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21 results on '"R. Pisoni"'

1. Improvements in Fatigue at Higher Achieved Hemoglobin Levels Among Chronic Kidney Disease Patients: A Systematic Review and Meta-Analysis

Author

Murilo Guedes, Bruce M. Robinson, Palone Ag, Cristina Pellegrino Baena, R. Pisoni, Lucas Henrique Olandoski Erbano, R. Pecoits-Filho, Camila Roginski Guetter, Jarcy Zee, and Thyago Proença de Moraes

Subjects
medicine.medical_specialty, Text mining, business.industry, Internal medicine, Meta-analysis, medicine, Hemoglobin levels, business, medicine.disease, Kidney disease
Abstract

Background: The impact anemia treatment with erythropoietin stimulating agents (ESA) on health-related quality of life (HRQOL) in chronic kidney disease (CKD) patients is controversial, particularly regarding optimal hemoglobin (Hb) target ranges.Methods: We conducted a systematic review and meta-analysis of observational studies and randomized controlled trials (RCT) with ESA to estimate the effect of different Hb ranges on physical HRQOL and functionality. We searched PubMed, EMBASE, CENTRAL, PEDro, PsycINFO and Web of Science databases, until May 2019Two authors independently extracted data from studies.We included observational and RCTs that enrolled CKD patients undergoing anemia treatment with ESA with different achieved Hb levels among groups. We excluded studies with achieved Hb < 9 g/dL. For the meta-analysis, we included RCTs with control groups achieving Hb 10-11.5 g/dL and active groups with Hb >11.5 g/dL. We analyzed the standardized mean difference (SMD) between groups for physical HRQOL.Results: Among 8,171 studies, fifteen RCTs and five observational studies were included for the systematic review. We performed the meta-analysis in a subset of eleven eligible RCTs. For physical role and physical function, SMDs were 0.0875 [CI:-0.0025 – 0.178] and 0.08 [CI: -0.03 – 0.19], respectively. For fatigue, SMD was 0.16 [0.09 - 0.24]. Subgroup analysis showed that trials with greater achieved Hb had greater pooled effects sizes — 0.21 [0.07 - 0.36] for Hb > 13 g/dL vs. 0.09 [0.02 - 0.16] for Hb 11.5-13 g/dL. Proportion of older and long-term diabetic patients across studies were associated with lower effect sizes.Conclusion: Achieved hemoglobin higher than currently recommended targets is associated with small but clinically significant improvement in fatigue. Younger and non-diabetic patients may experience more pronounced benefits of higher Hb levels after treatment with ESAs.

Published
2020

2. Impact of sex and glucose-lowering treatments on hypoglycaemic symptoms in people with type 2 diabetes and chronic kidney disease. The French Chronic Kidney Disease – Renal Epidemiology and Information Network (CKD-REIN) Study

Author

L. Frimat, Christian Jacquelinet, Serge Briançon, Denis Fouque, Elodie Speyer, Fabrizio Andreelli, R. Pisoni, Carole Ayav, Ziad A. Massy, Bénédicte Stengel, Maurice Laville, Beverley Balkau, Marie Metzger, Christian Combe, University of Versailles St.-Quentin, UMRS 1018, Villejuif, Service de Diabétologie [CHU Pitié-Salpétrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Néphrologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université de Lorraine (UL), Service de Néphrologie-transplantation-dialyse [Bordeaux], CHU Bordeaux [Bordeaux], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Centre d'investigation clinique - Epidémiologie clinique [Nancy] (CIC-EC), Centre d'investigation clinique [Nancy] (CIC), Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), Arbor Research Collaborative for Health, CKD REIN, Service de diabétologie [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), and CCSD, Accord Elsevier

Subjects
Male, medicine.medical_specialty, Databases, Factual, Epidemiology, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Renal function, 030209 endocrinology & metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, Cohort Studies, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Endocrinology, Internal medicine, Diabetes mellitus, Chronic kidney disease, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Diabetic Nephropathies, Renal Insufficiency, Chronic, ComputingMilieux_MISCELLANEOUS, Aged, Information Services, business.industry, Insulin, General Medicine, medicine.disease, 3. Good health, Metformin, Diabetes Mellitus, Type 2, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Albuminuria, Drug Therapy, Combination, Female, Sex, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, medicine.symptom, Glucose lowering treatments, business, Hypoglycaemia, medicine.drug, Kidney disease
Abstract

Aim To describe current practices of glucose-lowering treatments in people with diabetes and chronic kidney disease (CKD), the associated glucose control and hypoglycaemic symptoms, with an emphasis on sex differences. Methods Among the 3033 patients with CKD stages 3–5 recruited into the French CKD-REIN study, 645 men and 288 women had type 2 diabetes and were treated by glucose-lowering drugs. Results Overall, 31% were treated only with insulin, 28% with combinations of insulin and another drug, 42% with non-insulin glucose-lowering drugs. In CKD stage 3, 40% of patients used metformin, 12% at stages 4&5, similar for men and women; in CKD stage 3, 53% used insulin, similar for men and women, but at stages 4&5, 59% of men and 77% of women used insulin. Patients were reasonably well controlled, with a median HbA1c of 7.1% (54 mmol/mol) in men, 7.4% (57 mmol/mol) in women (P = 0.0003). Hypoglycaemic symptoms were reported by 40% of men and 59% of women; they were not associated with the estimated glomerular filtration rate, nor with albuminuria or with HbA1c in multivariable analyses, but they were more frequent in people treated with insulin, particularly with fast-acting and pre-mixed insulins. Conclusion Glucose-lowering treatment, HbA1c and hypoglycaemic symptoms were sex dependent. Metformin use was similar in men and women, but unexpectedly low in CKD stage 3; its use could be encouraged rather than resorting to insulin. Hypoglycaemic symptoms were frequent and need to be more closely monitored, with appropriate patient-education, especially in women.

Published
2019

3. Guideline attainment and morbidity/mortality rates in a large cohort of European haemodialysis patients (EURODOPPS)

Author

Brian Bieber, R. Pisoni, Anneke Kramer, Fergus Caskey, Christian Combe, Ziad A. Massy, Ayesha Sajjad, Keith McCullough, Kitty J Jager, Sophie Liabeuf, Bruce M. Robinson, Medical Informatics, ACS - Pulmonary hypertension & thrombosis, APH - Aging & Later Life, APH - Quality of Care, APH - Global Health, APH - Methodology, CHU Amiens-Picardie, Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, University of Amsterdam [Amsterdam] (UvA), Universiteit van Amsterdam (UvA), Arbor Research Collaborative for Health, UK Renal Registry (UKRR), Renal Association, University of Bristol [Bristol], Service de Néphrologie-transplantation-dialyse [Bordeaux], CHU Bordeaux [Bordeaux], Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Hôpital Ambroise Paré [AP-HP], and DESSAIVRE, Louise

Subjects
Male, medicine.medical_specialty, [SDV]Life Sciences [q-bio], medicine.medical_treatment, target, Renal Dialysis, Internal medicine, Outcome Assessment, Health Care, medicine, Humans, guidelines, Prospective Studies, Practice Patterns, Physicians', Prospective cohort study, Dialysis, Aged, Transplantation, chronic haemodialysis, business.industry, Proportional hazards model, Hazard ratio, Anemia, Guideline, mortality, Confidence interval, [SDV] Life Sciences [q-bio], Europe, Hospitalization, Survival Rate, hospital admission, Nephrology, Cohort, Hypertension, Practice Guidelines as Topic, Kidney Failure, Chronic, Female, Hemodialysis, Bone Diseases, Morbidity, business
Abstract

Background Haemodialysis patients experience a wide variety of intermediate complications, such as anaemia, hypertension and mineral bone disease (MBD). We aimed to assess the risk of death and hospital admissions as a function of the simultaneous attainment of different guideline targets (for hypertension, anaemia and MBD) in a large European cohort of dialysis patients. Methods EURODOPPS is part of the Dialysis Outcomes and Practice Patterns Study (DOPPS) international, prospective cohort study of adult, in-centre haemodialysis patients for whom clinical data are extracted from medical records. In the present analysis, 6317 patients from seven European countries were included between 2009 and 2011. The percentages of patients treated according to the international guidelines on anaemia, hypertension and MBD were determined. The overall degree of guideline attainment was considered to be high if four or all five of the evaluated targets were attained, moderate if two or three targets were attained, and low if fewer than two targets were attained. Fully adjusted multivariate Cox models were used to investigate the relationship of target attainment with mortality and first hospital admission. Results At baseline, the degree of target attainment was low in 1751 patients (28%), moderate in 3803 (60%) and high in 763 (12%). In the fully adjusted model using time-dependent covariates, low attainment was associated with higher all-cause mortality [hazard ratio (95% confidence interval) = 1.19 (1.05–1.34)] and high attainment was associated with lower all-cause mortality [0.82 (0.68–0.99)]. In a similar model that additionally accounted for death as a competing risk, low and high attainments were not associated with hospital admission. Conclusion In a large international cohort of dialysis patients, we have shown that more stringent application of guidelines is associated with lower mortality.

Published
2019

4. POS-526 UNDERSTANDING THE PATIENT EXPERIENCE AND CLINICAL COURSE DURING THE INCIDENT DIALYSIS PERIOD: DESIGN AND IMPLEMENTATION OF A DOPPS CHINA STUDY

Author

R. Pisoni, L. Henn, Li Zuo, Junhui Zhao, K. Hedman, Eric Wittbrodt, Glen James, Zhaohui Ni, J.J. Garcia-Sanchez, F. Khan, Murilo Guedes, James A. Sloand, R. Pecoits-Filho, Bruce G. Robinson, and X. Liang

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Clinical course, Diseases of the genitourinary system. Urology, Nephrology, Emergency medicine, Patient experience, medicine, RC870-923, China, business, Dialysis, Period (music)
Published
2021

5. SUN-095 INTERNATIONAL VARIATION IN CLINIC HEMOGLOBIN TARGETS AND ACHIEVED HEMOGLOBIN LEVELS IN ADVANCED CKD: RESULTS FROM THE CKD OUTCOMES AND PRACTICE PATTERNS STUDY (CKDOPPS)

Author

Antonio Alberto Lopes, Charlotte Tu, Bruce G. Robinson, Helmut Reichel, Jarcy Zee, J. Glen, H. van Haalen, Nidhi Sukul, Alaster M Allum, Michelle M.Y. Wong, R. Pecoits-Filho, Marcelo Barreto Lopes, R. Pisoni, Bénédicte Stengel, and James A. Sloand

Subjects
medicine.medical_specialty, Variation (linguistics), Nephrology, Practice patterns, business.industry, Internal medicine, medicine, Hemoglobin, Hemoglobin levels, business
Published
2020

7. MON-077 EXPLORING THE STATUS OF PERITONEAL DIALYSIS PRACTICES AND OUTCOMES IN SOUTH KOREA: PARTICIPATION IN THE PERITONEAL DIALYSIS OUTCOMES AND PRACTICE PATTERNS STUDY

Author

Brian Bieber, Yong-Lim Kim, Bruce G. Robinson, R. Pisoni, S.H. Park, Junhui Zhao, J. Leslie, K.H. Oh, Jeffrey Perl, and J. Albert

Subjects
medicine.medical_specialty, Nephrology, Practice patterns, business.industry, medicine.medical_treatment, medicine, Intensive care medicine, business, Peritoneal dialysis
Published
2019

9. CKD-MBD II

Author

T. Fujii, S. Suzuki, M. Shinozaki, H. Tanaka, S. Bell, S. Cooper, C. Lomonte, P. Libutti, D. Chimienti, F. Casucci, A. Bruno, M. Antonelli, P. Lisi, L. Cocola, C. Basile, A. Negri, E. Del Valle, M. Zanchetta, J. Zanchetta, M. C. Di Vico, M. Ferraresi, A. Pia, E. Aroasio, S. Gonella, E. Mongilardi, R. Clari, I. Moro, G. B. Piccoli, E. Gonzalez-Parra, L. Rodriguez-Osorio, A. Ortiz-Arduan, C. de la Piedra, J. Egido, M. V. Perez Gomez, A. A. Tabikh, B. Afsar, A. Kirkpantur, Y. Imanishi, M. Yamagata, Y. Nagata, M. Ohara, T. Michigami, T. Yukimura, M. Inaba, B. Bieber, B. Robinson, L. Mariani, S. Jacobson, L. Frimat, J. Bommer, R. Pisoni, F. Tentori, P. Ciceri, F. Elli, D. Brancaccio, M. Cozzolino, M. Adamczak, A. Wiecek, P. Kuczera, S. Sezer, Z. Bal, E. Tutal, O. Kal, D. Yavuz, I. Y ld r m, B. Sayin, R. Ozelsancak, S. Ozkurt, S. Turk, N. Ozdemir, R. Lehmann, M. Roesel, P. Fritz, N. Braun, C. Ulmer, W. Steurer, B. Dagmar, G. Ott, J. Dippon, D. Alscher, M. Kimmel, J. Latus, A. Turkvatan, M. Balci, S. Mandiroglu, B. Seloglu, M. Alkis, M. Serin, Y. Calik, S. Erkula, H. Gorboz, F. Mandiroglu, E. Lindley, M. Cruz Casal, S. Rogers, J. Pancirova, J. Kernc, J. B. Copley, D. Fouque, I. Kiss, Z. Kiss, A. Szabo, J. Szegedi, J. Balla, E. Ladanyi, B. Csiky, O. orkossy, M. Torok, S. Turi, C. Ambrus, G. Deak, A. Tisler, I. Kulcsar, V. K d r, A. Altuntas, A. Akp nar, H. Orhan, M. Sezer, V. Filiopoulos, N. Manolios, D. Arvanitis, I. Pani, K. Panagiotopoulos, D. Vlassopoulos, M. E. Rodriguez-Ortiz, A. Canalejo, C. Herencia, J. M. Martinez-Moreno, A. Peralta-Ramirez, P. Perez-Martinez, J. F. Navarro-Gonzalez, M. Rodriguez, M. Peter, K. Gundlach, S. Steppan, J. Passlick-Deetjen, J. R. Munoz-Castaneda, Y. Almaden, M. Rodriguez-Ortiz, J. Martinez-Moreno, I. Lopez, E. Aguilera-Tejero, N. Hanafusa, I. Masakane, S. Ito, S. Nakai, K. Maeda, H. Suzuki, M. Tsunoda, R. Ikee, N. Sasaki, M. Sato, N. Hashimoto, M.-H. Wang, K.-Y. Hung, C.-K. Chiang, J.-W. Huang, K.-C. Lu, C.-L. Lang, K. Okano, T. Yamashita, Y. Tsuruta, A. Hibi, N. Miwa, N. Kimata, K. Tsuchiya, K. Nitta, T. Akiba, L. Harb, H. Komaba, T. Kakuta, T. Suga, M. Fukagawa, H. Kikuchi, H. Shimada, R. Karasawa, M. Suzuki, M. Zhelyazkova-Savova, D. Gerova, D. Paskalev, V. Ikonomov, R. Zortcheva, B. Galunska, G. Jean, P. Deleaval, J.-M. Hurot, C. Lorriaux, B. Mayor, C. Chazot, H. Vannucchi, M. T. Vannucchi, J. C. Martins, J. L. Merino, J. L. Teruel, M. Fernandez-Lucas, J. J. Villafruela, B. Bueno, A. Gomis, V. Paraiso, C. Quereda, F. H. Ibrahim, N. Z. Fadhlina, E. K. Ng, K. M. Thong, B. L. Goh, D. M. Sulaiman, D. A. N. Fatimah, D. O. Evi, S. R. Siti, R. J. Wilson, M. Keith, B. Gros, A. Galan, J. A. Herrero, I. Oyaguez, M. A. Casado, S. Lucisano, G. Coppolino, A. Villari, V. Cernaro, R. Lupica, D. Trimboli, C. Aloisi, and M. Buemi

Subjects
Oncology, Transplantation, medicine.medical_specialty, Nephrology, business.industry, Internal medicine, medicine, business
Published
2013

10. Epidemiology and outcome research in CKD 5D

Author

L. Coentrao, C. Ribeiro, C. Santos-Araujo, R. Neto, M. Pestana, W. Kleophas, A. Karaboyas, Y. LI, J. Bommer, R. Pisoni, B. Robinson, F. Port, G. Celik, B. Burcak Annagur, M. Yilmaz, T. Demir, F. Kara, K. Trigka, P. Dousdampanis, N. Vaitsis, S. Aggelakou-Vaitsi, K. Turkmen, I. Guney, F. Turgut, L. Altintepe, H. Z. Tonbul, E. Abdel-Rahman, P. Sclauzero, G. Galli, G. Barbati, M. Carraro, G. O. Panzetta, M. Van Diepen, M. Schroijen, O. Dekkers, F. Dekker, A. Sikole, G. Severova- Andreevska, L. Trajceska, S. Gelev, V. Amitov, S. Pavleska- Kuzmanovska, H. Rayner, R. Vanholder, M. Hecking, B. Jung, M. Leung, F. Huynh, T. Chung, S. Marchuk, M. Kiaii, L. Er, R. Werb, C. Chan-Yan, M. Beaulieu, P. Malindretos, P. Makri, G. Zagkotsis, G. Koutroumbas, G. Loukas, E. Nikolaou, M. Pavlou, E. Gourgoulianni, M. Paparizou, M. Markou, E. Syrgani, C. Syrganis, J. Raimann, L. A. Usvyat, V. Bhalani, N. W. Levin, P. Kotanko, X. Huang, P. Stenvinkel, A. R. Qureshi, U. Riserus, T. Cederholm, P. Barany, O. Heimburger, B. Lindholm, J. J. Carrero, J. H. Chang, J. Y. Sung, J. Y. Jung, H. H. Lee, W. Chung, S. Kim, J. S. Han, K. Y. Na, A. Fragoso, A. Pinho, A. Malho, A. P. Silva, E. Morgado, P. Leao Neves, N. Joki, Y. Tanaka, M. Iwasaki, S. Kubo, T. Hayashi, Y. Takahashi, K. Hirahata, Y. Imamura, H. Hase, C. Castledine, J. Gilg, C. Rogers, Y. Ben-Shlomo, F. Caskey, J. S. Sandhu, G. S. Bajwa, S. Kansal, J. Sandhu, A. Jayanti, M. Nikam, L. Ebah, A. Summers, S. Mitra, J. Agar, A. Perkins, R. Simmonds, A. Tjipto, S. Amet, V. Launay-Vacher, M. Laville, A. Tricotel, C. Frances, B. Stengel, J.-Y. Gauvrit, N. Grenier, G. Reinhardt, O. Clement, N. Janus, L. Rouillon, G. Choukroun, G. Deray, A. Bernasconi, R. Waisman, A. P. Montoya, A. A. Liste, R. Hermes, G. Muguerza, R. Heguilen, E. L. Iliescu, V. Martina, M. A. Rizzo, P. Magenta, L. Lubatti, G. Rombola, M. Gallieni, C. Loirat, H. Mellerio, M. Labeguerie, B. Andriss, E. Savoye, M. Lassale, C. Jacquelinet, C. Alberti, Y. Aggarwal, J. Baharani, S. Tabrizian, S. Ossareh, M. Zebarjadi, P. Azevedo, F. Travassos, I. Frade, M. Almeida, J. Queiros, F. Silva, A. Cabrita, R. Rodrigues, C. Couchoud, J. Kitty, S. Benedicte, C. Fergus, C. Cecile, B. Sahar, V. Emmanuel, J. Christian, E. Rene, H. Barahimi, M. Mahdavi-Mazdeh, M. Nafar, M. Petruzzi, M. De Benedittis, M. Sciancalepore, L. Gargano, P. Natale, M. C. Vecchio, V. Saglimbene, F. Pellegrini, G. Gentile, P. Stroumza, L. Frantzen, M. Leal, M. Torok, A. Bednarek, J. Dulawa, E. Celia, R. Gelfman, J. Hegbrant, C. Wollheim, S. Palmer, D. W. Johnson, P. J. Ford, J. C. Craig, G. F. Strippoli, M. Ruospo, B. El Hayek, B. Hayek, E. Baamonde, E. Bosch, J. I. Ramirez, G. Perez, A. Ramirez, A. Toledo, M. M. Lago, C. Garcia-Canton, M. D. Checa, B. Canaud, B. Lantz, A. Granger-Vallee, P. Lertdumrongluk, N. Molinari, J. Ethier, M. Jadoul, B. Gillespie, C. Bond, S. Wang, T. Alfieri, P. Braunhofer, B. Newsome, M. Wang, B. Bieber, M. Guidinger, L. Zuo, X. Yu, X. Yang, J. Qian, N. Chen, J. Albert, Y. Yan, S. Ramirez, M. Beresan, A. Lapidus, M. Canteli, A. Tong, B. Manns, J. Craig, G. Strippoli, M. Mortazavi, B. Vahdatpour, S. Shahidi, A. Ghasempour, D. Taheri, S. Dolatkhah, A. Emami Naieni, M. Ghassami, M. Khan, K. Abdulnabi, P. Pai, M. Vecchio, M. A. Muqueet, M. J. Hasan, M. A. Kashem, P. K. Dutta, F. X. Liu, L. Noe, T. Quock, N. Neil, G. Inglese, M. Motamed Najjar, B. Bahmani, A. Shafiabadi, J. Helve, M. Haapio, P.-H. Groop, C. Gronhagen-Riska, P. Finne, R. Sund, M. Cai, S. Baweja, A. Clements, A. Kent, R. Reilly, N. Taylor, S. Holt, L. Mcmahon, M. Carter, F. M. Van der Sande, J. Kooman, R. Malhotra, G. Ouellet, E. L. Penne, S. Thijssen, M. Etter, A. Tashman, A. Guinsburg, A. Grassmann, C. Barth, C. Marelli, D. Marcelli, G. Von Gersdorff, I. Bayh, L. Scatizzi, M. Lam, M. Schaller, T. Toffelmire, Y. Wang, P. Sheppard, L. Neri, V. A. Andreucci, L. A. Rocca-Rey, S. V. Bertoli, D. Brancaccio, G. De Berardis, G. Lucisano, D. Johnson, A. Nicolucci, C. Bonifati, S. D. Navaneethan, V. Montinaro, M. Zsom, A. Bednarek-Skublewska, G. Graziano, J. N. Ferrari, A. Santoro, A. Zucchelli, G. Triolo, S. Maffei, S. De Cosmo, V. M. Manfreda, L. Juillard, A. Rousset, F. Butel, S. Girardot-Seguin, T. Hannedouche, M. Isnard, Y. Berland, P. Vanhille, J.-P. Ortiz, G. Janin, P. Nicoud, M. Touam, E. Bruce, B. Grace, P. Clayton, A. Cass, S. Mcdonald, Y. Furumatsu, T. Kitamura, N. Fujii, S. Ogata, H. Nakamoto, K. Iseki, Y. Tsubakihara, C.-C. Chien, J.-J. Wang, J.-C. Hwang, H.-Y. Wang, W.-C. Kan, N. Kuster, L. Patrier, A.-S. Bargnoux, M. Morena, A.-M. Dupuy, S. Badiou, J.-P. Cristol, J.-M. Desmet, V. Fernandes, F. Collart, N. Spinogatti, J.-M. Pochet, M. Dratwa, E. Goffin, J. Nortier, D. S. Zilisteanu, M. Voiculescu, E. Rusu, C. Achim, R. Bobeica, S. Balanica, T. Atasie, S. Florence, S. Anne-Marie, L. Michel, C. Cyrille, A. Strakosha, N. Pasko, S. Kodra, N. Thereska, A. Lowney, E. Lowney, R. Grant, M. Murphy, L. Casserly, T. O' Brien, W. D. Plant, J. Radic, D. Ljutic, V. Kovacic, M. Radic, K. Dodig-Curkovic, M. Sain, I. Jelicic, T. Hamano, C. Nakano, S. Yonemoto, A. Okuno, M. Katayama, Y. Isaka, M. Nordio, A. Limido, M. Postorino, M. Nichelatti, M. Khil, I. Dudar, V. Khil, I. Shifris, M. Momtaz, A. R. Soliman, M. I. El Lawindi, P. Dzekova-Vidimliski, S. Pavleska-Kuzmanovska, I. Nikolov, G. Selim, T. Shoji, R. Kakiya, N. Tatsumi-Shimomura, Y. Tsujimoto, T. Tabata, H. Shima, K. Mori, S. Fukumoto, H. Tahara, H. Koyama, M. Emoto, E. Ishimura, Y. Nishizawa, and M. Inaba

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, Epidemiology, Medicine, business, Intensive care medicine, Outcome (game theory)
Published
2012

11. Clinical Nephrology - Lab methods and other markers

Author

W. Kleophas, B. Bieber, B. Robinson, J. Duttlinger, D. Fliser, G. Lonneman, L. Rump, R. Pisoni, F. Port, H. Reichel, R. Daniela, A. Ciocalteu, I. A. Checherita, I. Peride, D. M. Spataru, A. Niculae, K. Laetitia, K. Amna, D. Laurence, H.-A. Aoumeur, M. Flamant, J.-P. Haymann, E. Letavernier, E. Vidal-Petiot, J.-J. Boffa, F. Vrtovsnik, F. Bianco, G. Pessolano, M. Carraro, G. O. Panzetta, N. Ebert, J. Gaedeke, O. Jakob, M. Kuhlmann, P. Martus, M. Van der Giet, E. Scha ner, I. Khan, Y. Law, K. Turgutalp, O. Ozhan, E. Gok Oguz, A. Kiykim, C. Donadio, Z. N. Hatmi, M. Mahdavi-Mazdeh, E. Morales, V. Gutierrez-Millet, J. Rojas-Rivera, A. Huerta, E. Gutierrez, E. Gutierrez-Solis, N. Polanco, J. Caro, E. Gonza z, M. Praga, M. Marco Mayayo, J. Valdivielso, M. Marti z, E. Fernaez Giraez, G. Obrador, N. Olvera, D. Ortiz de la Pe, V. Gutie ez, A. Villa, B. Redal-Baigorri, K. Sombolos, D. Tsakiris, J. Boletis, D. Vlahakos, K. Siamopoulos, V. Vargiemezis, P. Nikolaidis, C. Iatrou, E. Dafnis, C. Argyropoulos, K. Xynos, D. Schock-Kusch, Y. Shulhevich, S. Geraci, J. Hesser, D. Stsepankou, S. Neudecker, S. Koenig, F. Hoecklin, J. Pill, N. Gretz, F. Schweda, A. Schreiber, K. Kudo, T. Konta, S. O. Choi, J. S. Kim, M. K. Kim, J. W. Yang, B. G. Han, P. Delanaye, E. Cavalier, I. Masson, M. Mehdi, M. Nicolas, B. Lambermont, B. Dubois, P. Damas, J.-M. Krzesinski, J. Morel, A. Lautrette, M. Christophe, A. Gagneux-Brunon, F. Anne, L. Fre (C)ric, S. Bevc, R. Ekart, R. Hojs, M. Gorenjak, L. Puklavec, N. Hashimoto, A. Suzuki, K. Mitsumoto, M. Shimizu, K. Niihata, A. Kawabata, Y. Sakaguchi, T. Hayashi, T. Shoji, N. Okada, Y. Tsubakihara, T. Hamano, C. Nakano, N. Fujii, Y. Obi, S. Mikami, K. Inoue, I. Matsui, Y. Isaka, H. Rakugi, V. Edvardsson, B. Siguron, M. Thorsteinsdottir, R. Palsson, J. Matsumoto, N. Miyazaki, I. Murata, G. Yoshida, K. Morishita, H. Ushikoshi, K. Nishigaki, S. Ogura, S. Minatoguchi, U. Werneke, M. Ott, E. Salander-Renberg, D. Taylor, B. Stegmayr, S. Surel, M. Wenzlova, G. Silva Junior, A. P. Vieira, A. Couto Bem, M. Alves, A. Torres, G. Meneses, A. Martins, A. Liborio, E. Daher, G. Gluhovschi, M. Modilca, L. Daminescu, C. Gluhovschi, S. Velciov, L. Petrica, F. Gadalean, C. Balgradean, H. H. Schmeiser, M. Kolesnyk, N. Stepanova, L. Surzhko, N. Stashevska, V. Filiopoulos, D. Hadjiyannakos, D. Arvanitis, K. Panagiotopoulos, D. Vlassopoulos, N. Kaesler, T. Schettgen, E. Magdeleyns, V. Brandenburg, C. Vermeer, J. Floege, T. Kr, O. Randone, M. Ferraresi, E. Aroasio, A. Depascale, S. Scognamiglio, V. Consiglio, G. B. Piccoli, L. V. Jensen, S. Lizakowski, P. Rutkowski, L. Tylicki, M. Renke, B. Sulikowska, R. Donderski, R. Bednarski, Z. Heleniak, M. Przybylska, J. Manitius, B. Rutkowski, L. Bobrova, N. Kozlovskaya, K. Kanayama, M. Hasegawa, F. Kitagawa, J. Ishii, Y. Yuzawa, K. Tanaka, K. Sakai, S. Hara, Y. Suzuki, Y. Tanaka, A. Aikawa, F. Hinoshita, N. Hamano, E. Sasaki, A. Kato, T. Katsuki, A. Katsuma, E. Imai, M. Shibata, M. Tada, T. Shimbo, Y. Kikuchi, S. Oka, T. Muramatsu, N. Yanagisawa, K. Fukutake, Y. Yamamoto, A. Ajisawa, K. Tsuchiya, K. Nitta, M. Ando, X. Liang, P. Wang, Z. Liu, Z. Zhao, V. Luyckx, S. Bowker, A. Miekle, E. Toth, R. Heguilen, A. Malvar, R. Hermes, L. Cohen, G. Muguerza, B. Lococo, A. Bernasconi, O. Loboda, I. Dudar, V. Krot, V. Alekseeva, M. Ichinose, N. Sasagawa, K. Toyama, A. Saito, Y. Kayamori, D. Kang, H. W. Kim, K. Yoshioka, M. Hara, K. Ohashi, A. Maksudova, T. Khalfina, A. Cuoghi, E. Bellei, M. Caiazzo, S. Bergamini, G. Palladino, E. Monari, A. Tomasi, E. Loiacono, R. Camilla, V. Dapr, L. Morando, R. Gallo, L. Peruzzi, M. Conrieri, M. Bianciotto, F. M. Bosetti, R. Coppo, L. DI Lullo, F. Floccari, R. Rivera, A. Granata, R. Faiola, C. Feliziani, A. Villani, M. Malaguti, A. Santoboni, K. Kyriaki, J. Droulias, M. Bogdanova, V. V. Rameev, A. H. Simonyan, L. V. Kozlovskaya, M. R. Altiparmak, S. Trabulus, N. Akalin, A. S. Yalin, A. Esenkaya, S. F. Yalin, K. Serdengeae(C), D. Arita, T. Cunha, J. Perez, M. Sakata, L. Arita, M. Nogueira, Z. Jara, N. Souza, D. Casarini, M. Metzger, M. Vallet, A. Karras, M. Froissart, B. Stengel, P. Houillier, K. Paul, D. Kretzschmar, A. Yilmaz, B. Ba hlein, S. Titze, H.-R. Figulla, G. Wolf, M. Busch, Y. Korotchaeva, N. Gordovskaya, L. Kozlovskaya, K. P. Ng, P. Sharma, S. Stringer, M. Jesky, M. Dutton, C. Ferro, P. Cockwell, S. J. Moon, S. C. Lee, S. Y. Yoon, J. E. Lee, S. J. Han, B. Anna, T. Kirsch, L. Svjetlana, P. Joon-Keun, B. Jan, K. Johanna, H. Haller, M. Haubitz, A. Smirnov, I. Kayukov, N. Rafrafi, O. Degtereva, V. Dobronravov, M. Koch, H. Stefan, G. Dika, M.-H. Antoine, C. Husson, J. Kos, M. Milic, M. Fucek, D. Cvoriocec, M.-F. Bourgeade, J. L. Nortier, B. Jelakovic, E. H. Nawal, M. Naoufal, M. Nabila, E. M. Fadwa, E. K. Salma, B. Nisrine, Z. Mohamed, M. Guislaine, B. Mohamed Gharbi, R. Benyounes, G. G. Sotila, R. Sorin, D. Irina Magdalena, C. Roxana, R. Claudia, F. Correa Barcellos, P. H. Hallal, M. Bohlke, F. Boscolo Del Vechio, A. Reges, I. Santos, G. Mielke, M. Fortes, B. Antunez, M. Laganovic, I. Vukovic Lela, S. Karanovic, J. Seric, V. Premuic, M. Fitrek, L. Fodor, T. Meljkovic Vrkic, V. Bansal, D. Hoppensteadt, and J. Fareed

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, Medicine, Medical physics, Clinical nephrology, business
Published
2012

12. SO061DIALYSATE CALCIUM CONCENTRATION <3.0 MEQ/L IS NOT ASSOCIATED WITH IMPROVED OUTCOMES IN THE JAPAN-DIALYSIS OUTCOMES AND PRACTICE PATTERNS STUDY (J-DOPPS)

Author

Friedrich K. Port, Lisa Henn, Francesca Tentori, Eiichiro Kanda, Hideki Hirakata, R. Pisoni, Kazuhiko Tsuruya, and Kunitoshi Iseki

Subjects
Transplantation, medicine.medical_specialty, Nephrology, Practice patterns, business.industry, Calcium concentration, Medicine, Dialysis (biochemistry), business, Intensive care medicine
Published
2017

13. Dialysis Outcomes and Practice Patterns Study estimate of patient life-years attributable to modifiable haemodialysis practices in Sweden

Author

R. Pisoni, Margaret A. Eichleay, Björn Wikström, Jennifer L. Bragg-Gresham, Friedrich K. Port, and Stefan H. Jacobson

Subjects
Sweden, Nephrology, medicine.medical_specialty, Practice patterns, business.industry, Urology, medicine.medical_treatment, Guideline, Survival Rate, Catheter, Cross-Sectional Studies, Treatment Outcome, Renal Dialysis, Internal medicine, Relative risk, medicine, Humans, Guideline Adherence, Hemodialysis, Practice Patterns, Physicians', business, Intensive care medicine, Dialysis, Cohort study
Abstract

Objective. To examine the association of adherence to Swedish Society of Nephrology guidelines on haemodialysis treatment and patient outcomes in Sweden. Material and methods. A prevalent cross-sectional sample of Swedish haemodialysis patients was obtained from the Dialysis Outcomes and Practice Patterns Study (DOPPS II, 2002-2004), an international, prospective, cohort study that investigates relationships between patient outcomes and haemodialysis practices. The sample was used to estimate life-years gained through adherence to six potentially modifiable practice patterns: dialysis dose, anaemia, serum phosphorus, serum calcium, serum albumin and catheter use for vascular access. Cox proportional hazards regression models were used to calculate the relative risk of mortality for all patients outside each guideline. Results. The practices resulting in the largest patient-year gains were increasing patient albumin above 35 g/l and reducing facility catheter use to below 10%. Compliance with the albumin target levels could save approximately 441 life-years (or as many as 904 years). Similarly, by 2010, 409 life-years (or as many as 837 years) could be saved if vascular access target levels were achieved. Conclusion. The analysis suggests potential opportunities to improve haemodialysis patient care in Sweden. Estimates of life-years saved may serve as motivation for the improvement of patient care through adherence to published guidelines supported by international data from the DOPPS.

Published
2010

14. Incidence and risk factors for hip or other bone fractures among hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study

Author

L. Arab, J. L. Bragg-Gresham, Karl-Göran Prütz, Justin M. Albert, Tadao Akizawa, Nancy A. Mason, R. Pisoni, Takashi Akiba, Michel Jadoul, and Eric W. Young

Subjects
Adult, Male, Risk, medicine.medical_specialty, Time Factors, Adolescent, Drug-Related Side Effects and Adverse Reactions, medicine.medical_treatment, outcomes, Fractures, Bone, Sex Factors, Renal Dialysis, Risk Factors, Internal medicine, Prevalence, medicine, Humans, Risk factor, Serum Albumin, Dialysis, Aged, Aged, 80 and over, Hip fracture, hemodialysis, Hip Fractures, business.industry, Incidence, Incidence (epidemiology), Age Factors, Bone fracture, Middle Aged, medicine.disease, Kidney Transplantation, DOPPS, Surgery, bone fracture, Treatment Outcome, medicine.anatomical_structure, hip fracture, Parathyroid Hormone, Nephrology, Data Interpretation, Statistical, Hip bone, Relative risk, Female, Hyperparathyroidism, Secondary, Hemodialysis, business
Abstract

The available data on bone fractures in hemodialysis (HD) patients are limited to results of a few studies of subgroups of patients in the United States. This study describes the prevalence of hip fractures and the incidence and risk factors associated with hip and other fractures in representative groups of HD facilities (n=320) and patients (n=12 782) from the 12 countries in the second phase of the Dialysis Outcomes and Practice Patterns Study (2002-2004). Among prevalent patients, 2.6% had a prior hip fracture. The incidence of fractures was 8.9 per 1000 patient years for new hip fractures and 25.6 per 1000 for any new fracture. Older age (relative risk (RR)(HIP)=1.91, RR(ANY)=1.33, P0.0001), female sex (RR(HIP)=1.41, P=0.02; RR(ANY)=1.59, P0.0001), prior kidney transplant (RR(HIP)=2.35, P=0.04; RR(ANY)=1.76, P=0.007), and low serum albumin (RR(HIP)=1.85, RR(ANY)=1.45, per 1 g/dl lower, P0.0001) were predictive of new fractures. Elevated risk of new hip fracture was observed for selective serotonin reuptake inhibitors and combination narcotic medications (RR=1.63, RR=1.74, respectively, P0.05). Several medications were associated with risk of any new fracture: narcotic pain medications (RR=1.67, P=0.02), benzodiazepines (RR=1.31, P=0.03), adrenal cortical steroids (RR=1.40, P0.05), and combination narcotic medications (RR=1.72, P=0.001). Parathyroid hormone (PTH) levels900 pg/ml were associated with an elevated risk of any new fracture (RR=1.72, P0.05) versus PTH 150-300. The results suggest that greater selectivity in prescribing several classes of psychoactive drugs and more efficient treatment of secondary hyperparathyroidism may help reduce the burden of fractures in HD patients.

Published
2006

15. CKD 5D epidemiology and outcomes

Author

R. Arnold, B. A. Pussell, V. Grinius, M. C. Kiernan, C. S.-Y. Lin, A. V. Krishnan, D. Defedele, E. Loiacono, M. P. Puccinelli, L. Peruzzi, S. Maffei, R. Camilla, R. Gallo, G. Triolo, D. Bergamo, E. Palazzo, L. Vergano, F. Campolo, A. Amore, R. Coppo, A. Schneider, M. P. Schneider, A. G. Jardine, C. Wanner, C. Drechsler, M. Hecking, A. Karaboyas, H. Rayner, R. Saran, A. Sen, M. Inaba, J. Bommer, W. Horl, R. Pisoni, B. Robinson, G. Sunder-Plassmann, F. Port, L. A. Usvyat, S. Thijssen, P. Kotanko, N. W. Levin, C. Castledine, J. Gilg, C. Rogers, Y. Ben-Shlomo, and F. Caskey

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, Epidemiology, Medicine, business, Intensive care medicine
Published
2012

16. Symptoms of depression, prescription of benzodiazepines, and the risk of death in hemodialysis patients in Japan

Author

Shunichi Fukuhara, T. Akiba, Philip J. Held, Joseph Green, Justin M. Albert, Tadao Akizawa, Yoshihide Asano, Shin Yamazaki, R. Pisoni, Kiyoshi Kurokawa, H. Mihara, Akira Saito, and Friedrich K. Port

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Benzodiazepines, Japan, Renal Dialysis, Risk Factors, Internal medicine, Epidemiology, medicine, Humans, Prospective Studies, Medical prescription, Risk factor, Practice Patterns, Physicians', Psychiatry, Prospective cohort study, Depression (differential diagnoses), Dialysis, hemodialysis, business.industry, Depression, Antidepressive Agents, Hospitalization, Treatment Outcome, Anti-Anxiety Agents, Nephrology, Relative risk, antidepressants, Female, Hemodialysis, business
Abstract

Many hemodialysis patients in Japan have symptoms of depression, but whether those patients are treated appropriately is unknown. As part of the Dialysis Outcomes and Practice Patterns Study, data on symptoms of depression, physician-diagnosed depression, prescribed medications, and death were collected prospectively in cohorts in Japan ( n =1603) and 11 other countries ( n =5872). Symptoms of depression were as prevalent in Japan as elsewhere, but in Japan a much smaller percentage of patients had physician-diagnosed depression: only 2% in Japan vs 17% elsewhere. Antidepressants were much less commonly prescribed in Japan: only 1% in Japan vs 17% elsewhere for patients with many and frequent symptoms of depression, and 16% in Japan vs 34% elsewhere for patients with physician-diagnosed depression. In Japan, symptoms of depression were associated with prescription of benzodiazepines (without antidepressants), and patients with physician-diagnosed depression were twice as likely to be given benzodiazepines: 32% in Japan vs 16% elsewhere. Benzodiazepine monotherapy was associated with death (relative risk 1.56, 95% confidence interval (CI), 1.25–1.94), even after adjustments for 13 likely confounders (relative risk 1.27, 95% CI, 1.01–1.59). Hemodialysis patients in Japan with symptoms of depression are given not antidepressants but benzodiazepines, a practice associated with higher mortality.

Published
2006

17. Vascular damage and access in CKD

Author

T. Yoshida, M. Yamashita, M. Hayashi, A. Pletinck, G. Glorieux, E. Schepers, M. Van Landschoot, J. Van de Voorde, W. Van Biesen, R. Vanholder, Y. Yagi, S. Ito, S. Goto, M. Osaka, M. Yoshida, R. Pisoni, D. Fuller, R. Fluck, J. Fort, F. Locatelli, L. Spergel, D. Goodkin, F. Port, B. Robinson, S. Wilson, J. Robertson, G. Chen, P. Goel, D. Benner, M. Krishnan, T. Mayne, and A. Nissenson

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, medicine, Intensive care medicine, business
Published
2012

18. Response to time to consider the role of epoetin

Author

Jeffrey S. Berns, Harold I. Feldman, Bruce M. Robinson, F. K. Port, R. Pisoni, and Marshall M. Joffe

Subjects
Oncology, medicine.medical_specialty, business.industry, Proportional hazards model, Surrogate endpoint, medicine.medical_treatment, Confounding, Clinical trial, Nephrology, hemic and lymphatic diseases, Internal medicine, Medicine, Observational study, Hemodialysis, Dosing, business, Intensive care medicine, Dialysis, circulatory and respiratory physiology
Abstract

We thank Zhang and Thamer1 for their interest in our article examining hemoglobin (Hb) level and mortality among hemodialysis patients in the American arm of the Dialysis Outcomes and Practice Patterns Study Phase I.2 To reconcile in part the discrepancies between observational studies examining achieved Hb levels and clinical trials randomizing subjects to target Hb levels,3, 4, 5, 6 we hypothesized that the observational associations of higher Hb levels with longer survival would be less apparent in our Cox proportional hazards analysis accounting substantially more comprehensively for potentially confounding markers of health status and delivered dialysis care than was previously possible. As such, our goal was to examine the association of Hb level, not epoetin dosing, with survival, and Hb level was not a surrogate end point for survival, but rather our primary exposure variable.

Published
2006

19. Epidemiology & outcome in CKD 5D (1)

Author

W. Winkelmayer, J. Liu, A. Brookhart, H.-Y. Wang, W.-C. Kan, C.-C. Chien, T.-C. Fang, H.-F. Lin, Y.-H. Li, C.-H. Wang, C.-L. Chou, M. Yazawa, Y. Shibagaki, K. Kimura, S. Ohira, K. Ryo, T. Hasegawa, N. Hanafusa, Y. Tsubakihara, K. Iseki, H.-Y. Chen, I.-C. Cheng, Y.-J. Pan, Y.-L. Chiu, S.-P. Hsu, M.-F. Pai, J.-Y. Yang, Y.-S. Peng, T.-J. Tsai, K.-D. Wu, P. Dzekova-Vidimliski, G. Severova-Andreevska, S. Pavlevska, L. Trajceska, G. Selim, S. Gelev, A. Sikole, M. Hecking, A. Karaboyas, R. Saran, A. Sen, M. Inaba, W. H. Horl, R. Pisoni, B. Robinson, G. Sunder-Plassmann, F. K. Port, S. Chiroli, L. Perrault, D. Mitchell, C. Mattin, R. Krause, H. J. Roth, H.-J. Schober-Halstenberg, G. Edenharter, U. Frei, R. Wilson, M. Adena, P. Hodgkins, M. Keith, M. Smyth, C. Couchoud, R. Galland, N.-k. Man, J. Chanliau, V. Lemaitre, J. Traeger, G. von Gersdorff, O. Vega, M. Schaller, L. Usvyat, N. Levin, C. Barth, P. Kotanko, L. Rosales, S. Thijssen, H. Schmid, H. Schiffl, A. Romanos, S. Lederer, K. H. Chu, B. Lam, C. Tang, S. Wong, A. Cheuk, K. F. Yim, H. L. Tang, W. Lee, K. S. Fung, H. Chan, T. K. Ng, K. L. Tong, M. Doyle, A. Severn, J. Traynor, W. Metcalfe, J. Boyd, S. Cairns, J. Reilly, A. Henderson, K. Simpson, D. Tovbin, A. Douvdevani, V. Novack, A. Abd Elkadir, M. Zlotnik, Z. Djuric, N. Dimkovic, J. Popovic, Y. Furumatsu, S. Yamazaki, Y. Hayashino, M. Takegami, Y. Yamamoto, N. Kakudate, T. Wakita, T. Akizawa, T. Akiba, A. Saito, K. Kurokawa, S. Fukuhara, G. Voronovitsky, L. Pinelli, L. Paganti, J. Silva, R. Garofalo, E. Reiss, J. Gimenez Torrado, P. Lafroscia, M. Lugo, S. Laplante, P. Vanovertveld, M. Nordio, A. Limido, U. Maggiore, M. Nichelatti, M. Postorino, G. Quintaliani, L. Ebah, D. Kanigicherla, M. Nikam, G. Dutton, S. Mitra, L. Attipoe, J. Baharani, G. Magrini, A. Martorell, Y. Mashima, T. Konta, K. Kudo, K. Suzuki, A. Ikeda, S. Takasaki, I. Kubota, J. Chudek, K. Wieczorowska-Tobis, A. Wiecek, null Members of the \\'PolSenior\\' Study Group, J. M. des Grottes, F. Collart, H. Maheut, D. A. Goodkin, B. Bieber, B. M. Robinson, M. Jadoul, M. Djogan, I. Dudar, T. Sergeyeva, K. Yamagata, H. Nishi, S. Nishi, K. Hommel, M. Madsen, T. M. Blicher, A.-L. Kamper, I. Masakane, S. Ito, M. Seino, M. Ito, J. Nagasawa, H. C. Rayner, D. S. Fuller, B. W. Gillespie, H. Morgenstern, F. Tentori, R. L. Pisoni, J.-J. Wang, J.-C. Hwang, D. Mladenovska, G. Severova, V. Amitov, P. Yadav, J. J. Carrero, D. J. Jager, M. Verduijn, P. Ravani, J. De Meester, J. G. Heaf, P. Finne, A. J. Hoitsma, J. Pascual, F. Jarraya, A. V. Reisaeter, F. W. Dekker, K. J. Jager, H. Sammut, M. S. A. Ahmed, J. Sheppard, N. Attwood, G. Cserep, K. Sinnamon, I. Katsipi, A. Tatsiopoulos, C. Doulgerakis, P. Papanikolaou, E. Kardouli, G. Lamprinoudis, K. Kintzoglanakis, M. Gennadiou, J. Kyriazis, A. Granger Vallee, E. Covic, M. Morena, A. Fournier, B. Canaud, D. Bolignano, S. Rastelli, G. Curatola, G. Caridi, R. Tripepi, G. Tripepi, R. Politi, F. Catalano, D. Delfino, M. Ciccarelli, F. Mallamaci, and C. Zoccali

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, Epidemiology, medicine, Intensive care medicine, business, Outcome (game theory)
Published
2011

20. Epidemiology & outcome in CKD 5D (2)

Author

M. Fusaro, Tomoyuki Yamakawa, Nynke Halbesma, Ani Shamanadze, Jyoti Baharani, Nino Kankia, Federica Capurro, Maria Tsiatsiou, J. Thumma, Shunichi Fukuhara, Chris Maggs, Enrico Di Stasio, Peir-Haur Hung, S. Amet, Fabian Somers, Sergio Sisca, Caskey Yoav, Norio Hanafusa, Julie Gilg, Doriana Chiarinotti, Valeria Maria Saglimbene, Marco Amidone, C. Combe, Satyanarayana Reddy Vanga, Massimo Liberatori, Ilias Minasidis, M. Plebani, David Ansell, Yoav Ben-Shlomo, Chris A Rogers, Renata Kłak, Gilbert Deray, Marian Klinger, Carlo Navino, G. Crepaldi, Ikuto Masakane, Jorgen Hegbrant, Hiroshi Nishi, Brenda W. Gillespie, S. Maggi, Wei-Chih Kan, J. Zhang, Geison Stein, Francesco Pizzarelli, Giorgia De berardis, Mark Dominik Alscher, Belguzar Kara, Irakli Rtskhiladze, Jaime Madeira, Fergus Caskey, J. Brian Copley, Efstathios Mitsopoulos, João Paulo Martins, R. Cristofaro, Alan Kimber, Eleni Manou, Pasquale Esposito, Antonio Lupo, Jan Bartel, Fabio Pellegrini, Hal Morgenstern, Diana C. Grootendorst, David W. Johnson, Tamar Dzagania, A. D'Angelo, Tone Brit Hortemo Østhus, A. Naso, Paul Clesco, G. Ashuntantang, Rosamund Wilson, Varvara Kousoula, I-Nong Lee, Béla Borbás, Timothy Collier, Andreana De Mauri, Alexandre Hertig, Diogo Bento, Ana Cláudia Miranda, Dorothea Nitsch, Shigeichi Shoji, G. Tripepi, Cheng-Huang Shen, Jean-Yves Gauvrit, Anne Castot, Mariusz Kusztal, Toril Dammen, Joble Joseph, Dimitrios Chanouzas, Silvana Milani, Nicolas Grenier, Raymond T. Krediet, Wacław Kopeć, Sousuke Kagitani, Vittorio Ortalda, Olivier Clément, Pietro Dattolo, Chi-Joung Wang, Saskia le Cessie, Charles R.V. Tomson, Katarzyna Madziarska, Marilena Conte, Kenjiro Yamakawa, Vidojko Djordjevic, Bénédicte Stengel, Pei-Chun Chiang, Carmen Tzanno, Liljana Tozija, Clare Castledine, Krishna Appunu, Lucia Lisi, Stanimir Ljubenovic, Lela Zangurashvili, Eiji Ishimura, Clarissa Uezima, Martino De Leo, Megumi Sato, Shinichi Nishi, L. Calò, Ingrid Os, Maka Lomidze, Carmine Tinelli, Karolina Paunovic, Tewolde Yabarek, Honora Smith, João Cruz, Fernanda Nisihara, Eric Rondeau, Tomasz Gołębiowski, Tamar Khitarishvili, Masaaki Inaba, Nikola Stojcev, Paola Serbelloni, Nino Jashiashvili, Kunitoshi Iseki, Miomir Stojanovic, Ching-Tan Cheng, Magdalena Krajewska, Minoru Ito, Jonathan C. Craig, Józef Penar, Galina Severova Andreevska, Yuzuru Sato, Attilio Di Benedetto, Ewa Zukowska Szczechowska, Zorica Dimitrijevic, Nikoloz Abramishvili, David Metreveli, Senji Okuno, Saso Gelev, J. Harambat, Michele Messa, Pavlina Dzekova, Beatrix Szlanka, Kuan-Yu Hung, Yoshiki Nishizawa, Vili Amitov, S. Giannini, Antonio Dal Canton, Khatuna Buachidze, Marco Righetti, R. Pisoni, Maurice Laville, Chih-Yen Hsiao, Nicolas Janus, Carmen Kreft-Jais, Gianmichele Ferrario, Dinanda J. de Jager, Galina Severova, Bassam Fallouh, D. Miozzo, Satoko Ito, A.P. Kengue, Genevieve Reinhardt, Aleksandar Sikole, Yukinori Johtoku, Vincent Launay-Vacher, Svetlana Pavleska, N. Vajente, Giulia Antognoli, Naveed Aslam, Gjulsen Selim, Junichiro Nagasawa, Katarzyna Gosek, Amin Amro, M. Gallieni, Maka Barnova, Beata Strempska, Shang-Chih Liao, Dimitrios Tsakiris, Camille Francès, Yoshiharu Tsubakihara, Daniele Marcelli, Nicola Panocchia, Goran Paunovic, Mariangela De Maria, Eudoxia Ginikopoulou, Luigi Tazza, Stefano Michelassi, Annalisa De Silvestri, Irma Tschokhonelidze, Khai Ping Ng, Maria Tsikeloudi, Kunihiro Yamagata, Valjbona Preljevic, Olivera Stojceva-Taneva, Michael Smyth, Retha Steenkamp, Friedrich K. Port, Giovanni F.M. Strippoli, Christophe Ridel, Naoki Tsuboniwa, Kyoko Norimine, Chih-Chiang Chien, Adalberto Tommasi, Wacław Weyde, Gabriel Choukroun, Kenichi Kudo, Friedo W. Dekker, Paola David, Lada Trajcevska, Maurizio Bossola, Paul Roderick, Marie Patrice Halle, Peter Rutherford, Hsien-Yi Wang, Lada Trajceska, Elisabeth W. Boeschoten, Paola Tomei, Jyh-Chang Hwang, Nora Sarishvili, Torbjørn Leivestad, and Bruce G. Robinson

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, Epidemiology, Medicine, business, Intensive care medicine, Outcome (game theory)
Published
2011

21. Sequential Treatment of a Large Pituitary Corticotroph Neoplasm and Associated Neurological Signs in a Dog

Author

Del Magno, Sara, Fracassi, Federico, Grinwis, Guy C M, Mandrioli, Luciana, Gandini, Gualtiero, Rossi, Federica, Sirri, Rubina, Pisoni, Luciano, Tryfonidou, Marianna A, Meij, Björn P, dPB CR, Veterinair Pathologisch Diagnostisch Cnt, Applied Veterinary Research, PB AVM, Pathologie, Dep Pathobiologie, Orthopedie en neurochirurgie, dCSCA RMSC-1, dCSCA AVR, LS Algemene chirurgie, Del Magno S, Fracassi F, Grinwis GCM, Mandrioli L, Gandini G, Rossi F, Sirri R, Pisoni L, Tryfonidou MA, Meij BP., dPB CR, Veterinair Pathologisch Diagnostisch Cnt, Applied Veterinary Research, PB AVM, Pathologie, Dep Pathobiologie, Orthopedie en neurochirurgie, dCSCA RMSC-1, dCSCA AVR, and LS Algemene chirurgie

Subjects
PItuitary glan, hypercortisolism, radiotherapy, transphenoidal hypophysectomy, Cushing disease, Adenoma, Male, medicine.medical_specialty, 040301 veterinary sciences, medicine.medical_treatment, 030209 endocrinology & metabolism, Trilostane, Pituitary neoplasm, Metastasis, Malignant transformation, 0403 veterinary science, 03 medical and health sciences, 0302 clinical medicine, Dogs, medicine, Carcinoma, Neoplasm, Animals, Pituitary Neoplasms, Dog Diseases, Small Animals, Hypophysectomy, business.industry, 04 agricultural and veterinary sciences, medicine.disease, Surgery, Radiation therapy, Pituitary Gland, Corticotropic cell, Neoplasm Recurrence, Local, business, medicine.drug
Abstract

No standardized treatment guidelines are reported in veterinary medicine for dogs with large pituitary corticotroph neoplasms causing neurological signs, and such dogs usually have a short overall survival. When these dogs undergo pituitary surgery and the tumor regrows there are few reports of subsequent treatments. A 7 yr old male Maltese diagnosed with pituitary-dependent hypercortisolism developed seizures in conjunction with a large pituitary corticotroph adenoma and underwent transsphenoidal hypophysectomy. After 3 yr of clinical remission, hypercortisolism recurred, and trilostane therapy was initiated. One year later, the dog developed new neurological signs and computed tomography revealed regrowth of a large pituitary mass that was then treated with radiation therapy. The dog lived disease-free for 3 more yr. At postmortem examination, a more aggressive pituitary neoplasm than the one examined at the time of surgery was found, which is suggestive of malignant transformation into a carcinoma despite the absence of convincing metastasis.

Published
2019

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