1. A Real-world Efficacy of Nab-paclitaxel Monotherapy in Metastatic Breast Cancer
- Author
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Seock-Ah Im, Se Hyun Kim, So Yeon Park, Tae Yong Kim, Koung Jin Suh, Han Suk Ryu, Kyung-Hun Lee, In Ae Park, Jung Sun Kim, Jee Hyun Kim, Sae-Won Han, Go-Un Woo, Miso Kim, and Dae-Won Lee
- Subjects
Cancer Research ,medicine.medical_specialty ,Chemotherapy ,Paclitaxel ,business.industry ,medicine.medical_treatment ,Endocrine therapy ,Breast Neoplasms ,Retrospective cohort study ,Luminal a ,medicine.disease ,Gastroenterology ,Metastatic breast cancer ,Regimen ,Oncology ,Albumins ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Female ,business ,Objective response ,Retrospective Studies ,Nab-paclitaxel - Abstract
PurposeWe aimed to assess the real-world efficacy of nab-paclitaxel in metastatic breast cancer patients.Materials and MethodsThis is a retrospective study performed in two tertiary referral hospitals in Korea. Patients with metastatic breast cancer treated with nab-paclitaxel (Abraxane®) between March 2016 and March 2020 were enrolled.ResultsA total of 102 patients with metastatic breast cancer were included. Patients were heavily pre-treated with a median of four prior lines of chemotherapy (5 lines when including endocrine therapy in hormone-receptor-positive patients), and 66 patients (64.7%) were exposed to taxanes in the metastatic setting. According to St. Gallen molecular subtypes, 36 patients (35.3%) were luminal A, 28 (27.5%) were luminal B, 18 (17.7%) were human epidermal growth factor receptor 2–positive and 20 (19.6%) had triple-negative disease. Fifty patients (49.0%) were treated with a 3-weekly regimen (260 mg/m2 on day 1 every 3 weeks), and 52 (51.0%) were treated with a weekly regimen (100 mg/m2 every week). Objective response rate was 22.9%. After a median follow-up of 22.0 months, median progression-free survival (PFS) was 4.0 months (95% confidence interval [CI], 2.6 to 4.8) and median overall survival was 8.7 months (95% CI, 7.5 to 11.2). Patients treated with weekly regimen had longer PFS compared to 3-weekly regimen (5.5 vs. 2.3 months, p < 0.001). Multivariate analysis revealed the treatment regimen as an independent prognostic factor for PFS. There was no grade 3 or 4 hypersensitivity reaction.ConclusionThis real-world data shows that nab-paclitaxel is a reasonable treatment option in heavily pre-treated and/or taxane-exposed metastatic breast cancer patients.
- Published
- 2022