen’s Hospital, Yokohama, Kanagawa, Japan 5 Department of Otorhinolaryngology–Head and Neck Surgery, Keio University School of Medicine, Shinjuku, Tokyo, Japan 6 Department of Otolaryngology–Head and Neck Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan 7 Department of Otorhinolaryngology, International University of Health and Welfare Atami Hospital, Atami, Shizuoka, Japan 8 Department of Otorhinolaryngology, Saitama Red Cross Hospital, Saitama, Saitama, Japan 9 Department of Otorhinolaryngology, Kamio Memorial Hospital, Chiyoda, Tokyo, Japan 10 Department of Otorhinolaryngology, Ashikaga Red Cross Hospital, Ashikaga, Tochigi, Japan Correspondence to: Yorihisa Imanishi, email: yorihisa@ja2.so-net.ne.jp Keywords: febrile neutropenia; TPF; monocyte count; neutrophil count; head and neck squamous cell carcinoma Received: February 09, 2018 Accepted: March 07, 2018 Published: April 10, 2018 ABSTRACT Background: Febrile neutropenia (FN) is the most serious hematologic toxicity of systemic chemotherapy. However, accurate prediction of FN development has been difficult because the risk varies largely depending on the chemotherapy regimen and various individual factors. Methods: We retrospectively analyzed diverse clinical factors including pretreatment hematological parameters to clarify the reliable predictors of FN development during chemotherapy with a docetaxel, cisplatin, and fluorouracil (TPF) regimen in patients with head and neck squamous cell carcinoma. Results: Among the 50 patients, grade ≥3 neutropenia, grade 4 neutropenia, and FN developed in 36 (72%), 21 (42%), and 12 (24%) patients, respectively. Multivariate logistic regression revealed that a pretreatment absolute monocyte count (AMC)
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- 2018
29. Confiabilidad de un monitor automatizado para la medición de la presión arterial
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Víctor H Guzmán-Saldívar, Carlos G Ramos-Becerra, Agustín Macías-Chumacera, Fernando Grover-Páez, César Murguia-Soto, Patricia Quezada-Fernández, Sylvia E Totsuka-Sutto, Guillermo Alanis-Sánchez, David Cardona-Müller, and Ernesto Germán Cardona-Muñoz
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medicine.medical_specialty ,Correlation coefficient ,Stethoscope ,business.industry ,Significant difference ,Blood Pressure ,Blood Pressure Determination ,Sphygmomanometer ,General Medicine ,Repeatability ,Mercury sphygmomanometer ,Confidence interval ,law.invention ,Blood pressure ,law ,Internal medicine ,Hypertension ,medicine ,Cardiology ,business - Abstract
Background A correct blood pressure (BP) measurement is essential for the diagnosis and control of high BP. Aim: To evaluate the agreement and repeatability of BP measurements with the OMRON HEM-7320-LA device compared to a mercury sphygmomanometer. Material and Methods: A cross-sectional study comparing BP measurements made by two randomly selected trained nurses and an automatic oscillometric device. The mercurial sphygmomanometer was connected to the automated device via a “T” type connector and a dual-head stethoscope was used, allowing simultaneous measurements. The results were analyzed with one-factor analysis of variance, Bland-Altman's test, repeatability coefficient (RC), and intra-class correlation coefficient (ICC). Results: Forty-nine participants aged 56 ± 19 years were included. Nineteen had hypertension (38%). We did not observe a significant difference in either systolic (SBP) or diastolic blood pressure (DBP) pressure measurements between the observers and the device. The mean difference was −0.09 mmHg (95% confidence intervals (CI)-0.9 to 0.7) for SBP and −0.9 mmHg (95% CI −1.7 to −0.13) for DBP. The RC for SBP (6.2, 5.2 and 5.8 mmHg) and DBP (4.7, 4.2 y 5.2 mmHg) was similar between the observers and the device. The ICC for SBP was 0.990 (95% CI 0.983 to 0.995, p < 0.01) and 0.986 (95% CI 0.977 to 0.991, p < 0.01) for DBP. Conclusions: There was a high level of agreement and similar measurement repeatability in the measurements performed by the automatic device and the mercurial sphygmomanometer. No differences in BP measurements were observed.
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- 2018
30. Validation of the Omron HEM-7320-LA, upper arm blood pressure monitor with Intelli Wrap Technology Cuff HEM-FL1 for self-measurement and clinic use according to the European Society of Hypertension International Protocol revision 2010 in the Mexican population
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Ernesto Germán Cardona-Muñoz, Mayra B Jiménez-Cázarez, Sylvia E Totsuka-Sutto, Carlos G Ramos-Becerra, Fernando Grover-Páez, Víctor H Guzmán-Saldívar, Guillermo Alanis-Sánchez, David Cardona-Müller, and Mariana Rodríguez-De la Cerda
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Adult ,Male ,medicine.medical_specialty ,Diastole ,Blood Pressure ,Sphygmomanometer ,030204 cardiovascular system & hematology ,Assessment and Diagnosis ,diagnostic errors ,Ambulatory Care Facilities ,self-blood pressure monitoring ,03 medical and health sciences ,0302 clinical medicine ,Self measurement ,Internal Medicine ,Humans ,Medicine ,030212 general & internal medicine ,Aged ,oscillometry ,Advanced and Specialized Nursing ,Protocol (science) ,business.industry ,Blood Pressure Determination ,Mean age ,General Medicine ,Middle Aged ,Sphygmomanometers ,Mexican population ,home blood pressure monitoring ,Self Care ,Blood pressure ,Cuff ,Arm ,Physical therapy ,Female ,Cardiology and Cardiovascular Medicine ,business ,Devices and Technology - Abstract
Objective The aim of this study was to determine the accuracy of the Omron HEM-7320-LA with Intelli Wrap technology cuff HEM-FL1 for self-measurement and clinic blood pressure (BP) measurement according to the European Society of Hypertension International Protocol revision 2010. Participants and methods The evaluation was performed in 39 individuals. The mean age of the participants was 47.9±14 years; systolic BP was 145.2±24.3 mmHg (range: 97-190), diastolic BP was 90.9±12.9 mmHg (range: 68-120), and arm circumference was 30.8±4 cm (range: 25-38.5). Results The device successfully fulfilled the established criteria of the validation protocol. The device overestimated systolic BP by 0.6±5.7 mmHg and diastolic BP by 2.2±5.1 mmHg. The specially designed cuff HEM-FL1 to cover a broad range of arm circumferences and self-placement fulfilled the requirements of the International Protocol.
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- 2017
31. γ-H2AX formation in the urinary bladder of rats treated with two norharman derivatives obtained from o -toluidine and aniline
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Keiji Wakabayashi, Tomomi Morikawa, Kumiko Ogawa, Kohei Matsushita, Takeshi Toyoda, Noriyuki Miyoshi, and Y. Totsuka
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0301 basic medicine ,medicine.medical_specialty ,Urinary bladder ,Chemistry ,Cell growth ,Urology ,Urine ,Toxicology ,Stem cell marker ,medicine.disease_cause ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Endocrinology ,medicine.anatomical_structure ,In vivo ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,Immunohistochemistry ,Carcinogen ,Genotoxicity - Abstract
Aminomethylphenylnorharman (AMPNH) and aminophenylnorharman (APNH) are mutagenic norharman derivatives obtained from o-toluidine and aniline, respectively. APNH is carcinogenic to the urinary bladder of rats and present in urine samples of healthy volunteers, indicating that norharman derivatives may be associated with cancer development in the urinary bladder of humans. To evaluate the possible role of AMPNH and APNH in bladder carcinogenesis, we examined the formation of γ-H2AX, a DNA damage response marker, in the urinary bladder of rats. Seven-week-old male F344 rats were treated with 400 ppm AMPNH or 40 ppm APNH in the diet for 4 weeks. Animals were killed at the end of administration or after 2 weeks of recovery, and immunohistochemistry for γ-H2AX and Ki67, a cell proliferation marker, was performed. At week 4, γ-H2AX formation in bladder epithelial cells was significantly increased by APNH treatment as compared with that in controls. AMPNH also induced upregulation of γ-H2AX formation, although there was no statistical significance. After the recovery period, γ-H2AX-positive cells were reduced but remained significantly higher in AMPNH and APNH groups than in the control group. Ki67-positive cells were significantly increased by AMPNH and APNH at week 4 and reduced to the same level as the control after 2 weeks of recovery. Expression of KRT14, a bladder stem cell marker, was also increased in the basal layer by the two norharman derivatives. Thus, AMPNH and APNH showed in vivo genotoxicity in the bladder epithelium of rats, and APNH may be a potent causative agent of bladder carcinogenesis.
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- 2017
32. Changes in entropy on polarized-sensitive optical coherence tomography images after therapeutic subthreshold micropulse laser for diabetic macular edema: A pilot study
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Yohei Hashimoto, Motoshi Yamamoto, Fumiyuki Araki, Masahiro Yamanari, Ryo Obata, Takahiro Minami, Kiyohito Totsuka, Satoshi Kato, Taku Toyama, Koji Ueda, Takashi Ueta, Tomoyasu Shiraya, Han Peng Zhou, Satoshi Sugiyama, Nobuyori Aoki, and Koichiro Sugimoto
- Subjects
Male ,RNA viruses ,genetic structures ,Entropy ,Visual Acuity ,Pilot Projects ,Retinal Pigment Epithelium ,Plant Science ,Pathology and Laboratory Medicine ,White Blood Cells ,chemistry.chemical_compound ,Endocrinology ,Medical Conditions ,Animal Cells ,Edema ,Medicine and Health Sciences ,Prospective Studies ,Fluorescein Angiography ,Entropy (energy dispersal) ,Aged, 80 and over ,Laser Coagulation ,Multidisciplinary ,medicine.diagnostic_test ,Physics ,Tobacco Mosaic Virus ,medicine.anatomical_structure ,Optical Equipment ,Tobamoviruses ,Medical Microbiology ,Viral Pathogens ,Physical Sciences ,Viruses ,Medicine ,Thermodynamics ,Engineering and Technology ,Female ,Cellular Types ,Pathogens ,Anatomy ,medicine.symptom ,Tomography, Optical Coherence ,Research Article ,medicine.medical_specialty ,Endocrine Disorders ,Science ,Immune Cells ,Ocular Anatomy ,Immunology ,Plant Pathogens ,Equipment ,Refraction, Ocular ,Microbiology ,Macular Edema ,Plant Viral Pathogens ,Retina ,Signs and Symptoms ,Optical coherence tomography ,Ocular System ,Ophthalmology ,Diabetes Mellitus ,medicine ,Humans ,Microbial Pathogens ,Aged ,Diabetic Retinopathy ,Blood Cells ,Retinal pigment epithelium ,Choroid ,business.industry ,Lasers ,Macrophages ,Organisms ,Fovea centralis ,Biology and Life Sciences ,Retinal ,Cell Biology ,Plant Pathology ,eye diseases ,chemistry ,Metabolic Disorders ,sense organs ,Clinical Medicine ,business - Abstract
Purpose To investigate the dynamics of the healing process after therapeutic subthreshold micropulse laser (SMPL) for diabetic macular edema (DME) using polarization-sensitive optical coherence tomography (PS-OCT). Methods Patients with treatment-native or previously-treated DME were prospectively imaged using PS-OCT at baseline, 1, 2, 3, and 6 months. The following outcomes were evaluated: changes in the entropy value per unit area (pixel2) in the retinal pigment epithelium (RPE) on the B-scan image; changes in the entropy value in each stratified layer (retina, RPE, choroid) based on the ETDRS grid circle overlaid with en face entropy mapping, not only the whole ETDRS grid area but also a sector irradiated by the SMPL; and the relationship between edema reduction and entropy changes. Results A total of 11 eyes of 11 consecutive DME patients were enrolled. No visible signs of SMPL treatment were detected on PS-OCT images. The entropy value per unit area (pixel2) in the RPE tended to decrease at 3 and 6 months from baseline (35.8 ± 17.0 vs 26.1 ± 9.8, P = 0.14; vs 28.2 ± 18.3, P = 0.14). Based on the en face entropy mapping, the overall entropy value did not change in each layer in the whole ETDRS grid; however, decrease of entropy in the RPE was observed at 2, 3, and 6 months post-treatment within the SMPL-irradiated sectors (P < 0.01, each). There was a positive correlation between the change rate of retinal thickness and that of entropy in the RPE within the SMPL-irradiated sector at 6 months (r2 = 0.19, P = 0.039). Conclusion Entropy measured using PS-OCT may be a new parameter that facilitates objective monitoring of SMPL-induced functional changes in the RPE that could not previously be assessed directly. This may contribute to a more promising therapeutic evaluation of DME. Clinical trial This clinical study was registered in UMIN-CTR (ID: UMIN000042420).
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- 2021
33. Effect of endurance training and branched-chain amino acids on the signaling for muscle protein synthesis in CKD model rats fed a low-protein diet
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Yuri Totsuka, Takuya Yoshida, Miho Sugimoto, Hiromichi Kumagai, Shinji Miura, and Sachika Kakizawa
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Male ,0301 basic medicine ,medicine.medical_specialty ,Time Factors ,Physiology ,medicine.medical_treatment ,Muscle Proteins ,Renal function ,Biology ,Kidney ,Muscle hypertrophy ,03 medical and health sciences ,Low-protein diet ,Endurance training ,hemic and lymphatic diseases ,Internal medicine ,Diet, Protein-Restricted ,medicine ,Animals ,Phosphorylation ,Rats, Wistar ,Renal Insufficiency, Chronic ,Muscle, Skeletal ,PI3K/AKT/mTOR pathway ,Soleus muscle ,Interleukin-6 ,TOR Serine-Threonine Kinases ,Ribosomal Protein S6 Kinases, 70-kDa ,medicine.disease ,Animal Feed ,Exercise Therapy ,Disease Models, Animal ,Muscular Atrophy ,030104 developmental biology ,Endocrinology ,Proteolysis ,Physical Endurance ,Amino Acids, Branched-Chain ,Signal Transduction ,Kidney disease - Abstract
A low-protein diet (LPD) protects against the progression of renal injury in patients with chronic kidney disease (CKD). However, LPD may accelerate muscle wasting in these patients. Both exercise and branched-chain amino acids (BCAA) are known to increase muscle protein synthesis by activating the mammalian target of rapamycin (mTOR) pathway. The aim of this study was to investigate whether endurance exercise and BCAA play a role for increasing muscle protein synthesis in LPD-fed CKD (5/6 nephrectomized) rats. Both CKD and sham rats were pair-fed on LPD or LPD fortified with a BCAA diet (BD), and approximately one-half of the animals in each group was subjected to treadmill exercise (15 m/min, 1 h/day, 5 days/wk). After 7 wk, renal function was measured, and soleus muscles were collected to evaluate muscle protein synthesis. Renal function did not differ between LPD- and BD-fed CKD rats, and the treadmill exercise did not accelerate renal damage in either group. The treadmill exercise slightly increased the phosphorylation of p70s6 kinase, a marker of mTOR activity, in the soleus muscle of LPD-fed CKD rats compared with the sham group. Furthermore, BCAA supplementation of the LPD-fed, exercise-trained CKD rats restored the phosphorylation of p70s6 kinase to the same level observed in the sham group; however, the corresponding induced increase in muscle protein synthesis and muscle mass was marginal. These results indicate that the combination of treadmill exercise and BCAA stimulates cell signaling to promote muscle protein synthesis; however, the implications of this effect for muscle growth remain to be clarified.
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- 2017
34. Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice
- Author
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Akihide Tanimoto, Taro Uchida, Shiro Maeda, Tadashi Kaname, Yuji Taira, Akira Arasaki, Hiroaki Masuzaki, Katsuhiko Noguchi, Kimio Satoh, Masayuki Matsushita, Yuichi Totsuka, Chisayo Kozuka, Toshihiro Matsuzaki, Junichi Omura, Masato Tsutsui, Haruaki Kubota, Shin ichiro Kina, Nobuyuki Yanagihara, Junko Nakasone, Mika Kina-Tanada, Mayuko Sakanashi, Hiroaki Shimokawa, Hajime Sunakawa, Masayoshi Ishida, and Yusuke Ohya
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Nitric Oxide ,Endothelial NOS ,Cardiovascular System ,Nitric oxide ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,Insulin resistance ,Nitrate ,Internal medicine ,Internal Medicine ,Animals ,Medicine ,Endothelial dysfunction ,Nitrite ,Nitrites ,Metabolic Syndrome ,Nitrates ,business.industry ,medicine.disease ,Dietary Nitrite ,Mice, Inbred C57BL ,030104 developmental biology ,Endocrinology ,chemistry ,Biochemistry ,Metabolic syndrome ,business - Abstract
Nitric oxide (NO) is synthesised not only from l-arginine by NO synthases (NOSs), but also from its inert metabolites, nitrite and nitrate. Green leafy vegetables are abundant in nitrate, but whether or not a deficiency in dietary nitrite/nitrate spontaneously causes disease remains to be clarified. In this study, we tested our hypothesis that long-term dietary nitrite/nitrate deficiency would induce the metabolic syndrome in mice. To this end, we prepared a low-nitrite/nitrate diet (LND) consisting of an amino acid-based low-nitrite/nitrate chow, in which the contents of l-arginine, fat, carbohydrates, protein and energy were identical with a regular chow, and potable ultrapure water. Nitrite and nitrate were undetectable in both the chow and the water. Three months of the LND did not affect food or water intake in wild-type C57BL/6J mice compared with a regular diet (RD). However, in comparison with the RD, 3 months of the LND significantly elicited visceral adiposity, dyslipidaemia and glucose intolerance. Eighteen months of the LND significantly provoked increased body weight, hypertension, insulin resistance and impaired endothelium-dependent relaxations to acetylcholine, while 22 months of the LND significantly led to death mainly due to cardiovascular disease, including acute myocardial infarction. These abnormalities were reversed by simultaneous treatment with sodium nitrate, and were significantly associated with endothelial NOS downregulation, adiponectin insufficiency and dysbiosis of the gut microbiota. These results provide the first evidence that long-term dietary nitrite/nitrate deficiency gives rise to the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice, indicating a novel pathogenetic role of the exogenous NO production system in the metabolic syndrome and its vascular complications.
- Published
- 2017
35. Vasohibin-1 as a Novel Prognostic Factor for Head and Neck Squamous Cell Carcinoma
- Author
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Nako Maishi, Chisaho Torii, Kyoko Hida, Noritaka Ohga, Yoichi Ohiro, Masanobu Shindoh, Kosuke Akiyama, Yasufumi Sato, Yasunori Totsuka, Kanchu Tei, Yoshimasa Kitagawa, Mitsunobu Ono, and Yasuhiro Hida
- Subjects
Male ,Cancer Research ,Pathology ,medicine.medical_specialty ,Angiogenesis ,CD34 ,Antigens, CD34 ,Cell Cycle Proteins ,Disease-Free Survival ,03 medical and health sciences ,0302 clinical medicine ,Biomarkers, Tumor ,medicine ,Humans ,Lymph node ,Aged ,Vasohibin-1 ,Neovascularization, Pathologic ,Cluster of differentiation ,business.industry ,Gene Expression Profiling ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Head and neck squamous-cell carcinoma ,Staining ,Gene Expression Regulation, Neoplastic ,Treatment Outcome ,medicine.anatomical_structure ,Oncology ,Head and Neck Neoplasms ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Immunohistochemistry ,Female ,Neoplasm Recurrence, Local ,business ,030215 immunology - Abstract
Aim: We evaluated the prognostic value of vasohibin-1 (VASH1) expression in head and neck squamous cell carcinoma. Materials and Methods: Immunohistochemistry for VASH1 and cluster of differentiation 34 (CD34) was performed on 61 head and neck squamous cell carcinoma specimens. The association between VASH1 expression in the tumour and clinical outcomes was analyzed statistically. Results: VASH1 staining in normal tissue adjacent to cancerous tissue was negative, whereas it was positive in tumour blood vessels and AE1/AE3 and Ki67-positive tumour cells. Therefore, we examined the association between VASH1 expression in the tumour and clinical outcomes. Patients with high VASH1 expression in tumour had significantly shorter disease-free survival and more frequently had lymph node recurrence than those with low VASH1 expression. Conclusion: These results suggest that VASH1 expression is associated with tumour progression and may be useful as a prognostic marker of head and neck squamous cell carcinoma.
- Published
- 2017
36. Serum levels of P-glycoprotein and persistence of disease activity despite treatment in patients with systemic lupus erythematosus
- Author
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Ana Rosa Rincón-Sánchez, David Cardona-Müller, N. S. Fajardo-Robledo, Teresa Arcelia Garcia-Cobian, J. D. Murillo-Vazquez, Edsaul Emilio Perez-Guerrero, Arnulfo Hernán Nava-Zavala, M. L. Vazquez-Villegas, Sylvia E Totsuka-Sutto, Laura Gonzalez-Lopez, Ernesto Germán Cardona-Muñoz, Jorge I. Gamez-Nava, José Francisco Muñoz-Valle, and David Bonilla-Lara
- Subjects
Adult ,Serum ,Volunteers ,0301 basic medicine ,medicine.medical_specialty ,Adolescent ,Enzyme-Linked Immunosorbent Assay ,Drug resistance ,Severity of Illness Index ,Gastroenterology ,General Biochemistry, Genetics and Molecular Biology ,Persistence (computer science) ,Disease activity ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Refractory ,Prednisone ,Internal medicine ,Humans ,Lupus Erythematosus, Systemic ,Medicine ,In patient ,ATP Binding Cassette Transporter, Subfamily B, Member 1 ,skin and connective tissue diseases ,Glucocorticoids ,Aged ,P-glycoprotein ,Aged, 80 and over ,030203 arthritis & rheumatology ,Hematology ,biology ,business.industry ,General Medicine ,Middle Aged ,Cross-Sectional Studies ,030104 developmental biology ,Endocrinology ,Antibodies, Antinuclear ,biology.protein ,Female ,business ,Immunosuppressive Agents ,medicine.drug - Abstract
Around 25% of patients with systemic lupus erythematosus (SLE) could be refractory to conventional therapies. P-glycoprotein expression on cell surface has been implied on drug resistance, however, to date, it is unknown if P-gp serum levels are associated with SLE disease activity. Evaluate the association of serum P-gp levels and SLE with disease activity despite treatment. A cross-sectional study was conducted on 93 female SLE patients, all receiving glucocorticoids at stable doses for the previous 6 months before to baseline. SLE patients were classified into two groups: (a) patients with active disease [SLE disease activity index (SLEDAI) ≥ 3] despite treatment, and (b) patients with inactive disease (SLEDAI
- Published
- 2017
37. ALDH1 and podoplanin expression patterns predict the risk of malignant transformation in oral leukoplakia
- Author
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Tetsuya Kitamura, Umma Habiba, Yoichi M. Ito, Yoichi Ohiro, Yasunori Totsuka, Kyoko Hida, Aya Yanagawa Matsuda, Fumihiro Higashino, and Masanobu Shindoh
- Subjects
0301 basic medicine ,Oncology ,malignant transformation ,cancer stem cell ,Cancer Research ,medicine.medical_specialty ,Cell ,oral leukoplakia ,Malignant transformation ,03 medical and health sciences ,0302 clinical medicine ,Cancer stem cell ,Internal medicine ,medicine ,ALDH1 ,Oncogene ,business.industry ,Cancer ,Articles ,Cell cycle ,medicine.disease ,Molecular medicine ,podoplanin ,030104 developmental biology ,medicine.anatomical_structure ,Podoplanin ,030220 oncology & carcinogenesis ,Cancer research ,business - Abstract
Oral leukoplakia (OL) is a clinically diagnosed preneoplastic lesion of the oral cavity with an increased oral cancer risk. However, the risk of malignant transformation is still difficult to assess. The objective of the present study was to examine the expression patterns of aldehyde dehydrogenase 1 (ALDH1) and podoplanin in OL, and to determine their roles in predicting oral cancer development. In the present study, the expression patterns of ALDH1 and podoplanin were determined in samples from 79 patients with OL. The association between protein expression and clinicopathological parameters, including oral cancer-free survival, was analyzed during a mean follow-up period of 3.4 years. Expression of ALDH1 and podoplanin was observed in 61 and 67% patients, respectively. Kaplan-Meier analysis demonstrated that the expression of the proteins was correlated with the risk of progression to oral cancer. Multivariate analysis revealed that expression of ALDH1 and podoplanin was associated with 3.02- and 2.62-fold increased risk of malignant transformation, respectively. The malignant transformation risk of OL was considerably higher in cases with expression of both proteins. Point-prevalence analysis revealed that 66% of patients with co-expression of ALDH1 and podoplanin developed oral cancer. Taken together, our data indicate that ALDH1 and podoplanin expression patterns in OL are associated with oral cancer development, suggesting that ALDH1 and podoplanin may be useful biomarkers to identify OL patients with a substantially high oral cancer risk.
- Published
- 2016
38. Pharmacokinetic study of lascufloxacin in non-elderly healthy men and elderly men
- Author
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Kyoichi Totsuka, Masaaki Odajima, Hiroyuki Fukase, Yutaka Niwayama, Ippei Ikushima, and Shogo Sesoko
- Subjects
0301 basic medicine ,Microbiology (medical) ,Adult ,Male ,medicine.medical_specialty ,030106 microbiology ,Cmax ,Administration, Oral ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Pharmacokinetics ,Japan ,Oral administration ,Internal medicine ,medicine ,Elderly people ,Humans ,Pharmacology (medical) ,030212 general & internal medicine ,Fasting state ,Antibacterial agent ,Aged ,business.industry ,Fasting ,Healthy Volunteers ,Infectious Diseases ,Non elderly ,business ,Federal state ,Fluoroquinolones - Abstract
We conducted this phase I clinical study to examine the pharmacokinetic profiles and safety of lascufloxacin (LSFX), a novel quinolone antibacterial agent, in non-elderly Japanese healthy men and the effects of aging on LSFX pharmacokinetics in elderly Japanese healthy men. 1. After single-dose oral administration of LSFX 100–800 mg (capsules) to six healthy adults in fasting state, the Cmax and AUClast roughly increased in proportion to the doses. 2. After multiple-dose oral administration of LSFX 75 mg (tablets) once daily for 7 days to six healthy adults, plasma LSFX reached the steady state by Day 7. The cumulative factor of LSFX on Day 7 to Day 1 was 1.65 for the Cmax and 1.96 for the AUCtau. 3. Regarding pharmacokinetic parameters of plasma LSFX after single-dose administration of LSFX 75 mg tablets (final product) to 24 healthy adults in fed state, the Cmax was somewhat higher, 1.28 times more than that in fasting state, whereas no changes were found in the AUClast. We therefore proposed that food effects of LSFX on absorption were negligible. 4. No clinically significant safety problems of LSFX were found in a series of studies involving healthy adults conducted this time. 5. After single-dose oral administration of LSFX 200 mg (capsules) to six elderly people in fasting state, its pharmacokinetic parameters were similar to those in non-elderly people, with no significant safety concerns. Therefore, adjustment of dosage and administration was considered to be unnecessary for LSFX administration to elderly individuals.
- Published
- 2019
39. Automated detection of fundic gland polyps from endoscopic images using SSD
- Author
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Nagito Shichi, Tomoyuki Shibata, Arata Totsuka, and Junichi Hasegawa
- Subjects
Pathology ,medicine.medical_specialty ,Fundic Gland Polyp ,Computer science ,medicine - Published
- 2019
40. Cosmetic and Neuroprotective Placement of Custom-Made Ultra-High-Molecular-Weight Polyethylene Cranial Plate (SKULPIO) in Single-Step Surgery: Technical Note and Case Report
- Author
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Tomoya Oishi, Hiroki Namba, Shinichiro Koizumi, Takeaki Totsuka, Tomohiro Yamasaki, and Tetsuro Sameshima
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Skull Neoplasms ,Neurosurgical Procedures ,Meningioma ,03 medical and health sciences ,0302 clinical medicine ,Bone plate ,medicine ,Meningeal Neoplasms ,Humans ,Frontal Convexity Meningioma ,Craniotomy ,Aged ,medicine.diagnostic_test ,business.industry ,Skull ,Magnetic resonance imaging ,Middle Aged ,Plastic Surgery Procedures ,medicine.disease ,Cranioplasty ,Surgery ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Female ,Neurology (clinical) ,Neurosurgery ,Polyethylenes ,business ,Bone Plates ,030217 neurology & neurosurgery - Abstract
Background Cranioplasty is a common procedure in neurosurgery. However, cosmetic and neuroprotective reconstructions are necessary after cranioplasty. Treatment of patients with a meningioma with bone infiltration requires removal of the tumor-infiltrated bone and subsequent cranioplasty. We report an efficient technique for cosmetic and neuroprotective reconstructions using a custom-made ultra-high-molecular-weight polyethylene cranial plate (SKULPIO, Kyocera Medical, Kyoto, Japan) in a single-step surgery involving tumor removal and skull reconstruction. Methods We present 2 illustrative cases of a 49-year-old female with a right frontal convexity meningioma and 69-year-old male with a bilateral parasagittal atypical meningioma, both involving extensive skull invasion. We preoperatively planned craniotomy size to facilitate the removal of the tumor-infiltrated skull bone using the patients' 3-dimensional cranial models followed by the construction of a custom-made cranial plate. After tumor removal, we drilled out the outer table and the diploe of the cranial edge until the custom-made bone plate accurately fit the bone defect. Finally, the cranial plate was fixed using titanium plates and screws. Results Postoperative magnetic resonance imaging for each case revealed total meningioma removal and an aesthetically reconstructed skull. Using this technique, precise adjustment of the cranial edge to the plate contributes to a gapless and aesthetic reconstruction. Furthermore, the intact inner table of the skull firmly supports the custom-made bone plate. Conclusions This technique involving the placement of a custom-made cranial plate during a single-step surgery was found to be efficient for cosmetic and neuroprotective reconstructions.
- Published
- 2019
41. Effect of atorvastatin on oxidative damage and inflammation in experimental hindlimb ischemia–reperfusion model
- Author
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Teresa Arcelia Garcia-Cobian, Ernesto Germán Cardona-Muñoz, Simón Quetzalcoatl Rodríguez-Lara, Walter A Trujillo-Rangel, Leonel García-Benavides, Tannia Isabel Campos-Bayardo, Araceli Castillo-Romero, and Sylvia E Totsuka-Sutto
- Subjects
medicine.medical_specialty ,Atorvastatin ,Immunology ,lcsh:Medicine ,Inflammation ,medicine.disease_cause ,Vascular occlusion ,Oxidative damage ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Immunology and Allergy ,cardiovascular diseases ,business.industry ,lcsh:R ,Hindlimb ischemia ,Surgical procedures ,Tissue ischemia ,030220 oncology & carcinogenesis ,Cardiology ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Oxidative stress ,medicine.drug - Abstract
Ischemia–reperfusion is defined as cellular damage after the reperfusion of ischemic tissue, and it is likely to occur in relation to various diseases and surgical procedures. The purpose of this study was to evaluate the capability of atorvastatin to prevent oxidative damage and modulate the release of proinflammatory cytokines in rat hindlimb during ischemia–reperfusion injury. The animals were divided into 4 groups (ischemia–reperfusion + vehicle, ischemia–reperfusion + atorvastatin, sham, and healthy controls) with 15 rats per group. The animals were exposed to ischemia for 6 h, followed by 24 h, 7 days, and 14 days of reperfusion. Atorvastatin was administered by gavage 14 days before ischemia–reperfusion induction. We then measured the serum concentrations and mRNA transcript levels of TNF-α, IL-1β, IL-6, IL-10, SOD2, and CAT. Hematoxylin and eosin stain were performed for histological analyses. Animals subjected to ischemia–reperfusion showed increased serum and transcript levels of TNF-α, IL-1β, IL-6, and IL-10 expressions with a concurrent increase in mRNA transcripts levels compared with sham and healthy controls. Groups treated with atorvastatin showed a significant CAT increase in the first 24 h, but CAT levels decreased at 7 and 14 days. SOD2 enzyme increased in serum without significant changes in mRNA expression. Histological analysis showed inflammatory infiltrate, microhemorrhages, and distortion of the tissue architecture in the first 7 days. At 14 days, the tissue showed loss and damage to myocytes. However, animals treated with atorvastatin showed few histological changes and a decrease in inflammatory cytokines. No significant changes in NO2, NO3, or 8-OHdG were observed. Atorvastatin showed a protective effect on the inflammation and tissue damage induced by ischemia–reperfusion in the hindlimb. The antioxidant effect of atorvastatin in the hindlimb is already unclear, and further research is needed to elucidate the molecular mechanism of this drug in the extremities.
- Published
- 2018
42. Towards Objective Olfactory Evaluation Based On Peripheral Arterial Stiffness And Heart Rate Variability Indices
- Author
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Zu Soh, Takafumi Sasaoka, Shigeto Yamawaki, Toshio Tsuji, and Masaaki Totsuka
- Subjects
medicine.medical_specialty ,business.industry ,Sensory system ,Arteries ,medicine.disease ,Peripheral ,Smell ,03 medical and health sciences ,0302 clinical medicine ,Blood pressure ,Vascular Stiffness ,Odor ,Heart Rate ,Internal medicine ,Heart rate ,Odorants ,medicine ,Cardiology ,Arterial stiffness ,Heart rate variability ,Humans ,030223 otorhinolaryngology ,Beta (finance) ,business ,030217 neurology & neurosurgery - Abstract
This paper proposes an olfactory stimulation-biological response measurement system aiming for quantitative and objective evaluation the odor quality. The system calculates arterial stiffness index $\beta $ proposed by our group, the low frequency/high frequency (LF/HF), and heart rate (HR) during presenting odor stimuli. An experiment of olfactory sensory assessment using the proposed system is conducted. The experiment results showed that unpleasant odor increases arterial stiffness index $\beta $ and (LF/HF).
- Published
- 2018
43. Correction to A Novel o-Toluidine Metabolite in Rat Urine Associated with Urinary Bladder Carcinogenesis
- Author
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Yukari Totsuka, Takeji Takamura-Enya, Noriyuki Miyoshi, Takeshi Toyoda, Kumiko Ogawa, Kenji Watanabe, Kohei Matsushita, Yuya Tajima, Yuichiro Hirayama, Takanori Yamada, and Keiji Wakabayashi
- Subjects
chemistry.chemical_compound ,medicine.medical_specialty ,chemistry ,business.industry ,Metabolite ,o-Toluidine ,Urology ,Medicine ,General Medicine ,Urine ,Urinary bladder carcinogenesis ,Toxicology ,business - Published
- 2020
44. Activities of daily living as an additional predictor of complications and outcomes in elderly patients with acute myocardial infarction
- Author
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Takahiro Kobayashi, Hiroyuki Nakajima, Izumi Miyazawa, Tatsuya Usui, Jiro Yoshioka, Nobuyuki Urasawa, Nobuyuki Totsuka, and Tomoaki Mochidome
- Subjects
Male ,Activities of daily living ,Multivariate analysis ,health care facilities, manpower, and services ,medicine.medical_treatment ,Myocardial Infarction ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,0302 clinical medicine ,Postoperative Complications ,Japan ,Activities of Daily Living ,030212 general & internal medicine ,Myocardial infarction ,Hospital Mortality ,Original Research ,Aged, 80 and over ,General Medicine ,primary percutaneous coronary intervention ,humanities ,Killip classification ,Treatment Outcome ,Female ,medicine.medical_specialty ,acute myocardial infarction ,03 medical and health sciences ,Percutaneous Coronary Intervention ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Intensive care medicine ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Heart Failure ,business.industry ,Proportional hazards model ,Percutaneous coronary intervention ,Retrospective cohort study ,Chronological age ,medicine.disease ,Logistic Models ,disability ,Heart failure ,Clinical Interventions in Aging ,Multivariate Analysis ,Geriatrics and Gerontology ,business ,human activities - Abstract
Hiroyuki Nakajima,1 Jiro Yoshioka,2 Nobuyuki Totsuka,2 Izumi Miyazawa,2 Tatsuya Usui,2 Nobuyuki Urasawa,2 Takahiro Kobayashi,3 Tomoaki Mochidome4 1Department of Cardiology, Nagano Matsushiro General Hospital, 2Department of Cardiology, Nagano Red Cross Hospital, 3Department of Cardiology, Nagano Municipal Hospital, Nagano, 4Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan Background: Age is an important determinant of outcome in acute myocardial infarction (AMI). However, in clinical settings, there is an occasional mismatch between chronological age and physical age. We evaluated whether activities of daily living (ADL), which reflect physical age, also predict complications and prognosis in elderly patients with AMI.Design: Single-center, observational, and retrospective cohort study.Methods: Preserved ADL and low ADL were defined according to the scale for independence degree of daily living for the disabled elderly by the Japanese Ministry of Health, Labour, and Welfare. We examined 82 consecutive patients aged ≥75years with AMI who underwent primary percutaneous coronary intervention. Patients were divided into preserved ADL (n=52; mean age, 81.8±4.8years; male, 59.6%) and low ADL (n=30; mean age, 85.8±4.7years; male, 40.0%) groups according to prehospital ADL.Results: The prevalence of Killip class II–IV and in-hospital mortality rate were significantly higher with low ADL compared to that with preserved ADL (23.1% vs 60.0%, P=0.0019; 5.8% vs 30.0%, P=0.0068, respectively). Multivariate analysis showed that ADL was an independent predictor of Killip class II–IV and 1-year mortality after adjusting for age, sex, and other possible confounders (odds ratio 5.11, 95% confidence interval [CI] 1.52–17.2, P=0.0083; hazard ratio 4.32, 95% CI 1.31–14.3, P=0.017, respectively).Conclusion: Prehospital ADL is a significant predictor of heart failure complications and prognosis in elderly patients with AMI undergoing primary percutaneous coronary intervention, irrespective of age and sex. Keywords: acute myocardial infarction, activities of daily living, disability, Killip classification, primary percutaneous coronaryintervention
- Published
- 2016
45. Hypermutation and unique mutational signatures of occupational cholangiocarcinoma in printing workers exposed to haloalkanes
- Author
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Shigeru Marubashi, Yukari Totsuka, Katsuya Tsuchihara, Sachiyo Mimaki, Masahiko Kinoshita, Hiroyasu Esumi, Hirofumi Arakawa, Shoji Kubo, Yutaka Suzuki, Tomonari Matsuda, Atsushi Ochiai, Tatsuhiro Shibata, Masanori Goto, Shigekazu Takemura, Shoji Nakamori, Chikako Nakai, Shogo Tanaka, Motohiro Kojima, and Hitoshi Nakagama
- Subjects
0301 basic medicine ,Adult ,Male ,Salmonella typhimurium ,Cancer Research ,Pathology ,medicine.medical_specialty ,Genomic data ,Somatic hypermutation ,Original Manuscript ,Disease ,medicine.disease_cause ,digestive system ,Genome ,Cholangiocarcinoma ,03 medical and health sciences ,Propane ,0302 clinical medicine ,Japan ,Occupational Exposure ,Medicine ,Humans ,Exome ,Mutation ,Methylene Chloride ,business.industry ,Incidence (epidemiology) ,General Medicine ,Rare cancer ,digestive system diseases ,030104 developmental biology ,030220 oncology & carcinogenesis ,Cancer research ,Printing ,business - Abstract
Summary These occupational cholangiocarcinoma cases shared a high mutation burden, strand bias and unique trinucleotide mutational signatures, suggesting that the patients might have been exposed to a common strong mutagen. The underlying mechanisms of mutagenesis should be further investigated., Cholangiocarcinoma is a relatively rare cancer, but its incidence is increasing worldwide. Although several risk factors have been suggested, the etiology and pathogenesis of the majority of cholangiocarcinomas remain unclear. Recently, a high incidence of early-onset cholangiocarcinoma was reported among the workers of a printing company in Osaka, Japan. These workers underwent high exposure to organic solvents, mainly haloalkanes such as 1,2-dichloropropane (1,2-DCP) and/or dichloromethane. We performed whole-exome analysis on four cases of cholangiocarcinoma among the printing workers. An average of 44.8 somatic mutations was detected per Mb in the genome of the printing workers’ cholangiocarcinoma tissues, approximately 30-fold higher than that found in control common cholangiocarcinoma tissues. Furthermore, C:G-to-T:A transitions with substantial strand bias as well as unique trinucleotide mutational changes of GpCpY to GpTpY and NpCpY to NpTpY or NpApY were predominant in all of the printing workers’ cholangiocarcinoma genomes. These results were consistent with the epidemiological observation that they had been exposed to high concentrations of chemical compounds. Whole-genome analysis of Salmonella typhimurium strain TA100 exposed to 1,2-DCP revealed a partial recapitulation of the mutational signature in the printing workers’ cholangiocarcinoma. Although our results provide mutational signatures unique to occupational cholangiocarcinoma, the underlying mechanisms of the disease should be further investigated by using appropriate model systems and by comparison with genomic data from other cancers.
- Published
- 2016
46. Effectiveness of degradable and non-degradable implants to close large septal perforations in an experimental model
- Author
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Victor M. Hernández Martinez, Tania Isabel Campos Bayardo, Sylvia Elena Totsuka Sutto, Sara Pascoe Gonzalez, Ernesto Germán Cardona Muñoz, and Leonel García Benavides
- Subjects
medicine.medical_specialty ,Swine ,medicine.medical_treatment ,Perforation (oil well) ,Mucous membrane of nose ,Rhinoplasty ,03 medical and health sciences ,Dogs ,0302 clinical medicine ,Intestinal mucosa ,Absorbable Implants ,medicine ,Nasal septum ,Animals ,Dimethylpolysiloxanes ,Intestinal Mucosa ,030223 otorhinolaryngology ,Nasal Septum ,Nasal Septal Perforation ,business.industry ,Prostheses and Implants ,Surgery ,Nasal Mucosa ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Models, Animal ,Collagen ,Implant ,business - Abstract
Background Reparation of large nasal septum perforations continues to be challenging. Bipedicled mucoperichondrial and inter-positional grafts currently show the most promising results. New implants have emerged to be used as a support membrane to carry on the mucosal cells, taking advantage of the innate proliferative properties of the mucosal tissue. Objective To compare the effectiveness of two kinds of material; non-absorbable dimethylsiloxane (silicone elastomers) and absorbable porcine small intestinal submucosa (Surgisis), both used as an inter-positional graft without neighbouring flaps to close nasal septal perforations in an experimental model. Methods Fifteen dogs were divided into three groups. One group received Surgisis, the other sheets of dimethylsiloxane and the last group a sham group. The dogs were followed for 6 weeks. Results The initial perforation of the nasal septum showed complete mucosal closure in the dimethylsiloxane group. The Surgisis group, on the other hand, had a smaller reduction than that at the beginning (final mean area = 23.0 ± 5.4 mm(2) (p
- Published
- 2016
47. Effect of Anserine/Carnosine Supplementation on Verbal Episodic Memory in Elderly People
- Author
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Yuan Cao, Jun Kaneko, Etsuko Imabayashi, Hiroshi Matsuda, Hideo Satsu, Yoshinori Katakura, Mamoru Totsuka, Tatsuhiro Hisatsune, and Hiroki Kurashige
- Subjects
Male ,Aging ,Neuropsychological Tests ,law.invention ,chemistry.chemical_compound ,Randomized controlled trial ,law ,Image Processing, Computer-Assisted ,Anserine ,Episodic memory ,Oligonucleotide Array Sequence Analysis ,Carnosine ,General Neuroscience ,Brain ,Wechsler Adult Intelligence Scale ,Cognition ,General Medicine ,Middle Aged ,Verbal Learning ,Psychiatry and Mental health ,Clinical Psychology ,Cerebral blood flow ,Cytokines ,anserine and carnosine ,Female ,Psychology ,Alzheimer’s disease ,Research Article ,Adult ,inflammatory cytokine ,medicine.medical_specialty ,Memory, Episodic ,verbal memory ,Double-Blind Method ,Internal medicine ,medicine ,Humans ,cognitive function ,Aged ,elderly people ,Surgery ,Gene Expression Regulation ,chemistry ,Posterior cingulate ,randomized controlled trial ,Dietary Supplements ,perfusion MRI ,Geriatrics and Gerontology ,Verbal memory ,dementia - Abstract
Our goal in this study was to determine whether or not anserine/carnosine supplementation (ACS) is capable of preserving cognitive function of elderly people. In a double-blind randomized controlled trial, volunteers were randomly assigned to an ACS or placebo group at a 1:1 ratio. The ACS group took 1.0 g of an anserine/carnosine (3:1) formula daily for 3 months. Participants were evaluated by psychological tests before and after the 3-month supplementation period. Thirty-nine healthy elderly volunteers (60–78 years old) completed the follow-up tests. Among the tests, delayed recall verbal memory assessed by the Wechsler Memory Scale-Logical Memory showed significant preservation in the ACS group, compared to the placebo group (p = 0.0128). Blood analysis revealed a decreased secretion of inflammatory cytokines, including CCL-2 and IL-8, in the ACS group. MRI analysis using arterial spin labeling showed a suppression in the age-related decline in brain blood flow in the posterior cingulate cortex area in the ACS group, compared to the placebo group (p = 0.0248). In another randomized controlled trial, delayed recall verbal memory showed significant preservation in the ACS group, compared to the placebo group (p = 0.0202). These results collectively suggest that ACS may preserve verbal episodic memory and brain perfusion in elderly people, although further study is needed.
- Published
- 2016
48. Successful left ventricular assist device re-implantation with omental covering for MDRP device infection
- Author
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Yuichi Totsuka, Satoshi Yamashiro, Yukio Kuniyoshi, Hitoshi Inafuku, and Minoru Ono
- Subjects
Male ,Reoperation ,medicine.medical_specialty ,Percutaneous ,medicine.medical_treatment ,Myocardial Infarction ,Shock, Cardiogenic ,Biomedical Engineering ,Medicine (miscellaneous) ,030204 cardiovascular system & hematology ,Prosthesis Implantation ,Biomaterials ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Pseudomonas Infections ,Myocardial infarction ,Heart Failure ,Heart transplantation ,Intra-Aortic Balloon Pumping ,Septic shock ,business.industry ,Cardiogenic shock ,Middle Aged ,equipment and supplies ,medicine.disease ,Drug Resistance, Multiple ,Surgery ,Cardiac surgery ,Treatment Outcome ,medicine.anatomical_structure ,030228 respiratory system ,Ventricular assist device ,Pseudomonas aeruginosa ,Heart Transplantation ,Heart-Assist Devices ,Cardiology and Cardiovascular Medicine ,business ,Omentum ,Artery - Abstract
We present a case of paracorporeal left ventricular assist device (p-LVAD)-related infection, caused by multi-drug resistant Pseudomonas aeruginosae (MDRP), and successfully treated by p-LVAD re-implantation with omental covering. A 59-year-old man underwent p-LVAD implantation and coronary artery bypass grafting after percutaneous cardiopulmonary support and intra-aortic balloon pumping for cardiogenic shock due to acute myocardial infarction. Then, he was registered for heart transplantation. He suffered from blood stream infection causative organism of Pseudomonas aeruginosa, 2 months after that operation. He underwent re-median sternotomy and open drainage, 15 months after the p-LVAD implantation. However, he suffered from septic shock due to MDRP. He underwent p-LVAD re-implantation under hypothermic circulatory arrest and iodine gauze packing, followed by omental covering of the all artificial materials in his body 10 days after that operation. Soon after that, the infection was well controlled and the intravenous antibiotics could be discontinued 2 months after that operation. He successfully underwent heart transplantation, 17 months after that procedure. We concluded that p-LVAD re-implantation with omental covering is seemed to be useful in the treatment of massive device infection. This procedure might be a novel treatment for severe VAD-related infection until heart transplantation.
- Published
- 2016
49. Alternative Interventions to Prevent Oxidative Damage following Ischemia/Reperfusion
- Author
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Teresa Arcelia Garcia-Cobian, Araceli Castillo-Romero, Sylvia E Totsuka-Sutto, Simón Quetzalcoatl Rodríguez-Lara, Ernesto Germán Cardona-Muñoz, Leonel García-Benavides, and Ernesto Javier Ramírez-Lizardo
- Subjects
0301 basic medicine ,Aging ,medicine.medical_specialty ,Ischemia ,Review Article ,Oxidative phosphorylation ,Mitochondrion ,medicine.disease_cause ,Biochemistry ,Oxidative damage ,Phosphatidylinositol 3-Kinases ,03 medical and health sciences ,Internal medicine ,medicine ,Animals ,Humans ,lcsh:QH573-671 ,Ischemic Postconditioning ,Pathological ,Electron Transport Complex I ,lcsh:Cytology ,business.industry ,Cell Biology ,General Medicine ,medicine.disease ,Mitochondria ,Surgery ,Oxygen ,PPAR gamma ,Oxidative Stress ,030104 developmental biology ,Reperfusion Injury ,Cardiology ,Ischemic preconditioning ,business ,Reperfusion injury ,Oxidative stress - Abstract
Ischemia/reperfusion (I/R) lesions are a phenomenon that occurs in multiple pathological states and results in a series of events that end in irreparable damage that severely affects the recovery and health of patients. The principal therapeutic approaches include preconditioning, postconditioning, and remote ischemic preconditioning, which when used separately do not have a great impact on patient mortality or prognosis. Oxidative stress is known to contribute to the damage caused by I/R; however, there are no pharmacological approaches to limit or prevent this. Here, we explain the relationship between I/R and the oxidative stress process and describe some pharmacological options that may target oxidative stress-states.
- Published
- 2016
50. Blood Pressure is the Strongest Component Associated with Arterial Stiffness in Mexican Patients with Metabolic Syndrome
- Author
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Fernando Grover Páez, Guillermo Adrián Alanis Sánchez, Assen Ognianov Iantchoulev, David Cardona Müller, Ernesto G Cardona Muñoz, Carlos Gerardo Ramos Becerra, Sylvia E. Totsuka Sutto, and Sara Pascoe González
- Subjects
medicine.medical_specialty ,Waist ,Triglyceride ,business.industry ,Ethics committee ,General Medicine ,medicine.disease ,chemistry.chemical_compound ,Blood pressure ,Endocrinology ,Who recommendations ,chemistry ,Internal medicine ,medicine ,Arterial stiffness ,lipids (amino acids, peptides, and proteins) ,Metabolic syndrome ,business ,Body mass index - Abstract
Objective: To establish which of the metabolic syndrome (MetS) components are more related to arterial stiffness. Research Design and Methods: We recruited eighty-two non-smoking male patients, 40 to 77 years old, (42 without MetS and 41 with MetS). The local ethics committee approved the study and signed informed consent forms were obtained from patients. Body mass index (BMI) was calculated as weight (in kilograms) divided by the square of height (in meters), and waist measurements were according to WHO recommendations. Blood pressure and baPWV were measured with the “Vascular Profiler 1000” device (VP-1000) (Omron®, Kyoto, Japan). All blood sample determinations were obtained after a 12-h fasting period and processed within one h. We used an oxidase technique to measure fasting plasma glucose (FPG) and enzymatic methods to obtain total cholesterol, high-density lipoprotein cholesterol (HDL-c) and triglyceride values. Low-density lipoprotein cholesterol (LDL-c) was estimated using the Friedewald formula (LDL-C = Total Cholesterol − HDL-C − Triglycerides/5). Results: We observed strong and significant correlations between SBP and baPWV (r=.753, p=
- Published
- 2015
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