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3 results on '"Santiago Rayment Gomez"'

1. Iron Homeostasis in Full Term, Normal Birthweight Gambian Neonates Over the First Week of Life

Author

Andrew M. Prentice, Ousman Jarjou, Nuredin Mohammed, James H. Cross, Buba Touray, Carla Cerami, and Santiago Rayment-Gomez

Subjects
chemistry.chemical_classification, medicine.medical_specialty, medicine.diagnostic_test, biology, business.industry, Transferrin saturation, Birth weight, Gestational age, Ferritin, chemistry, Transferrin, Hepcidin, Internal medicine, Serum iron, biology.protein, Medicine, business, Full Term
Abstract

Background: Human neonates elicit a profound hypoferremia to protect against bacterial and fungal sepsis on their first day of life. We examined the transience of this effect by measuring iron and its chaperone proteins, inflammatory and hematological parameters over the first post-partum week. Methods: We prospectively studied term (>37 completed gestational weeks), normal weight (>2500g) newborns at Kanifing General Hospital, The Gambia. Blood was sampled from the umbilical cord vein (CDV) and artery (CDA). Neonatal venous blood was sampled at 6-24h (V1) in all babies who were then randomized to a second blood draw at 25-80h (V2), 81-136h (V3) or 137-192h (V4). Hepcidin, serum iron, transferrin saturation, transferrin, haptoglobin, CRP, AGP, sTfR, ferritin, TIBC, UIBC and full blood count were assayed. Findings: 278 neonates (54.3% males, gestational age 39.4±1.3wk, birth weight 3299±368g) were enrolled. We confirmed the profound early post-natal decrease in serum iron (CDV=22.7±7.0µmol/L to V1=7.3±4.3µmol/L, P

Published
2021

2. Iron Homeostasis over the First Week of Life: A Prospective Cohort Study in Hospital-Delivered Gambian Neonates

Author

Andrew M. Prentice, James H. Cross, Nuredin Mohammed, Santiago Rayment Gomez, Ousman Jarjou, Bubacarr J B Touray, and Carla Cerami

Subjects
Transferrin Saturation Measurement, Maternal, Perinatal and Pediatric Nutrition, medicine.medical_specialty, Nutrition and Dietetics, Randomization, biology, business.industry, Obstetrics, Medicine (miscellaneous), Gestational age, Phlebotomy, Umbilical cord, medicine.anatomical_structure, Hepcidin, biology.protein, Medicine, business, Prospective cohort study, Postpartum period, Food Science
Abstract

OBJECTIVES: Full-term newborns elicit an immediate postnatal hypoferremia at birth. We examined whether preterm and low birthweight babies are capable of a similar response. The transience of this innate defence in full-term babies was assessed by measuring iron, inflammatory and haematological parameters over the first postpartum week. METHODS: We conducted an observational study of 152 babies who were either preterm (>32 to

Published
2020

3. Early postnatal hypoferremia in low birthweight and preterm babies: A prospective cohort study in hospital-delivered Gambian neonates

Author

Ousman Jarjou, Bubacarr J B Touray, Santiago Rayment Gomez, James H. Cross, Carla Cerami, Andrew M. Prentice, and Nuredin Mohammed

Subjects
Male, 0301 basic medicine, Time Factors, Research paper, IL-22, Interleukin 22, Hepcidin, lcsh:Medicine, TSAT, Transferrin saturation, Transferrin saturation, KMC, Kanifing Municipal Council, UIBC, Unbound iron-binding capacity, PI, Principal investigator, 0302 clinical medicine, Total iron-binding capacity, FTB, Full-term birth, LBW, Low birthweight, Birth Weight, SCC, Scientific Coordinating Committee, KGH, Kanifing General Hospital, Prospective cohort study, Disease Resistance, lcsh:R5-920, sTfR, Soluble transferrin receptor, Sub-Saharan Africa, biology, medicine.diagnostic_test, Obstetrics, Gestational age, General Medicine, Fetal Blood, AGP, Alpha-1-acid glycoprotein, ELISA, Enzyme-linked immunosorbent assay, 030220 oncology & carcinogenesis, IL-6, Interleukin 6, CRP, C-reactive protein, Serum iron, WHO, World Health Organisation, lcsh:Medicine (General), CRP, Prematurity, EONS, Early-onset neonatal sepsis, Infant, Premature, TLR, Toll-like receptor, medicine.medical_specialty, PTB, Preterm birth, Low birthweight, Iron, GCP, Good Clinical Practice, Gestational Age, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, NBW, Normal birthweight, medicine, Humans, G6PD, Glucose-6-phosphate dehydrogenase, Septicaemia, Soluble transferrin receptor, business.industry, lcsh:R, C-reactive protein, Infant, Newborn, Infant, Neonates, Infant, Low Birth Weight, Nutritional immunity, 030104 developmental biology, Case-Control Studies, biology.protein, business, MRCG, Medical Research Council Unit The Gambia at LSHTM, TIBC, Total iron-binding capacity, Biomarkers, Full Term Birth
Abstract

Background: Neonates, particularly those born preterm (PTB) and with low birthweight (LBW), are especially susceptible to bacterial and fungal infections that cause an estimated 225,000 deaths annually. Iron is a vital nutrient for the most common organisms causing septicaemia. Full-term babies elicit an immediate postnatal hypoferremia assumed to have evolved as an innate defence. We tested whether PTB and LBW babies are capable of the same response. Methods: We conducted an observational study of 152 babies who were either PTB (born ≥32 to

Published
2020

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