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Trauma and chronic stress are believed to induce and exacerbate psychopathology by disrupting glutamate synaptic strength. However, in vivo in human methods to estimate synaptic strength are limited. In this study, we established a novel putative biomarker of glutamatergic synaptic strength, termed energy-per-cycle (EPC). Then, we used EPC to investigate the role of prefrontal neurotransmission in trauma psychopathology. Healthy control (n=18) and patients with posttraumatic stress (PTSD; n=16) completed 13C-acetate magnetic resonance spectroscopy scans to estimate prefrontal EPC, which is the ratio of neuronal energetic needs per glutamate neurotransmission cycle (VTCA/VCycle). Patients with PTSD were found to have 28% reduction in prefrontal EPC (t=3.0; df=32, p=0.005). There was no effect of sex on EPC, but age was negatively associated with prefrontal EPC across groups (r=–0.46, n=34, p=0.006). Controlling for age did not affect the study results. The feasibility and utility of EPC were established. Patients with PTSD were found to have reduced prefrontal glutamatergic synaptic strength. These findings suggest that reduced glutamatergic synaptic strength may contribute to the pathophysiology of PTSD and could be targeted by new treatments.HighlightsGlutamatergic synaptic strength is critical for brain function in health and disease.In vivo in human methods to estimate glutamatergic synaptic strength are limited.We here propose a new approach to estimate glutamatergic synaptic strength.The new method employs carbon-13 magnetic resonance spectroscopy (13C MRS).The utility of the new approach was demonstrated in posttraumatic stress disorder (PTSD).

Intraocular infection with Nocardia asteroides has not been reported in various extensive reviews of and experiments in ocular mycology, 1-5 but we believe that it is important to understand the ocular pathologic changes caused by infection with this fungus, because of its similarity both morphologically and pathologically to Mycobacterium tuberculosis. 6 Also, because fungous infections of the eye appear to be increasing in incidence as a result of the widespread use of topical antibiotics and corticosteroids. 7-9 It has been estimated that 5% of all patients in tuberculosis hospitals have nocardiosis that mistakenly has been diagnosed as tuberculosis. 10 The purpose of this paper is to present the intraocular pathologic findings in the normal rabbit after experimental infection of the eyes with N. asteroides. Nocard, 11 in 1888, isolated and described the species Nocardia farcineux which caused "la maladie des boeufs de la Guadeloupe," a lymphatic and visceral disease of

A CASE of panophthalmitis due to the gas-forming organism Clostridium welchii (Clostridium perfringens) was reported in this country by Berry in 1932. 1 Since then four cases have been added to the American literature 2 and 23 to the foreign. 3 The report by Kluver and O'Brien 2b gives an adequate review of the foreign literature up to 1936 and of the laboratory identification of the Cl. welchii bacillus. REPORT OF CASE A laborer aged 27 was admitted to the Cleveland Clinic Hospital on Nov. 24, 1950. The personal and medical histories were noncontributory. Twenty-eight hours prior to admission the patient had been struck in the left eye by a small fragment from the inside cement framework of a cellar window on which he was chipping with a hammer and chisel. The window was opened only for coal deliveries. He was not conscious of discomfort until three hours later, when

Metastatic carcinoma of the eye involving the retina alone is an extremely rare lesion; only two reports of previous cases have been found in a review of the literature. The first report was that by Arisawa 1 in 1914. However, Smoleroff and Agatston 3 reviewed this case, which was in Sattler's 2 textbook, and concluded that the tumor involved the optic disc as well as the retina. In their article they reported a case of secondary carcinoma limited only to the retina. Our report is of a secondary carcinoma of the macula of the right eye, the primary site of the tumor being the rectosigmoid. Report of Case A 51-year-old white man was first seen by one of us (W. D. R.) on Jan. 30, 1956. because of blurred vision of one month's duration in the right eye. The corrected vision in the right eye was limited to counting fingers

Excerpt Graves' disease may be considered to be a thyroid-pituitary syndrome. The two chief manifestations of the disorder are exophthalmos and hyperplastic goiter with hyperthyroidism. They usuall...

Despite the considerable progress achieved in the last 30 years, vomiting and, especially, nausea, continue to be two of the most distressing side-effects of cancer chemotherapy. In the late 1990s, several professional organisations published recommendations on the optimal antiemetic prophylaxis in patients submitted to chemotherapy and/or radiotherapy. The European Society of Medical Oncology (ESMO) and the Multinational Association of Supportive Care in Cancer (MASCC) published the results of the third Consensus Conference on antiemetics held in Perugia in June 2009 in Annals of Oncology in 2010 [1]. An update of these recommendations, including studies published from 1 January 2009 to 30 June 2015, was discussed in Copenhagen in June 2015 and is presented in this paper. The methodology for the guideline process is described in detail in the 2010 publication [1]. To change a 2010 recommendation or for a new guideline recommendation to be accepted, a consensus of at least 67% of the expert panellists was needed. As a general rule, the panel considered changes of 10% or greater to be sufficient to warrant the changing of a recommendation. Refereed/Peer-reviewed