1. Predictors of Survival Outcomes in Non-Metastatic Renal Cell Carcinoma in Latin America and Spain: A Multicentric Analysis
- Author
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Isabela Werneck da Cunha, Francisco Rodríguez, Joan Palou, Guilhermo Gueglio, Max Moura de Oliveira, Thiago Camelo Mourão, Pablo Martínez, Pablo Mingote, Rubén G. Bengió, C. Scorticati, Ricardo Decia, Gustavo Cardoso Guimarães, Ana Maria Autran, Maria Paula Curado, Carlos Ameri, Álvaro Zúñiga, Sidney Glina, Diego Abreu, Walter Henriques da Costa, Stênio de Cássio Zequi, and Fernando P. Secin
- Subjects
Oncology ,medicine.medical_specialty ,Latin Americans ,Nephrology ,business.industry ,Renal cell carcinoma ,Internal medicine ,medicine ,Non metastatic ,business ,medicine.disease - Abstract
Background: Renal cell carcinoma (RCC) is a lethal neoplasia. Data from Latin America are scarce, and the distinct ethnic origins of this population could affect predictive or prognostic factors. Objective: We aim to describe a large cohort of non-metastatic renal cell carcinoma, identifying the demographic, clinical, and pathological prognostic factors for survival. Methods: We used a multi-institutional retrospective cohort involving 5,670 patients who underwent radical or partial nephrectomy across seven Latin American countries and Spain from 1980 to 2016. The variables were compared, and Kaplan–Meier curves were used to estimate the overall survival (OS) and cancer-specific survival (CSS). Results: The clear cell subtype represented 66.7% of RCC, followed by chromophobe (13.7%), papillary (5.2%), and others (14.4%). Furthermore, 72.3% of renal masses were 7 cm (HR: 1.64). Conclusions: Our findings agreed with those reported for some developed countries. We emphasize that ASA and peri-renal fat invasion as prognostic factors deserve further study. Information regarding microvascular invasion should be regularly incorporated in pathological reports.
- Published
- 2019