1. Glycemic variability evaluated by continuous glucose monitoring system is associated with the 10-y cardiovascular risk of diabetic patients with well-controlled HbA1c
- Author
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Xiaoming Ye, Shuo Lin, Xixiang Tang, Suhua Li, Yanming Chen, Qian Xiaoxian, Qiongli Yin, Yina Wang, Man-man Wang, and Panwei Mu
- Subjects
Adult ,Blood Glucose ,Male ,medicine.medical_specialty ,endocrine system diseases ,Cvd risk ,Clinical Biochemistry ,030209 endocrinology & metabolism ,030204 cardiovascular system & hematology ,Biochemistry ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,medicine ,Humans ,Glycemic ,Glycated Hemoglobin ,Framingham Risk Score ,business.industry ,Continuous glucose monitoring ,Blood Glucose Self-Monitoring ,Biochemistry (medical) ,Glycemic Load ,Type 2 Diabetes Mellitus ,General Medicine ,Middle Aged ,Endocrinology ,Diabetes Mellitus, Type 2 ,Cardiovascular Diseases ,Glycemic Index ,Female ,business - Abstract
The present study aimed to identify the relationship between glycemic variability (GV) and the 10-y risk of cardiovascular disease (CVD) in type 2 diabetes mellitus (T2DM) patients with good glycemic control.Two-hundred forty consecutive T2DM patients (HbA1c≤7.0%) without CVD were included to calculate the 10-y CVD risk by Framingham risk score (FRS), and divided into 3 groups: low-risk group (FRS≤10%), intermediate-risk group (10%, ≤20%) and high-risk group (20%). Inter-group differences of GV were determined by comparing the SD of blood glucose (SDBG), mean amplitudes of glycemic excursion (MAGE), and mean of daily differences (MODD) gathered from 72-h continuous glucose monitoring system.The levels of SDBG and MAGE significantly increased along with the raises of 10-y CVD risk of T2DM patients (p0.01). FRS was positively correlated with age, systolic blood pressure, SDBG and MAGE (r=0.717, 0.525, 0.509 and 0.485 respectively, p0.01), while negatively correlated with the level of HDL-C (r=-0.348, p0.01). Furthermore, multivariate logistic regression analysis confirmed that increased MAGE [OR: 1.623(1.198-2.316), p0.001] and patients with high urine albumin excretion rates [OR: 1.743(1.247-2.793), p0.001] were independent predictors for high 10-y CVD risk.GV predicts independently the 10-y CVD risk of T2DM patients with well-controlled HbA1c.
- Published
- 2016