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Background Isolated pulmonary vasculitis (IPV) is a single-organ vasculitis of unknown etiology and may mimic chronic thromboembolic pulmonary hypertension (CTEPH). The aim of this study was to review our clinical experience with pulmonary endarterectomy in patients with CTEPH secondary to IPV. Methods Data were collected prospectively for consecutive patients who underwent pulmonary endarterectomy and had a diagnosis of IPV at or after surgery. Results We identified nine patients (six female, median age 48 (23–55) years) with IPV. The diagnosis was confirmed after histopathological examination of all surgical materials. The mean duration of disease before surgery was 88.0 ±70.2 months. Exercise-induced dyspnea was the presenting symptom in all patients. Pulmonary endarterectomy was bilateral in six patients and unilateral in three. No mortality was observed, however, one patient had pulmonary artery stenosis and stent implantation was performed. All patients received immunosuppressive therapies after surgery. Mean pulmonary artery pressure decreased significantly from 30(19–67) mm Hg to 21(15–49) mm Hg after surgery (p Conclusions Isolated pulmonary vasculitis can mimic CTEPH, and these patients can be diagnosed with pulmonary endarterectomy. Furthermore, surgery has not only diagnostic but also therapeutic value for IPV when stenotic and/or thrombotic lesions are surgically accessible. A multidisciplinary experienced CTEPH team is critical for management of these unique patients.

Aim: It is aimed whether there is a relationship between dosimetric data of localized prostate cancer patients who have been treated with curative radiotherapy and gastrointestinal (GIS), genitourinary (GUS), anal and sexual side effects and whether there is a difference between dosimetric data and clinical findings between risk groups. Method : Eighty-seven patients who received curative radiotherapy for localized prostate cancer between 2014 - 2019 were included in the study. Dosimetrically; whether there was a relationship between V30, V40, V50, V60, V65, V70, V75 for rectum and bladder; D90 for the penile bulb, V72, V74, V76 for the bulbomembranous urethra, V30, V45, V53, Dmax for the anus and V45 (cc) for the intestine data and the side effects was analyzed. It was evaluated whether there was a relationship between testosterone values and sexual side effects. The Kolmogorov-Smirnov test, One Way ANOVA (F-test), and paired-sample T-test were used as statistical methods. For statistical significance, p

OZET Amac: Cox Orantili Hazard (COH) modeli sagkalim analizinde en sik kullanilan cok degiskenli regresyon modelidir. Ancak uygulamada orantili hazard (OH) varsayimini saglamak her zaman mumkun olmamaktadir. Bu durumda Parametrik Hizlandirilmis Basarisizlik (Olum) Zamani (HBZ) modelleri uygulanir. Bu calismada HBZ ve COH modelleri meme kanseri tanisi olan hastalara uygulanarak sonuclar karsilastirilmistir. Gerec ve Yontem: Bu calismada 697 erken evre meme kanserli hastanin retrospektif sagkalim verileri analiz edilmistir. Bagimli degisken olan genel sagkalim ve 13 bagimsiz degiskenle test edilmistir. Anlamli cikan degiskenler coklu regresyon analizi olan COH modeli ile yapilan regresyonla tahmin edilmeye calisilmistir. HBZ modeli icin verilerin olasi log-normal, log-lojistik, Weibull ve ustel dagilimlarina ait Hazard Fonksiyonlarina bakilmistir. Bulgular: Yas gruplari, tumor derecesi, noral invazyon ve ekstra kapsul tutulumu COH varsayimini saglamamasina ragmen, istatistiksel olarak anlamli cikan 9 bagimsiz degisken cok degiskenli COX modeline girdiginde sadece metastatik lenf nodu sayisi ve menopoz degiskenleri anlamli bulunmustur. HBZ modeli icin, bagimli degisken olan genel sagkalima ait, AIC degerine ve hazard fonksiyonu dagilimlarina gore en uygun HBZ modelinin Log-lojistik oldugu gorulmustur. Log-lojistik regresyonu sonucunda ise metastatik lenf nodu sayisi, menopoz ve tumor boyutu degiskenleri anlamli cikmistir. Sonuc: Literaturde COH modeli en sik kullanilan sagkalim modellerinin basinda gelir. Hazardlarin orantili olmadigi durumlarda COH regresyon modeli yerine HBZ regresyon modeli gibi modellerin kullanimi daha uygun olabilir.

Objective: Obstruction of the internal thoracic arteries (ITAs) by the Nuss bars in minimally invasive repair of pectus excavatum (MIRPE) has been documented in the literature. In this study, we aim to investigate the patency of ITAs before and after repair of the pectus excavatum with the Nuss procedure, by using color Doppler ultrasonography (US). Materials and Methods: Nineteen patients who underwent Nuss procedure were included in this study prospectively. Color Doppler US examinations were performed for comparing ITA patency after insertion of the Nuss bars and after their removal. Patients were evaluated according to gender, age, symmetry of deformity, Haller index, and the number of Nuss bars inserted. Results: Nineteen patients operated with MIRPE (17 male and 2 females with a mean age 21.78 +/- 6.35) were enrolled in the study. Eight patients (42.1%) with normal ITA blood flow preoperatively had normal blood flow after removal of the bar. In preoperative examination, 6 patients had bilateral (n=2) or unilateral (n=4) obstruction of the ITA and 5 patients had bilateral (n=2) or unilateral (n=3) abnormally disturbed flow. After the bar removal only 2 (10%) of the affected patients (57.9 %) still had obstruction whereas patent blood flow of the ITAs has been noted in 9 patients. Conclusion: We have shown that after the Nuss bar removal, only 10% of the ITAs are compromised.

ABS TRACT Objective: Left ventricular hypertrophy (LVH) is highly predictive of cardiovascular (CV) events in dialysis patients. The impact of different left ventricular (LV) geometric patterns on cardiovascular outcome has not been well established. The aim of this prospective observational study was to define the patterns of LVH and find out their impact on future cardiovascular events in patients on continuous ambulatory peritoneal dialysis (CAPD). Ma te ri al and Met hods: Patients we re followed up between 1999 and 2006 for cardiovascular events. Left ventricular mass and geometric patterns were determined by echocardiography. Kaplan-Meier method and Cox re gression analysis were used to evaluate the impact of LV geometric patterns on CV event free sur vival. Results: Sixty-five CAPD patients were enrolled in the study and were followed for 76 ± 15 months. There were a total of 16 (14 fatal, two non-fatal) CV events. Mean event-free survival time for patients without LVH was 79 ± 3 months (95% CI of 73 to 86 months). The mean CV event-free survival for the patients with concentric LV hypertrophy and eccentric hypertrophy was 75 ± 3 months (95% CI of 69 to 81 months), and 76 ± 3 months (95% CI of 69 to 82 months) respectively. Patients with eccentric [hazard ratio (HR): 20.2] and concentric (HR:18.7) LV hypertrophy had shorter time to CV event when compared to the patients without LV hypertrophy (p= 0.042). Conclusion: Left ventricular hypertrophy is a marker of poor cardiovascular prognosis irrespective of its pattern. Both eccentric and concentric LV hypertrophy are associated with shorter CV eventfree survival compared to normal geometry and concentric remodeling.