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Undifferentiated embryonal sarcoma of the liver is a malignancy with poor prognosis observed more frequently in children between 6 and 10 years old and very rarely found in adults. We present a case of embryonal sarcoma of the liver in a 60-year-old woman without significant medical history who presented to our attention with constitutional symptoms. Preoperative assessments did not show alterations in blood chemistry or tumor markers. Imaging studies showed a huge mass lying in the right abdominal quadrants, strictly adherent to the liver. The tumor was partially cystic with a thickened wall, sporadic contrast enhancement, and solid component. The patient underwent excision of the mass with associated liver bisegmentectomy S5-S6. Postoperative course was uneventful. The definitive histological diagnosis revealed the presence of embryonal sarcoma of the liver. We describe the clinical, histopathological, and therapeutic options adopted in the multimodal treatment of this disease.

Appendiceal neuroendocrine neoplasms (NENs) are rare and usually incidentally discovered. Most cases are clinically indolent, although the rare aggressive ones are poorly predictable. The aim of this study was to test the applicability and prognostic significance of the new World Health Organization (WHO) classification and to test the several pathologic features and TNM staging systems (American Joint Committee on Cancer and European Neuroendocrine Tumor Society) in these tumors. A multi-institutional retrospective series of 138 appendiceal NENs was selected on the basis of the availability of both pathologic material and clinical information, including follow-up data. All cases were reviewed to record pathologic features and to apply year 2000 and 2010 WHO classifications, as well as European Neuroendocrine Tumor Society and American Joint Committee on Cancer TNM stages. Clinical and pathologic characteristics were compared with disease outcome by contingency, univariate, and multivariate survival analyses. Although up to one third of cases presented several malignancy-associated pathologic features, only 4 patients died of the disease. Adverse outcome was significantly associated with extramural extension (including mesoappendix), well-differentiated carcinoma diagnosis (2000 WHO classification), pT3-4 stage, older age, and presence of positive resection margins, but not with tumor size, mitotic or proliferative indexes, and, consequently, 2010 WHO grading. In the appendix, at variance with midgut/hindgut NENs, the 2000 WHO classification performs better than the grading-based 2010 WHO scheme and, together with tumor stage, is the most relevant parameter associated with clinical aggressiveness.

Mortality rates of cancer of the larynx in the town of Torino, in the whole of Italy and in France during 1950–71 are reported. Age standardized mortality rates as well as mortality rates truncated to the period 35–64 years of age are reported in Table 1 for males and in Table 2 for females. Graph 1 represents age specific mortality rates for cancer of the larynx in the three areas in 1966–67. Graphs 2, 3 and 4 report mortality rates in males in the three ares for cohort of birth. All rates are annual/100.000. An increase of mortality for cancer of the larynx in men is well documented in the town of Torino. From 1951 to 1966 the mortality rate truncated to age 35–64 increased from 6.3 to 12.0. The proportion of mortality for cancer of the larynx/mortality for all cancers during the same period increased from 3.1 % to 5.4%. In Italy, the mortality rate in men aged 35–64 was 6.5 in 1952 and 9.3 in 1967: during the same period the proportion of mortality for cancer of the larynx/mortality for all cancers increased from 3.8 % to 4.4 %. In France, the tendency to an increase of mortality for laryngeal cancer after 1951 was absent or debatable, although both the mortality rates of cancer of the larynx and the proportion of mortality for cancer of the larynx/mortality for all cancers were consistently higher than in Italy or in Torino. However, in 1966–67 at ages 35–44 the mortality rate for cancer of the larynx in men was higher in Torino than in France (Graph 1).

The present report shows that the province of Torino, Italy, (6830 sq Km, population in 1966, 2.074.893) is a high risk area for laryngeal cancer. A total of 875 cases occurring in residents in the province were forwarded to the Cancer Registry of Piedmont (RTP) in 1965–69. A histological report was available in 67.9 % cases, while in 21.8 % the death certificate was the only document with diagnosis of laryngeal cancer (table 1). Cases were uniformly distributed throughout the 5 years covered by the study: the number of cases with death certificate only progressively decreased from 59 in 1965 to 21 in 1969 (table 3). For the purposes of the present study, the province of Torino has been divided into 3 areas, i.e. the city of Torino (population 1.107.919), the 23 suburbs (total population 340.951) and the non-metropolitan part of the province (population 626.023). Among the three areas, the relative frequency of laryngeal cancer/all malignant tumours recorded at the RTP in men was 5.78 % in the city of Torino, 6.43 % in the suburbs and 4.77 % in the non-metropolitan part of the province (table 4). The difference between the city of Torino and the suburbs was not significant (p > 0.05) while the difference both between the city of Torino and the non metropolitan part of the province and between the suburbs and the non metropolitan areas was significant (p < 0.05 and p ∼ 0.01 respectively). In other cancer registries (3) the relative frequencies of laryngeal cancer were under 2.86 % with the exception of Israel (3.24 %) and Bombay (9.26 %). In women, the relative frequency of laryngeal cancer fluctuated between 0.25 and 0.32 % in the different areas of the province of Torino, i.e. in the same order of those observed in other cancer registries with the exception of Bombay (2.07%) (3). In the province of Torino considered as a whole, age standardized annual incidence/100.000 of laryngeal cancer was 12.6 in men and 0.6 in women. Incidences truncated to ages 35–64 were 25.5 and 0.9 respectively (table 5). In men these rates are approximately 5–7 times higher than those recorded in Norway, Sweden and Denmark and about 3.5–6 times higher than those recorded in the six cancer registries operating in Great Britain. A comparison between the province of Torino and other cancer registries on age specific incidences (table 6, text-fig. 3) shows that the ratio province of Torino/other registries is relatively higher at age 35–44 than later in life. This is considered as evidence of an increase of the environmental carcinogenic load in the province of Torino during recent years. In men, age standardized incidences and incidences truncated to ages 35–64 were slightly but not significantly higher in the city of Torino than in the suburbs. On the other hand, in both the city of Torino and the suburbs they were 1.5–1.7 times higher than in the non-metropolitan part of the province (table 5). The difference concerned mainly age groups over 55 (text-fig. 2). However, the incidence of laryngeal cancer truncated to ages 35–64 in the non-metropolitan part of the province of Torino was still 7.2 times higher than in the rural population of Norway and 2.1–4.1 times higher than in the six cancer registries operating in Great Britain (3). This suggests that factors connected with life in the metropolitan area of Torino (such as air pollution) are a minor cause of the excess of laryngeal cancer in the province of Torino.

Two cases of inverted urothelial papilloma are presented. In the first case the inverted papilloma was in the ureter and varying degrees of cellular atypia were demonstrated on histology: 7 years later, a single bladder lesion consisting of papillary transitional cell carcinoma and inverted papilloma developed in the same patient. In the second case a bladder tumor consisting of inverted papilloma mixed with papillary infiltrating transitional cell carcinoma was detected. The peculiar morphological findings, histogenesis and biological behavior of inverted urothelial lesions are discussed.