8 results on '"Shenzhong Jiang"'
Search Results
2. Management of thyrotoxicosis occurring after surgery for Cushing’s disease: a case series
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Yong Yao, Renzhi Wang, Chengxian Yang, Kan Deng, Xinjie Bao, Lin Lu, Ming Feng, Shenzhong Jiang, Bing Xing, and Huijuan Zhu
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medicine.medical_specialty ,Maintenance dose ,business.industry ,Medical record ,030209 endocrinology & metabolism ,Context (language use) ,Cushing's disease ,Disease ,medicine.disease ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Adrenal insufficiency ,Original Article ,business ,Complication ,030217 neurology & neurosurgery ,Hydrocortisone ,medicine.drug - Abstract
Background Thyrotoxicosis is a rare complication of surgery for Cushing's disease (CD). In clinical practice, given the rarity of this condition, patients may be misdiagnosed, and thus not treated appropriately. This study describes the clinical features and management of thyrotoxicosis in this context. Methods We retrospectively screened a pituitary database for CD patients who underwent surgery at Peking Union Medical College Hospital between 2010 and 2017. The electronic medical records and documentation of 732 patients were searched in order to identify instances of thyrotoxicosis. Results Fourteen patients developed postoperative thyrotoxicosis after CD remission, representing 1.9% of all the CD patients who underwent surgery and 2.5% of the CD patients who were in remission after surgery. The onset of thyrotoxicosis occurred at a median of 3.5 months after surgery. At the onset, 13 patients (92.9%) were on a maintenance dose of hydrocortisone and were managed using a higher dose of hydrocortisone. One patient had normal adrenal function and was managed by observation first, then using anti-thyroid drugs. Thyrotoxicosis was transient in all but one patient, and lasted 1.9±0.7 months (range, 1-3.2 months). Conclusions Thyrotoxicosis is a rare complication that develops during the recovery period following surgery for CD. It occurs only after the surgical resolution of hypercortisolism, and in particular alongside adrenal insufficiency during the 4 months following CD remission. Awareness of this situation should be promoted among physicians, and patients should be managed on the basis of the clinical setting and manifestation.
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- 2021
3. Corrigendum: Xanthomatous Hypophysitis: A Case Report and Comprehensive Literature Review
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Zhu Jianyu, Lian Duan, Jie Liu, Jinghua Fan, Wenze Wang, Li Xiaoxu, Huijuan Zhu, Kan Deng, Zhicheng Wang, Shenzhong Jiang, Yi Zhang, and Yong Yao
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pathological examination ,medicine.medical_specialty ,recurrence ,business.industry ,Hypophysitis ,Endocrinology, Diabetes and Metabolism ,Correction ,medicine.disease ,RC648-665 ,Dermatology ,xanthomatous hypophysitis ,Diseases of the endocrine glands. Clinical endocrinology ,surgery ,Endocrinology ,medicine ,business ,clinical characteristics - Published
- 2021
4. Xanthomatous Hypophysitis: A Case Report and Comprehensive Literature Review
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Yi Zhang, Lian Duan, Kan Deng, Jinghua Fan, Yong Yao, Shenzhong Jiang, Li Xiaoxu, Zhu Jianyu, Huijuan Zhu, Zhicheng Wang, Wenze Wang, and Jie Liu
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pathological examination ,medicine.medical_specialty ,recurrence ,Hypophysitis ,Endocrinology, Diabetes and Metabolism ,xanthomatous hypophysitis ,Diseases of the endocrine glands. Clinical endocrinology ,Lesion ,surgery ,Endocrinology ,Biopsy ,medicine ,Pathological ,clinical characteristics ,Pituitary stalk ,medicine.diagnostic_test ,business.industry ,medicine.disease ,RC648-665 ,Diabetes insipidus ,Histopathology ,Systematic Review ,Radiology ,medicine.symptom ,business ,Rare disease - Abstract
PurposeXanthomatous hypophysitis (XHP) is an extremely rare form of primary hypophysitis for which there is a lack of clinical experience. A comprehensive understanding of its clinical characteristics, diagnosis and treatment is needed.MethodsHere, we report a case study and conduct a systematic review of XHP. Thirty-six cases were included, and their clinical manifestations, endocrine assessment, imaging features, treatment and follow-up data were collected and analyzed.ResultsThe mean age at diagnosis was 39.1 years, and females were predominant (75.0%). The most common symptom was headache (68.6%), and 66.7% of female patients presented menstrual disorders. The most common pituitary dysfunction was growth hormone (GH) deficiency. More than half of patients exhibited central diabetes insipidus (CDI). The majority of patients had an imaging presentation of a cystic lesion with peripheral enhancement. Pituitary stalk thickening was observed in half of the patients. Total lesion resection was achieved in 57.1% of cases. The recurrence rate after partial resection and biopsy was significantly higher than that after total lesion resection (57.1% vs. 0.0%, P = 0.0147). The most common pituitary hormone abnormalities to resolve after surgery were hyperprolactinemia (100.0%) and GH deficiency (91.7%). The typical pathological feature was inflammatory infiltration of foamy histiocytes, which showed positivity for CD68.ConclusionDiagnosis of XHP is difficult when relying on clinical symptoms and imaging features. Therefore, surgical histopathology is necessary. Based on the available evidence, total lesion resection is recommended for treatment. However, the long-term prognosis for this rare disease remains unclear.
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- 2021
5. Suprasellar Mature Cystic Teratoma Mimicking Rathke’s Cleft Cyst: A Case Report and Systematic Review of the Literature
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Renzhi Wang, Yan You, Shenzhong Jiang, Zhaojian Wang, and Xinjie Bao
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Adult ,medicine.medical_specialty ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,rare lesion ,Mature Cystic Teratoma ,Diseases of the endocrine glands. Clinical endocrinology ,Resection ,Diagnosis, Differential ,mature cystic teratomas ,Endocrinology ,medicine ,Humans ,Sella Turcica ,Cyst ,Central Nervous System Cysts ,Original Research ,neuropathology ,Rathke's cleft cyst ,sellar region ,business.industry ,Teratoma ,Endoscopy ,RC648-665 ,medicine.disease ,Radiation therapy ,Rare Lesion ,Female ,case ,Intermittent headache ,Radiology ,business - Abstract
In this article, we present a 31-year-old female who presented with intermittent headache and oligomenorrhea of over 10 years’ duration. Imaging revealed a large suprasellar mass with sellar extension. The patient underwent an endoscopic endonasal trans-sphenoidal surgery to resection of the mass. Clinical, radiological, and operative findings from this patient were initially considered to be Rathke’s cleft cyst (RCC). However, postoperative histological examinations revealed a mature cystic teratoma. No radiotherapy was performed after surgery. At the most recent follow-up, approximately 1 year later, the patient is doing well with no headache and no recurrence of the teratoma.
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- 2021
6. Preoperative Somatostatin Analogues in Patients with Newly-diagnosed Acromegaly: A Systematic Review and Meta-analysis of Comparative Studies
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Chengxian Yang, Ge Li, Shenzhong Jiang, Renzhi Wang, and Xinjie Bao
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medicine.medical_specialty ,Pituitary diseases ,medicine.medical_treatment ,MEDLINE ,lcsh:Medicine ,030209 endocrinology & metabolism ,Cochrane Library ,Article ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Acromegaly ,Adjuvant therapy ,medicine ,Combined Modality Therapy ,Humans ,lcsh:Science ,Transsphenoidal surgery ,Multidisciplinary ,business.industry ,lcsh:R ,medicine.disease ,Surgery ,CNS cancer ,Treatment Outcome ,Meta-analysis ,Surgical oncology ,lcsh:Q ,Growth Hormone-Secreting Pituitary Adenoma ,business ,Somatostatin ,030217 neurology & neurosurgery - Abstract
Biochemical remission after transsphenoidal surgery is still unsatisfied in acromegaly patients with macroadenomas, especially with invasive macroadenomas. Concerning the impact of preoperative somatostatin analogues (SSAs) on surgical outcomes, previous studies with limited cases reported conflicting results. To assess current evidence of preoperative medical treatment, we performed a systematic review and meta-analysis of comparative studies. A literature search was conducted in Pubmed, Embase, and the Cochrane Library. Five randomized controlled trials (RCT) and seven non-RCT comparative studies were included. These studies mainly focused on pituitary macroadenomas though a small number of microadenoma cases were included. For safety, preoperative SSAs were not associated with elevated risks of postoperative complications. With respect to efficacy, the short-term cure rate was improved by preoperative SSAs, but the long-term cure rate showed no significant improvement. For invasive macroadenomas, the short-term cure rate was also improved, but the long-term results were not evaluable in clinical practice because adjuvant therapy was generally required. In conclusion, preoperative SSAs are safe in patients with acromegaly, and the favorable impact on surgical results is restricted to the short-term cure rate in macroadenomas and invasive macroadenomas. Further well-designed RCTs to examine long-term results are awaited to update the finding of this meta-analysis.
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- 2019
7. Clinical profiles of silent corticotroph adenomas compared with silent gonadotroph adenomas after adopting the 2017 WHO pituitary classification system
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Xinjie Bao, Renzhi Wang, Yong Yao, Ming Feng, Shenzhong Jiang, Kan Deng, Zhu Jianyu, Wei Lian, and Bing Xing
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Oncology ,medicine.medical_specialty ,business.industry ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Human physiology ,Gonadotrophs ,World Health Organization ,World health ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,ACTH-Secreting Pituitary Adenoma ,Adrenocorticotropic Hormone ,Comparable size ,Female preponderance ,Recurrence ,Internal medicine ,medicine ,Humans ,Female ,Corticotropic cell ,business ,030217 neurology & neurosurgery - Abstract
Silent corticotroph adenomas (SCAs) can be redefined according to the 2017 World Health Organization pituitary classification system with the introduction of T‑PIT, a transcription factor. We studied the clinical features of these redefined SCAs.We compared 112 patients with SCAs and 198 patients with silent gonadotroph adenomas (SGAs) who underwent surgery from January 2019 to May 2020.The prevalence of SCAs increased from 21.3 to 30.2% under the new classification rules. T-PIT-positive, adrenocorticotropic hormone-negative SCAs and T-PIT-positive, adrenocorticotropic hormone-positive SCAs exhibited similar clinical features. SCAs exhibited significant female preponderance (90.2% vs. 29.8%, P 0.0001); more frequent invasion (36.6% vs. 7.6%, P 0.0001), especially multiple-site invasion (P 0.0001); and marked cystic changes on imaging compared with SGAs (54.5% vs. 19.2%, P 0.0001). SCAs had a softer tumor consistency (89.2% vs. 61.1%, P 0.0001). Gross total resection was achieved in 66.1% of SCAs and 66.2% of SGAs (P 0.9999). The overall recurrence/progression rates of SCAs and SGAs were 9.8% and 6.6% at 14.1 and 13.5 months of follow-up, respectively (P = 0.3765). The proportion of patients with more than two recurrences requiring multiple surgeries and radiation was similar between SCAs and SGAs (7.1% vs. 3.0%, P = 0.1514). However, multiple recurrences of SCAs affected younger patients than SGAs (39.0 vs. 53.5 years, P = 0.0433).The prevalence of SCAs increased with the introduction of T-PIT. SCAs and SGAs exhibited comparable size and recurrence/progression rates, but SCAs showed increased invasion and more marked cystic change. Aggressive SCAs tended to affect younger patients. Close long-term monitoring for SCA recurrence/progression is required.
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- 2021
8. Machine Learning-Based Radiomics Predicts Radiotherapeutic Response in Patients With Acromegaly
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Shenzhong Jiang, Yanghua Fan, Renzhi Wang, Min Hua, Ming Feng, and Shanshan Feng
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0301 basic medicine ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,030209 endocrinology & metabolism ,Feature selection ,Logistic regression ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,03 medical and health sciences ,Endocrinology ,0302 clinical medicine ,Radiomics ,Acromegaly ,medicine ,magnetic resonance imaging ,Original Research ,radiotherapeutic response ,lcsh:RC648-665 ,Receiver operating characteristic ,business.industry ,Retrospective cohort study ,medicine.disease ,Radiation therapy ,receiver operating characteristics ,030104 developmental biology ,Feature (computer vision) ,radiomics ,acromegaly ,Radiology ,business - Abstract
Background: Prediction of radiotherapeutic response before radiotherapy could help determine individual treatment strategies for patients with acromegaly. Objective: To develop and validate a machine-learning-based multiparametric MRI radiomics model to non-invasively predict radiotherapeutic response in patients with acromegaly. Methods: This retrospective study included 57 acromegaly patients who underwent postoperative radiotherapy between January 2008 and January 2016. Manual lesion segmentation and radiomics analysis were performed on each pituitary adenoma, and 1561 radiomics features were extracted from each sequence. A radiomics signature was built with a support vector machine using leave-one-out cross-validation for feature selection. Multivariable logistic regression analysis was used to select appropriate clinicopathological features to construct a clinical model, which was then combined with the radiomics signature to construct a radiomics model. The performance of this radiomic model was assessed using receiver operating characteristics (ROC) analysis and its calibration, discriminating ability, clinical usefulness. Results: At 3-years after radiotherapy, 25 patients had achieved remission and 32 patients had not. The clinical model incorporating seven clinical features had an area under the ROC (AUC) of 0.86 for predicting radiotherapeutic response, and performed better than any single clinical feature. The radiomics signature constructed with six radiomics features had a significantly higher AUC of 0.92. The radiomics model showed good discrimination abilities and calibration, with an AUC of 0.96. Decision curve analysis confirmed the clinical utility of the radiomics model. Conclusion: Using pre-radiotherapy clinical and MRI data, we developed a radiomics model with favorable performance for individualized non-invasive prediction of radiotherapeutic response, which may help in identifying acromegaly patients who are likely to benefit from radiotherapy.
- Published
- 2019
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