Author: "Nevado A" / Topic: medicine.medical_specialty - Searchworks@Jio Institute Digital Library Search Results

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262 results on '"Nevado A"'

1. All for One and One for All: Voluntary Physicians in the Intensive Medicine Units During the COVID-19 Outbreak in Spain

Author: Emilio Nevado-Losada, Abelardo García-de-Lorenzo, Teresa Nunez-Villaveiran, Alejandro González-Castro, Pau Garro, [Nunez-Villaveiran T] Plastic and Reconstructive Surgery Unit, Hospital General de Granollers, Granollers, Spain. [González-Castro A] Intensive Care Department, Hospital Universitario Marques de Valdecilla, Santander, Spain. [Nevado-Losada E] Intensive Care Department, Hospital Universitario Príncipe de Asturias, Madrid, Spain. [García-de-Lorenzo A] Intensive Care Department, Hospital Universitario La Paz, Madrid, Spain. [Garro P] Intensive Care Department, Hospital General de Granollers, Granollers, Spain, and Hospital General de Granollers
Subjects: hospital organization, medicine.medical_specialty, Critical Care, Coronavirus disease 2019 (COVID-19), surge capacity, intensive care medicine, COVID-19 (Malaltia), mass critical care, disaster medicine, 03 medical and health sciences, Medicina intensiva, 0302 clinical medicine, Physicians, Intensive care, Pandemic, Humans, Medicine, 030212 general & internal medicine, Pandemics, Retrospective Studies, Original Research, Surge Capacity, business.industry, Critically ill, Hospitals - Planificació, Public Health, Environmental and Occupational Health, COVID-19, Outbreak, 030208 emergency & critical care medicine, Intensive Care Units, Health Care Facilities, Manpower, and Services::Health Facilities::Hospital Units::Intensive Care Units [HEALTH CARE], instalaciones, servicios y personal de asistencia sanitaria::centros sanitarios::unidades hospitalarias::unidades de cuidados intensivos [ATENCIÓN DE SALUD], Spain, Turnover, Emergency medicine, business, Disaster medicine
Abstract: Objectives:Our purpose was to determine the intensive care units’ (ICU’s) medical staff surge capacity during the coronavirus disease 2019 (COVID-19) outbreak in Spring 2020 in Spain.Methods:A multicenter retrospective survey was performed addressing the medical specialties present in the ICUs and the increase in bed capacity during this period.Results:Sixty-seven centers (62.04%) answered the questionnaire. The ICU bed capacity during the pandemic outbreak increased by 160% (95% confidence interval [CI], 128.97-191.03%). The average number of beds per intensive care medicine (ICM) specialist was 1.5 ± 0.60 and 3.71 ± 2.44 beds/specialist before and during the COVID-19 outbreak, respectively. Non-ICM specialists and residents were present in 50 (74.63%) and 23 (34.3%) ICUs during the outbreak, respectively. The number of physicians (ICM and non-ICM residents and specialists) in the ICU increased by 89.40% (95% CI, 64.26114.53%). The increase in ICM specialists was, however, 4.94% (95% CI, −1.35-11.23%). Most non-ICM physicians were anesthetists, followed by pediatricians and cardiologists.Conclusions:The majority of ICUs in our study were able to rapidly expand critical care capacity by adapting areas outside of the normal ICU to manage critically ill patients, and by extending the critical care staff with noncritical care physicians working as force multipliers.
Published: 2020
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2. High prevalence of variants in skeletal dysplasia associated genes in individuals with short stature and minor skeletal anomalies

Author: Silvia Modamio-Høybjør, Isabel González-Casado, Angel Campos-Barros, Francisca Díaz-González, José Antonio Bermúdez de la Vega, Fernando Santos-Simarro, Atilano Carcavilla, Ana C Barreda-Bonis, Carolina de la Torre, Purificación Ros-Pérez, Inés Mulero-Collantes, Sara Benito-Sanz, Angela del Pozo, Mario Solís, Jesús González de Buitrago Amigo, Julián Nevado, Lucia Sentchordi-Montané, André M. Travessa, Pablo Prieto, Miriam Aza-Carmona, Pilar Bahíllo-Curieses, Elena Vallespín, Jaime Cruz-Rojo, Manuel Parrón-Pajares, Joaquín Ramírez-Fernández, Karen E. Heath, Pablo Ruiz-Ocaña, Carlos Goetz, and Carolina Bezanilla-López
Subjects: Male, Proband, Heterozygote, medicine.medical_specialty, Adolescent, Skeletal anomalies, Endocrinology, Diabetes and Metabolism, Dwarfism, Osteochondrodysplasias, Bioinformatics, Short stature, Bone and Bones, Endocrinology, Internal medicine, Prevalence, Humans, Medicine, Growth Plate, Child, Gene, High prevalence, Anthropometry, business.industry, Genetic Variation, High-Throughput Nucleotide Sequencing, Infant, General Medicine, medicine.disease, Body Height, Pedigree, PTPN11, Dysplasia, Child, Preschool, Female, medicine.symptom, business, General Economics, Econometrics and Finance
Abstract: Objective Next generation sequencing (NGS) has expanded the diagnostic paradigm turning the focus to the growth plate. The aim of the study was to determine the prevalence of variants in genes implicated in skeletal dysplasias in probands with short stature and mild skeletal anomalies. Design Clinical and radiological data were collected from 108 probands with short stature and mild skeletal anomalies. Methods A customized skeletal dysplasia NGS panel was performed. Variants were classified using ACMG recommendations and Sherloc. Anthropometric measurements and skeletal anomalies were subsequently compared in those with or without an identified genetic defect. Results Heterozygous variants were identified in 21/108 probands (19.4%). Variants were most frequently identified in ACAN (n = 10) and IHH (n = 7) whilst one variant was detected in COL2A1, CREBBP, EXT1, and PTPN11. Statistically significant differences (P < 0.05) were observed for sitting height/height (SH/H) ratio, SH/H ratio standard deviation score (SDS), and the SH/H ratio SDS >1 in those with an identified variant compared to those without. Conclusions A molecular defect was elucidated in a fifth of patients. Thus, the prevalence of mild forms of skeletal dysplasias is relatively high in individuals with short stature and mild skeletal anomalies, with variants in ACAN and IHH accounting for 81% of the cases. An elevated SH/H ratio appears to be associated with a greater probability in detecting a variant, but no other clinical or radiological feature has been found determinant to finding a genetic cause. Currently, we cannot perform extensive molecular studies in all short stature individuals so detailed clinical and radiological phenotyping may orientate which are the candidate patients to obtain worthwhile results. In addition, detailed phenotyping of probands and family members will often aid variant classification.
Published: 2021
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3. Longitudinal Changes in Epigenetic Age Acceleration in Aviremic Human Immunodeficiency Virus–Infected Recipients of Long-term Antiretroviral Treatment

Author: Gabriel Saiz-Medrano, Rocío Montejano, Julián Nevado, Julen Cadiñanos, María Jiménez-González, Rosa de Miguel, Mario Mayoral-Muñoz, Pilar Barruz, Beatriz Mena-Garay, Berta Rodés, Andrés Esteban-Cantos, Jose R. Arribas, Javier Rodriguez-Centeno, Eulalia Valencia, and Jose I Bernardino
Subjects: Adult, Epigenomics, Male, 0301 basic medicine, Aging, medicine.medical_specialty, Human immunodeficiency virus (HIV), HIV Infections, medicine.disease_cause, Epigenesis, Genetic, 03 medical and health sciences, 0302 clinical medicine, Antiretroviral Therapy, Highly Active, Internal medicine, Hiv infected, medicine, Antiretroviral treatment, Humans, Immunology and Allergy, Longitudinal Studies, 030212 general & internal medicine, Epigenetics, Related factors, Clinical events, business.industry, Confounding, Middle Aged, Regimen, 030104 developmental biology, Infectious Diseases, Anti-Retroviral Agents, Female, business
Abstract: Background Human immunodeficiency virus (HIV) infection induces epigenetic age acceleration (EAA), but it remains unclear whether epigenetic aging continues to accelerate during successful antiretroviral therapy (ART) and prolonged virological suppression. Methods We longitudinally analyzed 63 long-term aviremic HIV-infected adults. Using blood DNA methylation patterns, we calculated EAA measures based on 3 epigenetic clocks (Horvath’s clock, PhenoAge, and GrimAge). We recorded the emergence of serious AIDS-related and non-AIDS-related events throughout the study to assess its association with EAA. Results All participants were on stable ART and were virologically suppressed. After 4 years of follow-up, PhenoAge-EAA and GrimAge-EAA showed no differences, whereas Horvath-EAA slightly decreased (median difference, –0.53 years; P = .015). Longitudinal changes in EAA measures were independent of changes in CD4 cell counts, the ART regimen, or other HIV-related factors. Nineteen percent of participants experienced a serious clinical event during the study. Horvath-EAA was significantly higher at baseline in participants with clinical events (P = .027). After adjusting for confounders, we found a trend toward an association of higher levels of all EAA measures at baseline with serious clinical events. Conclusions Epigenetic aging did not accelerate in long-term aviremic HIV-infected adults after 4 years of successful ART. EAA measures deserve further study as potential tools for predicting clinical events.
Published: 2021
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4. The portrayal of dwarfism without skeletal dysplasia in art: Proportionate short stature due to growth hormone deficiency and other disorders

Author: Victor L. Ruiz-Pérez, Julián Nevado, Harry Pachajoa, Pablo Lapunzina, Jair Tenorio-Castaño, Ángel Campos Barros, and Eduardo E. Castilla
Subjects: medicine.medical_specialty, Dwarfism, Combined pituitary hormone deficiency, Osteochondrodysplasias, Isolated growth hormone deficiency, Short stature, Growth hormone deficiency, Genetics, Personal history, Humans, Medicine, Dwarfism, Pituitary, Psychiatry, Growth Disorders, Genetics (clinical), Proportionate short stature, Human Growth Hormone, business.industry, medicine.disease, Body Height, Dysplasia, Harassment, medicine.symptom, business, Art, Genetic diseases
Abstract: In this article, we analyze several works of art which portray individuals with short stature ("dwarfism"). We have focused on eight individuals who we believe have short stature due to growth hormone deficiency (GHD) or closely related disorders, rather than skeletal dysplasia. We discuss them individually, suggest the potential diagnosis, review the characteristics of their life and personal history, and briefly outline the artistic framework in which these works of art were created. This work is a posthumous tribute to the people with short stature portrayed in these works of art, who likely experienced harassment and inappropriate treatment by others and called by derogatory names. We have tried to acknowledge their identities with the respect they deserve.
Published: 2021
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5. High Blood Pressure and Risk of Dementia: A Two-Sample Mendelian Randomization Study in the UK Biobank

Author: Sarah M. Goodday, Alejo J. Nevado-Holgado, Danielle Newby, Marco Fernandes, Noel J. Buckley, Laura Winchester, William Sproviero, Albert Prats-Uribe, Daniel Prieto Alhambra, and Liu Shi
Subjects: 0301 basic medicine, medicine.medical_specialty, Blood Pressure, Disease, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, Mendelian randomization, Humans, Medicine, Dementia, Family history, Biological Psychiatry, Biological Specimen Banks, business.industry, Confounding, Mendelian Randomization Analysis, medicine.disease, Biobank, United Kingdom, 030104 developmental biology, Blood pressure, Hypertension, business, 030217 neurology & neurosurgery, Genome-Wide Association Study, circulatory and respiratory physiology
Abstract: Background Findings from randomized controlled trials have yielded conflicting results on the association between blood pressure (BP) and dementia traits. We tested the hypothesis that a causal relationship exists between systolic BP (SBP) and/or diastolic BP (DBP) and risk of Alzheimer’s disease (AD). Methods We performed a generalized summary Mendelian randomization (GSMR) analysis using summary statistics of a genome-wide association study meta-analysis of 299,024 individuals of SBP or DBP as exposure variables against three different outcomes: 1) AD diagnosis (International Genomics of Alzheimer's Project), 2) maternal family history of AD (UK Biobank), and 3) paternal family history of AD (UK Biobank). Finally, a combined meta-analysis of 368,440 individuals that included these three summary statistics was used as final outcome. Results GSMR applied to the International Genomics of Alzheimer's Project dataset revealed a significant effect of high SBP lowering the risk of AD (βGSMR = −0.19, p = .04). GSMR applied to the maternal family history of AD UK Biobank dataset (SBP [βGSMR = −0.12, p = .02], DBP [βGSMR = −0.10, p = .05]) and to the paternal family history of AD UK Biobank dataset (SBP [βGSMR = −0.16, p = .02], DBP [βGSMR = −0.24, p = 7.4 × 10−4]) showed the same effect. A subsequent combined meta-analysis confirmed the overall significant effect for the other SBP analyses (βGSMR = −0.14, p = .03). The DBP analysis in the combined meta-analysis also confirmed a DBP effect on AD (βGSMR = −0.14, p = .03). Conclusions A causal effect exists between high BP and a reduced late-life risk of AD. The results were obtained through careful consideration of confounding factors and the application of complementary MR methods on independent cohorts.
Published: 2021
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6. Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries

Author: Stephen R Knight, Catherine A Shaw, Riinu Pius, Thomas M Drake, Lisa Norman, Adesoji O Ademuyiwa, Adewale O Adisa, Maria Lorena Aguilera, Sara W Al-Saqqa, Ibrahim Al-Slaibi, Aneel Bhangu, Bruce M Biccard, Peter Brocklehurst, Ainhoa Costas-Chavarri, Kathryn Chu, Anna Dare, Muhammed Elhadi, Cameron J Fairfield, J Edward Fitzgerald, Dhruv Ghosh, James Glasbey, Mark I. van Berge Henegouwen, J.C. Allen Ingabire, T Peter Kingham, Marie Carmela Lapitan, Ismaïl Lawani, Bettina Lieske, Richard Lilford, Janet Martin, Kenneth A McLean, Rachel Moore, Dion Morton, Dmitri Nepogodiev, Faustin Ntirenganya, Francesco Pata, Thomas Pinkney, Ahmad Uzair Qureshi, Antonio Ramos-De la Medina, Aya Riad, Hosni Khairy Salem, Joana Simões, Richard Spence, Neil Smart, Stephen Tabiri, Hannah Thomas, Thomas G Weiser, Malcolm West, John Whitaker, Ewen M Harrison, Arben Gjata, Maria Marta Modolo, Sebastian King, Erick Chan, Sayeda Nazmun Nahar, Ade Waterman, Dominique Vervoort, Alemayehu Ginbo Bedada, Bernardo De Azevedo, Ana Gabriela Figueiredo, Manol Sokolov, Venerand Barendegere, Gerald Ekwen, Arnav Agarwal, Qinyang Liu, Juan Camilo Correa, Kalisya Luc Malemo, Jacques Bake, Jakov Mihanovic, Kamila Kuncarová, Julius Orhalmi, Hosni Salem, Jyri Teras, Aristotelis Kechagias, Alexis P Arnaud, Judith Lindert, Vasileios Kalles, Maria-Lorena Aguilera-Arevalo, Gustavo Recinos, Zsolt Baranyai, Basant Kumar, Harish Neelamraju Lakshmi, Sanoop Koshy Zachariah, Philip Alexander, Sunil Kumar Venkatappa, C Pramesh, Radhian Amandito, Christina Fleming, Luca Ansaloni, Gianluca Pellino, Ahmed M. Altibi, Ibrahim Nour, Intisar Hamdun, Ali M. Ghellai, Donatas Venskutonis, Tomas Poskus, Justas Zilinskas, Precious Malemia, Yong Yong Tew, Elaine Borg, Sarah Ellul, fatima Zahraa Wafqui, David W Borowski, Anne Sophie van Dalen, Cameron Wells, Harissou Adamou, Adesoji Ademuyiwa, Adewale Adisa, Kjetil Søreide, Sara Al Saqqa, Osaid Alser, Haya Tahboub, Helmut Alfredo Segovia Lohse, Sebastian Shu Yip, Piotr Major, António Sampaio Soares, Matei Razvan Bratu, Andrey Litvin, Armen Vardanyan, JC Allen Ingabire, Ahmad Gudal, Naif Albati, Jovan Juloski, Miran Rems, Sarah Rayne, Stephanie Van Straten, Yoshan Moodley, Irene Ortega Vázquez, Jaime Ruiz-Tovar, Kithsiri Janakantha Senanayake, Sujeewa Priyantha Bandara Thalgaspitiya, Omer Abdelbagi Omer, Anmar Homeida, Yucel Cengiz, Daniel Clerc, Muhammad Alshaar, Hanen Bouaziz, Yuksel Altinel, Matthew Doe, Maryna Freigofer, Ella Teasdale, Rakan Kabariti, Joshua Michael Clements, Stephen Richard Knight, Ahsan Ashfaq, Ijeoma Azodo, Gabriela Wagner, Ivan Trostchansky, Mayaba Maimbo, David Linyama, Helidon Nina, Amanda Zeko, Claudio Gabriel Fermani, Santiago Villalobos, Federico Carballo, Pablo Farina, Sebastian Guckenheimer, Marilla Dickfos, Ankit Ajmera, Chester Chong, Ralph Gourlay, Sikandar Hussaini, Yi Jia Lee, Adeeb Majid, Peter Martin, Rebecca Miles, Owen James Morris, Jamie Phua, William Ridley, Tarunpreet Saluja, Ryan Renxin Tan, Jen Teh, Anna Wells, Bharti Arora, Qaasim Dollie, Debbie Ho, Yanru Ma, Omattage Mahasha Perera, Anthony Truong, Amanda Caroline Dawson, Bryan Lim, Upuli Pahalawatta, Jacqueline Phan, Xiao-Ming Sarah Woon-Shoo-Tong, Andrea Yeoh, Lillian Charman, Andrew Drane, Sharon Laura, Charmaine Chu Wen Lo, Amy Mozes, Rita Poon, Hao Han Tan, Ellen Wall, Prakshi Chopra, Jasmine De Giovanni, Bal Dhital, Brian Draganic, Alexander Duller, Jonathan Gani, Yao Kuan Goh, Jun Young Jeong, Brendan McManus, Prakash Nagappan, Peter Pockney, Anya Rugendyke, Mahsa Sarrami, Stephen Smith, Vanessa Wills, Hsu Ven Wong, Geoffrey Ye, Geoffrey Zhang, Ethan Brooker, Daniel Feng, Bonnie Lau, Carlin Ngai, Sarah Birks, David Gyorki, Jaime Otero de Pablos, Ali Abbosh, Chris Gillespie, Ahmed Mahmoud, Bianca Kwan, Joshua Lawson, Andrea Warwick, Janne Bingham, Andrew J Cockbain, Nagendra Naidu Dudi-Venkata, Jordan Ellaby-Hall, Ben Finlay, Emily Humphries, Jade Pisaniello, Monique Pisaniello, Salma Salih, Tarik Sammour, Haidar Hadri Abd Wahab, April De Silva, Nicola Hayward, Kartik Iyer, Guy Maddern, Gian Andrea Prevost, Naga Annapureddy, Krishna Pranathi Settipalli, Jeremy Yeo, Lucy Hempenstall, Lily Pham, Shaun Purcell, Cherry Talavera, Ashish I Vaska, Gurpreet Chaggar, Phillip Chrapko, Annelise Cocco, Sarah Michelle Crystal Jade Coulter-Nile, Grahame Ctercteko, James French, Houchen Gong, Martijn Gosselink, Thuvarahan Jegathees, Ivan Jin, Michelle Kalachov, Kathryn Kiefhaber, Katherine Lee, Jason Luong, Steven Phan, Henry Pleass, Kelly Veale, Zhi Zeng, Angela Au, Ashe DeBiasio, Idy Deng, Jananee Myooran, Amrita Nair, Peter Stewart, Anton Stift, Lukas Walter Unger, Kerstin Wimmer, Nabila Ahmed, Syed Hasan, Saber Rahman, Margaret O'Shea, Greg Padmore, Adrian Peters, Pietro Perduca, Guenda Pulcina, Nicolas Tinton, Frederic Buxant, Elsa Dabin, Giulia Garofalo, Francis Dossou, Freddy Houehanou Rodrigue Gnangnon, Yacoubou Imorou Souaibou, Pako Motlaleselelo, Omphile Tlhomelang, Igor Lima Buarque, Gustavo Mendonça Ataíde Gomes, Aldo Vieira Barros, Ilia Batashki, Nikolai Damianov, Vladislav Stoyanov, Dragomir Dardanov, Svilen Maslyankov, Plamen Petkov, George Todorov, Evgeni Zhivkov, Aygulya Akisheva, Miguel Angel Castilla Moreno, Geno Genov, Ivelina Ilieva, Tsvetomir Ivanov, Martin Karamanliev, Azhar Khan, Emil Mitkov, Tsanko Yotsov, Boyko Atanasov, Nikolay Belev, Mihail Slavchev, Carlos Nsengiyumva, Elgan Jones, Simon Stock, Steve Kyota, James Brown, Tresor Mabanza K., Lemery Nigo Samuel, Chidi Otuneme, Ngwang Prosper, Franklin Umenze, Marylise Boutros, Natasha Caminsky, Sinziana Dumitra, Richard Garfinkle, Dominique Morency, Ebram Salama, Alexander Banks, Lorenzo Ferri, Haitian He, Amit Katz, Alexander Sender Liberman, Sarkis Meterissian, Allison Pang, Elena Parvez, Usmaan Hameed, Fahima Osman, Sangita Sequeira, Natalie Coburn, Alisha Jaffer, Paul Karanicolas, Matthew Mosseler, Reilly Musselman, Xinyuan Liu, Ching Wan Yip, Juan Sebastian Garces-Otero, Carolina Guzman, Sebastian Sierra, Andres Uribe Valencia, Paulo Andrés Cabrera Rivera, Saul Camelo, Andrea Gonzalez, Alejandro González-Orozco, Manuel Santiago Mosquera Paz, Carlos J- Perez Rivera, Felipe Gonzalez, Andres Isaza-Restrepo, Laura Nino- Torres, Natalia Arias Madrid, Maria Clara Mendoza Arango, Justin Tsandiraki, Damir Jemendžic, Branislav Kocman, Oliver Šuman, Renata Canic, Darko Jurišic, Ivana Karakas, Ana Krizanovic Rupcic, Vlatka Pitlovic, Josip Samardžic, Mario Kopljar, Ivan Bacic, Edgar Domini, Robert Karlo, Danijela Miljanic, Andrea Simic, Mariam Ahmed, Majdi Al Nassrallah, Rabiya Altaf, Talal Amjad, Ruba Eltoum, Heba Haidar, Alhassan Hassan, Omar Khalil, Marwan Qasem, Rommel Ramesh, Gautham Sajith, Maham Wisal, Jan Žatecký, Michele Bujda, Katerina Jirankova, Ales Paclik, Aya Abdallah, Mariam Abdulgawad Almogy, Esraa Ayman El-sawy, Ahmed Moustafa ElFayoumy, Nourhan Elghareeb, Nourhan Ahmed Esmat, Ahmed Fadel, Abdullah Habater, Heba Hamdy, Amr Hefni, Marwa Kamal, Norhan Mohamed Abobakr, Ahmed Sayed, Nancy Shaker, Ehab Taha, Hoda Tharwat, Omar Zakaria, Ibrahem Abdelmotaleb, Ali Al-Dhufri, Hamza S. Al-Himyari, Enas El sheikh, Asmaa Eldmaty, Aya Elkhalawy, Ahmed M.Elkhashen, Kithara Magdy, Safa Mostafa, Habib Doutoum Sadia, Mohamed mahmoud Saleh, Dina Samir, Mohamed Yahia Mohamed Ali, Mahmoud A. Nassar, Samar Abdelhady, Aly Abdelrazek, Israa Abdelsalam, Aya El-Sawy, Eman Essam, Mohamed Gadelkarim, Khaled Ghaly, Mohamed Hassabalnaby, Rana Masarani, Nourhan Mohamed Shaaban, Ahmed Sabry, Menatalla Salem, Nourhan Akram Soliman, Diaaaldin Zahran, Moustafa Ramadan Abou El.soud, Esraa Tarek Badr, Hala Borham, Nehal Elmeslemany, Mohammad Elsayed, Fawzia Elsherif, Sara Eslam, Gehad Gaber, Sondos Ibrahim, Yara Kamh, Abdelrahman Mahmoud, Shimaa gamal Mohamed, Eman Morshedy, Cinderella Omar, Fatima Salem Soliman, Shaza Abdelkawy, Naglaa Abdelmohsen, Mahmoud Abdelshakour, Ahmed Dahy, Norhan Gamal, Mohammed Gamal, Ahmad Hasan, Helal Hetta, Nehad Mousa, Mohamed Omar, Somia Rabie, Mahmoud Saad, Bakeer Saleh, Marwa Sayed Mohamed, Muhammad Shawqi, Heba Abdelhady Mousa, Mostafa Alnoury, Mohamed Elbealawy, Ahmed Elshafey, Muhammad Essam Ibrahim El Desouki Muhammad Ahmed, Mennatullah Ghonaim, Fawzy Hgag, Mohamed Ibrahim, Mahmoud Morsy, Mohamed Reda Loaloa, Ahmed Refaat, Hadeer Samir, Fatma Shahien, Mohamed Sobhy, Fathy Sroor, Esraa Abdellatif, Marina Adel, Amr Abdelghani Afifi, Eman Afifi, Marco Antaky, Amr Dawoud, Naira El Zoghby, Amira El-remaily, Ali Abdelazez Elzanfaly, Ahmed Gadallah, Fatma Alzahraa Gamal, Omar Hashem, Shrouk Medhat Youssef, Aliaa Muhammad Attyah, Malak Munir, Omar Shazly, Esraa Taha, Karim Wilson, Sawsan Adel, Asmaa Ali, Esraa Eid, Esraa Elhelow, Marwa Elmahdy, Bassant Elshatby, Amany Hossam el-din Zakaria, Ahmad Hossny, Eman Ibrahim, Ahmed M.Yonis, Maram Metwalli, Basant Yousry, Esraa Zid, Mina A Yacoub, Ahmed Abdelhakim, Nervana Abouelsoad, Mo'min Alkhatib, Ahmed Ashraf, Alaa Ashraf, Yasmin Elazab, Mahmoud Elfanty, Osama Elkabir, Mai Elsayed, Ahmed Elshimy, Hager Elsobky, John Eskander, Ahmed Gad, Ward Hamsho, Noura Khaled Abdelwahed, Menna Magdy, Dalia Moharam, Abeer Osama, Shereen Ramadan, Radwa Roum, Taqwa Sayed, Tarneem Shehada, Ahmed Mohy Zidan, Khalid Abbas, Amr Ali, Mohamed Attia, Mohamed Balata, Ayman El Nakeeb, Mohamed Ibrahim Elsayed Elewaily, Ahmed Elfallal, Hossam Elfeki, Ahmed Elkhadragy, Sameh Emile, Helmy Ezzat, Hasnaa Hosni, Islam Mansour, Waleed Omar, Gehad Othman, Kareem Sadek, Mostafa Shalaby, Noura Shehab-Eldeen, Rawda Anas khalifa, Helmy Badr, Mostafa Eldeep, Ahmed Eldeep, Amany Eldoseuky mohammed, Salwa Khallaf, Eman Magdy Hegazy, Rokia Mahmoud, Pola Mikhail, Mahmoud Morsi, Sara Mowafy, Dina Raafat, Amina Safy, Marwa Sera, Ahmed shible Sera, Mostafa Salim Mohamed AbdAllah, Muhammad Abdelkader, Abdulrahman Osama Abdou, Ahmedgaber Ahmed, Shireen Gaafar, Fatma Ibrahim negm, Mina Lapic, Ahmed Maher, Hagar Mahmoud, Ahmed Mostafa, Mohamed Samir, Fatma Samy, Nourhan Semeda, Hind I. Shalaby, Alaa El-taweel, Ahmed Galal Elnagar, Ahmed Gamal Hemidan, Mohamed Hussein, Ahmed.A. Kandil, Mf Moawad, Ayat Allah Nasser Hamamah, Mostafa Soliman, Mohamed Abdelkhalek, Noura Abdelmaksoud Tawakel, Ahmed Mohamed Abdelwahed, Alrawy Abdou, Khalid Atallah, Mohammed Yasser Elsherbeny, Eman Emara, Mohamed Hamdy, Omar Hamdy, Amira Haron, Salma Ismail, Islam Hany Metwally, Nihal Mohamed Hamed Elgaml, Ahmed Nassar, Basel Refky, Mirna Sadek, Mahmoud Saleh, Asmaa Yunes, Mai Zakaria, Mohammed Zuhdy, Notila Fayed, Mohammed Mustafa Hassan Mohammed, Sander Kütner, Priit Melnik, Indrek Seire, Toomas Ümarik, Eppu Ainoa, Verner Eerola, Hanna Koppatz, Laura Koskenvuo, Ville Sallinen, Sini Takala, Jevgeni Katunin, Arto Turunen, Niki Christou, Muriel Mathonnet, Vincent Lavoue, Krystel Nyangoh Timoh, Lucie Soulabaille, Romain Lesourd, Aude Merdrignac, Laurent Sulpice, Benoît André, Elodie Chantalat, Charlotte Vaysse, Bertrand Dousset, Sebastien Gaujoux, Gregory Martin, Octavian Clonda, Domantas Juodis, Klaus Kienle, Andras Mravik, Samuel Palmer, Gabor Szabadhegyi, Anita Eseenam Agbeko, Solomon Gyabaah, Frank Enoch Gyamfi, Nuhu Naabo, Atta Owusu senior, Joseph Yorke, Frank Owusu, Francis Abantanga, Theophilus Teddy Kojo Anyomih, Abdul-Jalilu Mohammed Muntaka, Emmanuel Owusu Abem, Mohammed Sheriff, Paul M. Wondoh, Dimitrios Balalis, Dimitrios Korkolis, Georgios Gkiokas, Eirini Pantiora, Theodosios Theodosopoulos, Argyrios Ioannidis, Konstantinos Konstantinidis, Sofia Konstantinidou, Nikolaos Machairas, Anna Paspala, Anastasia Prodromidou, Christos Chouliaras, Konstantinos Papadopoulos, Ioannis Baloyiannis, Ioannis Mamaloudis, George Tzovaras, Ioanna Akrida, Maria-Ioanna Argentou, Stylianos Germanos, Evangelos Iliopoulos, Ioannis Maroulis, George Skroubis, George Theofanis, Christos Chatzakis, Orestis Ioannidis, Lydia Loutzidou, Panagiotis Karathanasis, Nikolaos Michalopoulos, Charalampos Theodoropoulos, Dimitrios Theodorou, Tania Triantafyllou, Zoe Garoufalia, Natasha Hasemaki, Michalis Kontos, Gregory Kouraklis, Stylianos Kykalos, Theodore Liakakos, Eustratia Mpaili, Alexandros Papalampros, Dimitrios Schizas, Athanasios Syllaios, Ekaterini Christina Tampaki, Antonios Tsimpoukelis, Maria Ioanna Antonopoulou, Eirini Deskou, Dimitrios K. Manatakis, Dimitrios Papageorgiou, Menelaos Zoulamoglou, Christos Anthoulakis, Michalis Margaritis, Nikolaos Nikoloudis, Veronica Campo, André Ceballos, Mario-Andrés Flores, Waleska Giron, Donghyun Ko, Gabriel Martinez, Verónica Rivera Lara, Nataly Rueda, Andres Sanchez, Jorge Carlos Guillermo Tejeda Garrido, Alvaro Eduardo Alvarez Rivera, Elvis Benjamin Bamaca Ixcajoc, Lilian Elizabeth Barreda Zelaya, Patricia Chacòn-Herrera, Ligia Margarita Corea Ruiz, Guillermo Echeverria-Davila, Mario Garcia, Danilo García, Edgar Fernando Gutiérrez Mayen, Noriega José, Nery Mazariegos, Diego Méndez, Michael Paniagua Espinoza, David Bardos, Marton Benke, Kristof Illes, Balint András Kokas, Réka Szabó, Akhila Appukuttan, Anjitha Asok, Vijaykumar D.k, Kapil Malik, Praveen Ravishankaran, Ritesh Tapkire, Guru Moorthy, Joyner Abraham, Ramesh Muthuvel, John Alapatt, Abhay Kattepur, Nizamudheen Pareekutty, Mebanshanbor Garod, Caleb Harris, Cliff Wanniang, Ashish Gupta, Deepak Nehra, Sanjeev Parshad, Rajgopal Acharya, Rajendra Badwe, Manish Bhandare, Urvashi Jain, Karishma Kirti, Nita Nair, Shailesh Shrikhande, Purvi Thakkar, Premkumar Anandan, Archana C S, Arun Holenarasipur Narasannaiah, Tejaswi Jagarlamudi, Rashmi M R, Mallikarjuna Manangi, Abhishek Raghavendra, K. Seshagiri Rao, Vinay S, Vinay Sajjan, Aneesh Shenoy, Santhosh Shivashankar Chikkanayakanahalli, Kavya Tharanath, Sushmita V, Peter Adidharma, Raksheeth Agarwal, Phebe Anggita Gultom, Ghafur Rasyid Arifin, Matthew Billy, Zatira Elfizri, Alessa Fahira, Devi Felicia, Triana Hardianti Gunardi, Nadya Johanna, Nadia Rahmadiani Nugrahadi, Sonar Soni Panigoro, Siti Rahmayanti, Retta Catherina Sihotang, Santi Yuanita Brata, Hadi Winoto, Nastaran Barati, Manoochehr Karami, Hamidreza Khorshidi, Homa Naderifar, Mazin A. Abdulla, Maggie Coleman, Ronan J Doherty, Rob Hannon, Brenda Murphy, Aine Stakelum, Des Winter, Lylas Aljohmani, Richard Farnan, Yeshey Seldon, Tanna Tan, Shriya Varghese, Mohammad Alherz, Muaaz Ather, Mohammad Bajilan, Vivien Graziadei, Isobel Pilkington, Omar Quidwai, Paul Ridgway, Haaris Shiwani, Abd al-Rahman Tahir, Eimear Blunnie, Daniel Burke, Niall Kennedy, Kate Macdonagh, Maeve O'Neill, Siobhan Rooney, Giuseppe Falco, Guglielmo Ferrari, Simone Mele, Gabriela Elisa Nita, Lara Ugoletti, Maurizio Zizzo, Gianmaria Confalonieri, Giovanni Pesenti, Fulvio Tagliabue, Gianluca Baronio, Deborah Ongaro, Giacomo Pata, Bruno Compagnoni, Renato Salvadori, Lucio Taglietti, Nicola D'Alessandro, Pierpaolo Di Lascio, Giovanni Pascale, Luca Bortolasi, Tommaso Campagnaro, Massimo Carlini, Giorgio Lisi, Davide Lombardi, Corrado Pedrazzani, Domenico Spoletini, Giulia Turri, Paola Violi, Donato Francesco Altomare, Fabrizio Aquilino, Nicola Musa, Vincenzo Papagni, Arcangelo Picciariello, Leonardo Vincenti, Dario Andreotti, Savino Occhionorelli, Matteo Tondo, Stefano Maria Massimiliano. Basso, Riccardo Cirelli, Marco Enrico Mario Maino, Guglielmo Niccolò Piozzi, Emanuele Picone, Rosa Scaramuzzo, Giovanni Sinibaldi, Alfonso Amendola, Lorenzo Anastasio, Luigi Bucci, Emanuele Caruso, Antonio Castaldi, Sara Di Maso, Vincenza Paola Dinuzzi, Giovanni Esposito, Maria Gaudiello, Mariano Cesare Giglio, Paola Antonella Greco, Gaetano Luglio, Andrea Manfreda, Ester Marra, Federica Mastella, Gianluca Pagano, Roberto Peltrini, Vincenzo Pepe, Michele Sacco, Viviana Sollazzo, Giovanni Spiezio, Ettore Cianchetti, Nunzia Menduni, Michele Maria Carvello, Francesca Di Candido, Antonino Spinelli, Fabio Corsi, Luca Sorrentino, Fabio Marino, Emanuele Luigi Giuseppe Asti, Luigi Bonavina, Emanuele Rausa, Martina Asta, Andrea Belli, Francesco Bianco, Carmela Cervone, Paolo Delrio, Armando Falato, Andrea Fares Bucci, Rita Guarino, Ugo Pace, Daniela Rega, Emilia De Luca, Gaetano Gallo, Giuseppe Sammarco, Giuseppe Sena, Giuseppina Vescio, Letizia Santandrea, Giampaolo Ugolini, Davide Zattoni, Nicola Chetta, Gaetano Logrieco, Serafino Vanella, Gianluca Garulli, Nicola Zanini, Andrea Bondurri, Francesco Cammarata, Francesco Colombo, Diego Foschi, Giulia Maria Beatrice Lamperti, Anna Maffioli, Gianluca Matteo Sampietro, Al'ona Yakushkina, Gloria Zaffaroni, Enrico Cicuttin, Maria Grazia Sibilla, Harmony Impellizzeri, Marco Inama, Gianluigi Moretto, Sylvie Mochet, Elisa Ponte, Antonella Usai, Stefano Mancini, Andrea Sagnotta, Luigi Solinas, Elisa Bolzonaro, Nicolò Tamini, Gianluca Curletti, Raffaele Galleano, Michele Malerba, Sofia Campanella, Gianfranco Cocorullo, Francesco Colli, Paolino De Marco, Nicolò Falco, Tommaso Fontana, Leonel jospin Kamdem Mambou, Antonella La Brocca, Leo Licari, Brenda Randisi, Giovanna Rizzo, Giulia Rotolo, Giuseppe Salamone, Roberta Tutino, Paolina Venturelli, Stefano Malabarba, Alessandro Sgrò, Ivan Vella, Bruno Cirillo, Daniele Crocetti, Giorgio De Toma, Pierfrancesco Lapolla, Andrea Mingoli, Paolo Sapienza, Angela Belvedere, Stefania Bianchini, Margherita Binetti, Arianna Birindelli, Valeria Tonini, Mauro Podda, Fabio Pulighe, Michele De Rosa, Lorenzo Bono, Felice Borghi, Paolo Geretto, Maria Carmela Giuffrida, Corrado Lauro, Alessandra Marano, Luca Pellegrino, Paola Salusso, Diego Sasia, Michela Campanelli, Alberto Realis Luc, Mario Trompetto, Roberto Cardia, Nicola Cillara, Antonio Nicola Giordano, Antonio Costanzo, Mario Alessandro Giovilli, Luca Turati, Silvestro Canonico, Guido Sciaudone, Francesco Selvaggi, Lucio Selvaggi, Nader Albsoul, Ahmad AlBsoul, Ala'a Aldeen Alkhatib, Osama Alsallaq, Justin Z. Amarin, Rami Ayoub, Isam Bsisu, M S El Muhtaseb, Mohammad Jabaiti, Jamal Melhem, Yasmeen Z. Qwaider, Mohammad Hasan Salameh, Ahmad Suleihat, Haya H. Suradi, Mohammad Alammarin, Almoutuz Aljaafreh, Mohammad Bani hani, Zeina Bani hani, Farah Bani Hani, Toqa Fahmawee, Shadi Hamouri, Cyrine Katanani, Ra'fat Tawalbeh, Tamara Tawalbeh, Hassan Zawahrah, Mohamad K. Abou Chaar, Lana Abusalem, Mahmoud Al-Masri, Hani Al-Najjar, Lutfi Barghuthi, Zahra Ahmed, Adnan Maulana, Omar Ngotho, Charbel Kamau, Aruyaru Stanley Mwenda, Fridah Bosire, Elizabeth Mwachiro, Robert Parker, Ian Simel, Kimutai Sylvester, Abdulmunem Ahmed Mustafa Althini, Sofian Elbarouni, Aya Elseed Elbeshina, Ahmed Gwea, Ans Malek, Wedad Albashir Masoud Farag, Abdulwahab Abdalei, Abu Baker Abdel Malik, Areej Abo-khammash, Ma'aly Abuhlaiga, Nour Adnan, Marwa Albaggar, Asma Alfitory, Asma Aljanfi, Fakhruddin Almuzghi, Zohoor Altumei, Fatima Alzabti, Hana Ashoushan, Mohamed Assalhi, Joma Azzubia, Sondos Bnhameida, Malik Delhen, Houssein Elshafei, Hana Elteir, Fatima Esbaga, Abdel Aziz Gobbi, Fatma Hamouda, Hamdan Hilan, Rania Ismail, Fieruz Jebran, Muataz Kasbour, Galia Maderi, Saja Mohammad, Burooj Mohammed, Habib Murtadi, Hamassat Mustafa, Mohamed Rajab, Sarah Trenba, Mariam Wafaa, Eman Al Sagheir, Alabas Almigheerbi, Ahmed Alzahaf, Sumayyah Ghayth Bahroun, Najah Ben Dallah, Mahmoud Elshaibani, Haitem Eswaye, Maha Karar, Samah Omar, Eman Younes, Maha Younes, Dafer Zreeg, Saleh Abujamra, Firas Ashour, Mala Elgammudi, Wesal Omar F. Aljadidi, Enas Saddouh, Randa Sharif, Aya Alabuzidi, AbdulMawlay Alwerfally, Sarra Aribi, Fatma Bibas, Taha Elfaituri, Yasmine Elhajjaji, Ala Khaled, Wegdan Khalil, Tesneem Layas, Enas Soula, Ahmed Tarek, Muad fathi khalleefah Abu hallalah, Hazem Abdelkarem Ahmed, Tagwa Alsharef, Abdulsalam Ali Ben Saoud, Tasnim El Gharmoul, Ahmed Elhadi, Safa Elrais, Abdulhalim Shebani, Heba Zarti, Asaid Zeiton, Marijus Ambrazevicius, Nerijus Kaselis, Migle Stakyte, Oleg Aliosin, Agne Cizauskaite, Sarunas Dailidenas, Vitalijus Eismontas, Migle Kybransiene, Vitalija Nutautiene, Narimantas Samalavicius, Dainius Simcikas, Algirdas Slepavicius, Albinas Tamosiunas, Nerijus Ubartas, Paulius Zeromskas, Saulius Bradulskis, Edvinas Dainius, Juozas Juocas, Egle Kubiliute, Juozas Kutkevicius, Aurimas Opolskis, Audrius Parseliunas, Andrejus Subocius, Egle Virbickaite, Diana Zuikyte, Algirdas Bogusevicius, Kristina Buzaite, Daiva Cepuliene, Ieva Cesleviciene, Vaidotas Cesna, Jolanta Gribauskaite, Povilas Ignatavicius, Mantas Jokubauskas, Monika Liugailaite, Ernest Margelis, Ruta Mazelyte, Lina Pankratjevaite, Matas Pažusis, Agne Rackeviciute, Justina Saladyte, Monika Škimelyte, Vygintas Šlenfuktas, Monika Sudeikyte, Algimantas Tamelis, Tomas Vanagas, Žygimantas Žumbakys, Aivaras Atkociunas, Audrius Dulskas, Justas Kuliavas, Justas Birutis, Sigitas Paškevicius, Mindaugas Šatkauskas, Donatas Danys, Matas Jakubauskas, Lina Jakubauskiene, Marius Kryzauskas, Vytautas Lipnickas, Gabija Makunaite, Fanjandrainy Rasoaherinomenjanahary, Herizo Rasolofonarivo, Luc Hervé Samison, Bitiel Banda, Vanessa Msosa, Ahmad Imran Ahmad Izzuddin, Andre Das, Ying Yee Gan, Tan Shong Sheng, Jia yng Siaw, Mohd Fadliyazid Ab Rahim, Dyg Zahratul Hamrak Abang Jamari, Nurfariza Che Husin, Muhd Yusairi Kamarulzaman, Yi Ping Lim, Nil Amri Mohamed Kamil, Mohd Razeen Mohd Hassan, Saidah Mohd Sahid, Johari Mustafa, Elaine Hui Been Ng, Wan Khamizar Wan Khazim, Ng Chang Ern, P.g. Lingeshan, Syariz Ezuan Sulaiman, Sue Ean Ang, Muhammad Navid Bin Mohamad Sithik, Yih Jeng Cheong, Mahadevan Deva Tata, Law Jia Xian, Aravinthan Kadravello, I-Ern Koh, Li-Yen Ng, Yuki Julius Ng We Yong, Kandasami Palayan, Chi Xuan Sam, Phuah Siow Jin, Jeremy Tan Ern Hwei, Yita Tang, Alvin Zubin Ter, Michael Pak-Kai Wong, Andee Dzulkarnaen Zakaria, Zaidi Zakaria, Fitjerald Henry, Thyivya Kalaiselvan, Muhammad Fairuz Shah Abd Karim, Mohamed Rezal Abdul Aziz, Nora Abdul Aziz, Tak Loon Khong, Peng Choong Lau, Hiong Chin Lim, April Camilla Roslani, Jonathan Chen Ken Seak, Sui-Weng Wong, Lai Fen Wong, Leow Yeen Chin, Mercy Chinemerem Anyanwu, Zachary Busuttil, Thomas Calleja, Kurt Lee Chircop, Ruth Cutajar, Andrew Michael Dimech, Joseph Galea, Kiara Gascon Perai, Ruth Gatt, Lisa Kelman, Elizabeth Micallef, Favour Nwolu, Kim Sammut, Joanna Thompson, Sean Warwicker, Matthew Zammit, Fernando Cordera, Efraín Cruz González, Jorge Sánchez-García, Francisco José Barbosa Camacho, Francisco Javier Barrera López, Carlos Jose Zuloaga Fernandez del Valle, Eric Acosta, Iván Romarico González Espinoza, Perla Moreno, Ana Olivia Cortes-Flores, Clotilde Fuentes Orozco, Alejandro Gonzalez Ojeda, Samantha Corro Díaz González, Laura Martinez, Bonifacio Mosqueda Amador, Armando Novoa, Dennet Arturo Olazo Espejo, Alejandro Jimenez, Federico Lopez Rosales, Elva Gabriela Vanoye, Luis Alberto Garcia Gonzalez, Roberto Carlos Miranda-Ackerman, Manuel Solano-Genesta, Alethia Alvarez-Cano, Hector Hugo Romero-Garza, Heriberto Medina-Franco, Lorelí Mejía-Fernández, Noel Salgado-Nesme, Omar Vergara-Fernandez, Guadalupe Montserrat Gutiérrez-Mota, Francisco Xavier Hernandez Vera, Anabella Llantada Lopez, Gilberto Morgan Villela, Felipe de Jesus Ramirez Padilla, Walezka Tapia Marin, Mónica Martínez Maldonado, Ramses Sánchez Suárez, José Manuel Troche, Chaymae Benyaiche, Oumaima Outani, Souadka Amine, Amine Benkabbou, Anass Mohammed Majbar, Raouf Mohsine, Ali Rafik, Thida Oung, Moe Moe Tin, Philipp Plarre, Anna Alberga, Nina Sluiter, Jurriaan Tuynman, Robin Blok, Didem Cömert, Roel Hompes, Marianne Kalff, Merel Elisabeth Stellingwerf, Pieter Tanis, Mark van Berge Henegouwen, Elise Maria van Praag, Daan Wisselink, Michael Gerhards, Josephine Lopes Cardozo, Emma Westerduin, Joske de Jonge, Aaw van Geloven, Kaz van Schilt, Frank den Boer, Simone Stoots, Stijn Vlek, Jamie Adams, Ibrahim S. Al-Busaidi, Gabrielle Budd, Seung il Choi, Michael Jen Jie Chu, Anurag Ganugapati, Lucy McKinstry, Rebecca Pascoe, Simon Richards, Kenrick Rosser, Annie Stevenson, Rebecca White, Shebani Farik, Jin Kwun, Ahmed Murad, Sarah Cowan, Timothy Hall, Michael Hayton, Laminou Malam Sani, Souleymane Oumarou Garba, Ibrahim Amadou Magagi, Oumarou Habou, Halima Aliyu, Muhammad Daniyan, Tunde T. Sholadoye, Lawal Abdullahi, Lofty-John Anyanwu, Aminu Mohammad Mohammad, Abubakar Bala Muhammad, Abdurrahman Abba Sheshe, Ibrahim Suleiman, Alaba Adesina, Ajibola Awolowo, Clement Onuoha, Omotayo Salami, Ogechukwu Taiwo, Agboola Taiwo, Stephen Kache, Jerry Godfrey Makama, Danjuma Sale, Olajide Abiola, Akinlabi Ajao, Anthony Ajiboye, Amarachukwu Etonyeaku, Julius Olaogun, Ademola Adebanjo, Opeoluwa Adesanya, Michael Olatunji Afolayan, Olanrewaju Balogun, Ayomide Makanjuola, Samuel Nwokocha, Rufus Wale Ojewola, Thomas Olagboyega Olajide, Adewale Aderounmu, Abdul-Rashid Adesunkanmi, Augustine Agbakwuru, Adeleke Akeem Aderogba, Olusegun Isaac Alatise, Olukayode Arowolo, Oladejo Lawal, Tajudeen Mohammed, Chinedu Ndegbu, Olalekan Olasehinde, Funmilola Wuraola, Akinbolaji Akinkuolie, Arinzechukwu Mosanya, Omobolaji Ayandipo, Peter Elemile, Taiwo Akeem Lawal, Samuel Ali SANI, Stephen Garba, Rebecca Hauwa SANI, Samson Olori, Henry Onyebuashi, Ifeanyi Umoke, Adedire Adenuga, Ademola Adeyeye, Olufemi Habeeb, Bashir Lawal, Abdulrasheed Nasir, Eirik Kjus Aahlin, Didrik Kjønås, Elisabeth Myrseth, Jibran Abbasy, Abdul Alvi, Omair Saleem, Asma Afzal, Anam Nazir, Muhammad Farooq, Ayesha Liaqat, Syed Asghar Naqi, Ali Raza, Muzna Sarfraz, Muhammad Sarwar, Muntaha Banglani, Ambreen Munir, Rahmat Sehrish, Bushra Ayub, Raza Sayyed, Amna Altaf, Saima Ayub, Komal Saeed, Bilal Syed, Sana Amir Akbar, Abdul Wahid Anwer, Ruqayya Naheed Khan, Amina Iqbal Khan, Shahid Khattak, Sameen Mohtasham, Muhammad Asad Parvaiz, Aamir Ali Syed, Abdul Basit Ansari, Noman Shahzad, Tanwir Khaliq, Isbah Rashid, Shahzad Hussain Waqar, Hasan Abu Al-saleem, Amjad Abu Alqumboz, Mohammad Alqadi, Adham Amro, Rawan Assa, Eman Awesat, Rawan Ayyad, Mohammed Hammad, Ayat Haymony, Bassel Hijazi, Bara Hmeidat, Rowaa Lahaseh, Aseel Qawasmi, Alaa Rajabi, Mohammed Shehada, Sundus Shkokani, Yasmine Yaghi, Nadine Yaghi, Mohammad AlZohour, Mohammad Farid, Yousef Mahmoud Habes, Wesam Juba, Yanal Nubani, Abdelrahman Rabee, Mohammad Sa'deh, Saeed Abed, Iyad Al basos, Mohammad Alswerki, Dina Ashour, Israa Awad, Samar Diab, Alaa El Jamassi, Sahar El-Kahlout, Somaya Elhout, Ahmed N K Hajjaj, Doaa Hasanain, Baraa Nabil hajjaj, Mohammed Obaid, Eman Saikaly, Ahmed Salhi, Hiba Al-Tammam, Murad Almasri, Muath Baniowda, Doha Beshtawi, Ali Horoub, Rami Misk, Bayan Mohammad, Rami Qasrawi, Tasnim Sholi, Samar Abu-Nimeh, Abrar Abu-srour, Sadi A. Abukhalaf, Samer Adawi, Barah Alsalameh, Kholoud Ayesh, Muawiyah Elqadi, Ahmad Hammouri, Fatima Karim Mustafa, Natalie Marzouqa, Shatha Melhem, Dima Miqdad, Balqees Mohamad, Mhammed Rawhi, Ayman B. Abu Ahammala, Ahmed Abu Ataya, Israa Abu Jayyab, Samar Al-Shwaikh, Othman Alagha, Mohammed Alasttal, Haneen Awadallah, Mahmood Elblbessy, Jehad Fares, Akram Jarbou, Ibtisam Mahfouz, Moath A. Albahnasawi, Asmaa' Abo mahadi, Hasan Abuelhatal, Ayham Abuelqomboz, Abdelrahman Almoqayyad, Abdallah Alwali, Reem Balaawi, Mahmoud Hamouda, Mohammed Humeid, Abdullah Jedyan, Tasneem Mahmoud Abu hamam, Ghadeer Matar, Ali Salem, Tahani Samra, Nureddin Shaheen, Karam Shihada, Ayoob A.Nemer, Mahmoud Abu Al Amrain, Abdulwhhab Abu Alamrain, Najlaa Abu Jamie, Mohammed R. Abu-Rous, Nada Alfarra, Mohammed AlTaweel, Noor Alwhaidi, Ramadan Hamed, Bader Saqqa, Ahmad Shaheen, Dana Aljaber, Loay Aljaberi, Malak Alwaheidi, Assef Jawaada, Hani Khaldi, Rami Qahoush, Jalil Qari, Rana Saadeh, Ahlam Salim, Aseel Yacoub, Abbas Abbas, Rana Abu shua`ib, Baraa Abu Zainah, Mahmoud AbuSirrees, Basheer Babaa, Ola Barhoush, Asef Belal qadomi, Laith Daraghmeh, Reema Haji, Alaa Khatatbeh, Lana Khatib, Salsabeel Qarariah, Yara Quzmar, Khalil Safadi, Roqaya Salameh, Mohammad Hassan, Shifaa Herzallah, Loai Massad, Ahmed Nazzal, Ranin Nazzal, Dennis Escobar, Gustavo Miguel Machain V, Agustin Rodriguez Gonzalez, Jorge Emerson Chachaima Mar, Nathaly Olga Chinchihualpa Paredes, Vicente Cuba, Walter Lopez, Maria Milagros Niquen Jimenez, Nestor Alberto Sanchez Bartra, Olenka Sapallanay Ojeda, Diego Sequeiros, Andrea Toscano Pacheco, María Vergara, Sol Abarca, Rodrigo Alcorta, Giuliano Borda-Luque, Ivan Edward Eusebio Zegarra, Claudia Luján López, Mirella Marrufo, Cinthya Mogrovejo, Andrea Nomura, Yamile Rodríguez Angeles, Maitza Rosario Vidal Meza, Gabriela Zavala, José Neiser Castillo Arrascue, Jomara Caroline Hidrogo Cabrera, José Julio Mariano Larrea vera, Miguel Osorio, Edgar Alcides Ylatoma Díaz, Mark Anthony Fontanilla, Joseph Roy Fuentes, Anna Leah Salazar, Genieve Dominguez, Marc Paul Lopez, Shiela Macalindong, Mark Augustine Onglao, Arjel Ramirez, Marie Dione Sacdalan, Mayou Martin Tampo, Gemma Leonora Uy, Jeremiah Mangahas, Kenneth Yabut, Joannes Paul Cañete, Bernalynn Eris Cansana, Ernes John Castro, Maria Kaiserin Lipana, Manuel Francisco Roxas, Vlu Jean Zara, Maciej Chrol, Paula Franczak, Michal Orlowski, Piotr Budzynski, Andrzej Budzynski, Pawel Bury, Agata Czerwinska, Jadwiga Dworak, Jacek Dziedzic, Michal Kisielewski, Jan Kulawik, Anna Lasek, Piotr Malczak, Marcin Migaczewski, Michal Pedziwiatr, Magdalena Pisarska, Dorota Radkowiak, Mateusz Rubinkiewicz, Anna Rzepa, Tomasz Skoczylas, Maciej Stanek, Katarzyna Truszkiewicz, Mateusz Wierdak, Marek Winiarski, Piotr Zarzycki, Anna Zub-Pokrowiecka, Piotr Kowalewski, Rafal Roszkowski, Maciej Waledziak, Miguel Tomé, Sara Patrocinio, Ines Guerreiro, Filipe Almeida, Xavier de Sousa, Nuno Monteiro, Maria Teresa Costa Santos, Daniela de Oliveira, Marta Lopes Serra, Daniela Morgado, Christian Neves, Ana Carolina Oliveira, Alice Pimentel, Sofia Silva, Márcia Carvalho, Lúcia Carvalho, Joana Magalhães, Leonor Matos, Tânia Monteiro, Carlota Ramos, Vanessa Santos, José Barbosa, Jose Costa-Maia, Vítor Devezas, Ana Fareleira, Cristina Fernandes, Diana Gonçalves, Henrique Mora, Marina Morais, Fabiana Silva de Sousa, Sara Catarino Santos, Ana Logrado, André Tojal, Edgar Amorim, Miguel F. Cunha, Ana Fazenda, João Pedro Melo Neves, Inês Isabel Sampaio da Nóvoa Gomes Miguel, Diogo Veiga, José Azevedo, Hugo Cardoso Louro, Mariana Leite, Maria Bairos Menezes, Bárbara Gama, Diana Brito, Marta Cristina Cruz Martins, André Graça e Magalhães, Ana Catarina Longras, Rita Lourenço, Diana Matos, Luis Castro, Filipa Policarpo, Joana Romano, Cristina Monteiro, Diogo Pinto, Marina Duarte, Sónia Fortuna Martins, Mariline Oliveira, Diogo Galvão, Lisandra Martins, Anaisa Silva, Viorel Taranu, Bárbara Vieira, Jessica Neves, Simone Oliveira, Hugo Ribeiro, Margarida Cinza, Rosa Felix, Arnaldo Machado, Joana Oliveira, Joana Patrício, Rita Pedroso de Lima, Mário Pereira, Miguel Rocha Melo, Cristina Velez, Alberto Abreu da Silva, Mariana Claro, Daniel Costa Santos, Andreia Ferreira, Hugo Capote, Daniela Rosado, Filipa Taré, Oriana Nogueira, Miguel Ângelo, José Miguel Baiao, Andreia Guimarães, João Marques, Miguel Nico Albano, Marta Silva, Ana Valente da Costa, Teresa Vieira Caroço, Sara Almeida Braga, Ines Capunge, Marta Fragoso, João Guimarães, Bruno Pinto, João Ribeiro, Miguel Angel, Guilherme Fialho, Monica Guerrero, Filipa Campos Costa, Diogo Cardoso, Vasco Cardoso, Magda Alves, Inês Estalagem, Tiago Louro, Cláudia Marques, Rita Martelo, Miguel Morgado, Rita Canotilho, Ana Margarida Correia, Pedro Martins, Mariana Peyroteo, João Gomes, Rita Monteiro, Manuela Romano, Daniela Macedo Alves, Rita Peixoto, Catarina Quintela, Maria João Jervis, Débora Melo, André Pacheco, Valter Paixão, Vera Pedro, Joana Pimenta, João Pimenta de Castro, Ana Rocha, Mircea Beuran, Cezar Ciubotaru, Bogdan Diaconescu, Sorin Hostiuc, Ionut Negoi, Bogdan Stoica, NA NA, Evgeny Anokhin, Georgy Kuznetsov, Giorgi Oganezov, Fedor Paramzin, Ekaterina Romanova, Valeryan Rutkovskii, Vasilii Rutkovskii, Mikhail Shushval, Mikhail Zabiyaka, Khasan Dzhumabaev, Valerii Ivanov, Zaman Mamedli, Sergey Achkasov, Artem Balkarov, Elnur Nabiev, Marat Nagudov, Evgeny Rybakov, Karina Saifutdinova, Oleg Sushkov, Lule Joseph, Isaac Ndayishimiye, Ntirenganya Faustin, Alphonse Zeta Mutabazi, Jean Paul Mvukiyehe, Vizir J.P Nsengimana, Carine Uwakunda, Mohammad Monir Abbas, Nouf Akeel, Murad Aljiffry, Kholoud Awaji, Ali Farsi, Ghader Jamjoum, Ahmad Khoja, Ashraf Maghrabi, Nadim Malibary, Mohammed Nassif, Abdulaziz Saleem, Abdullah Sultan, Wail Tashkandi, Hanaa Tashkandi, Nora Trabulsi, Mouhamadou Bachir Ba, Adja Coumba Diallo, Abdourahmane Ndong, Vladica Cuk, Uroš Jankovic, Sharon Zhiling Koh, Frederick Koh, Kuok Chung Lee, Kai Yin Lee, Sean Lee, Wei Qi Leong, Su Ann Lui, Prajwala Prakash, Jan Grosek, Gregor Norcic, Ales Tomazic, Nicolas Fitchat, Robert Jaich, Devorah Wineberg, Modise Zacharia Koto, Daniella Baiocchi, Damian Clarke, Christina Johanna Steenkamp, Sharon Bannister, Adam Boutall, Galya Chinnery, Anna Coccia, Angela Dell, Parveen Karjiker, Christo Kloppers, Nicholas Loxton, Tumi Mabogoane, Francois Malherbe, Eugenio Panieri, Shreya Rayamajhi, Tirsa van Wyngaard, Claire Warden, T E Madiba, Nivashen Pillay, Savannah Brooks, Charlise Kruger, Lisa Hannah Van Der Merwe, Ferhana Gool, Maahir Kariem, Heather Bougard, Nazmie Kariem, Fazlin Noor, Reantha Pillay, Leandi Steynfaardt, Lucía González González, José Miguel Marín Santos, Paula Martín-Borregón, Javier Martínez Caballero, Cristina Nevado García, Pastora Rodriguez Fraga, Gonzalo De Castro Parga, Maria Pilar Fernández Veiga, Lucía Garrido López, Hugo Infante Pino, Irene Lages Cal, Marta López Otero, Manuel Nogueira Sixto, Marta Paniagua García Señorans, Laura Rodríguez Fernández, Alejandro Ruano Poblador, Erika Rufo Crespo, Raquel Sanchez-Santos, Vincenzo Vigorita, Ester Alonso Batanero, Dorisme Asnel, Isabel Cifrian Canales, Elisa Contreras Saiz, Irene De Santiago Alvarez, Tamara Díaz Vico, Sebastian Fernandez Arias, Daniel Fernández Martínez, Carmen García Bernardo, Luis Joaquín García Flórez, Carmen Garcia Gutierrez, Manuel García Munar, Carlos Alberto Márquez Zorrilla Molina, Marta Merayo, José Luis Michi Campos, Maria Moreno Gijon, Jorge L. Otero-Diez, Jose Luis Rodicio Miravalles, Lorena Solar-Garcia, Aida Suárez Sánchez, Nuria Truan, Cristina Alejandre Villalobos, Yurena Caballero Díaz, Marta Jimenez, Dacil Montesdeoca, Antonio Navarro-Sánchez, Victor Vega, Juan Beltrán de Heredia, Zahira Gómez, Carlos Jezieniecki, Ana Patricia Legido Morán, Mario Montes-Manrique, Mario Rodriguez-Lopez, María Ruiz Soriano, Jeancarlos Trujillo Díaz, Andrea Vazquez Fernandez, Nuria Argudo, Miguel Pera, Laia Torrent Jansà, Melody García Domínguez, Ignacio Goded, Marta Roldón Golet, Issa Talal El-Abur, Alejandra Utrilla Fornals, Vanesa Zambrana Campos, Maria Del Mar Aguilar Martinez, Marina Bosch, Luis García-Catalá, Luis Sánchez-Guillén, Eva Artigau, Nuria Gomez Romeu, David Julià Bergkvist, Beatriz Espina Perez, Olga Morató, Carles Olona, Beatriz Diéguez, Alexander Forero-Torres, Manuel Losada, Segundo Gomez-Abril, Paula Gonzálvez, Rosario Martinez, Sergio Navarro Martínez, Carmen Payá-Llorente, Álvaro Pérez Rubio, Sandra Santarrufina Martinez, Juan Carlos Sebastián Tomás, Ramon Trullenque Juan, Alberto Gegúndez Simón, Paloma Maté, Maria Isabel Prieto-Nieto, Ines Rubio-Perez, Aitor Urbieta, Marina Vicario Bravo, David Abelló, Matteo Frasson, Alvaro Garcia-Granero, Alfredo Abad Gurumeta, Ane Abad-Motos, Elena Lucena-de Pablo, Beatriz Nozal, Javier Ripollés-Melchor, Rut Salvachúa, Esther Ferrero, Luis Garcia-Sancho Tellez, Antonio L. Picardo, Jose Alberto Rojo López, Laura Patricia Zorrilla Matilla, Carmen Cagigas Fernandez, Sonia Castanedo Bezanilla, José Estevez Tesouro, Maria Jose Fernandez-Diaz, Juan García Cardo, Marcos Gomez Ruiz, Erik Gonzalez-Tolaretxipi, Jaime Jimeno Fraile, Cristobal Poch, Montserrat Rodriguez-Aguirre, Noemí Troche Pesqueira, Maria Soledad Trugeda-Carrera, Javier de la Torre, Ruth Blanco-Colino, Eloy Espin-Basany, Martin Espinosa-Bravo, Clara Morales Comas, Eduardo Reyes Afonso, Joaquín Rivero Déniz, Christian Siso Raber, Mireia Verdaguer Tremolosa, Pramodh Chandrasinghe, Sumudu Kumarage, Nimeshi Wijekoon Arachchilage, Ahmed Abdalla Ahmed Elkamel, Mohammed A. Adam, Nina Blomme, Anders Thorell, Fredrik Wogensen, Andreas Älgå, Dhirar Ansarei, Fuat Celebioglu, Göran Heinius, Linda Nigard, Emil Pieniowski, Sandra Ahlqvist, Ida Björklund, Andreas Frånberg, Martina Håkansson, Karin Adamo, Oskar Franklin, Malin Sund, Rebecca Wiberg, Yvette Andersson, Abbas Chabok, Maziar Nikberg, Alexander Kugelberg, Claudia Canonica, Dimitrios Christoforidis, Fabrizio Fasolini, Paolo Gaffuri, Mauro Giuliani, Francesco Meani, Sotirios Georgios Popeskou, Silvia Pozza, Wiebke Wandschneider, Lorenz Peterer, Lukas Werner Widmer, Bernd Zimmermann, Panagiotis Bakoleas, Iris Chanousi, Lydia Charalampidou, Lukasz Filip Grochola, Franziska Heid, Sotirios Ntaoulas, Michail Outos, Georgios Peros, Hanna Podolska-Skoczek, Katharina Beate Reinisch, Christian Zielasek, Nicolas Demartines, Jérôme Gilgien, Amaniel Kefleyesus, Pénélope St-Amour, Arnaud Toussaint, Maryam Alhimyar, Bayan Alsaid, Amr Alyafi, Ahmad Alkhaledi, Basel Kouz, Ahmad Omarain, Yusra Al-Sabbagh, Haya Alkhatib, Samer Sara, Ahmad Alhaj, Aghyad Danial, Lama Kadoura, Sarah Maa Albared, Yamen Monawar, Louei Nahas, Barook Abd, Ahmad Saad, Habib Wakkaf, Hatem Bouzaiene, Montassar Ghalleb, Elif Akaydin, Ata Cem Akbaba, Onur Atakul, Ege Baltaci, Sevval Besli, Gökçen Burgu, Ulukan Cenal, Cansu de Muijnck, Hasan Can Demirkaya, Alper Dogruoz, Zeynep Ipek Gezer, Yasemin Gündogdu, Merve Kara, Hasan Kürsad Korkmaz, Gökalp Kagan Kurtoglu, Volkan Ozben, Berk Baris Ozmen, Ahmet Murat Pektas, Eda Kübra Sel, Nilüfer Yenidünya, Fuat Baris Bengur, Berke Mustafa Oral, Tahir Koray Yozgatli, Seymur Abdullayev, Mehmet Emin Gunes, Nuri Alper Sahbaz, Tuba Banaz, Kübra Kargici, Omer Faruk Kuyumcu, Erkan Yanikoglu, Merve Yesilsancak, Duygu Yilmaz, Melik Kagan Aktas, Ahmet Rencuzogullari, Arda Isik, Sezai Leventoglu, Ali Yalçinkaya, Osman Yüksel, Mustafa U Kalayci, Yasin Kara, Inanc Samil Sarici, Alp Akin, Gökçe nur Alemdag, Ekin Arslan, Bahadir Emre Baki, Muhammed Selim Bodur, Adnan Calik, Bahar Candas Altinbas, Irem 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Husain, Elspeth Murray, Ahmed Mustafa, Ashar Asif, Arya Gokul, Max Shah, Mabel Temisanren Akitikori, Alexandros Charalabopoulos, Sophie Davidson, Sinead McNally, Shamil Rupani, Fatema Juma, Sarah Catherine Mills, Laura Muirhead, Kate Sellars, Una Walsh, Oliver Warren, Alice Chambers, Richard Hunt, Stephen Boyce, Hannah Cornwall, Isabel Tol, Eleftherios Orestis Argyriou, Nicola Eardley, Meical Povey, Joanna M S Aithie, Ahmer Irfan, Mari-Claire McGuigan, Robert Starr, Craig Russell Warren, Jess Archibald, Georgia Kirby, Ivan Kisyov, Chun Kheng Khoo, Rachel Lee, Dana Photiou, Rowan Davis, Uday Prasad, P Zichu Yang, Jonathan Bird, Edmund Leung, Virginia Summerour, Chelise Currow, Jianshen Kiam, Gerald Jack Soon Tan, Anitha Muthusami, Ibifunke Pegba-Otemolu, Tomas Urbonas, Joseph Nunoo-Mensah, Edgaras Smolskas, Alex Boddy, Gianpiero Gravante, David Hunter, David Andrew, Amanda Koh, Amari Thompson, Lawrence Adams, Hollie A Clements, Kasun De Silva, Ogbonnia Ekpete, Seraj Haque, Scott Henderson, Bilal Ibrahim, Thummini Jayasinghe, Jennifer Livie, Keir Mailley, Gopikrishnan Nair, Daniel Tan, Caitlin Baggaley, Aleksander Dawidziuk, Bartosz Szyszka, Charlotte Barter, Nirav Gandhi, Karen Hassell, Samantha Hitchin, Jennett Kelsall, Eva Nagy, Ashrafun Nessa, Lisa Whisker, Fady Yanni, Mahmoud Ali, Deeksha Arora, Sunanda Hediwattege, Navam Kumarasinghe, Munir Rathore, Athula Tennakoon, Syed Mustafa Ali Ahmad, Oreoluwa Bajomo, Fahema Nadira, Valerio Celentano, Ewen Griffiths, Rama Santhosh Karri, Jason Kei Chak Mak, Michelle Pipe, Muhammad Iqbal Bhatti, Mohamed Rabie, Connor Boyle, David Hamilton, Aishath Mihuna, James Chean Khun Ng, Gary Nicholson, Agata Oliwa, Robert Pearson, Anna Rose, Shun Qi Yong, Catherine Boereboom, Michael Hanna, Catherine Walter, Thomas Samuel Greensmith, Rachel Mitchell, Eimear Monaghan, James Crawford, Susan Moug, James Blackwell, Hannah Boyd-Carson, Philip Herrod, Omar Al-Allaf, Miriam Beattie, Cameron Bullock, Shivang Burman, Gemma Clark, Nicolas Flamey, Oliver Flannery, Alexander Harding, Ben Kodiatt, Samuel Lawday, Shivani Mahapatra, Navin Mukundu Nagesh, Michael Ng, Dupinderjit Rye, Andrel Yoong, Laura Clark, Chris Deans, Monisha Edirisooriya, Emma Victoria Carrington, Tsz Lun Ernest Wong, Baasil Yusuf, Carla Chamberlain, Kathryn Duke, Elizabeth Kmiotek, Azel Botes, Natalie Condie, Timothy Schrire, Reena Shah, Iolo Thomas-Jones, Charlotte Yates, Natasha Anthony, Edward Matthews, Kapil Sahnan, James Tankel, Sally Tucker, Jasmine Winter Beatty, Paul Ziprin, William Duggan, Anastasia Kantartzi, Shruthi Sridhar, Rachel Alys Khaw, Prakhar Srivastava, Charlotte Underwood, Homero Alves do Canto Brum, Sharat Chopra, Laura Davis, Rebecca Hughes, Joshua Tulley, Justin Alberts, Thomas Athisayaraj, Mojolaoluwa Olugbemi, Kasim Ahmad, Claudia Chan, Gavin Chapman, Hannah Fleming, Benjamin Fox, Julia Grewar, Kate Hulse, Duncan Rutherford, Mackay Sinead, Scott Smith, Doug Speake, Peter G Vaughan-Shaw, Natasha Christodoulides, Simrit Kudhail, Matthew Welch, Syed Muhibullah Husaini, Simon Lambracos, Chikamuche Anyanwu, Rishi Suresh, Jimmy Scott Thomas, Elizabeth Gleeson, Rebecca Platoff, Areeba Saif, Zachary Enumah, Eric Etchill, Alodia Gabre-Kidan, Mitchell Bernstein, Francesco Maria Carrano, Joseph Connors, Patricio Lynn, Marcovalerio Melis, Elliot Newman, Deshka S Foster, Kenneth Perrone, Ashley Titan, Sarwat Ahmad, Andrea Chao M.D. Bafford, Marco Dal Molin, Nader Hanna, Syed Nabeel Zafar, Mark Hemmila, Lena Napolitano, Jane J Wong, Julia Chandler, Lauren Wood, Sherry Wren, Taylor Ottesen, Lucia You, Kristin Yu, María del pilar Arciénega Yañez, Martin Ferreira Fernandes, Daniel González, Santiago Cubas, María Catalina González, Vanessa Zubiaurre, Rodrigo Demolin, Nicolas Giroff, Pablo Sciuto, Maite Campos, Gabriela Rodríguez Cantera, Garg Deepika, Elliot Simuchimba, Anadi Bulaya, Chali Chibuye, Bright Chirengendure, Mary-Rose Kabale, Kizito Kabongo, James Munthali, Oliver Mweso, Francis Pikiti, James Otieno, Log Tung Lai, Brighid Blackman, Sophie Richards, Suren Subramaniam, Rafid Karim, Nathan Kok, Yanni Dion Lee, Shabina Ali, Aanjaneya Sinha, Robert Corrigan, Nicole Barnes, Florence Wong, Grace Dennis, Julia Jedamzik, Emil Phillips, Wivine Piette, Marie Van hentenryck, Houenoukpo Koco, Souliath Lawani, Mamo Woldu Kassa, Tainá Santos Bezerra, Petar Gribnev, Dobromir Dimitrov, Panche Krastev, Sovannarith Oum, Divine Tim Bonghaseh, Maryam Al Farsi, Nourah Alsharqawi, Veronica Acevedo, Andrea Carolina Castillo Barbosa, Felipe Giron, Jimmy Paul Leon Rodriguez, Darko Kucan, Damir Rosko, Neven Barsic, Domagoj Župan, Amgad Hegazi, Vendula Truncíková, Vladimir Fryba, Mostafa Mohamed, Ahmed Sultan, Ahmed Nagi, Abdallah Rashad Temerik, Mohamed Elemam Elshawy, Moustafa Ibrahim Mahmoud, Shrouk Omar, Mohamed Anwar, Tarek Rageh, Aya Elmokadem, Khaled Gaballa, Sandra Teppo, Antti Turunen, Pasi Pengermä, Quentin Ballouhey, Damien Bergeat, Ariane Weyl, Elisabeth Hain, Adam Gyedu, Edwin Yenli, Dorcas Osei-Poku, Vaia-Aliki Rompou, Athanasios Zoikas, Apostolos Gaitanidis, Georgios Koukis, Konstantinos Perivoliotis, Panagiotis Tavlas, Konstantinos Galanos-Demiris, George Zografos, Ioannis Karavokyros, Georgia Xanthopoulou, Eirini Iordanidou, Fernanda Ayau, Allan Garcia, Pekli Damján, Deepender Wason, Ashika B L, Ervandy Rangganata, Prerna Kamath, Donal B O'Connor, Margherita Pinto, Fabrizio Perrone, Francesca Paola Tropeano, Francesca Troilo, Daniela Bossi, Dario Scala, Lucrezia Pulitanò, Marcella Carella, Andrea Pietrabissa, Alice Gori, Giorgio Giraudo, Veronica De Simone, Alfio Alessandro Russo, Bartolomeo Braccio, Raed Al-Taher, Sarah Athamneh, Andrea Parker, Adnan Sawiee, Amina Kattia, Malik Salem, Osama Tababa, Zuhour Shaeeb, Vilius Syminas, Jonas Jurgaitis, Gyte Damuleviciene, Saulius Svagzdys, Narindra Njarasoa Mihaja Razafimanjato, Ling Chieng Loo, Ing Ching Tiong, Wan Farahiyah Wan Muhmad, Harinthiran Vijeyan, Teoh Li Ying, Gabriella Grech, Rodrigo Arrangoiz, Vania Brickelia Jimenez Ley, Daniel Arizpe, Elizabeth Lagunes Lara, Elizabeth Victoria Castro López, Jose Eaazim, Marije Gordinou de Gouberville, Vivian Bastiaenen, Simone Rottier, Fouad Nahab, Maria Yeonhee Ji, Mohammed Seyoji, Callistus Nwachukwu, Okechukwu Emeghara, Sayyid Egbunu Muhammed, Ayodeji Idowu, Olamiposi Sowemimo, Olakayode Ogundoyin, Oluwatosin Akande, Alexander Lott, Maliha Nadeem, Ahsan Ali Laghari, Asif Loya, Hassan Mushtaq, Muhammad Tariq Abdullah, Baseel Abuhilal, Mohammad Atawneh, Hamdan Hamdan, Belal Alhabil, Abedelrahman Srour, Ibrahim Mousa, Luis Da Silva Medina, Katarzyna Bartosiak, Pedro Ferreira, Vítor Francisco, Ricardo Lemos, Luísa Frutuoso, Sara Fernandes, Telma Fonseca, Jorge Pereira, Juan Rachadell, Ana Torre, Filipe Madeira Martins, Ana Cristina Carvalho, Joana Rodrigues Ferreira, Bruno Ribeiro da Silva, Helena Devesa, Ana Vieira, Inês Mónica, Margarida Amaro, Diogo Sousa, Marta Reia, João Louro, Ana Martins, Joaquina Dominguez, Inês Santos, Nuno Miguel Freitas Oliveira, José Carlos Pereira, Pedro Silva-Vaz, Ligia Freire, Ricardo Escrevente, Valentina Madalina Negoita, Dmitry Shakhmatov, Yves Nezerwa, Radosav Radulovic, Gareth Obery, Francois Viljoen, Tome Mendes, Antonio Suarez, Enrique Moncada, Maria Fernandez-Hevia, Carolina Curtis Martínez, Julia Maria Gil Garcia, Mariana González Zunzarren, Tarig Idris, Karolina Eklöv, Oskar Grahn, Leila Amin, Malin Blomqvist, Costanza Ajani, Rebecca Kraus, Nico Seeger, Melissa Willemin, Fadi Rayya, Mohammad Ayash, Raneem Msouti, Israa Kannas, Eias Abazid, Asil Esper, Skander Slim, Akil Serdar Kavcar, Erman Aytac, Ahmet Cem Dural, Ayse Ilker, Ismail Cem Eray, Eray Kurnaz, Saygin Altiner, Mustafa Deniz Tepe, Can Sahin, Evrim Savli, Aryon Innocent, Lilian Babirye, Andrii Diachenko, Vladislav Hordoskiy, Heather Curry, Charlene Yat Che Chau, Harry Robertson, Arin Mahmoud, Hannah Lennon, Lynette Loi, Emily Kirkham, Cameron McCann, Daniel Watts, Binay Gurung, Michael Wilson, Thomas Tribedi, Eleonora Garofalo, Baryab Zahra, Scott MacDonald, Ian Daniels, Nathan Ng, Shivun Khosla, James Olivier, Sum Yu Pansy Yue, Gayathri Suresh, Jack Wellington, Emmanuel Lorejo, Mafdi Mossaad, Madison Crutcher, Marjan Alimi, Ioana Baiu, Hossam Abdou, Alison Conway, Connor Peck, Mauro Andres Perdomo Perez, Stanley Zulu, Mildred Nakazwe, Sule Burger, Justine Davies, Rachel Donaldson, Chikwendu Ede, O James Garden, Chiapo Lesetedi, Charles Mabedi, Laura Magill, Felix Makinde Alakaloko, Alex Makupe, Mark Monahan, Soloman Mulira, Elmi Muller, Jospeh Musowoyo, Jean Léon Olory-Togbe, Tracey Roberts, Martin Smith, Viki Tayler, John Windsor, Raul Yepez, Sudha Sundar, Emmy Runigamugabo, Azmina Verjee, José Chen, Leonid Daya, Nouhaila El Aroussi, Valeria Farina, Tchianze Gnintedeme Olivier, Mauricio Gonzales Nacarino, Aamr Hammani, Sarah Honjo, Rebecca Jacobs, Hitomi Kimura, Mugisha Nkoronko, Jasson Javier Oscullo Yepez, Wei Pin Hung, Ankit Raj, Alina Romani Pozo, Muna Rommaneh, Samuel Chimbioputo Sassamela Fabiano, Camila Milagros Shiroma Gago, Abhishekh Srinivas, Chia-Yen Sung, Aswan Tai, Yener Cristyell Valle Aranda, Sara Venturini, Jean Wilguens Lartigue, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de chirurgie, Knight S.R., Shaw C.A., Pius R., Drake T.M., Norman L., Ademuyiwa A.O., Adisa A.O., Aguilera M.L., Al-Saqqa S.W., Al-Slaibi I., Bhangu A., Biccard B.M., Brocklehurst P., Costas-Chavarri A., Chu K., Dare A., Elhadi M., Fairfield C.J., Fitzgerald J.E., Ghosh D., Glasbey J., van Berge Henegouwen M.I., Ingabire J.C.A., Kingham T.P., Lapitan M.C., Lawani I., Lieske B., Lilford R., Martin J., Mclean K.A., Moore R., Morton D., Nepogodiev D., Ntirenganya F., Pata F., Pinkney T., Qureshi A.U., Ramos-De la Medina A., Riad A., Salem H.K., Simoes J., Spence R., Smart N., Tabiri S., Thomas H., Weiser T.G., West M., Whitaker J., Harrison E.M., Gjata A., Modolo M.M., King S., Chan E., Nahar S.N., Waterman A., Vervoort D., Bedada A.G., De Azevedo B., Figueiredo A.G., Sokolov M., Barendegere V., Ekwen G., Agarwal A., Liu Q., Camilo Correa J., Malemo K.L., Bake J., Mihanovic J., Kuncarova K., Orhalmi J., Salem H., Teras J., Kechagias A., Arnaud A.P., Lindert J., Kalles V., Aguilera-Arevalo M.-L., Recinos G., Baranyai Z., Kumar B., Neelamraju Lakshmi H., Zachariah S.K., Alexander P., Kumar Venkatappa S., Pramesh C., Amandito R., Fleming C., Ansaloni L., Pellino G., Altibi A.M., Nour I., Hamdun I., Ghellai A.M., Venskutonis D., Poskus T., Zilinskas J., Malemia P., Tew Y.Y., Borg E., Ellul S., Wafqui F.Z., Borowski D.W., van Dalen A.S., Wells C., Adamou H., Ademuyiwa A., Adisa A., Soreide K., Al Saqqa S., Alser O., Tahboub H., Segovia Lohse H.A., Shu Yip S., Major P., Sampaio Soares A., Bratu M.R., Litvin A., Vardanyan A., Allen Ingabire J.C., Gudal A., Albati N., Juloski J., Rems M., Rayne S., Van Straten S., Moodley Y., Ortega Vazquez I., Ruiz-Tovar J., Senanayake K.J., Thalgaspitiya S.P.B., Omer O.A., Homeida A., Cengiz Y., Clerc D., Alshaar M., Bouaziz H., Altinel Y., Doe M., Freigofer M., Teasdale E., Kabariti R., Clements J.M., Ashfaq A., Azodo I., Wagner G., Trostchansky I., Maimbo M., Linyama D., Nina H., Zeko A., Fermani C.G., Villalobos S., Carballo F., Farina P., Guckenheimer S., Dickfos M., Ajmera A., Chong C., Gourlay R., Hussaini S., Lee Y.J., Majid A., Martin P., Miles R., Morris O.J., Phua J., Ridley W., Saluja T., Tan R.R., Teh J., Wells A., Arora B., Dollie Q., Ho D., Ma Y., Perera O.M., Truong A., Dawson A.C., Lim B., Pahalawatta U., Phan J., Woon-Shoo-Tong X.-M.S., Yeoh A., Charman L., Drane A., Laura S., Lo C.C.W., Mozes A., Poon R., Tan H.H., Wall E., Chopra P., De Giovanni J., Dhital B., Draganic B., Duller A., Gani J., Goh Y.K., Jeong J.Y., McManus B., Nagappan P., Pockney P., Rugendyke A., Sarrami M., Smith S., Wills V., Wong H.V., Ye G., Zhang G., Brooker E., Feng D., Lau B., Ngai C., Birks S., Gyorki D., Otero de Pablos J., Abbosh A., Gillespie C., Mahmoud A., Kwan B., Lawson J., Warwick A., Bingham J., Cockbain A.J., Dudi-Venkata N.N., Ellaby-Hall J., Finlay B., Humphries E., Pisaniello J., Pisaniello M., Salih S., Sammour T., Abd Wahab H.H., De Silva A., Hayward N., Iyer K., Maddern G., Prevost G.A., Annapureddy N., Settipalli K.P., Yeo J., Hempenstall L., Pham L., Purcell S., Talavera C., Vaska A.I., Chaggar G., Chrapko P., Cocco A., Coulter-Nile S.M.C.J., Ctercteko G., French J., Gong H., Gosselink M., Jegathees T., Jin I., Kalachov M., Kiefhaber K., Lee K., Luong J., Phan S., Pleass H., Veale K., Zeng Z., Au A., DeBiasio A., Deng I., Myooran J., Nair A., Stewart P., Stift A., Unger L.W., Wimmer K., Ahmed N., Hasan S., Rahman S., O'Shea M., Padmore G., Peters A., Perduca P., Pulcina G., Tinton N., Buxant F., Dabin E., Garofalo G., Dossou F., Gnangnon F.H.R., Imorou Souaibou Y., Motlaleselelo P., Tlhomelang O., Lima Buarque I., Mendonca Ataide Gomes G., Vieira Barros A., Batashki I., Damianov N., Stoyanov V., Dardanov D., Maslyankov S., Petkov P., Todorov G., Zhivkov E., Akisheva A., Castilla Moreno M.A., Genov G., Ilieva I., Ivanov T., Karamanliev M., Khan A., Mitkov E., Yotsov T., Atanasov B., Belev N., Slavchev M., Nsengiyumva C., Jones E., Stock S., Kyota S., Brown J., Mabanza K. T., Nigo Samuel L., Otuneme C., Prosper N., Umenze F., Boutros M., Caminsky N., Dumitra S., Garfinkle R., Morency D., Salama E., Banks A., Ferri L., He H., Katz A., Liberman A.S., Meterissian S., Pang A., Parvez E., Hameed U., Osman F., Sequeira S., Coburn N., Jaffer A., Karanicolas P., Mosseler M., Musselman R., Liu X., Yip C.W., Garces-Otero J.S., Guzman C., Sierra S., Uribe Valencia A., Cabrera Rivera P.A., Camelo S., Gonzalez A., Gonzalez-Orozco A., Mosquera Paz M.S., Perez Rivera C.J., Gonzalez F., Isaza-Restrepo A., Nino- Torres L., Arias Madrid N., Mendoza Arango M.C., Tsandiraki J., Jemendzic D., Kocman B., Suman O., Canic R., Jurisic D., Karakas I., Krizanovic Rupcic A., Pitlovic V., Samardzic J., Kopljar M., Bacic I., Domini E., Karlo R., Miljanic D., Simic A., Ahmed M., Al Nassrallah M., Altaf R., Amjad T., Eltoum R., Haidar H., Hassan A., Khalil O., Qasem M., Ramesh R., Sajith G., Wisal M., Zatecky J., Bujda M., Jirankova K., Paclik A., Abdallah A., Abdulgawad Almogy M., Ayman El-sawy E., ElFayoumy A.M., Elghareeb N., Esmat N.A., Fadel A., Habater A., Hamdy H., Hefni A., Kamal M., Mohamed Abobakr N., Sayed A., Shaker N., Taha E., Tharwat H., Zakaria O., Abdelmotaleb I., Al-Dhufri A., Al-Himyari H.S., El sheikh E., Eldmaty A., Elkhalawy A., M.Elkhashen A., Magdy K., Mostafa S., Sadia H.D., Saleh M.M., Samir D., Yahia Mohamed Ali M., A. Nassar M., Abdelhady S., Abdelrazek A., Abdelsalam I., El-Sawy A., Essam E., Gadelkarim M., Ghaly K., Hassabalnaby M., Masarani R., Mohamed Shaaban N., Sabry A., Salem M., Soliman N.A., Zahran D., Abou El.soud M.R., Badr E.T., Borham H., Elmeslemany N., Elsayed M., Elsherif F., Eslam S., Gaber G., Ibrahim S., Kamh Y., Mohamed S.G., Morshedy E., Omar C., Salem Soliman F., Abdelkawy S., Abdelmohsen N., Abdelshakour M., Dahy A., Gamal N., Gamal M., Hasan A., Hetta H., Mousa N., Omar M., Rabie S., Saad M., Saleh B., Sayed Mohamed M., Shawqi M., Abdelhady Mousa H., Alnoury M., Elbealawy M., Elshafey A., Essam Ibrahim El Desouki Muhammad Ahmed M., Ghonaim M., Hgag F., Ibrahim M., Morsy M., Reda Loaloa M., Refaat A., Samir H., Shahien F., Sobhy M., Sroor F., Abdellatif E., Adel M., Afifi A.A., Afifi E., Antaky M., Dawoud A., El Zoghby N., El-remaily A., Elzanfaly A.A., Gadallah A., Gamal F.A., Hashem O., Medhat Youssef S., Muhammad Attyah A., Munir M., Shazly O., Wilson K., Adel S., Ali A., Eid E., Elhelow E., Elmahdy M., Elshatby B., Hossam el-din Zakaria A., Hossny A., Ibrahim E., M.Yonis A., Metwalli M., Yousry B., Zid E., A Yacoub M., Abdelhakim A., Abouelsoad N., Alkhatib M., Ashraf A., Elazab Y., Elfanty M., Elkabir O., Elshimy A., Elsobky H., Eskander J., Gad A., Hamsho W., Khaled Abdelwahed N., Magdy M., Moharam D., Osama A., Ramadan S., Roum R., Sayed T., Shehada T., Zidan A.M., Abbas K., Attia M., Balata M., El Nakeeb A., Elewaily M.I.E., Elfallal A., Elfeki H., Elkhadragy A., Emile S., Ezzat H., Hosni H., Mansour I., Omar W., Othman G., Sadek K., Shalaby M., Shehab-Eldeen N., Anas khalifa R., Badr H., Eldeep M., Eldeep A., Eldoseuky mohammed A., Khallaf S., Magdy Hegazy E., Mahmoud R., Mikhail P., Morsi M., Mowafy S., Raafat D., Safy A., Sera M., Sera A.S., AbdAllah M.S.M., Abdelkader M., Abdou A.O., Ahmed A., Gaafar S., Ibrahim negm F., Lapic M., Maher A., Mahmoud H., Mostafa A., Samir M., Samy F., Semeda N., Shalaby H.I., El-taweel A., Galal Elnagar A., Hemidan A.G., Hussein M., Kandil A.A., Moawad M., Nasser Hamamah A.A., Soliman M., Abdelkhalek M., Abdelmaksoud Tawakel N., Abdelwahed A.M., Abdou A., Atallah K., Elsherbeny M.Y., Emara E., Hamdy M., Hamdy O., Haron A., Ismail S., Metwally I.H., Mohamed Hamed Elgaml N., Nassar A., Refky B., Sadek M., Saleh M., Yunes A., Zakaria M., Zuhdy M., Fayed N., Mohammed M.M.H., Kutner S., Melnik P., Seire I., Umarik T., Ainoa E., Eerola V., Koppatz H., Koskenvuo L., Sallinen V., Takala S., Katunin J., Turunen A., Christou N., Mathonnet M., Lavoue V., Nyangoh Timoh K., Soulabaille L., Lesourd R., Merdrignac A., Sulpice L., Andre B., Chantalat E., Vaysse C., Dousset B., Gaujoux S., Martin G., Clonda O., Juodis D., Kienle K., Mravik A., Palmer S., Szabadhegyi G., Agbeko A.E., Gyabaah S., Gyamfi F.E., Naabo N., Owusu senior A., Yorke J., Owusu F., Abantanga F., Anyomih T.T.K., Muntaka A.-J.M., Owusu Abem E., Sheriff M., Wondoh P.M., Balalis D., Korkolis D., Gkiokas G., Pantiora E., Theodosopoulos T., Ioannidis A., Konstantinidis K., Konstantinidou S., Machairas N., Paspala A., Prodromidou A., Chouliaras C., Papadopoulos K., Baloyiannis I., Mamaloudis I., Tzovaras G., Akrida I., Argentou M.-I., Germanos S., Iliopoulos E., Maroulis I., Skroubis G., Theofanis G., Chatzakis C., Ioannidis O., Loutzidou L., Karathanasis P., Michalopoulos N., Theodoropoulos C., Theodorou D., Triantafyllou T., Garoufalia Z., Hasemaki N., Kontos M., Kouraklis G., Kykalos S., Liakakos T., Mpaili E., Papalampros A., Schizas D., Syllaios A., Tampaki E.C., Tsimpoukelis A., Antonopoulou M.I., Deskou E., Manatakis D.K., Papageorgiou D., Zoulamoglou M., Anthoulakis C., Margaritis M., Nikoloudis N., Campo V., Ceballos A., Flores M.-A., Giron W., Ko D., Martinez G., Rivera Lara V., Rueda N., Sanchez A., Tejeda Garrido J.C.G., Alvarez Rivera A.E., Bamaca Ixcajoc E.B., Barreda Zelaya L.E., Chacon-Herrera P., Corea Ruiz L.M., Echeverria-Davila G., Garcia M., Garcia D., Gutierrez Mayen E.F., Jose N., Mazariegos N., Mendez D., Paniagua Espinoza M., Bardos D., Benke M., Illes K., Kokas B.A., Szabo R., Appukuttan A., Asok A., Vijaykumar D.K., Malik K., Ravishankaran P., Tapkire R., Moorthy G., Abraham J., Muthuvel R., Alapatt J., Kattepur A., Pareekutty N., Garod M., Harris C., Wanniang C., Gupta A., Nehra D., Parshad S., Acharya R., Badwe R., Bhandare M., Jain U., Kirti K., Nair N., Shrikhande S., Thakkar P., Anandan P., C S A., Holenarasipur Narasannaiah A., Jagarlamudi T., M R R., Manangi M., Raghavendra A., Rao K.S., S V., Sajjan V., Shenoy A., Shivashankar Chikkanayakanahalli S., Tharanath K., V S., Adidharma P., Agarwal R., Anggita Gultom P., Arifin G.R., Billy M., Elfizri Z., Fahira A., Felicia D., Gunardi T.H., Johanna N., Nugrahadi N.R., Panigoro S.S., Rahmayanti S., Sihotang R.C., Brata S.Y., Winoto H., Barati N., Karami M., Khorshidi H., Naderifar H., Abdulla M.A., Coleman M., Doherty R.J., Hannon R., Murphy B., Stakelum A., Winter D., Aljohmani L., Farnan R., Seldon Y., Tan T., Varghese S., Alherz M., Ather M., Bajilan M., Graziadei V., Pilkington I., Quidwai O., Ridgway P., Shiwani H., Tahir A.A.-R., Blunnie E., Burke D., Kennedy N., Macdonagh K., O'Neill M., Rooney S., Falco G., Ferrari G., Mele S., Nita G.E., Ugoletti L., Zizzo M., Confalonieri G., Pesenti G., Tagliabue F., Baronio G., Ongaro D., Pata G., Compagnoni B., Salvadori R., Taglietti L., D'Alessandro N., Di Lascio P., Pascale G., Bortolasi L., Campagnaro T., Carlini M., Lisi G., Lombardi D., Pedrazzani C., Spoletini D., Turri G., Violi P., Altomare D.F., Aquilino F., Musa N., Papagni V., Picciariello A., Vincenti L., Andreotti D., Occhionorelli S., Tondo M., Basso S.M.M., Cirelli R., Maino M.E.M., Piozzi G.N., Picone E., Scaramuzzo R., Sinibaldi G., Amendola A., Anastasio L., Bucci L., Caruso E., Castaldi A., Di Maso S., Dinuzzi V.P., Esposito G., Gaudiello M., Giglio M.C., Greco P.A., Luglio G., Manfreda A., Marra E., Mastella F., Pagano G., Peltrini R., Pepe V., Sacco M., Sollazzo V., Spiezio G., Cianchetti E., Menduni N., Carvello M.M., Di Candido F., Spinelli A., Corsi F., Sorrentino L., Marino F., Asti E.L.G., Bonavina L., Rausa E., Asta M., Belli A., Bianco F., Cervone C., Delrio P., Falato A., Fares Bucci A., Guarino R., Pace U., Rega D., De Luca E., Gallo G., Sammarco G., Sena G., Vescio G., Santandrea L., Ugolini G., Zattoni D., Chetta N., Logrieco G., Vanella S., Garulli G., Zanini N., Bondurri A., Cammarata F., Colombo F., Foschi D., Lamperti G.M.B., Maffioli A., Sampietro G.M., Yakushkina A., Zaffaroni G., Cicuttin E., Sibilla M.G., Impellizzeri H., Inama M., Moretto G., Mochet S., Ponte E., Usai A., Mancini S., Sagnotta A., Solinas L., Bolzonaro E., Tamini N., Curletti G., Galleano R., Malerba M., Campanella S., Cocorullo G., Colli F., De Marco P., Falco N., Fontana T., Kamdem Mambou L.J., La Brocca A., Licari L., Randisi B., Rizzo G., Rotolo G., Salamone G., Tutino R., Venturelli P., Malabarba S., Sgro A., Vella I., Cirillo B., Crocetti D., De Toma G., Lapolla P., Mingoli A., Sapienza P., Belvedere A., Bianchini S., Binetti M., Birindelli A., Tonini V., Podda M., Pulighe F., De Rosa M., Bono L., Borghi F., Geretto P., Giuffrida M.C., Lauro C., Marano A., Pellegrino L., Salusso P., Sasia D., Campanelli M., Realis Luc A., Trompetto M., Cardia R., Cillara N., Giordano A.N., Costanzo A., Giovilli M.A., Turati L., Canonico S., Sciaudone G., Selvaggi F., Selvaggi L., Albsoul N., AlBsoul A., Alkhatib A.A., Alsallaq O., Amarin J.Z., Ayoub R., Bsisu I., El Muhtaseb M.S., Jabaiti M., Melhem J., Qwaider Y.Z., Salameh M.H., Suleihat A., Suradi H.H., Alammarin M., Aljaafreh A., Bani hani M., Bani hani Z., Bani Hani F., Fahmawee T., Hamouri S., Katanani C., Tawalbeh R., Tawalbeh T., Zawahrah H., Abou Chaar M.K., Abusalem L., Al-Masri M., Al-Najjar H., Barghuthi L., Ahmed Z., Maulana A., Ngotho O., Kamau C., Stanley Mwenda A., Bosire F., Mwachiro E., Parker R., Simel I., Sylvester K., Althini A.A.M., Elbarouni S., Elbeshina A.E., Gwea A., Malek A., Masoud Farag W.A., Abdalei A., Abdel Malik A.B., Abo-khammash A., Abuhlaiga M., Adnan N., Albaggar M., Alfitory A., Aljanfi A., Almuzghi F., Altumei Z., Alzabti F., Ashoushan H., Assalhi M., Azzubia J., Bnhameida S., Delhen M., Elshafei H., Elteir H., Esbaga F., Gobbi A.A., Hamouda F., Hilan H., Ismail R., Jebran F., Kasbour M., Maderi G., Mohammad S., Mohammed B., Murtadi H., Mustafa H., Rajab M., Trenba S., Wafaa M., Al Sagheir E., Almigheerbi A., Alzahaf A., Bahroun S.G., Ben Dallah N., Elshaibani M., Eswaye H., Karar M., Omar S., Younes E., Younes M., Zreeg D., Abujamra S., Ashour F., Elgammudi M., Omar F. Aljadidi W., Saddouh E., Sharif R., Alabuzidi A., Alwerfally A., Aribi S., Bibas F., Elfaituri T., Elhajjaji Y., Khaled A., Khalil W., Layas T., Soula E., Tarek A., Abu hallalah M.F.K., Ahmed H.A., Alsharef T., Ben Saoud A.A., El Gharmoul T., Elhadi A., Elrais S., Shebani A., Zarti H., Zeiton A., Ambrazevicius M., Kaselis N., Stakyte M., Aliosin O., Cizauskaite A., Dailidenas S., Eismontas V., Kybransiene M., Nutautiene V., Samalavicius N., Simcikas D., Slepavicius A., Tamosiunas A., Ubartas N., Zeromskas P., Bradulskis S., Dainius E., Juocas J., Kubiliute E., Kutkevicius J., Opolskis A., Parseliunas A., Subocius A., Virbickaite E., Zuikyte D., Bogusevicius A., Buzaite K., Cepuliene D., Cesleviciene I., Cesna V., Gribauskaite J., Ignatavicius P., Jokubauskas M., Liugailaite M., Margelis E., Mazelyte R., Pankratjevaite L., Pazusis M., Rackeviciute A., Saladyte J., Skimelyte M., Slenfuktas V., Sudeikyte M., Tamelis A., Vanagas T., Zumbakys Z., Atkociunas A., Dulskas A., Kuliavas J., Birutis J., Paskevicius S., Satkauskas M., Danys D., Jakubauskas M., Jakubauskiene L., Kryzauskas M., Lipnickas V., Makunaite G., Rasoaherinomenjanahary F., Rasolofonarivo H., Samison L.H., Banda B., Msosa V., Ahmad Izzuddin A.I., Das A., Gan Y.Y., Shong Sheng T., Siaw J.Y., Ab Rahim M.F., Abang Jamari D.Z.H., Che Husin N., Kamarulzaman M.Y., Lim Y.P., Mohamed Kamil N.A., Mohd Hassan M.R., Mohd Sahid S., Mustafa J., Ng E.H.B., Wan Khazim W.K., Chang Ern N., Lingeshan P.G., Sulaiman S.E., Ang S.E., Bin Mohamad Sithik M.N., Cheong Y.J., Deva Tata M., Jia Xian L., Kadravello A., Koh I.-E., Ng L.-Y., Ng We Yong Y.J., Palayan K., Sam C.X., Siow Jin P., Tan Ern Hwei J., Tang Y., Ter A.Z., Wong M.P.-K., Zakaria A.D., Zakaria Z., Henry F., Kalaiselvan T., Abd Karim M.F.S., Abdul Aziz M.R., Abdul Aziz N., Khong T.L., Lau P.C., Lim H.C., Roslani A.C., Seak J.C.K., Wong S.-W., Wong L.F., Yeen Chin L., Anyanwu M.C., Busuttil Z., Calleja T., Chircop K.L., Cutajar R., Dimech A.M., Galea J., Gascon Perai K., Gatt R., Kelman L., Micallef E., Nwolu F., Sammut K., Thompson J., Warwicker S., Zammit M., Cordera F., Cruz Gonzalez E., Sanchez-Garcia J., Barbosa Camacho F.J., Barrera Lopez F.J., Zuloaga Fernandez del Valle C.J., Acosta E., Gonzalez Espinoza I.R., Moreno P., Cortes-Flores A.O., Fuentes Orozco C., Gonzalez Ojeda A., Corro Diaz Gonzalez S., Martinez L., Mosqueda Amador B., Novoa A., Olazo Espejo D.A., Jimenez A., Lopez Rosales F., Vanoye E.G., Garcia Gonzalez L.A., Miranda-Ackerman R.C., Solano-Genesta M., Alvarez-Cano A., Romero-Garza H.H., Medina-Franco H., Mejia-Fernandez L., Salgado-Nesme N., Vergara-Fernandez O., Gutierrez-Mota G.M., Hernandez Vera F.X., Llantada Lopez A., Morgan Villela G., Ramirez Padilla F.D.J., Tapia Marin W., Martinez Maldonado M., Sanchez Suarez R., Troche J.M., Benyaiche C., Outani O., Amine S., Benkabbou A., Majbar A.M., Mohsine R., Rafik A., Oung T., Tin M.M., Plarre P., Alberga A., Sluiter N., Tuynman J., Blok R., Comert D., Hompes R., Kalff M., Stellingwerf M.E., Tanis P., van Berge Henegouwen M., van Praag E.M., Wisselink D., Gerhards M., Lopes Cardozo J., Westerduin E., de Jonge J., van Geloven A., van Schilt K., den Boer F., Stoots S., Vlek S., Adams J., Al-Busaidi I.S., Budd G., Choi S.I., Chu M.J.J., Ganugapati A., McKinstry L., Pascoe R., Richards S., Rosser K., Stevenson A., White R., Farik S., Kwun J., Murad A., Cowan S., Hall T., Hayton M., Malam Sani L., Oumarou Garba S., Amadou Magagi I., Habou O., Aliyu H., Daniyan M., Sholadoye T.T., Abdullahi L., Anyanwu L.-J., Mohammad Mohammad A., Muhammad A.B., Sheshe A.A., Suleiman I., Adesina A., Awolowo A., Onuoha C., Salami O., Taiwo O., Taiwo A., Kache S., Makama J.G., Sale D., Abiola O., Ajao A., Ajiboye A., Etonyeaku A., Olaogun J., Adebanjo A., Adesanya O., Afolayan M.O., Balogun O., Makanjuola A., Nwokocha S., Ojewola R.W., Olajide T.O., Aderounmu A., Adesunkanmi A.-R., Agbakwuru A., Akeem Aderogba A., Alatise O.I., Arowolo O., Lawal O., Mohammed T., Ndegbu C., Olasehinde O., Wuraola F., Akinkuolie A., Mosanya A., Ayandipo O., Elemile P., Lawal T.A., Ali SANI S., Garba S., Hauwa SANI R., Olori S., Onyebuashi H., Umoke I., Adenuga A., Adeyeye A., Habeeb O., Lawal B., Nasir A., Aahlin E.K., Kjonas D., Myrseth E., Abbasy J., Alvi A., Saleem O., Afzal A., Nazir A., Farooq M., Liaqat A., Naqi S.A., Raza A., Sarfraz M., Sarwar M., Banglani M., Munir A., Sehrish R., Ayub B., Sayyed R., Altaf A., Ayub S., Saeed K., Syed B., Akbar S.A., Anwer A.W., Khan R.N., Khan A.I., Khattak S., Mohtasham S., Parvaiz M.A., Syed A.A., Ansari A.B., Shahzad N., Khaliq T., Rashid I., Waqar S.H., Abu Al-saleem H., Abu Alqumboz A., Alqadi M., Amro A., Assa R., Awesat E., Ayyad R., Hammad M., Haymony A., Hijazi B., Hmeidat B., Lahaseh R., Qawasmi A., Rajabi A., Shehada M., Shkokani S., Yaghi Y., Yaghi N., AlZohour M., Farid M., Habes Y.M., Juba W., Nubani Y., Rabee A., Sa'deh M., Abed S., Al basos I., Alswerki M., Ashour D., Awad I., Diab S., El Jamassi A., El-Kahlout S., Elhout S., Hajjaj A.N.K., Hasanain D., Nabil hajjaj B., Obaid M., Saikaly E., Salhi A., Al-Tammam H., Almasri M., Baniowda M., Beshtawi D., Horoub A., Misk R., Mohammad B., Qasrawi R., Sholi T., Abu-Nimeh S., Abu-srour A., Abukhalaf S.A., Adawi S., Alsalameh B., Ayesh K., Elqadi M., Hammouri A., Karim Mustafa F., Marzouqa N., Melhem S., Miqdad D., Mohamad B., Rawhi M., Abu Ahammala A.B., Abu Ataya A., Abu Jayyab I., Al-Shwaikh S., Alagha O., Alasttal M., Awadallah H., Elblbessy M., Fares J., Jarbou A., Mahfouz I., Albahnasawi M.A., Abo mahadi A., Abuelhatal H., Abuelqomboz A., Almoqayyad A., Alwali A., Balaawi R., Hamouda M., Humeid M., Jedyan A., Mahmoud Abu hamam T., Matar G., Salem A.L., Samra T., Shaheen N., Shihada K., A.Nemer A., Abu Al Amrain M., Abu Alamrain A., Abu Jamie N., Abu-Rous M.R., Alfarra N., AlTaweel M., Alwhaidi N., Hamed R., Saqqa B., Shaheen A., Aljaber D., Aljaberi L., Alwaheidi M., Jawaada A., Khaldi H., Qahoush R., Qari J., Saadeh R., Salim A., Yacoub A., Abbas A., Abu shua'ib R., Abu Zainah B., AbuSirrees M., Babaa B., Barhoush O., Belal qadomi A., Daraghmeh L., Haji R., Khatatbeh A., Khatib L., Qarariah S., Quzmar Y., Safadi K., Salameh R., Hassan M., Herzallah S., Massad L., Nazzal A., Nazzal R., Escobar D., Machain V G.M., Rodriguez Gonzalez A., Chachaima Mar J.E., Chinchihualpa Paredes N.O., Cuba V., Lopez W., Niquen Jimenez M.M., Sanchez Bartra N.A., Sapallanay Ojeda O., Sequeiros D., Toscano Pacheco A., Vergara M., Abarca S., Alcorta R., Borda-Luque G., Eusebio Zegarra I.E., Lujan Lopez C., Marrufo M., Mogrovejo C., Nomura A., Rodriguez Angeles Y., Vidal Meza M.R., Zavala G., Castillo Arrascue J.N., Hidrogo Cabrera J.C., Larrea vera J.J.M., Osorio M., Ylatoma Diaz E.A., Fontanilla M.A., Fuentes J.R., Salazar A.L., Dominguez G., Lopez M.P., Macalindong S., Onglao M.A., Ramirez A., Sacdalan M.D., Tampo M.M., Uy G.L., Mangahas J., Yabut K., Canete J.P., Cansana B.E., Castro E.J., Lipana M.K., Roxas M.F., Zara V.J., Chrol M., Franczak P., Orlowski M., Budzynski P., Budzynski A., Bury P., Czerwinska A., Dworak J., Dziedzic J., Kisielewski M., Kulawik J., Lasek A., Malczak P., Migaczewski M., Pedziwiatr M., Pisarska M., Radkowiak D., Rubinkiewicz M., Rzepa A., Skoczylas T., Stanek M., Truszkiewicz K., Wierdak M., Winiarski M., Zarzycki P., Zub-Pokrowiecka A., Kowalewski P., Roszkowski R., Waledziak M., Tome M., Patrocinio S., Guerreiro I., Almeida F., de Sousa X., Monteiro N., Costa Santos M.T., de Oliveira D., Lopes Serra M., Morgado D., Neves C., Oliveira A.C., Pimentel A., Silva S., Carvalho M., Carvalho L., Magalhaes J., Matos L., Monteiro T., Ramos C., Santos V., Barbosa J., Costa-Maia J., Devezas V., Fareleira A., Fernandes C., Goncalves D., Mora H., Morais M., Silva de Sousa F., Catarino Santos S., Logrado A., Tojal A., Amorim E., Cunha M.F., Fazenda A., Melo Neves J.P., Sampaio da Novoa Gomes Miguel I.I., Veiga D., Azevedo J., Cardoso Louro H., Leite M., Bairos Menezes M., Gama B., Brito D., Cruz Martins M.C., Graca e Magalhaes A., Longras A.C., Lourenco R., Matos D., Castro L., Policarpo F., Romano J., Monteiro C., Pinto D., Duarte M., Fortuna Martins S., Oliveira M., Galvao D., Martins L., Silva A., Taranu V., Vieira B., Neves J., Oliveira S., Ribeiro H., Cinza M., Felix R., Machado A., Oliveira J., Patricio J., Pedroso de Lima R., Pereira M., Rocha Melo M., Velez C., Abreu da Silva A., Claro M., Costa Santos D., Ferreira A., Capote H., Rosado D., Tare F., Nogueira O., Angelo M., Baiao J.M., Guimaraes A., Marques J., Nico Albano M., Silva M., Valente da Costa A., Vieira Caroco T., Almeida Braga S., Capunge I., Fragoso M., Guimaraes J., Pinto B., Ribeiro J., Angel M., Fialho G., Guerrero M., Campos Costa F., Cardoso D., Cardoso V., Alves M., Estalagem I., Louro T., Marques C., Martelo R., Morgado M., Canotilho R., Correia A.M., Martins P., Peyroteo M., Gomes J., Monteiro R., Romano M., Alves D.M., Peixoto R., Quintela C., Jervis M.J., Melo D., Pacheco A., Paixao V., Pedro V., Pimenta J., Pimenta de Castro J., Rocha A., Beuran M., Ciubotaru C., Diaconescu B., Hostiuc S., Negoi I., Stoica B., NA N.A., Anokhin E., Kuznetsov G., Oganezov G., Paramzin F., Romanova E., Rutkovskii V., Shushval M., Zabiyaka M., Dzhumabaev K., Ivanov V., Mamedli Z., Achkasov S., Balkarov A., Nabiev E., Nagudov M., Rybakov E., Saifutdinova K., Sushkov O., Joseph L., Ndayishimiye I., Faustin N., Mutabazi A.Z., Mvukiyehe J.P., Nsengimana V.J.P., Uwakunda C., Abbas M.M., Akeel N., Aljiffry M., Awaji K., Farsi A., Jamjoum G., Khoja A., Maghrabi A., Malibary N., Nassif M., Saleem A., Sultan A., Tashkandi W., Tashkandi H., Trabulsi N., Ba M.B., Diallo A.C., Ndong A., Cuk V., Jankovic U., Koh S.Z., Koh F., Lee K.C., Lee K.Y., Lee S., Leong W.Q., Lui S.A., Prakash P., Grosek J., Norcic G., Tomazic A., Fitchat N., Jaich R., Wineberg D., Koto M.Z., Baiocchi D., Clarke D., Steenkamp C.J., Bannister S., Boutall A., Chinnery G., Coccia A., Dell A., Karjiker P., Kloppers C., Loxton N., Mabogoane T., Malherbe F., Panieri E., Rayamajhi S., van Wyngaard T., Warden C., Madiba T.E., Pillay N., Brooks S., Kruger C., Van Der Merwe L.H., Gool F., Kariem M., Bougard H., Kariem N., Noor F., Pillay R., Steynfaardt L., Gonzalez Gonzalez L., Marin Santos J.M., Martin-Borregon P., Martinez Caballero J., Nevado Garcia C., Rodriguez Fraga P., De Castro Parga G., Fernandez Veiga M.P., Garrido Lopez L., Infante Pino H., Lages Cal I., Lopez Otero M., Nogueira Sixto M., Paniagua Garcia Senorans M., Rodriguez Fernandez L., Ruano Poblador A., Rufo Crespo E., Sanchez-Santos R., Vigorita V., Alonso Batanero E., Asnel D., Cifrian Canales I., Contreras Saiz E., De Santiago Alvarez I., Diaz Vico T., Fernandez Arias S., Fernandez Martinez D., Garcia Bernardo C., Garcia Florez L.J., Garcia Gutierrez C., Garcia Munar M., Marquez Zorrilla Molina C.A., Merayo M., Michi Campos J.L., Moreno Gijon M., Otero-Diez J.L., Rodicio Miravalles J.L., Solar-Garcia L., Suarez Sanchez A., Truan N., Alejandre Villalobos C., Caballero Diaz Y., Jimenez M., Montesdeoca D., Navarro-Sanchez A., Vega V., Beltran de Heredia J., Gomez Z., Jezieniecki C., Legido Moran A.P., Montes-Manrique M., Rodriguez-Lopez M., Ruiz Soriano M., Trujillo Diaz J., Vazquez Fernandez A., Argudo N., Pera M., Torrent Jansa L., Garcia Dominguez M., Goded I., Roldon Golet M., Talal El-Abur I., Utrilla Fornals A., Zambrana Campos V., Aguilar Martinez M.D.M., Bosch M., Garcia-Catala L., Sanchez-Guillen L., Artigau E., Gomez Romeu N., Julia Bergkvist D., Espina Perez B., Morato O., Olona C., Dieguez B., Forero-Torres A., Losada M., Gomez-Abril S., Gonzalvez P., Martinez R., Navarro Martinez S., Paya-Llorente C., Perez Rubio A., Santarrufina Martinez S., Sebastian Tomas J.C., Trullenque Juan R., Gegundez Simon A., Mate P., Prieto-Nieto M.I., Rubio-Perez I., Urbieta A., Vicario Bravo M., Abello D., Frasson M., Garcia-Granero A., Abad Gurumeta A., Abad-Motos A., Lucena-de Pablo E., Nozal B., Ripolles-Melchor J., Salvachua R., Ferrero E., Garcia-Sancho Tellez L., Picardo A.L., Rojo Lopez J.A., Zorrilla Matilla L.P., Cagigas Fernandez C., Castanedo Bezanilla S., Estevez Tesouro J., Fernandez-Diaz M.J., Garcia Cardo J., Gomez Ruiz M., Gonzalez-Tolaretxipi E., Jimeno Fraile J., Poch C., Rodriguez-Aguirre M., Troche Pesqueira N., Trugeda-Carrera M.S., de la Torre J., Blanco-Colino R., Espin-Basany E., Espinosa-Bravo M., Morales Comas C., Reyes Afonso E., Rivero Deniz J., Siso Raber C., Verdaguer Tremolosa M., Chandrasinghe P., Kumarage S., Wijekoon Arachchilage N., Abdalla Ahmed Elkamel A., A. Adam M., Blomme N., Thorell A., Wogensen F., Alga A., Ansarei D., Celebioglu F., Heinius G., Nigard L., Pieniowski E., Ahlqvist S., Bjorklund I., Franberg A., Hakansson M., Adamo K., Franklin O., Sund M., Wiberg R., Andersson Y., Chabok A., Nikberg M., Kugelberg A., Canonica C., Christoforidis D., Fasolini F., Gaffuri P., Giuliani M., Meani F., Popeskou S.G., Pozza S., Wandschneider W., Peterer L., Widmer L.W., Zimmermann B., Bakoleas P., Chanousi I., Charalampidou L., Grochola L.F., Heid F., Ntaoulas S., Outos M., Peros G., Podolska-Skoczek H., Reinisch K.B., Zielasek C., Demartines N., Gilgien J., Kefleyesus A., St-Amour P., Toussaint A., Alhimyar M., Alsaid B., Alyafi A., Alkhaledi A., Kouz B., Omarain A., Al-Sabbagh Y., Alkhatib H., Sara S., Alhaj A., Danial A., Kadoura L., Maa Albared S., Monawar Y., Nahas L., Abd B., Saad A., Wakkaf H., Bouzaiene H., Ghalleb M., Akaydin E., Akbaba A.C., Atakul O., Baltaci E., Besli S., Burgu G., Cenal U., de Muijnck C., Demirkaya H.C., Dogruoz A., Gezer Z.I., Gundogdu Y., Kara M., Korkmaz H.K., Kurtoglu G.K., Ozben V., Ozmen B.B., Pektas A.M., Sel E.K., Yenidunya N., Bengur F.B., Oral B.M., Yozgatli T.K., Abdullayev S., Gunes M.E., Sahbaz N.A., Banaz T., Kargici K., Kuyumcu O.F., Yanikoglu E., Yesilsancak M., Yilmaz D., Aktas M.K., Rencuzogullari A., Isik A., Leventoglu S., Yalcinkaya A., Yuksel O., Kalayci M.U., Kara Y., Sarici I.S., Akin A., Alemdag G.N., Arslan E., Baki B.E., Bodur M.S., Calik A., Candas Altinbas B., Cihanyurdu I., Erkul O., Gul B., Guner A., Kose B., Semiz A., Sevim S., Tayar S., Tomas K., Tufek O.Y., Turkyilmaz S., Ulusahin M., Usta A., Yildirim R., Guler S.A., Tatar O.C., Varol E., Kirimtay B., Uysal M., Yildiz A., Kose E., Ciftci A.B., Colak E., Eraslan H., Kucuk G.O., Yemez K., Lule H., Bienfait M., Bua E., Okalany N., Basarab M., Bielosludtsev O., Kolhanova K., Perepelytsia K., Romanukha K., Savenkov D., Siryi S., Tereshchenko M., Viacheslav N., Volovetskyi A., Kebkalo A., Tryliskyy Y., Tyselskiy V., Bruce E., Chow B.L., Iddles E., McGuckin S., Newall N., Ramsay G., Sharma P., Stewart C., Wong J., Badran A., Bath M., Belais F., Butt E., Joshi K., Kapur M., Shaw M., Townson A., Williams C.Y.K., Gray T., Greig R., Husain M., Murray E., Mustafa A., Asif A., Gokul A., Shah M., Akitikori M.T., Charalabopoulos A., Davidson S., McNally S., Rupani S., Juma F., Mills S.C., Muirhead L., Sellars K., Walsh U., Warren O., Chambers A., Hunt R., Boyce S., Cornwall H., Tol I., Argyriou E.O., Eardley N., Povey M., Aithie J.M.S., Irfan A., McGuigan M.-C., Starr R., Warren C.R., Archibald J., Kirby G., Kisyov I., Khoo C.K., Lee R., Photiou D., Davis R., Prasad U., Yang P.Z., Bird J., Leung E., Summerour V., Currow C., Kiam J., Tan G.J.S., Muthusami A., Pegba-Otemolu I., Urbonas T., Nunoo-Mensah J., Smolskas E., Boddy A., Gravante G., Hunter D., Andrew D., Koh A., Thompson A., Adams L., Clements H.A., De Silva K., Ekpete O., Haque S., Henderson S., Ibrahim B., Jayasinghe T., Livie J., Mailley K., Nair G., Tan D., Baggaley C., Dawidziuk A., Szyszka B., Barter C., Gandhi N., Hassell K., Hitchin S., Kelsall J., Nagy E., Nessa A., Whisker L., Yanni F., Ali M., Arora D., Hediwattege S., Kumarasinghe N., Rathore M., Tennakoon A., Ali Ahmad S.M., Bajomo O., Nadira F., Celentano V., Griffiths E., Karri R.S., Mak J.K.C., Pipe M., Bhatti M.I., Rabie M., Boyle C., Hamilton D., Mihuna A., Ng J.C.K., Nicholson G., Oliwa A., Pearson R., Rose A., Yong S.Q., Boereboom C., Hanna M., Walter C., Greensmith T.S., Mitchell R., Monaghan E., Crawford J., Moug S., Blackwell J., Boyd-Carson H., Herrod P., Al-Allaf O., Beattie M., Bullock C., Burman S., Clark G., Flamey N., Flannery O., Harding A., Kodiatt B., Lawday S., Mahapatra S., Mukundu Nagesh N., Ng M., Rye D., Yoong A., Clark L., Deans C., Edirisooriya M., Carrington E.V., Wong T.L.E., Yusuf B., Chamberlain C., Duke K., Kmiotek E., Botes A., Condie N., Schrire T., Shah R., Thomas-Jones I., Yates C., Anthony N., Matthews E., Sahnan K., Tankel J., Tucker S., Winter Beatty J., Ziprin P., Duggan W., Kantartzi A., Sridhar S., Khaw R.A., Srivastava P., Underwood C., Alves do Canto Brum H., Chopra S., Davis L., Hughes R., Tulley J., Alberts J., Athisayaraj T., Olugbemi M., Ahmad K., Chan C., Chapman G., Fleming H., Fox B., Grewar J., Hulse K., Rutherford D., Sinead M., Speake D., Vaughan-Shaw P.G., Christodoulides N., Kudhail S., Welch M., Husaini S.M., Lambracos S., Anyanwu C., Suresh R., Thomas J.S., Gleeson E., Platoff R., Saif A., Enumah Z., Etchill E., Gabre-Kidan A., Bernstein M., Carrano F.M., Connors J., Lynn P., Melis M., Newman E., Foster D.S., Perrone K., Titan A., Ahmad S., Bafford A.C.M.D., Dal Molin M., Hanna N., Zafar S.N., Hemmila M., Napolitano L., Wong J.J., Chandler J., Wood L., Wren S., Ottesen T., You L., Yu K., Arcienega Yanez M.D.P., Ferreira Fernandes M., Gonzalez D., Cubas S., Gonzalez M.C., Zubiaurre V., Demolin R., Giroff N., Sciuto P., Campos M., Rodriguez Cantera G., Deepika G., Simuchimba E., Bulaya A., Chibuye C., Chirengendure B., Kabale M.-R., Kabongo K., Munthali J., Mweso O., Pikiti F., Otieno J., Lai L.T., Blackman B., Subramaniam S., Karim R., Kok N., Lee Y.D., Ali S., Sinha A., Corrigan R., Barnes N., Wong F., Dennis G., Jedamzik J., Phillips E., Piette W., Van hentenryck M., Koco H., Lawani S., Kassa M.W., Santos Bezerra T., Gribnev P., Dimitrov D., Krastev P., Oum S., Bonghaseh D.T., Al Farsi M., Alsharqawi N., Acevedo V., Castillo Barbosa A.C., Giron F., Leon Rodriguez J.P., Kucan D., Rosko D., Barsic N., Zupan D., Hegazi A., Truncikova V., Fryba V., Mohamed M., Nagi A., Rashad Temerik A., Elshawy M.E., Mahmoud M.I., Anwar M., Rageh T., Elmokadem A., Gaballa K., Teppo S., Pengerma P., Ballouhey Q., Bergeat D., Weyl A., Hain E., Gyedu A., Yenli E., Osei-Poku D., Rompou V.-A., Zoikas A., Gaitanidis A., Koukis G., Perivoliotis K., Tavlas P., Galanos-Demiris K., Zografos G., Karavokyros I., Xanthopoulou G., Iordanidou E., Ayau F., Garcia A., Damjan P., Wason D., B L A., Rangganata E., Kamath P., O'Connor D.B., Pinto M., Perrone F., Tropeano F.P., Troilo F., Bossi D., Scala D., Pulitano L., Carella M., Pietrabissa A., Gori A., Giraudo G., De Simone V., Russo A.A., Braccio B., Al-Taher R., Athamneh S., Parker A., Sawiee A., Kattia A., Tababa O., Shaeeb Z., Syminas V., Jurgaitis J., Damuleviciene G., Svagzdys S., Razafimanjato N.N.M., Chieng Loo L., Tiong I.C., Wan Muhmad W.F., Vijeyan H., Li Ying T., Grech G., Arrangoiz R., Jimenez Ley V.B., Arizpe D., Lagunes Lara E., Castro Lopez E.V., Eaazim J., Gordinou de Gouberville M., Bastiaenen V., Rottier S., Nahab F., Ji M.Y., Seyoji M., Nwachukwu C., Emeghara O., Muhammed S.E., Idowu A., Sowemimo O., Ogundoyin O., Akande O., Lott A., Nadeem M., Laghari A.A., Loya A., Mushtaq H., Abdullah M.T., Abuhilal B., Atawneh M., Hamdan H., Alhabil B., Srour A., Mousa I., Da Silva Medina L., Bartosiak K., Ferreira P., Francisco V., Lemos R., Frutuoso L., Fernandes S., Fonseca T., Pereira J., Rachadell J., Torre A., Madeira Martins F., Carvalho A.C., Rodrigues Ferreira J., Ribeiro da Silva B., Devesa H., Vieira A., Monica I., Amaro M., Sousa D., Reia M., Louro J., Martins A., Dominguez J., Santos I., Freitas Oliveira N.M., Pereira J.C., Silva-Vaz P., Freire L., Escrevente R., Negoita V.M., Shakhmatov D., Nezerwa Y., Radulovic R., Obery G., Viljoen F., Mendes T., Suarez A., Moncada E., Fernandez-Hevia M., Curtis Martinez C., Gil Garcia J.M., Gonzalez Zunzarren M., Idris T., Eklov K., Grahn O., Amin L., Blomqvist M., Ajani C., Kraus R., Seeger N., Willemin M., Rayya F., Ayash M., Msouti R., Kannas I., Abazid E., Esper A., Slim S., Kavcar A.S., Aytac E., Dural A.C., Ilker A., Eray I.C., Kurnaz E., Altiner S., Tepe M.D., Sahin C., Savli E., Innocent A., Babirye L., Diachenko A., Hordoskiy V., Curry H., Chau C.Y.C., Robertson H., Lennon H., Loi L., Kirkham E., McCann C., Watts D., Gurung B., Wilson M., Tribedi T., Garofalo E., Zahra B., MacDonald S., Daniels I., Ng N., Khosla S., Olivier J., Yue 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M., Galea, J., Gascon Perai, K., Gatt, R., Kelman, L., Micallef, E., Nwolu, F., Sammut, K., Thompson, J., Warwicker, S., Zammit, M., Cordera, F., Cruz Gonzalez, E., Sanchez-Garcia, J., Barbosa Camacho, F. J., Barrera Lopez, F. J., Zuloaga Fernandez del Valle, C. J., Acosta, E., Gonzalez Espinoza, I. R., Moreno, P., Cortes-Flores, A. O., Fuentes Orozco, C., Gonzalez Ojeda, A., Corro Diaz Gonzalez, S., Martinez, L., Mosqueda Amador, B., Novoa, A., Olazo Espejo, D. A., Jimenez, A., Lopez Rosales, F., Vanoye, E. G., Garcia Gonzalez, L. A., Miranda-Ackerman, R. C., Solano-Genesta, M., Alvarez-Cano, A., Romero-Garza, H. H., Medina-Franco, H., Mejia-Fernandez, L., Salgado-Nesme, N., Vergara-Fernandez, O., Gutierrez-Mota, G. M., Hernandez Vera, F. X., Llantada Lopez, A., Morgan Villela, G., Ramirez Padilla, F. D. J., Tapia Marin, W., Martinez Maldonado, M., Sanchez Suarez, R., Troche, J. M., Benyaiche, C., Outani, O., Amine, S., Benkabbou, A., Majbar, A. M., Mohsine, R., Rafik, A., Oung, T., Tin, M. M., Plarre, P., Alberga, A., Sluiter, N., Tuynman, J., Blok, R., Comert, D., Hompes, R., Kalff, M., Stellingwerf, M. E., Tanis, P., van Berge Henegouwen, M., van Praag, E. M., Wisselink, D., Gerhards, M., Lopes Cardozo, J., Westerduin, E., de Jonge, J., van Geloven, A., van Schilt, K., den Boer, F., Stoots, S., Vlek, S., Adams, J., Al-Busaidi, I. S., Budd, G., Choi, S. I., Chu, M. J. J., Ganugapati, A., Mckinstry, L., Pascoe, R., Richards, S., Rosser, K., Stevenson, A., White, R., Farik, S., Kwun, J., Murad, A., Cowan, S., Hall, T., Hayton, M., Malam Sani, L., Oumarou Garba, S., Amadou Magagi, I., Habou, O., Aliyu, H., Daniyan, M., Sholadoye, T. T., Abdullahi, L., Anyanwu, L. -J., Mohammad Mohammad, A., Muhammad, A. B., Sheshe, A. A., Suleiman, I., Adesina, A., Awolowo, A., Onuoha, C., Salami, O., Taiwo, O., Taiwo, A., Kache, S., Makama, J. G., Sale, D., Abiola, O., Ajao, A., Ajiboye, A., Etonyeaku, A., Olaogun, J., Adebanjo, A., Adesanya, O., Afolayan, M. O., Balogun, O., Makanjuola, A., Nwokocha, S., Ojewola, R. W., Olajide, T. O., Aderounmu, A., Adesunkanmi, A. -R., Agbakwuru, A., Akeem Aderogba, A., Alatise, O. I., Arowolo, O., Lawal, O., Mohammed, T., Ndegbu, C., Olasehinde, O., Wuraola, F., Akinkuolie, A., Mosanya, A., Ayandipo, O., Elemile, P., Lawal, T. A., Ali SANI, S., Garba, S., Hauwa SANI, R., Olori, S., Onyebuashi, H., Umoke, I., Adenuga, A., Adeyeye, A., Habeeb, O., Lawal, B., Nasir, A., Aahlin, E. K., Kjonas, D., Myrseth, E., Abbasy, J., Alvi, A., Saleem, O., Afzal, A., Nazir, A., Farooq, M., Liaqat, A., Naqi, S. A., Raza, A., Sarfraz, M., Sarwar, M., Banglani, M., Munir, A., Sehrish, R., Ayub, B., Sayyed, R., Altaf, A., Ayub, S., Saeed, K., Syed, B., Akbar, S. A., Anwer, A. W., Khan, R. N., Khan, A. I., Khattak, S., Mohtasham, S., Parvaiz, M. A., Syed, A. A., Ansari, A. B., Shahzad, N., Khaliq, T., Rashid, I., Waqar, S. H., Abu Al-saleem, H., Abu Alqumboz, A., Alqadi, M., Amro, A., Assa, R., Awesat, E., Ayyad, R., Hammad, M., Haymony, A., Hijazi, B., Hmeidat, B., Lahaseh, R., Qawasmi, A., Rajabi, A., Shehada, M., Shkokani, S., Yaghi, Y., Yaghi, N., Alzohour, M., Farid, M., Habes, Y. M., Juba, W., Nubani, Y., Rabee, A., Sa'Deh, M., Abed, S., Al basos, I., Alswerki, M., Ashour, D., Awad, I., Diab, S., El Jamassi, A., El-Kahlout, S., Elhout, S., Hajjaj, A. N. K., Hasanain, D., Nabil hajjaj, B., Obaid, M., Saikaly, E., Salhi, A., Al-Tammam, H., Almasri, M., Baniowda, M., Beshtawi, D., Horoub, A., Misk, R., Mohammad, B., Qasrawi, R., Sholi, T., Abu-Nimeh, S., Abu-srour, A., Abukhalaf, S. A., Adawi, S., Alsalameh, B., Ayesh, K., Elqadi, M., Hammouri, A., Karim Mustafa, F., Marzouqa, N., Melhem, S., Miqdad, D., Mohamad, B., Rawhi, M., Abu Ahammala, A. B., Abu Ataya, A., Abu Jayyab, I., Al-Shwaikh, S., Alagha, O., Alasttal, M., Awadallah, H., Elblbessy, M., Fares, J., Jarbou, A., Mahfouz, I., Albahnasawi, M. A., Abo mahadi, A., Abuelhatal, H., Abuelqomboz, A., Almoqayyad, A., Alwali, A., Balaawi, R., Hamouda, M., Humeid, M., Jedyan, A., Mahmoud Abu hamam, T., Matar, G., Salem, A. L., Samra, T., Shaheen, N., Shihada, K., A. Nemer, A., Abu Al Amrain, M., Abu Alamrain, A., Abu Jamie, N., Abu-Rous, M. R., Alfarra, N., Altaweel, M., Alwhaidi, N., Hamed, R., Saqqa, B., Shaheen, A., Aljaber, D., Aljaberi, L., Alwaheidi, M., Jawaada, A., Khaldi, H., Qahoush, R., Qari, J., Saadeh, R., Salim, A., Yacoub, A., Abbas, A., Abu shua'ib, R., Abu Zainah, B., Abusirrees, M., Babaa, B., Barhoush, O., Belal qadomi, A., Daraghmeh, L., Haji, R., Khatatbeh, A., Khatib, L., Qarariah, S., Quzmar, Y., Safadi, K., Salameh, R., Hassan, M., Herzallah, S., Massad, L., Nazzal, A., Nazzal, R., Escobar, D., Machain V, G. M., Rodriguez Gonzalez, A., Chachaima Mar, J. E., Chinchihualpa Paredes, N. O., Cuba, V., Lopez, W., Niquen Jimenez, M. M., Sanchez Bartra, N. A., Sapallanay Ojeda, O., Sequeiros, D., Toscano Pacheco, A., Vergara, M., Abarca, S., Alcorta, R., Borda-Luque, G., Eusebio Zegarra, I. E., Lujan Lopez, C., Marrufo, M., Mogrovejo, C., Nomura, A., Rodriguez Angeles, Y., Vidal Meza, M. R., Zavala, G., Castillo Arrascue, J. N., Hidrogo Cabrera, J. C., Larrea vera, J. J. M., Osorio, M., Ylatoma Diaz, E. A., Fontanilla, M. A., Fuentes, J. R., Salazar, A. L., Dominguez, G., Lopez, M. P., Macalindong, S., Onglao, M. A., Ramirez, A., Sacdalan, M. D., Tampo, M. M., Uy, G. L., Mangahas, J., Yabut, K., Canete, J. P., Cansana, B. E., Castro, E. J., Lipana, M. K., Roxas, M. F., Zara, V. 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I., Veiga, D., Azevedo, J., Cardoso Louro, H., Leite, M., Bairos Menezes, M., Gama, B., Brito, D., Cruz Martins, M. C., Graca e Magalhaes, A., Longras, A. C., Lourenco, R., Matos, D., Castro, L., Policarpo, F., Romano, J., Monteiro, C., Pinto, D., Duarte, M., Fortuna Martins, S., Oliveira, M., Galvao, D., Martins, L., Silva, A., Taranu, V., Vieira, B., Neves, J., Oliveira, S., Ribeiro, H., Cinza, M., Felix, R., Machado, A., Oliveira, J., Patricio, J., Pedroso de Lima, R., Pereira, M., Rocha Melo, M., Velez, C., Abreu da Silva, A., Claro, M., Costa Santos, D., Ferreira, A., Capote, H., Rosado, D., Tare, F., Nogueira, O., Angelo, M., Baiao, J. M., Guimaraes, A., Marques, J., Nico Albano, M., Silva, M., Valente da Costa, A., Vieira Caroco, T., Almeida Braga, S., Capunge, I., Fragoso, M., Guimaraes, J., Pinto, B., Ribeiro, J., Angel, M., Fialho, G., Guerrero, M., Campos Costa, F., Cardoso, D., Cardoso, V., Alves, M., Estalagem, I., Louro, T., Marques, C., Martelo, R., Morgado, M., Canotilho, R., Correia, A. M., Martins, P., Peyroteo, M., Gomes, J., Monteiro, R., Romano, M., Alves, D. M., Peixoto, R., Quintela, C., Jervis, M. J., Melo, D., Pacheco, A., Paixao, V., Pedro, V., Pimenta, J., Pimenta de Castro, J., Rocha, A., Beuran, M., Ciubotaru, C., Diaconescu, B., Hostiuc, S., Negoi, I., Stoica, B., Na, N. A., Anokhin, E., Kuznetsov, G., Oganezov, G., Paramzin, F., Romanova, E., Rutkovskii, V., Shushval, M., Zabiyaka, M., Dzhumabaev, K., Ivanov, V., Mamedli, Z., Achkasov, S., Balkarov, A., Nabiev, E., Nagudov, M., Rybakov, E., Saifutdinova, K., Sushkov, O., Joseph, L., Ndayishimiye, I., Faustin, N., Mutabazi, A. Z., Mvukiyehe, J. P., Nsengimana, V. J. P., Uwakunda, C., Abbas, M. M., Akeel, N., Aljiffry, M., Awaji, K., Farsi, A., Jamjoum, G., Khoja, A., Maghrabi, A., Malibary, N., Nassif, M., Saleem, A., Sultan, A., Tashkandi, W., Tashkandi, H., Trabulsi, N., Ba, M. B., Diallo, A. C., Ndong, A., Cuk, V., Jankovic, U., Koh, S. Z., Koh, F., Lee, K. C., Lee, K. Y., Lee, S., Leong, W. Q., Lui, S. A., Prakash, P., Grosek, J., Norcic, G., Tomazic, A., Fitchat, N., Jaich, R., Wineberg, D., Koto, M. Z., Baiocchi, D., Clarke, D., Steenkamp, C. J., Bannister, S., Boutall, A., Chinnery, G., Coccia, A., Dell, A., Karjiker, P., Kloppers, C., Loxton, N., Mabogoane, T., Malherbe, F., Panieri, E., Rayamajhi, S., van Wyngaard, T., Warden, C., Madiba, T. E., Pillay, N., Brooks, S., Kruger, C., Van Der Merwe, L. H., Gool, F., Kariem, M., Bougard, H., Kariem, N., Noor, F., Pillay, R., Steynfaardt, L., Gonzalez Gonzalez, L., Marin Santos, J. M., Martin-Borregon, P., Martinez Caballero, J., Nevado Garcia, C., Rodriguez Fraga, P., De Castro Parga, G., Fernandez Veiga, M. P., Garrido Lopez, L., Infante Pino, H., Lages Cal, I., Lopez Otero, M., Nogueira Sixto, M., Paniagua Garcia Senorans, M., Rodriguez Fernandez, L., Ruano Poblador, A., Rufo Crespo, E., Sanchez-Santos, R., Vigorita, V., Alonso Batanero, E., Asnel, D., Cifrian Canales, I., Contreras Saiz, E., De Santiago Alvarez, I., Diaz Vico, T., Fernandez Arias, S., Fernandez Martinez, D., Garcia Bernardo, C., Garcia Florez, L. J., Garcia Gutierrez, C., Garcia Munar, M., Marquez Zorrilla Molina, C. A., Merayo, M., Michi Campos, J. L., Moreno Gijon, M., Otero-Diez, J. L., Rodicio Miravalles, J. L., Solar-Garcia, L., Suarez Sanchez, A., Truan, N., Alejandre Villalobos, C., Caballero Diaz, Y., Jimenez, M., Montesdeoca, D., Navarro-Sanchez, A., Vega, V., Beltran de Heredia, J., Gomez, Z., Jezieniecki, C., Legido Moran, A. 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P., Cagigas Fernandez, C., Castanedo Bezanilla, S., Estevez Tesouro, J., Fernandez-Diaz, M. J., Garcia Cardo, J., Gomez Ruiz, M., Gonzalez-Tolaretxipi, E., Jimeno Fraile, J., Poch, C., Rodriguez-Aguirre, M., Troche Pesqueira, N., Trugeda-Carrera, M. S., de la Torre, J., Blanco-Colino, R., Espin-Basany, E., Espinosa-Bravo, M., Morales Comas, C., Reyes Afonso, E., Rivero Deniz, J., Siso Raber, C., Verdaguer Tremolosa, M., Chandrasinghe, P., Kumarage, S., Wijekoon Arachchilage, N., Abdalla Ahmed Elkamel, A., A. Adam, M., Blomme, N., Thorell, A., Wogensen, F., Alga, A., Ansarei, D., Celebioglu, F., Heinius, G., Nigard, L., Pieniowski, E., Ahlqvist, S., Bjorklund, I., Franberg, A., Hakansson, M., Adamo, K., Franklin, O., Sund, M., Wiberg, R., Andersson, Y., Chabok, A., Nikberg, M., Kugelberg, A., Canonica, C., Christoforidis, D., Fasolini, F., Gaffuri, P., Giuliani, M., Meani, F., Popeskou, S. G., Pozza, S., Wandschneider, W., Peterer, L., Widmer, L. 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K., Rencuzogullari, A., Isik, A., Leventoglu, S., Yalcinkaya, A., Yuksel, O., Kalayci, M. U., Kara, Y., Sarici, I. S., Akin, A., Alemdag, G. N., Arslan, E., Baki, B. E., Bodur, M. S., Calik, A., Candas Altinbas, B., Cihanyurdu, I., Erkul, O., Gul, B., Guner, A., Kose, B., Semiz, A., Sevim, S., Tayar, S., Tomas, K., Tufek, O. Y., Turkyilmaz, S., Ulusahin, M., Usta, A., Yildirim, R., Guler, S. A., Tatar, O. C., Varol, E., Kirimtay, B., Uysal, M., Yildiz, A., Kose, E., Ciftci, A. B., Colak, E., Eraslan, H., Kucuk, G. O., Yemez, K., Lule, H., Bienfait, M., Bua, E., Okalany, N., Basarab, M., Bielosludtsev, O., Kolhanova, K., Perepelytsia, K., Romanukha, K., Savenkov, D., Siryi, S., Tereshchenko, M., Viacheslav, N., Volovetskyi, A., Kebkalo, A., Tryliskyy, Y., Tyselskiy, V., Bruce, E., Chow, B. L., Iddles, E., Mcguckin, S., Newall, N., Ramsay, G., Sharma, P., Stewart, C., Wong, J., Badran, A., Bath, M., Belais, F., Butt, E., Joshi, K., Kapur, M., Shaw, M., Townson, A., Williams, C. Y. K., Gray, T., Greig, R., Husain, M., Murray, E., Mustafa, A., Asif, A., Gokul, A., Shah, M., Akitikori, M. T., Charalabopoulos, A., Davidson, S., Mcnally, S., Rupani, S., Juma, F., Mills, S. C., Muirhead, L., Sellars, K., Walsh, U., Warren, O., Chambers, A., Hunt, R., Boyce, S., Cornwall, H., Tol, I., Argyriou, E. O., Eardley, N., Povey, M., Aithie, J. M. S., Irfan, A., Mcguigan, M. -C., Starr, R., Warren, C. R., Archibald, J., Kirby, G., Kisyov, I., Khoo, C. K., Lee, R., Photiou, D., Davis, R., Prasad, U., Yang, P. Z., Bird, J., Leung, E., Summerour, V., Currow, C., Kiam, J., Tan, G. J. S., Muthusami, A., Pegba-Otemolu, I., Urbonas, T., Nunoo-Mensah, J., Smolskas, E., Boddy, A., Gravante, G., Hunter, D., Andrew, D., Koh, A., Thompson, A., Adams, L., Clements, H. 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Korkolis, Dimitrios, Gkiokas, Georgios, Pantiora, Eirini, Theodosopoulos, Theodosios, Ioannidis, Argyrios, Konstantinidis, Konstantinos, Konstantinidou, Sofia, Machairas, Nikolaos, Paspala, Anna, Prodromidou, Anastasia, Chouliaras, Christos, Papadopoulos, Konstantinos, Baloyiannis, Ioannis, Mamaloudis, Ioannis, Tzovaras, George, Akrida, Ioanna, Argentou, Maria-Ioanna, Germanos, Stylianos, Iliopoulos, Evangelos, Maroulis, Ioannis, Skroubis, George, Theofanis, George, Chatzakis, Christos, Ioannidis, Orestis, Loutzidou, Lydia, Karathanasis, Panagiotis, Michalopoulos, Nikolaos, Theodoropoulos, Charalampos, Theodorou, Dimitrios, Triantafyllou, Tania, Garoufalia, Zoe, Hasemaki, Natasha, Kontos, Michalis, Kouraklis, Gregory, Kykalos, Stylianos, Liakakos, Theodore, Mpaili, Eustratia, Papalampros, Alexandros, Schizas, Dimitrios, Syllaios, Athanasios, Tampaki, Ekaterini Christina, Tsimpoukelis, Antonios, Antonopoulou, Maria Ioanna, Deskou, Eirini, Manatakis, Dimitrios K, Papageorgiou, Dimitrios, Zoulamoglou, Menelaos, Anthoulakis, Christos, Margaritis, Michalis, Nikoloudis, Nikolaos, Campo, Veronica, Ceballos, André, Flores, Mario-Andrés, Giron, Waleska, Ko, Donghyun, Martinez, Gabriel, Rivera Lara, Verónica, Rueda, Nataly, Sanchez, Andres, Tejeda Garrido, Jorge Carlos Guillermo, Alvarez Rivera, Alvaro Eduardo, Bamaca Ixcajoc, Elvis Benjamin, Barreda Zelaya, Lilian Elizabeth, Chacòn-Herrera, Patricia, Corea Ruiz, Ligia Margarita, Echeverria-Davila, Guillermo, Garcia, Mario, García, Danilo, Gutiérrez Mayen, Edgar Fernando, José, Noriega, Mazariegos, Nery, Méndez, Diego, Paniagua Espinoza, Michael, Bardos, David, Benke, Marton, Illes, Kristof, Kokas, Balint András, Szabó, Réka, Appukuttan, Akhila, Asok, Anjitha, D K, Vijaykumar, Malik, Kapil, Ravishankaran, Praveen, Tapkire, Ritesh, Moorthy, Guru, Abraham, Joyner, Muthuvel, Ramesh, Alapatt, John, Kattepur, Abhay, Pareekutty, Nizamudheen, Garod, Mebanshanbor, Harris, Caleb, Wanniang, Cliff, Gupta, Ashish, Nehra, Deepak, Parshad, 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Tanna, Varghese, Shriya, Alherz, Mohammad, Ather, Muaaz, Bajilan, Mohammad, Graziadei, Vivien, Pilkington, Isobel, Quidwai, Omar, Ridgway, Paul, Shiwani, Haaris, Tahir, Abd Al-Rahman, Blunnie, Eimear, Burke, Daniel, Kennedy, Niall, Macdonagh, Kate, O'Neill, Maeve, Rooney, Siobhan, Falco, Giuseppe, Ferrari, Guglielmo, Mele, Simone, Nita, Gabriela Elisa, Ugoletti, Lara, Zizzo, Maurizio, Confalonieri, Gianmaria, Pesenti, Giovanni, Tagliabue, Fulvio, Baronio, Gianluca, Ongaro, Deborah, Pata, Giacomo, Compagnoni, Bruno, Salvadori, Renato, Taglietti, Lucio, D'Alessandro, Nicola, Di Lascio, Pierpaolo, Pascale, Giovanni, Bortolasi, Luca, Campagnaro, Tommaso, Carlini, Massimo, Lisi, Giorgio, Lombardi, Davide, Pedrazzani, Corrado, Spoletini, Domenico, Turri, Giulia, Violi, Paola, Altomare, Donato Francesco, Aquilino, Fabrizio, Musa, Nicola, Papagni, Vincenzo, Picciariello, Arcangelo, Vincenti, Leonardo, Andreotti, Dario, Occhionorelli, Savino, Tondo, Matteo, Basso, Stefano Maria Massimiliano, Cirelli, Riccardo, Maino, Marco Enrico Mario, Piozzi, Guglielmo Niccolò, Picone, Emanuele, Scaramuzzo, Rosa, Sinibaldi, Giovanni, Amendola, Alfonso, Anastasio, Lorenzo, Bucci, Luigi, Caruso, Emanuele, Castaldi, Antonio, Di Maso, Sara, Dinuzzi, Vincenza Paola, Esposito, Giovanni, Gaudiello, Maria, Giglio, Mariano Cesare, Greco, Paola Antonella, Luglio, Gaetano, Manfreda, Andrea, Marra, Ester, Mastella, Federica, Pagano, Gianluca, Peltrini, Roberto, Pepe, Vincenzo, Sacco, Michele, Sollazzo, Viviana, Spiezio, Giovanni, Cianchetti, Ettore, Menduni, Nunzia, Carvello, Michele Maria, Di Candido, Francesca, Spinelli, Antonino, Corsi, Fabio, Sorrentino, Luca, Marino, Fabio, Asti, Emanuele Luigi Giuseppe, Bonavina, Luigi, Rausa, Emanuele, Asta, Martina, Belli, Andrea, Bianco, Francesco, Cervone, Carmela, Delrio, Paolo, Falato, Armando, Fares Bucci, Andrea, Guarino, Rita, Pace, Ugo, Rega, Daniela, De Luca, Emilia, Gallo, Gaetano, Sammarco, Giuseppe, Sena, Giuseppe, Vescio, Giuseppina, Santandrea, 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Miqdad, Dima, Mohamad, Balqees, Rawhi, Mhammed, Abu Ahammala, Ayman B, Abu Ataya, Ahmed, Abu Jayyab, Israa, Al-Shwaikh, Samar, Alagha, Othman, Alasttal, Mohammed, Awadallah, Haneen, Elblbessy, Mahmood, Fares, Jehad, Jarbou, Akram, Mahfouz, Ibtisam, Albahnasawi, Moath A, Abo Mahadi, Asmaa', Abuelhatal, Hasan, Abuelqomboz, Ayham, Almoqayyad, Abdelrahman, Alwali, Abdallah, Balaawi, Reem, Hamouda, Mahmoud, Humeid, Mohammed, Jedyan, Abdullah, Mahmoud Abu Hamam, Tasneem, Matar, Ghadeer, Salem, Ali, Samra, Tahani, Shaheen, Nureddin, Shihada, Karam, A Nemer, Ayoob, Abu Al Amrain, Mahmoud, Abu Alamrain, Abdulwhhab, Abu Jamie, Najlaa, Abu-Rous, Mohammed R, Alfarra, Nada, AlTaweel, Mohammed, Alwhaidi, Noor, Hamed, Ramadan, Saqqa, Bader, Shaheen, Ahmad, Aljaber, Dana, Aljaberi, Loay, Alwaheidi, Malak, Jawaada, Assef, Khaldi, Hani, Qahoush, Rami, Qari, Jalil, Saadeh, Rana, Salim, Ahlam, Yacoub, Aseel, Abbas, Abbas, Abu Shua Ib, Rana, Abu Zainah, Baraa, AbuSirrees, Mahmoud, Babaa, Basheer, Barhoush, 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Willemin, Melissa, Rayya, Fadi, Ayash, Mohammad, Msouti, Raneem, Kannas, Israa, Abazid, Eias, Esper, Asil, Slim, Skander, Kavcar, Akil Serdar, Aytac, Erman, Dural, Ahmet Cem, Ilker, Ayse, Eray, Ismail Cem, Kurnaz, Eray, Altiner, Saygin, Tepe, Mustafa Deniz, Sahin, Can, Savli, Evrim, Innocent, Aryon, Babirye, Lilian, Diachenko, Andrii, Hordoskiy, Vladislav, Curry, Heather, Chau, Charlene Yat Che, Robertson, Harry, Mahmoud, Arin, Lennon, Hannah, Loi, Lynette, Kirkham, Emily, McCann, Cameron, Watts, Daniel, Gurung, Binay, Wilson, Michael, Tribedi, Thomas, Garofalo, Eleonora, Zahra, Baryab, MacDonald, Scott, Daniels, Ian, Ng, Nathan, Khosla, Shivun, Olivier, James, Yue, Sum Yu Pansy, Suresh, Gayathri, Wellington, Jack, Lorejo, Emmanuel, Mossaad, Mafdi, Crutcher, Madison, Alimi, Marjan, Baiu, Ioana, Abdou, Hossam, Conway, Alison, Peck, Connor, Perdomo Perez, Mauro Andres, Zulu, Stanley, Nakazwe, Mildred, Burger, Sule, Davies, Justine, Donaldson, Rachel, Ede, Chikwendu, Garden, O James, Lesetedi, Chiapo, Mabedi, Charles, Magill, Laura, Makinde Alakaloko, Felix, Makupe, Alex, Monahan, Mark, Mulira, Soloman, Muller, Elmi, Musowoyo, Jospeh, Olory-Togbe, Jean Léon, Roberts, Tracey, Smith, Martin, Tayler, Viki, Windsor, John, Yepez, Raul, Sundar, Sudha, Runigamugabo, Emmy, Verjee, Azmina, Chen, José, Daya, Leonid, El Aroussi, Nouhaila, Farina, Valeria, Gnintedeme Olivier, Tchianze, Gonzales Nacarino, Mauricio, Hammani, Aamr, Honjo, Sarah, Jacobs, Rebecca, Kimura, Hitomi, Nkoronko, Mugisha, Oscullo Yepez, Jasson Javier, Pin Hung, Wei, Raj, Ankit, Romani Pozo, Alina, Rommaneh, Muna, Sassamela Fabiano, Samuel Chimbioputo, Shiroma Gago, Camila Milagros, Srinivas, Abhishekh, Sung, Chia-Yen, Tai, Aswan, Valle Aranda, Yener Cristyell, Venturini, Sara, and Wilguens Lartigue, Jean
Subjects: Pediatrics, Colorectal cancer, IMPACT, Disease, Colorectal Neoplasm, 030204 cardiovascular system & hematology, Cancer, surgery, postoperative mortality, 0302 clinical medicine, Postoperative Complications, Global health, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, General Medicine, DISEASES, Income, cancer surgery, Colorectal Neoplasms, Breast Neoplasm, Cohort study, Human, Adult, Developed Countrie, medicine.medical_specialty, Global surgery, General surgery, International multicentre study, Cancer surgery, Breast Neoplasms, Department of Error, NO, Developing Countrie, 03 medical and health sciences, Breast cancer, Stomach Neoplasms, medicine, Humans, Developing Countries, Neoplasm Staging, business.industry, Developed Countries, Odds ratio, CARE, medicine.disease, 3126 Surgery, anesthesiology, intensive care, radiology, Prospective Studie, Postoperative Complication, business
Abstract: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Background: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit.
Published: 2021
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7. Utilization of the Signature Method to Identify the Early Onset of Sepsis From Multivariate Physiological Time Series in Critical Care Monitoring

Author: Alejo J. Nevado-Holgado, James Morrill, Andrey Kormilitzin, Sam Howison, Sumanth Swaminathan, and Terry Lyons
Subjects: medicine.medical_specialty, Multivariate statistics, Critical Care, Psychological intervention, MEDLINE, Critical Care and Intensive Care Medicine, Sepsis, 03 medical and health sciences, 0302 clinical medicine, medicine, False positive paradox, Humans, Intensive care medicine, Retrospective Studies, Early onset, Series (stratigraphy), Models, Statistical, business.industry, Reproducibility of Results, 030208 emergency & critical care medicine, Regression analysis, medicine.disease, Intensive Care Units, Early Diagnosis, 030228 respiratory system, business, Algorithms
Abstract: Objectives: Patients in an ICU are particularly vulnerable to sepsis. It is therefore important to detect its onset as early as possible. This study focuses on the development and validation of a new signature-based regression model, augmented with a particular choice of the handcrafted features, to identify a patient’s risk of sepsis based on physiologic data streams. The model makes a positive or negative prediction of sepsis for every time interval since admission to the ICU. Design: The data were sourced from the PhysioNet/Computing in Cardiology Challenge 2019 on the “Early Prediction of Sepsis from Clinical Data.” It consisted of ICU patient data from three separate hospital systems. Algorithms were scored against a specially designed utility function that rewards early predictions in the most clinically relevant region around sepsis onset and penalizes late predictions and false positives. Setting: The work was completed as part of the PhysioNet 2019 Challenge alongside 104 other teams. Patients: PhysioNet sourced over 60,000 ICU patients with up to 40 clinical variables for each hour of a patient’s ICU stay. The Sepsis-3 criteria was used to define the onset of sepsis. Interventions: None. Measurements and Main Results: The algorithm yielded a utility function score which was the first placed entry in the official phase of the challenge.
Published: 2020
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8. Implementation of chromosomal microarrays in a cohort of patients with intellectual disability at the Argentinean public health system

Author: Romina Armando, Julián Nevado, Vanesa Lotersztein, Cinthia Martínez, María Ángeles Mori, Sandra Rozental, María Palomares, Lucía D. Espeche, Rubén Martín Arenas, Pablo Lapunzina, Myriam Perez, Andrea Solari, Mabel Segovia, and Liliana Dain
Subjects: 0301 basic medicine, medicine.medical_specialty, Pediatrics, business.industry, Public health, General Medicine, medicine.disease, Subtelomere, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Neurodevelopmental disorder, 030220 oncology & carcinogenesis, Cohort, Intellectual disability, Genetics, Etiology, Medicine, Multiplex ligation-dependent probe amplification, Copy-number variation, business, Molecular Biology
Abstract: Intellectual disability is a neurodevelopmental disorder in which genetic, epigenetic and environmental factors are involved. In consequence, the determination of its etiology is usually complex. Though many countries have migrated from conventional cytogenetic analysis to chromosomal microarrays as the first-tier genetic test for patients with this condition, this last technique was implemented in our country a few years ago. We report on the results of the implementation of chromosomal microarrays in a cohort of 133 patients with intellectual disability and dysmorphic features, normal karyotype and normal subtelomeric MLPA results in an Argentinean public health institution. Clinically relevant copy number variants were found in 12% of the patients and one or more copy number variants classified as variants of uncertain significance were found in 5.3% of them. Although the diagnostic yield of chromosomal microarrays is greater than conventional cytogenetics for these patients, there are financial limitations to adopt this technique as a first-tier test in our country, especially in the public health system.
Published: 2020
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9. Real-world effectiveness, its predictors and onset of action of cholinesterase inhibitors and memantine in dementia: retrospective health record study

Author: Qiang Liu, Chi Hun Kim, Christopher Lucas, Alejo J. Nevado-Holgado, Goran Nenadic, Azad Dehghan, Ivan Koychev, Andrey Kormilitzin, and Nemanja Vaci
Subjects: medicine.medical_specialty, Medication prescription, State Medicine, 050105 experimental psychology, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Memantine, Internal medicine, medicine, Humans, Dementia, 0501 psychology and cognitive sciences, Effects of sleep deprivation on cognitive performance, Cognitive decline, Retrospective Studies, business.industry, 05 social sciences, Montreal Cognitive Assessment, Cognition, medicine.disease, Cognitive test, Psychiatry and Mental health, Acetylcholinesterase, Cholinesterase Inhibitors, business, 030217 neurology & neurosurgery, medicine.drug
Abstract: BackgroundThe efficacy of acetylcholinesterase inhibitors and memantine in the symptomatic treatment of Alzheimer's disease is well-established. Randomised trials have shown them to be associated with a reduction in the rate of cognitive decline.AimsTo investigate the real-world effectiveness of acetylcholinesterase inhibitors and memantine for dementia-causing diseases in the largest UK observational secondary care service data-set to date.MethodWe extracted mentions of relevant medications and cognitive testing (Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores) from de-identified patient records from two National Health Service (NHS) trusts. The 10-year changes in cognitive performance were modelled using a combination of generalised additive and linear mixed-effects modelling.ResultsThe initial decline in MMSE and MoCA scores occurs approximately 2 years before medication is initiated. Medication prescription stabilises cognitive performance for the ensuing 2–5 months. The effect is boosted in more cognitively impaired cases at the point of medication prescription and attenuated in those taking antipsychotics. Importantly, patients who are switched between agents at least once do not experience any beneficial cognitive effect from pharmacological treatment.ConclusionsThis study presents one of the largest real-world examination of the efficacy of acetylcholinesterase inhibitors and memantine for symptomatic treatment of dementia. We found evidence that 68% of individuals respond to treatment with a period of cognitive stabilisation before continuing their decline at the pre-treatment rate.
Published: 2020
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10. Coexistence of autosomal dominant polycystic kidney disease type 1 and hereditary renal hypouricemia type 2: A model of early‐onset and fast cyst progression

Author: Pablo Lapunzina, Rocío Mena, Carlos Peces, Rafael Selgas, Pilar Barruz, Emilio Cuesta, Ramón Peces, and Julián Nevado
Subjects: Adult, 0301 basic medicine, medicine.medical_specialty, Renal Tubular Transport, Inborn Errors, TRPP Cation Channels, Glucose Transport Proteins, Facilitative, Tolvaptan, Autosomal dominant polycystic kidney disease, 030105 genetics & heredity, urologic and male genital diseases, Gastroenterology, Young Adult, 03 medical and health sciences, Internal medicine, Genetics, medicine, Humans, Cyst, Renal Insufficiency, Chronic, Hypouricemia, Genetics (clinical), Polycystic Kidney Diseases, PKD1, biology, urogenital system, business.industry, Acute kidney injury, Acute Kidney Injury, Polycystic Kidney, Autosomal Dominant, medicine.disease, female genital diseases and pregnancy complications, 030104 developmental biology, Child, Preschool, Mutation, biology.protein, Female, business, medicine.drug, SLC2A9, Kidney disease
Abstract: Autosomal dominant polycystic kidney disease (ADPKD) is a heterogeneous inherited disease characterized by renal and extrarenal manifestations with progressive fluid-filled cyst development leading to end-stage renal disease. The rate of disease progression in ADPKD exhibits high inter- and intrafamilial variability suggesting involvement of modifier genes and/or environmental factors. Renal hypouricemia (RHUC) is an inherited disorder characterized by impaired tubular uric acid transport with severe complications, such as acute kidney injury and chronic kidney disease (CKD). However, the two disorders have distinct and well-delineated genetic, biochemical, and clinical findings. Only a few cases of coexistence of ADPKD and RHUC (type 1) in a single individual have been reported. We report a family with two members: an ADPKD 24-year-old female which presented bilateral renal cysts in utero and hypouricemia since age 5, and her mother with isolated hypouricemia. Next-generation sequencing identified two mutations in two genes PKD1 and SLC2A9 in this patient and one isolated SLC2A9 mutation in her mother, showing RHUC type 2, associated to CKD. The coexistence of these two disorders provides evidence of SLC2A9 variant could act as a modifier change, with synergistic actions, that could promote cystogenesis and rapid ADPKD progression. This is the first case of coexistence of PKD1 and SLC2A9 mutations treated with tolvaptan.
Published: 2020
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11. Schuurs–Hoeijmakers Syndrome (PACS1 Neurodevelopmental Disorder): Seven Novel Patients and a Review

Author: Beatriz Olivia Camarena Gómez, Angel Carracedo, Beatriz Morte, María Palomares-Bralo, Patricia Arias, Carmen Ayuso, Marta Pacio-Míguez, Fernando Santos-Simarro, Jair Tenorio-Castaño, Alma Kuechler, Pedro Arias, Feliciano J. Ramos, Eduardo F Tizzano, Sergio Ramos, Fermina López-Grondona, Luis A. Pérez-Jurado, María Pilar Méndez Perez, Julián Nevado, Berta Almoguera, Francisco Barros, Enrique Galán-Gómez, Sixto García-Miñaur, Alba Alcochea, Irene Valenzuela, Victor Martinez-Glez, Frank J. Kaiser, Ivon Cuscó, I. Lorda-Sánchez, Juan Pié, Pablo Lapunzina, Juan Carrión, UAM. Departamento de Medicina, Institut Català de la Salut, [Tenorio-Castaño J] CIBERER, Centro de Investigación Biomédica en Red de Enfermedades Raras, ISCIII, 28029 Madrid, Spain. Overgrowth Syndromes Laboratory, INGEMM, Instituto de Genética Médica y Molecular, IdiPAZ, Hospital Universitario la Paz, Universidad Autónoma de Madrid (UAM), 28046 Madrid, Spain. The SIDE Consortium: Spanish Intellectual Disability Exome Consortium, 28046 Madrid, Spain. Ithaca, European Reference Network, Hospital Universitario La Paz, 28046 Madrid, Spain. [Morte B] CIBERER, Centro de Investigación Biomédica en Red de Enfermedades Raras, ISCIII, 28029 Madrid, Spain. The SIDE Consortium: Spanish Intellectual Disability Exome Consortium, 28046 Madrid, Spain. [Nevado J] CIBERER, Centro de Investigación Biomédica en Red de Enfermedades Raras, ISCIII, 28029 Madrid, Spain. The SIDE Consortium: Spanish Intellectual Disability Exome Consortium, 28046 Madrid, Spain. Ithaca, European Reference Network, Hospital Universitario La Paz, 28046 Madrid, Spain. Structural and Functional Genomics—INGEMM, Instituto de Genética Médica y Molecular, IdiPAZ, Hospital Universitario la Paz, Universidad Autónoma de Madrid (UAM), 28046 Madrid, Spain. [Martinez-Glez V] CIBERER, Centro de Investigación Biomédica en Red de Enfermedades Raras, ISCIII, 28029 Madrid, Spain. Ithaca, European Reference Network, Hospital Universitario La Paz, 28046 Madrid, Spain. Structural and Functional Genomics—INGEMM, Instituto de Genética Médica y Molecular, IdiPAZ, Hospital Universitario la Paz, Universidad Autónoma de Madrid (UAM), 28046 Madrid, Spain. Clinical Genetics—INGEMM, Instituto de Genética Médica y Molecular, IdiPAZ, Hospital Universitario la Paz, Universidad Autónoma de Madrid (UAM), 28046 Madrid, Spain. [Santos-Simarro F] CIBERER, Centro de Investigación Biomédica en Red de Enfermedades Raras, ISCIII, 28029 Madrid, Spain. The SIDE Consortium: Spanish Intellectual Disability Exome Consortium, 28046 Madrid, Spain. Ithaca, European Reference Network, Hospital Universitario La Paz, 28046 Madrid, Spain. Clinical Genetics—INGEMM, Instituto de Genética Médica y Molecular, IdiPAZ, Hospital Universitario la Paz, Universidad Autónoma de Madrid (UAM), 28046 Madrid, Spain. [García-Miñaúr S] CIBERER, Centro de Investigación Biomédica en Red de Enfermedades Raras, ISCIII, 28029 Madrid, Spain. Ithaca, European Reference Network, Hospital Universitario La Paz, 28046 Madrid, Spain. Clinical Genetics—INGEMM, Instituto de Genética Médica y Molecular, IdiPAZ, Hospital Universitario la Paz, Universidad Autónoma de Madrid (UAM), 28046 Madrid, Spain. [Valenzuela I, Tizzano E] Ithaca, European Reference Network, Hospital Universitario La Paz, 28046 Madrid, Spain. Àrea de Genètica Clínica i Molecular, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Genètica de la Medicina, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Cuscó I] Àrea de Genètica Clínica i Molecular, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Genètica de la Medicina, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
Subjects: 0301 basic medicine, Pediatrics, medicine.medical_specialty, PACS1 Gene, Medicina, Medizin, Intellectual disability, Disease, 030105 genetics & heredity, +T%22">Pathogenic variant c.607C > T, QH426-470, phosphofurin acidic cluster sorting protein 1, pathogenic variant c.607C &gt, Trastorns neuroconductuals - Aspectes genètics, Very frequent, 03 medical and health sciences, Neurodevelopmental disorder, Other subheadings::Other subheadings::/genetics [Other subheadings], Genetics, Medicine, Craniofacial, education, rare disorders, PACS1, Genetics (clinical), education.field_of_study, business.industry, Otros calificadores::Otros calificadores::/genética [Otros calificadores], Deficiència mental - Aspectes genètics, trastornos mentales::trastornos del desarrollo neurológico [PSIQUIATRÍA Y PSICOLOGÍA], afecciones patológicas, signos y síntomas::signos y síntomas::manifestaciones neurológicas::manifestaciones neuroconductuales::discapacidad intelectual [ENFERMEDADES], Congenital malformations, Schuurs-Hoeijmakers syndrome, medicine.disease, +T%22">pathogenic variant c.607C > T, 030104 developmental biology, intellectual disability, Phosphofurin acidic cluster sorting protein 1, Schuurs–Hoeijmakers syndrome, Rare disorders, Phospho-furin acidic cluster sorting protein 1, business, Mental Disorders::Neurodevelopmental Disorders [PSYCHIATRY AND PSYCHOLOGY], Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Neurobehavioral Manifestations::Intellectual Disability [DISEASES], +phosphofurin+acidic+cluster+sorting+protein+1%22">Pathogenic variant c.607C > phosphofurin acidic cluster sorting protein 1
Abstract: Schuurs–Hoeijmakers syndrome (SHMS) or PACS1 Neurodevelopmental disorder is a rare disorder characterized by intellectual disability, abnormal craniofacial features and congenital malformations. SHMS is an autosomal dominant hereditary disease caused by pathogenic variants in the PACS1 gene. PACS1 is a trans-Golgi-membrane traffic regulator that directs protein cargo and several viral envelope proteins. It is upregulated during human embryonic brain development and has low expression after birth. So far, only 54 patients with SHMS have been reported. In this work, we report on seven new identified SHMS individuals with the classical c.607C > T: p.Arg206Trp PACS1 pathogenic variant and review clinical and molecular aspects of all the patients reported in the literature, providing a summary of clinical findings grouped as very frequent (≥75% of patients), frequent (50–74%), infrequent (26–49%) and rare (less than ≤25%), This work was possible thanks to the funding provided by the project “Proyecto Piloto para la mejora del diagnóstico genético en personas y familias afectadas o con sospecha de padecer enfermedades raras de base genética” of the Ministry of Health, under the grant BOCM-20181126-24 provided by the Consejería de Sanidad de la Comunidad de Madrid. Funding to J.P. and F.J.R. was partially provided by the group research grant DGA/FEDER B32_17R/B32_20R
Published: 2021

12. Associations between brain volumes and cognitive tests with hypertensive burden in UK Biobank

Author: William Sproviero, Danielle Newby, Lenore J. Launer, Marco Fernandes, Andrey Kormilitzin, Alejo J. Nevado-Holgado, Dai Wang, and Laura Winchester
Subjects: Male, medicine.medical_specialty, hypertension, Neuropsychological Tests, Cardiovascular, Hippocampus, Risk Factors, Internal medicine, Image Processing, Computer-Assisted, medicine, Humans, Dementia, Cognitive Dysfunction, Effects of sleep deprivation on cognitive performance, Cognitive decline, Aged, Biological Specimen Banks, Aged, 80 and over, business.industry, General Neuroscience, Confounding, Brain, Cognition, General Medicine, Middle Aged, cognitive decline, medicine.disease, Magnetic Resonance Imaging, White Matter, United Kingdom, Hyperintensity, Cognitive test, Psychiatry and Mental health, Clinical Psychology, Cross-Sectional Studies, Blood pressure, Cardiology, epidemiology, Female, Atrophy, Geriatrics and Gerontology, business, Research Article, dementia
Abstract: Background: Mid-life hypertension is an established risk factor for cognitive impairment and dementia and related to greater brain atrophy and poorer cognitive performance. Previous studies often have small sample sizes from older populations that lack utilizing multiple measures to define hypertension such as blood pressure, self-report information, and medication use; furthermore, the impact of the duration of hypertension is less extensively studied. Objective: To investigate the relationship between hypertension defined using multiple measures and length of hypertension with brain measure and cognition. Methods: Using participants from the UK Biobank MRI visit with blood pressure measurements (n = 31,513), we examined the cross-sectional relationships between hypertension and duration of hypertension with brain volumes and cognitive tests using generalized linear models adjusted for confounding. Results: Compared with normotensives, hypertensive participants had smaller brain volumes, larger white matter hyperintensities (WMH), and poorer performance on cognitive tests. For total brain, total grey, and hippocampal volumes, those with greatest duration of hypertension had the smallest brain volumes and the largest WMH, ventricular cerebrospinal fluid volumes. For other subcortical and white matter microstructural regions, there was no clear relationship. There were no significant associations between duration of hypertension and cognitive tests. Conclusion: Our results show hypertension is associated with poorer brain and cognitive health however, the impact of duration since diagnosis warrants further investigation. This work adds further insights by using multiple measures defining hypertension and analysis on duration of hypertension which is a substantial advance on prior analyses—particularly those in UK Biobank which present otherwise similar analyses on smaller subsets.
Published: 2022

13. CHRONOSIG: Digital Triage for Secondary Mental Healthcare using Natural Language Processing - rationale and protocol

Author: Andrea Cipriani, Anthony A. James, Dan W Joyce, Alejo J. Nevado-Holgado, Andrey Kormilitzin, and Julia Hamer-Hunt
Subjects: Protocol (science), medicine.medical_specialty, Referral, Computer science, business.industry, computer.software_genre, Clinical decision support system, Triage, Mental health, Harm, Acute care, Health care, medicine, Artificial intelligence, business, computer, Natural language processing
Abstract: BackgroundAccessing specialist secondary mental health care in the NHS in England requires a referral, usually from primary or acute care. Community mental health teams triage these referrals deciding on the most appropriate team to meet patients’ needs. Referrals require resource-intensive review by clinicians and often, collation and review of the patient’s history with services captured in their electronic health records (EHR). Triage processes are, however, opaque and often result in patients not receiving appropriate and timely access to care that is a particular concern for some minority and under-represented groups. Our project, funded by the National Institute of Health Research (NIHR) will develop a clinical decision support tool (CDST) to deliver accurate, explainable and justified triage recommendations to assist clinicians and expedite access to secondary mental health care.MethodsOur proposed CDST will be trained on narrative free-text data combining referral documentation and historical EHR records for patients in the UK-CRIS database. This high-volume data set will enable training of end-to-end neural network natural language processing (NLP) to extract ‘signatures’ of patients who were (historically) triaged to different treatment teams. The resulting algorithm will be externally validated using data from different NHS trusts (Nottinghamshire Healthcare, Southern Health, West London and Oxford Health). We will use an explicit algorithmic fairness framework to mitigate risk of unintended harm evident in some artificial intelligence (AI) healthcare applications. Consequently, the performance of the CDST will be explicitly evaluated in simulated triage team scenarios where the tool augments clinician’s decision making, in contrast to traditional “human versus AI” performance metrics.DiscussionThe proposed CDST represents an important test-case for AI applied to real-world process improvement in mental health. The project leverages recent advances in NLP while emphasizing the risks and benefits for patients of AI-augmented clinical decision making. The project’s ambition is to deliver a CDST that is scalable and can be deployed to any mental health trust in England to assist with digital triage.
Published: 2021
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14. Birth of two healthy girls following preimplantation genetic diagnosis and gestational surrogacy in a rapidly progressive autosomal dominant polycystic kidney disease case using tolvaptan

Author: Rafael Selgas, Emilio Cuesta, Ramón Peces, Carlos Peces, Pablo Lapunzina, Rocío Mena, and Julián Nevado
Subjects: Transplantation, medicine.medical_specialty, business.industry, Obstetrics, Tolvaptan, Autosomal dominant polycystic kidney disease, Preimplantation genetic diagnosis, medicine.disease, Nephrology, medicine, Gestation, Letters to the Editor, AcademicSubjects/MED00340, business, medicine.drug
Published: 2021
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15. Safety of hospital discharge before return of bowel function after elective colorectal surgery

Author: J Chapman, S, Blanco-Colino, R, Pérez-Ajates, S, O Anabitarte Bautista, Hodson, J, C Glasbey, J, Pata, F, Pellino, G, Sgrò, A, Soares, A, T van Elst, S Van Straten, Nepogodiev, D, Borakati, A, F Bath, M, H Yasin, I, Mclean, K, Arthur, T, Kovacevic, M, Delibegovic, S, Karamanliev, M, Swamad, M, Žebrák, R, Paramasivam, R, Martensen, A, M Larsen, H, Rädeker, L, E Frey, P, Kechagias, A, Venara, A, Duchalais, E, Ioannidis, A, Pasquali, S, Simioni, A, Farina, V, Podda, M, Lorenzon, L, Schaeff, V, Otto, A, Jakubauskas, M, R van Elst, T, Chu, M, Pvb, Fagan, I Wells, C, A Alagoa João, Juloski, J, Y El Kasmy El Kasmi, Espin-Basany, E, Clerc, D, Ciubotaru, C, Popescu, S, Yanishev, A, Lee, S, B Ozkan, B, A Yagız Sen, K Aktas, M, E Baki, B, Yüksek, B, Kamarajah, S, A Khaw, R, Mills, E, Goodson, R, Thakral, N, D Ablett, A, Adra, M, Kwek, I, M Khan, S, Quinn, P, R Manley, L, Badran, A, Ramjeeawon, A, Campbell, A, L Tan, H, S Rye, D, Rajaraman, N, G Norman, J, Vutipongsatorn, K, Solomou, G, Akhbari, M, Ali, A, Murray, V, M Baker, D, D Brandao, B, Stainer, B, Thavayogan, R, Jones, D, O Onafowokan, O, Gharooni, A, Dabab, N, Carlton-Carew, S, Kungwengwe, G, Gabriel, M, Sewart, E, C Shortland, T, Lawday, S, Pockney, P, Dawson, A, D Brumfitt, C, Stewart, P, B, Ng, K Luong, J, Ivanov, V, Borisova, A, Neykov, V, Kunčarová, K, Kološová, B, Antonova, T, Farkašová, M, L Harbjerg, J, Brandsborg, S, Brinck, S, D Kjaer, M, Mark-Christensen, A, P Unbehaun, K, Dalsgaard, P, D Lycke, K, Lenaoures, P, Brigand, C, Dumange, E, Gout, M, Moehwald, C, Prem, M, Alhalabi, O, Sliwinski, S, Krupp, J, Gablenz, E, Schmitzer, L, Kopp, A, Steinle, J, Gsenger, J, J Pohl, L, Riccardi, M, M Christodoulou, I, Konstantinidis, M, Machairas, N, Zoikas, A, Balalis, D, K Manatakis, D, L Aguilera, M, Marano, L, Fleres, F, Lovisetto, F, Sasia, D, Segalini, E, Pata, G, Lucchi, A, Sagnotta, A, Campagnaro, T, Petrelli, F, Gallo, G, Papandrea, M, Testa, V, Sinibaldi, G, F Di Candido, Colombo, F, Perrone, G, Aresu, S, Biancafarina, A, Canonico, G, Pagnanelli, M, Curletti, G, Bini, R, A de Manzoni Garberini, Impellizzeri, H, Cillara, N, Tutino, R, Picciariello, A, Coletta, D, Savino, G, Ferrara, F, Tamini, N, Talamo, G, Parini, D, Giamundo, P, A Lo Conte, Pagano, G, Ripetti, V, Pesce, A, Menduni, N, Giudicissi, R, Goldin, E, Rega, D, Belli, A, Andriola, V, Gordini, L, Foppa, C, Piccolo, G, Birindelli, A, Ferrari, C, Ballarini, Z, Tirelli, F, Milone, M, M De Rosa, S Pipitone Federico, N, Molteni, B, L Tilocca, P, Sancini, G, N Piozzi, G, Lauretta, A, Poillucci, G, Mulas, S, Simcikas, D, Portelli, L, Jwm van Wijnbergen, L Dinger, T, Sfh Ten Doesschate, Ashm van Dalen, D van den Bos, D, Hansmann, M, J Medina Feliz, Z Kuiper, S, Abdulrahman, Z, R Pruijssers, S, Farik, S, M Elliott, B, P Geneta, V, Wilton, S, Kandelaki, H, L Peng, S, Campbell, S, K Lim, Y, S Yassaie, S, Murray, M, Haran, C, Tan, J, Castro, J, Laranjeira, A, Catarino, S, Neves-Marques, C, G Correia, J, N Vieira, B, C Quintela, A, L Serra, M, Maciel, J, Cunha, M, J Aparício, D, Neves, J, Azevedo, J, Romano, M, Eiró, F, Romano, J, Monteiro, C, Claro, M, R Almeida, M, Peyroteo, M, D Machado, N, Capote, H, Ferreira, M, Sousa, X, Devesa, H, Cavadas, D, Guerreiro, I, Costa, M, Rosete, M, Salman, M, English, C, Mohammed, N, Litvin, A, V Ćuk, V, Mészárosová, K, Jaich, R, H De Lima, Brooks, S, Marx, M, M Nshalati Salvation, J García Cardo, Mora-Guzmán, I, J Sancho Muriel, U de Andres Olabarria, Muriel, P, C Jimenez Viñas, Alconchel, F, O Esteban Sinovas, C Fairén Oro, M López Otero, S Figueroa Jiménez, O Claramonte Bellmunt, J Martínez Caballero, Rubio-Pérez, I, M Aguilar-Martínez, M, J Segura-Sampedro, J, C Olmedo Moreno, D Negre Parra, M Estévez Diz, A, Martín-Balbuena, R, C Bustamante Recuenco, E Licardie Bolaños, R, Fernández, P, A Díaz Padillo, Forero-Torres, A, I Alberdi San Román, H Salvador Rosés, M Merayo Álvarez, P Villarejo Campos, C Lopes Moreira, C, P Uriol Peralta, M Serrano Navidad, Ripollés-Melchor, J, Garcea, A, H Gómez Facundo, P Troncoso Pereira, V Pérez Guarinos, C, Blaser, B, Piazza, G, Gagliardi, B, Serin, H, S Yurdaor, S, Arslan, E, Kopac, O, Uyanik, A, B Ozmen, B, Tiftik, E, Aksoy, B, Yalcinkaya, A, Ozoglu, F, D Kocer, M, Bilicen, G, N Cinar, E, Uslu, Ö, Kaya, Y, Demirci, K, Wong, J, Mmh, Farhan-Alanie, Suresh, G, Asif, A, J Finch, B, Bhahirathan, Y, Herron, J, Z Yi Tew, Obukofe, R, Russell, C, Suchett-Kay, I, Netke, T, Williams, L, Kisiel, A, Y Liu, F, Claireaux, H, James, P, Mondal, A, Kalderon, R, H Nadama, H, Al-Saraff, Z, Jph, Tam, Powell-Chandler, A, Wood, F, Rebecca, Gorgievska, Ragavoodoo, A, Thakrar, C, Rojoa, D, Palmer, C, Davidson, K, Giacci, L, Hale, J, W Gan, F, Makin-Taylor, R, Y Hey, C, Toh, C, M Findlay, J, Griffiths, N, Ganesananthan, S, Jasionowska, S, Poustie, M, Wong, C, Turner, T, Pyc, W, Sloper, W, Warner, C, Coey, J, Mason, D, Sait, S, Kowal, M, Owen, M, Saiyed, A, Ashworth, I, Akbari, K, Curran, M, Martin, P, Parker, D, Kwok, K, Lye, C, Ghaly, M, Sammour, T, Lewis, D, Mundasad, R, Wilkes, A, Ctercteko, G, Maslyankov, S, Dimov, R, Iliev, S, Dimitrov, D, Marek, F, Örhalmi, J, Skalický, P, Skalický, T, Chrz, K, Christensen, P, Worsøe, J, S Kristensen, E, J Emmertsen, K, S Loeve, U, L Mihaljevic, A, Herrle, F, M Konstantinidis, K, Korkolis, D, Karanikas, I, Vincenti, L, Anania, G, Borghi, F, Agresta, F, Maretto, I, Parisi, A, Bucci, L, G De Palma, Guglielmi, A, Cucinotta, E, F La Torre, Cianchi, F, Guerrieri, M, Trompetto, M, Persiani, R, Micheletto, G, Delrio, P, Cantafio, S, Ronconi, M, Pag, Bisagni, M De Prizio, Franceschi, A, Galleano, R, Cavallini, M, Brescia, A, D'Ambra, L, Benevento, A, Niolu, P, Calgaro, M, Colangelo, E, Grottola, T, F Altomare, D, Puleo, S, Salamone, G, Pietrabissa, A, Poggioli, G, Erdas, E, Ottonello, R, Tonini, V, Selvaggi, F, Sammarco, G, Ceccarelli, G, C De Nisco, Surgo, D, Taglietti, L, Ozolins, A, Sivinš, A, Poskus, T, Psaila, J, A Bemelman, W, J Graat, L, Langenhoff, B, Bpl, Wijnhoven, Ahw van de 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Kenny R., Kan P., Lee D.E., Khosla S., Samake M., Shaban F., Aftab R., Gough M., Woodburn B., Vayalapra S., McMurrugh K., Jimulia D., Deol S., Pike S., Embury-Young Y., Patel M., Kilgallon E., Keating R., Walsh A., Khan H., Logue G., Orekoya M., Alasmar M., Charalambides M., Llavall A.C., Williamson E., Bharwada Y., Zearmal S., Evans H., Panikkar M., de la Cruz G., Caplan J., Ruparelia A., Tanvir T., Soare C., Pang Y.L., Trotter J., Zaidi A., Thakrar V., Pulickal P., Ahmed H., Parnell J., Lennock S., Ford V., Brignall R., O'Neill D., Hanna R., Kane R., Nicola M., Rajput K., Xiao Y., Michael S., Wright E., Juniper S., Thompson E., Hoskyns L., Kanitkar A., Ross C., Unsworth A., Rshaidat H., Demarre K., Chiang A., Bareh A., van Dellen J., Faqihinejad C., Gadhvi A., Grant R., Lewsey J., Morris A., Martin H., McClarty C., Sanyal S., Alsaif A., Palkhi A., Bhopal S., Burford C., Huq T., Irwin E., Matthews L., Ngu W.S., Hosfield T., Muneeb F., Page O., Zeb E., Al-Azzawi A., McIntosh J., Vucicevic A., Hughes M., Brooks L., Fanibi B., Dixon M., Njoku P., Morris D., Jobson J., Chowdhury H., Joseph N., Zulkefley N., Hunt G., Christodoulou T., Wright O., Soman S., Jamal M., Beqiri S., Borgas P., Christie S., Pereira F., Browne S., Yiu J., Dworkin A., Brayley J., Palmer A., Charalambos M., Jones C.S., Toner S., Cowden R., Lee L., Nicol P., Holman O., Imtiaz M., Albert V., Leung S.P., Erotocritou M., Stroud R., Wilkin R., Thomson W., Mackee L., Kler A., Reynolds L., Mohamed S.H., Majeed Y., Fakim B., Jones A., Liversedge G., Carrington Z., Windebank J., Izzarina A., Akbani U., Craven J., Aldarragi A., Harding S., Millward A., Bedford M., Gopalan V., Midgen A., Khadka P., Cheng O., Taneja S., Manobharath N., Kok J.Y., Lim D.W.E., Buick T., Boland M., Piya S., Devlin R., Fairfield C.J., George R.J., Rahi M., Zaman S., Hajiev S., Ross T., Crisp E., Thompson C., Charalambous A., Hollywood J.L., Hammond R.F.L., Matthews J., Mendonca V., Spinty J., Khan K., Cheng J., Glynn N., 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M., Frade S., Senhorinho R., Peixoto R., Alves-Vale C., Lamas M., O'Connor D.B., Hoo M., Gopaul A., Scanlon K., O'Dwyer N., Jovanovic M., Panyko A., Van Vuuren S., Centeno A., Bernado I.R., Senorans M.P.G., Amor L.G., Ramirez A.C., Abrisqueta J., Gomez M.E., Arroyo A., Cerdan C., Romeu N.G., Enriquez-Navascues J.M., Collado-Roura F., Curchod P., Gaspar S., Imadalou L., Mutlu D., Akyol C., Uygur F.A., Eray I.C., Biyiklioglu O., Cetin M.F., Isik A.E., Karip B., Dogan H., Sarigul L., Tunc E., Aydin T., Bodur S., Karabulut K., Francis A.A., Al-hadithi A., Lau I.S.F., Smith E., Mahapatra S., McAuliffe O., Imam L., Akram B., Hossaini S., Davies R., Ko M., Collins J., Pandya A., Reilly S., Archer J., Livie J., Chaudhry F.A., Ntakomyti E., Diallo R., Bylinski T., Wright J., Masiha E., Tung J., Shirazi B., Neilson A., Epton S., Patel N., Trussell S., Couldrey A., Donnelly C., Eftychiou S., Salman M., Skejo, Licari L., Men, Chapman, S. 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Z., Abdulrahman, Z., Pruijssers, S. R., Geneta, V. P., Chu, M., Wilton, S., Kandelaki, H., Peng, S. L., Campbell, S., Lim, Y. K., Yassaie, S. S., Murray, M., Haran, C., Tan, J., Castro, J., Laranjeira, A., Catarino, S., Neves-Marques, C., Correia, J. G., Vieira, B. N., Quintela, A. C., Serra, M. L., Maciel, J., Cunha, M., Aparicio, D. J., Neves, J., Azevedo, J., Romano, M., Eiro, F., Romano, J., Monteiro, C., Claro, M., Capote, H., Ferreira, M., Sousa, X., Peyroteo, M., Machado, N. D., Guerreiro, I., Costa, M., Rosete, M., Salman, M., English, C., Mohammed, N., Litvin, A., Cuk, V. V., Meszarosova, K., Jaich, R., De Lima, H., Brooks, S., Marx, M., Salvation, M. N., Cardo, J. G., Mora-Guzman, I., Muriel, J. S., de Andres Olabarria, U., Muriel, P., Vinas, C. J., Alconchel, F., Sinovas, O. E., Oro, C. F., Otero, M. L., Jimenez, S. F., Bellmunt, O. C., Caballero, J. M., Rubio-Perez, I., Aguilar-Martinez, M. M., Segura-Sampedro, J. J., Moreno, C. O., Parra, D. N., Diz, A. M. 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M., Griffiths, N., Ganesananthan, S., Jasionowska, S., Poustie, M., Wong, C., Turner, T., Pyc, W., Sloper, W., Warner, C., Coey, J., Mason, D., Sait, S., Kowal, M., Owen, M., Saiyed, A., Ashworth, I., Akbari, K., Curran, M., Martin, P., Parker, D., Kwok, K., Lye, C., Ghaly, M., Sammour, T., Lewis, D., Mundasad, R., Wilkes, A., Ctercteko, G., Maslyankov, S., Dimov, R., Iliev, S., Dimitrov, D., Marek, F., Orhalmi, J., Skalicky, P., Skalicky, T., Chrz, K., Christensen, P., Worsoe, J., Kristensen, E. S., Emmertsen, K. J., Loeve, U. S., Mihaljevic, A. L., Herrle, F., Konstantinidis, K. M., Korkolis, D., Karanikas, I., Vincenti, L., Anania, G., Borghi, F., Agresta, F., Maretto, I., Parisi, A., Bucci, L., De Palma, G., Guglielmi, A., Cucinotta, E., La Torre, F., Cianchi, F., Guerrieri, M., Trompetto, M., Persiani, R., Micheletto, G., Delrio, P., Cantafio, S., Ronconi, M., Bisagni, P. A. 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G., Hubner, M., Petermann, D., Sauvain, M. O., Ozben, V., Gecim, I. E., Disci, E., Rencuzogullari, A., Kurt, A., Bisgin, T., Pehlivan, M., Isik, A., Onur, E., Leventoglu, S., Keskin, M., Guner, A., Sahin, S. T., Ozbalci, G. S., Pergel, A., Albayrak, D., Bruce, D., Fearnhead, N., Arthur, J., Harron, M., Beattie, G., Titu, L., Saunders, M., Phillips, J., Dindyal, S., Cresswell, B., Gercek, Y., Lee, J., Linn, T., Faulkner, G., Lockwood, S., Rees, J., Charalabopoulos, A., Campbell, B., Kontovounisios, C., Amarnath, T., Johnson, M., Epanomeritakis, E., Vigs, S., Nastro, P., Gilliam, A., Smolarek, S., Wilson, T., Orbell, J., Mcintyre, R., Agarwal, T., Hainsworth, P., Patel, P., Vijay, J., Liu, B., Rao, P. D., Roxburgh, C., Vipond, M., Youssef, H., Thorn, C., Schizas, A., Denley, S., Bowley, D., Das, K., Cuming, T., Saha, A., Chung, L., Pitt, J., Davis, P., Jones, O., Taylor, M., Bhargava, A., Haji, A., Watson, N., Bloom, I., Singh, B., Norwood, M., Gurjar, S., Stylianides, N., Mirza, S., Evans, M., Williams, G., Patil, P., Hernon, J., Finch, G., Green, S., Chapple, K., Fafemi, O., Warusavitarne, J., Samee, A., Carden, C., Ong, L., Verma, K., Joseph, A., Rawat, N., Pinkney, T., Oke, O., Glen, P., Maxwell-Armstrong, C., Oliphant, R., Garner, J., Moug, S. J., Middleton, S., Lund, J. N., Smart, N. J., Osborn, G., Moore, T., Raymond, T., Knowles, C. H., Hany, T. S., Clarke, R., Khera, G., Brady, R., Sellahewa, C., Mason, C., Torrance, A., Lasithiotakis, K., Knight, J., Pullybank, A., Ainsworth, P., Reid, F., Ramwell, A., Maslekar, S., George, R., Skull, A., Holtham, S., Muhammad, K., Lal, R., Varcada, M., Smith, F. M., Howlader, M., Defriend, D., Kirk, S., Richards, T., Evans, C., Borg, C. 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W., Gabbas, G., Marziali, I., Mazzocato, S., Vergari, R., Piazzai, F., Kubolli, I., Aggiusti, A., Paolucci, A., Ortenzi, M., Olivieri, M., Belluco, C., Antona, A. D., Basso, S., Morino, M., Mistrangelo, M., Clerico, G., De Santi, G., Bitonti, M. F., Frattalone, M., Fico, V., Santullo, F., Belia, F., Spinelli, A., Marco, M., Bevilacqua, M., Tringali, D., Bevilacqua, E., Panizzo, V., La Manna, V., Migliore, G., Aversano, A., Bucci, A. F., Marino, F., Carbone, F., Incollingo, P., Romano, F. M., Zalla, T., Baraghini, M., Romoli, L., Calussi, M., Vellei, S., Genzano, C., Feroci, F., Vita, M., Barberis, A., Serra, D., Grassia, M., Romelli, M., Ruggiero, S., Percassi, A., Piccinini, A. 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X., Peckham, H., Yeoh, T., Yong, S. Q., Chen, J. Y., Siva, S., Sam, Z. H., Gilani, M., Goh, Y. N., Muthukumar, M. G., Phillips, S., Tjoakarfa, J., Giri, A., Suresan, S., Thomas, P., Johnson, T. A., Williams, R. I., Rashid, A., Kushairi, A., Rais, A., James, A., Bugelli, M., Chechelnitskaya, Y., Sandhu, N., Tandon, R., Gray, M., Kumar, A., Ciurleo, C., Nyamali, I., Hiremath, S., Sinha, S., Chowdhary, M., Bradley, E., Mctiernan, M., Macdonald, S., Sharkey, S., Mclaughlin, N., Amey, C., Kraria, L., Skan, O., Kind, C., Tupper, P., Van Rhee, C., Honeyman, S. I., Menon, G., Jegatheeswaran, L., Madhavan, A., Warne, M., Malcolm, F. L., Lessware, T., Wilkerson, H. T., Chatterjee-Woolman, S., Yoong, A., Ahmed, W. U. R., Longshaw, A., Flannery, O., Green, R., Leaning, M., Cragg, J., Sharriff, H., Doherty, C., Kwan, K. W. L., Sanders-Crook, L., Bhatia, S., Eames, S., Lewis, F., Kirupananthan, P., Boh, Z. Y., Dass, S., Soma, A., Newton, A., Hill, M., Shafiq, Y., Brkljac, M., Boyce, L., English, W. J., Lam, S., Chipeta, C., Jain, C., Garofalidou, T., Novotny, S. A., Locke, S., Bowman, C., Begaj, A., Murphy, C., Radcliffe, K., Chong, J. T., Jeffrey, E., Chaudhury, N., Rajendran, K., Akbar, Z., Walters, B., Kulendrarajah, B., Tran, N., Shrestha, S., Parmar, S., Gallagher, C., Hennessy, L., Pentti, E., Badhrinarayanan, S., Fung, A., Mansoor, M., Kenny, R., Kan, P., Lee, D. E., Khosla, S., Samake, M., Shaban, F., Aftab, R., Gough, M., Woodburn, B., Vayalapra, S., Mcmurrugh, K., Jimulia, D., Deol, S., Pike, S., Embury-Young, Y., Patel, M., Kilgallon, E., Keating, R., Walsh, A., Khan, H., Logue, G., Orekoya, M., Alasmar, M., Charalambides, M., Llavall, A. C., Williamson, E., Bharwada, Y., Zearmal, S., Evans, H., Panikkar, M., de la Cruz, G., Caplan, J., Ruparelia, A., Tanvir, T., Soare, C., Pang, Y. L., Trotter, J., Zaidi, A., Thakrar, V., Pulickal, P., Ahmed, H., Parnell, J., Lennock, S., Ford, V., Brignall, R., O'Neill, D., Hanna, R., Kane, R., Nicola, M., Rajput, K., Xiao, Y., Michael, S., Wright, E., Juniper, S., Thompson, E., Hoskyns, L., Kanitkar, A., Ross, C., Unsworth, A., Rshaidat, H., Demarre, K., Chiang, A., Bareh, A., van Dellen, J., Faqihinejad, C., Gadhvi, A., Grant, R., Lewsey, J., Morris, A., Martin, H., Mcclarty, C., Sanyal, S., Alsaif, A., Palkhi, A., Bhopal, S., Burford, C., Huq, T., Irwin, E., Matthews, L., Ngu, W. S., Hosfield, T., Muneeb, F., Page, O., Zeb, E., Al-Azzawi, A., Mcintosh, J., Vucicevic, A., Hughes, M., Brooks, L., Fanibi, B., Dixon, M., Njoku, P., Morris, D., Jobson, J., Chowdhury, H., Joseph, N., Zulkefley, N., Hunt, G., Christodoulou, T., Wright, O., Soman, S., Jamal, M., Beqiri, S., Borgas, P., Christie, S., Pereira, F., Browne, S., Yiu, J., Dworkin, A., Brayley, J., Palmer, A., Charalambos, M., Jones, C. S., Toner, S., Cowden, R., Lee, L., Nicol, P., Holman, O., Imtiaz, M., Albert, V., Leung, S. P., Erotocritou, M., Stroud, R., Wilkin, R., Thomson, W., Mackee, L., Kler, A., Reynolds, L., Mohamed, S. H., Majeed, Y., Fakim, B., Jones, A., Liversedge, G., Carrington, Z., Windebank, J., Izzarina, A., Akbani, U., Craven, J., Aldarragi, A., Harding, S., Millward, A., Bedford, M., Gopalan, V., Midgen, A., Khadka, P., Cheng, O., Taneja, S., Manobharath, N., Kok, J. Y., Lim, D. W. E., Buick, T., Boland, M., Piya, S., Devlin, R., Fairfield, C. J., George, R. J., Rahi, M., Zaman, S., Hajiev, S., Ross, T., Crisp, E., Thompson, C., Charalambous, A., Hollywood, J. L., Hammond, R. F. L., Matthews, J., Mendonca, V., Spinty, J., Khan, K., Cheng, J., Glynn, N., Muhammad, U., Khan, M., Anderson, L., Mccormack, K., Mak, J., Patrawala, S., Milinkovic, N., Schofield, R., Chauhan, M., Hartley, L., Hind, J., Nelson, L., Ratnasingham, D., Whitehead, T., Dimitriadis, S., Marshall, K., Flint, E. J., Horner, C., Heybourne, A., Morgan, H., Wickstone, C., Panagiotou, D., O'Connell, E., Dean, K., Iqbal, R., Walsh, L., Yu, N., Rana, N., Massie, E., Ng, J., Jung, M., Lee, Y. D., Harris, M., White, S., Boev, B., Tonchev, P., Prochazka, V., Risko, J., Skalicky, A., Ravn, S., Ojakaar, A., Dorr-Harim, C., Koutserimpas, C., Giraudo, G., Armellini, A., Ruzzenente, A., Mazzeo, C., De Padua, C., Luc, A. R., Maroli, A., Vitali, M., Gusai, G. P., Quattromani, R., Virgilio, E., Berti, S., Di Mola, F. F., Papagni, V., Tuminello, F., Vittori, L., Longheu, A., Loche, G. A., Braccio, B., De Luca, E., Resta, G., Ancans, G., Tamosiunas, A., Petrulionis, M., Abdulrahman, N., van de Pas, K. G. H., Thomas, G., Brandsma, A. M., Davids, J., Rottier, S. J., de Roy van Zuidewijn, D., Hawkins, R., Ong, H. I., Li, Y., Desmond, B., Winstanley, J., Martins, M., Americano, M., Frade, S., Senhorinho, R., Peixoto, R., Alves-Vale, C., Lamas, M., O'Connor, D. B., Hoo, M., Gopaul, A., Scanlon, K., O'Dwyer, N., Jovanovic, M., Panyko, A., Van Vuuren, S., Centeno, A., Bernado, I. R., Senorans, M. P. G., Amor, L. G., Ramirez, A. C., Abrisqueta, J., Gomez, M. E., Arroyo, A., Cerdan, C., Romeu, N. G., Enriquez-Navascues, J. M., Collado-Roura, F., Curchod, P., Gaspar, S., Imadalou, L., Mutlu, D., Akyol, C., Uygur, F. A., Eray, I. C., Biyiklioglu, O., Cetin, M. F., Isik, A. E., Karip, B., Dogan, H., Sarigul, L., Tunc, E., Aydin, T., Bodur, S., Karabulut, K., Francis, A. A., Al-hadithi, A., Lau, I. S. F., Smith, E., Mahapatra, S., Mcauliffe, O., Imam, L., Akram, B., Hossaini, S., Davies, R., Ko, M., Collins, J., Pandya, A., Reilly, S., Archer, J., Livie, J., Chaudhry, F. A., Ntakomyti, E., Diallo, R., Bylinski, T., Wright, J., Masiha, E., Tung, J., Shirazi, B., Neilson, A., Epton, S., Patel, N., Trussell, S., Couldrey, A., and Donnelly, C.
Subjects: operative, Male, postoperative discharge, Postoperative Complications, 0302 clinical medicine, Colostomy, CRITERIA, Prospective Studies, Bowel function, Colectomy, IMAGINE, stoma, intestines, Proctectomy, Ileostomy, digestive, oral, and skin physiology, patient discharge, colorectal surgery, hospital discharge, bowel function, RECOVERY, Middle Aged, adult, colostomy, elective surgical procedures, female, follow-up studies, humans, ileostomy, ileus, male, middle aged, multivariate analysis, patient readmission, patient safety, postoperative complications, prospective studies, recovery of function, colectomy, proctectomy, Patient Discharge, Colorectal surgery, ileus - - discharge - bowel function - elective - colorectal surgery, Elective Surgical Procedures, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Patient Safety, Cohort study, safety, Adult, medicine.medical_specialty, Ileus, Patient Readmission, defecation, 03 medical and health sciences, medicine, Hospital discharge, Humans, colorectal surgery, colorectal resection, Colorectal resection, defecation, postoperative complications, colorectal surgery, intestines, patient discharge, patient readmission, safety, surgical procedures, operative, colorectal resection, ileus, business.industry, Recovery of Function, Odds ratio, medicine.disease, digestive system diseases, surgical procedures, Surgery, Multivariate Analysis, Defecation, business, Follow-Up Studies
Abstract: Ileus is common after colorectal surgery and is associated with an increased risk of postoperative complications. Identifying features of normal bowel recovery and the appropriateness for hospital discharge is challenging. This study explored the safety of hospital discharge before the return of bowel function.A prospective, multicentre cohort study was undertaken across an international collaborative network. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The main outcome of interest was readmission to hospital within 30 days of surgery. The impact of discharge timing according to the return of bowel function was explored using multivariable regression analysis. Other outcomes were postoperative complications within 30 days of surgery, measured using the Clavien-Dindo classification system.A total of 3288 patients were included in the analysis, of whom 301 (9·2 per cent) were discharged before the return of bowel function. The median duration of hospital stay for patients discharged before and after return of bowel function was 5 (i.q.r. 4-7) and 7 (6-8) days respectively (P 0·001). There were no significant differences in rates of readmission between these groups (6·6 versus 8·0 per cent; P = 0·499), and this remained the case after multivariable adjustment for baseline differences (odds ratio 0·90, 95 per cent c.i. 0·55 to 1·46; P = 0·659). Rates of postoperative complications were also similar in those discharged before versus after return of bowel function (minor: 34·7 versus 39·5 per cent; major 3·3 versus 3·4 per cent; P = 0·110).Discharge before return of bowel function after elective colorectal surgery appears to be safe in appropriately selected patients.El íleo es frecuente tras la cirugía colorrectal y se asocia con un aumento del riesgo de las complicaciones postoperatorias. Identificar las características de una recuperación normal del tránsito y la idoneidad para el alta hospitalaria es una tarea difícil. Este estudio examinó la seguridad del alta hospitalaria antes del restablecimiento de la función intestinal. MÉTODOS: Se llevó a cabo un estudio de cohortes prospectivo y multicéntrico a través de una red de colaboración internacional. Se incluyeron pacientes adultos sometidos a resección electiva colorrectal entre enero y abril 2018. El objetivo principal fue el reingreso hospitalario durante los 30 primeros días tras la intervención. Se utilizó un análisis de regresión multivariable para evaluar el impacto del momento del alta en función del restablecimiento de la función intestinal. El objetivo secundario fue las complicaciones postoperatorias en los primeros 30 días después de la cirugía, valoradas mediante el sistema de clasificación de Clavien-Dindo.Se incluyeron en el análisis 3.288 pacientes, de los cuales 301 (9,2%) fueron dados de alta antes del restablecimiento de la función intestinal. La mediana de la estancia hospitalaria de los pacientes dados de alta antes y después del restablecimiento de la función intestinal fue 5 (rango intercuartílico: 4-7) y 7 (6-8) días, respectivamente (P 0,001). No hubo diferencias significativas en las tasas de reingreso entre estos grupos (6,6% versus 8,0%; P = 0,499), y este resultado se mantuvo en el análisis multivariable tras el ajuste por diferencias basales (razón de opotunidades, odds ratio, OR 0,90; i.c. del 95% 0,55-1,46, P = 0,659). Las tasas de complicaciones postoperarorias fueron similares en aquellos dados de alta antes o después del restablecimiento de la función intestinal (complicaciones menores: 34,7% versus 39,5%; complicaciones mayores 3,3% versus 3,4%; P = 0,110). CONCLUSIÓN: Dar de alta antes del restablecimiento de la función intestinal tras cirugía colorrectal electiva parece ser seguro en pacientes debidamente seleccionados.
Published: 2020
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16. Timing of nasogastric tube insertion and the risk of postoperative pneumonia: an international, prospective cohort study

Author: Glasbey J. C., Bibi S., Pata F., Ozkan B. B., Van Straten S., Hodson J., Chapman S. J., Blanco-Colino R., Pellino G., Sgro A., Soares A., van Elst T., Nepogodiev D., Borakati A., Bath M. F., Yasin I. H., Mclean K., Arthur T., Kovacevic M., Delibegovic S., Karamanliev M., Swamad M., Zebrak R., Paramasivam R., Martensen A., Larsen H. M., Radeker L., Frey P. E., Kechagias A., Venara A., Duchalais E., Ioannidis A., Pasquali S., Simioni A., Farina V., Podda M., Lorenzon L., ItSURG I., Schaeff V., Otto A., Jakubauskas M., van Elst T. R., Chu M., Fagan P. V. B., Wells C. I., Alagoa Joao A., Juloski J., Perez-Ajates S., Anabitarte Bautista O., El Kasmy Y., Espin-Basany E., Clerc D., Ciubotaru C., Popescu S., Yanishev A., Lee S., Yagiz Sen A., Aktas M. K., Baki B. E., Yuksek B., Kamarajah S., Khaw R. A., Mills E., Goodson R., Thakral N., Collaborative S., Ablett A. D., Adra M., Kwek I., Khan S. M., Quinn P., Manley L. R., Badran A., Ramjeeawon A., Campbell A., Tan H. L., Rye D. S., Rajaraman N., Norman J. G., Vutipongsatorn K., Solomou G., Akhbari M., Ali A., Murray V., Baker D. M., Brandao B. D., Stainer B., Thavayogan R., Jones D., Onafowokan O. O., Gharooni A., Dabab N., Carlton-Carew S., Kungwengwe G., Gabriel M., Sewart E., Shortland T. C., Lawday S., Pockney P., Dawson A., Brumfitt C. D., Stewart P., Ng B., Luong J. K., Ivanov V., Borisova A., Neykov V., Kuncarova K., Kolosova B., Antonova T., Farkasova M., Harbjerg J. L., Brandsborg S., Brinck S., Kjaer M. D., Mark-Christensen A., Unbehaun K. P., Dalsgaard P., Lycke K. D., LeNaoures P., Brigand C., Dumange E., Gout M., Moehwald C., Prem M., Alhalabi O., Sliwinski S., Krupp J., Gablenz E., Schmitzer L., Kopp A., Steinle J., Gsenger J., Pohl L. J., Riccardi M., Christodoulou I. M., Konstantinidis M., Machairas N., Zoikas A., Balalis D., Manatakis D. K., Aguilera M. L., Marano L., Fleres F., Lovisetto F., Sasia D., Segalini E., Pata G., Lucchi A., Sagnotta A., Campagnaro T., Petrelli F., Gallo G., Papandrea M., Testa V., Sinibaldi G., Di Candido F., Colombo F., Perrone G., Biancafarina A., Canonico G., Pagnanelli M., Curletti G., Bini R., de Manzoni Garberini A., Impellizzeri H., Cillara N., Tutino R., Picciariello A., Coletta D., Savino G., Ferrara F., Tamini N., Talamo G., Parini D., Giamundo P., lo Conte A., Pagano G., Ripetti V., Pesce A., Menduni N., Giudicissi R., Goldin E., Rega D., Belli A., Andriola V., Gordini L., Foppa C., Piccolo G., Birindelli A., Ferrari C., Ballarini Z., Tirelli F., Milone M., De Rosa M., Pipitone Federico N. S., Molteni B., Tilocca P. L., Sancini G., Piozzi G. N., Lauretta A., Poillucci G., Mulas S., Simcikas D., Portelli L., van Wijnbergen J. W. M., Dinger T. L., ten Doesschate S. F. H., van Dalen A. S. H. M., van den Bos D. D., Hansmann M., Medina Feliz J., Kuiper S. Z., Abdulrahman Z., Pruijssers S. R., Farik S., Elliott B. M., Geneta V. P., Wilton S., Kandelaki H., Peng S. L., Campbell S., Lim Y. K., Yassaie S. S., Murray M., Haran C., Tan J., Castro J., Laranjeira A., Catarino S., Neves-Marques C., Correia J. G., Vieira B. N., Quintela A. C., Serra M. L., Maciel J., Cunha M., Aparicio D. J., Neves J., Azevedo J., Romano M., Eiro F., Romano J., Monteiro C., Claro M., Almeida M. R., Peyroteo M., Machado N. D., Capote H., Ferreira M., Sousa X., Devesa H., Cavadas D., Guerreiro I., Costa M., Rosete M., Salman M., English C., Mohammed N., Litvin A., Cuk V. V., Meszarosova K., Jaich R., De Lima H., Brooks S., Marx M., Nshalati Salvation M., Garcia Cardo J., Mora-Guzman I., Sancho Muriel J., de Andres Olabarria U., Muriel P., Jimenez Vinas C., Alconchel F., Esteban Sinovas O., Gomez del Pulgar A., Fairen Oro C., Lopez Otero M., Figueroa Jimenez S., Claramonte Bellmunt O., Martinez Caballero J., Rubio-Perez I., Aguilar-Martinez M. M., Segura-Sampedro J. J., Olmedo Moreno C., Negre Parra D., Estevez Diz A. M., Martin-Balbuena R., Bustamante Recuenco C., Licardie Bolanos R. E., Fernandez P., Diaz Padillo A., Forero-Torres A., Alberdi San Roman I., Salvador Roses H., Merayo Alvarez M., Villarejo Campos P., Lopes Moreira C. C., Uriol Peralta P., Serrano Navidad M., Ripolles-Melchor J., Garcea A., Gomez Facundo H., Troncoso Pereira P., V Perez Guarinos C., Blaser B., Piazza G., Gagliardi B., Serin H., Yurdaor S. S., Arslan E., Kopac O., Uyanik A., Ozmen B. B., Tiftik E., Aksoy B., Yalcinkaya A., Ozoglu F., Kocer M. D., Bilicen G., Cinar E. N., Uslu O., Kaya Y., Demirci K., Wong J., Farhan-Alanie M. M. H., Suresh G., Asif A., Finch B. J., Bhahirathan Y., Herron J., Yi Tew Z., Obukofe R., Russell C., Suchett-Kay I., Netke T., Williams L., Kisiel A., Liu F. Y., Claireaux H., James P., Mondal A., Kalderon R., Nadama H. H., Al-Saraff Z., Tam J. P. H., Powell-Chandler A., Wood F., Gorgievska R., Ragavoodoo A., Thakrar C., Rojoa D., Palmer C., Davidson K., Giacci L., Hale J., Gan F. W., Makin-Taylor R., Hey C. Y., Toh C., Findlay J. M., Griffiths N., Ganesananthan S., Jasionowska S., Poustie M., Wong C., Turner T., Pyc W., Sloper W., Warner C., Coey J., Mason D., Sait S., Kowal M., Owen M., Saiyed A., Ashworth I., Akbari K., Curran M., Martin P., Parker D., Kwok K., Lye C., Ghaly M., Sammour T., Lewis D., Mundasad R., Wilkes A., Ctercteko G., Maslyankov S., Dimov R., Iliev S., Dimitrov D., Marek F., Orhalmi J., Skalicky P., Skalicky T., Chrz K., Christensen P., Worsoe J., Kristensen E. S., Emmertsen K. J., Loeve U. S., Mihaljevic A. L., Herrle F., Konstantinidis K. M., Korkolis D., Karanikas I., Vincenti L., Anania G., Borghi F., Agresta F., Maretto I., Parisi A., Bucci L., De Palma G., Guglielmi A., Cucinotta E., La Torre F., Cianchi F., Guerrieri M., Trompetto M., Persiani R., Micheletto G., Delrio P., Cantafio S., Ronconi M., Bisagni P. A. G., De Prizio M., Franceschi A., Galleano R., Cavallini M., Brescia A., D'Ambra L., Benevento A., Niolu P., Calgaro M., Colangelo E., Grottola T., Altomare D. F., Puleo S., Salamone G., Pietrabissa A., Poggioli G., Erdas E., Ottonello R., Tonini V., Selvaggi F., Sammarco G., Ceccarelli G., De Nisco C., Surgo D., Taglietti L., Ozolins A., Sivins A., Poskus T., Psaila J., Bemelman W. A., Graat L. J., Langenhoff B., Wijnhoven B. P. L., van de Ven A. H. W., Poelman M., Stassen L. P. S., Slooter G., Acherman Y. I. Z., Hoff C., Gerhards M. F., Stommel M. W. J., Hazebroek E. J., van Geloven A. A. W., Schasfoort R. A., van Leeuwen B. L., Tuynman J. B., van Tilburg M. W. A., Boerma E. G., Sharma P., Jenkins B., Bissett I. P., Herd A., Gordon A., Vernon D., Omundsen M., Ly J., Reddy A., Bonnet G., Harmston C., Morales M., Francisco V., Costa S., Manso A., Amorim E., Pereira J., Cardoso J., Ouro S., Caratao M., Nascimento C., Ribeiro da Silva B., Taranu V., Dias R., Mendes J., Allen M., Silva A., Carlos S., Barbosa E., Carneiro C., Ramos L., Lencastre L., Martins R., Silva-Vaz P., Ridgway P. F., McNamara D. A., Cahill R., Hogan A., Larkin J., O'Connell P. R., Negoi I., Abelevich A., Cuk V. M., Vician M., Ede C., Sardiwalla I., Mulira S., Montwedi D., Oyomno M., Sabia D., Portugal Porras V., Vigorita V., Sanz Ortega G., Garcia J., Espi Macias A., Blanco Antona F., Lujan Mompean J. A., Salvans Ruiz S., Villarejo-Campos P., Romero Simo M., Sanchez-Guillen L., Jimenez-Gomez L. M., Sanchez Lopez A., Golda T., Julia Bergkvist D., Nevado C., Noguera Aguilar J. F., cRicardo Felipe B., Septiem J., Rodriguez Sanchez A., Canete-Gomez J., Ruiz Montesinos I., Millan-Scheiding M., Prieto-Nieto I., Frasson M., Garcia Olmo D., Hubner M., Petermann D., Sauvain M. O., Ozben V., Gecim I. E., Disci E., Rencuzogullari A., Kurt A., Bisgin T., Pehlivan M., Isik A., Onur E., Leventoglu S., Haksal M. C., Erturk M. S., Keskin M., Guner A., Tutcu Sahin S., Ozbalci G. S., Pergel A., Albayrak D., Bruce D., Fearnhead N., Arthur J., Harron M., Beattie G., Titu L., Saunders M., Phillips J., Dindyal S., Cresswell B., Gercek Y., Lee J., Linn T., Faulkner G., Lockwood S., Rees J., Charalabopoulos A., Campbell B., Kontovounisios C., Amarnath T., Johnson M., Epanomeritakis E., Vigs S., Nastro P., Gilliam A., Smolarek S., Wilson T., Orbell J., McIntyre R., Agarwal T., Hainsworth P., Patel P., Vijay J., Liu B., Dhruva Rao P., Roxburgh C., Vipond M., Youssef H., Thorn C., Schizas A., Denley S., Bowley D., Das K., Cuming T., Saha A., Chung L., Pitt J., Davis P., Jones O., Taylor M., Bhargava A., Haji A., Watson N., Bloom I., Singh B., Norwood M., Gurjar S., Stylianides N., Mirza S., Evans M., Williams G., Patil P., Hernon J., Finch G., Green S., Chapple K., Fafemi O., Warusavitarne J., Samee A., Carden C., Ong L., Verma K., Joseph A., Rawat N., Pinkney T., Oke O., Glen P., Maxwell-Armstrong C., Oliphant R., Garner J., Moug S. J., Middleton S., Lund J. N., Smart N. J., Osborn G., Moore T., Raymond T., Knowles C. H., Hany T. S., Clarke R., Khera G., Brady R., Sellahewa C., Mason C., Torrance A., Lasithiotakis K., Knight J., Pullybank A., Ainsworth P., Reid F., Ramwell A., Maslekar S., George R., Skull A., Holtham S., Muhammad K., Lal R., Varcada M., Smith F. M., Howlader M., Defriend D., Kirk S., Richards T., Evans C., Borg C. M., Telford K., Sarfraz N., Busby K., Hollingshead J., Speake D., Pawa N., West D., Chadwick M., Komolafe O., Richardson S., Thornton M., Goede A., Osborne C., Bandyopadhyay D., Foong J., Lee Y. J., Liebenberg P., Mijalkov D., Wells A., Bull N., Ajmera A., Warburton T., Morgan S., Mahmoud A., Schachtel M., Mikhail B., Fomin I., Mekaeil B., Taylor N., Stevenson C., Drane A., Pahalawatta U., Lai L. T., Debiasio A., Jun H. J. S., Hengpoonthana R., Mendis D. M., Robb P. M., Lee H. J., Wyche A. A. B., Davis L. T., Chrimes A., Agarwal A., Zhao J., Williams S., Jayalath J. M. S. N., Khor S., Muddasani T., Childs S., Ridgway S., Blefari N. D. A., Tam H., Puchalski N., Ngai C., Mackenzie J., Johnson N., Holmes M., Zuzek R., Saluja T., Gould T., Goh Y. K., Selvaraj T., Beh Y. Z., Dudi-Venkata N. N., Horne D., Borrow J. L., Campbell C., Cousins G., Jackson L., Maheepala K., Zhao S., Holden E., Tutt L., Thompson B., Collins H., Louie F., Buckland B., Smith D., Chong C., Chua T. H., Nayak C., Redmond J., Tan R. R., Gramlick M., Teh J. S., Ng S. Y., Britten-Jones P., Mohd Rosli R., Pham H. D. V., Jegathees T., Coulter-Nile S. M. C. J., Gosselink M. P., Wang Y. L., Maciaszek M., Chrapko P. S., Nair A., Thirugnanasundralingam V., Muir K., Salibasic M., Pavlov V., Paycheva T., Lyulenina E., Kolev N., Nguen D., Mitkov Y., Mitkov E., Vladova P., Dimitrov V., Hussain M., Gabarski A., Ivanov T., Yotsov T., Ilieva I., Akisheva A., Shoshkova M., Nawaz E., Feradova H., Mladenov T., Jozaf V., Klail T., Pos M., Adel A., Sotona O., Bartos M., Amjad T., Maly O., Berec S., Hanusova M., Hurny M., Risko J., Ludvik M., Stercz M., Treskon R., Pospisil M., Hlavacova L., Tomanova D., Chodora S., Houdek O., Novicky R., Sobotkova K., Cha S., Suta Kimle K., Jirankova K., Bujda M., Paclik A., Trap A., Jurgens-Lahnstein J., Storm M., Damgaard I., Olawi F., Ehlern F., Raos M., Kristensen F. P., Bonnerup K., Amiri S., Enevoldsen M., Hojgaard Pedersen J., Jepsen B. N., Hillgaard T. K., Erichsen S. B., Nielsen C. V., Madsen C. P., Bjerke J., Skejo C. D., Aabling R. R., Sorensen J. 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A., De Angelis M., Mereu A., Adamo V., Bianco C., Ricciardiello M., Campanaro C., Panaccio P., Esposito L. M., D'Ascanio F., Pietroletti R., Chetta N., Aquilino F., Di Marco F., Amico A., Schembari E., Puglisi S., Licari L., Campanella S., Profita G., Falco N., Rotolo G., Venturelli P., De Marco P., Marciano M., Argenti F., Milani M. S., Malabarba S., Giambartolomei G., Vella I., Gronchi F., Ruggieri A., Roggiani A., Balsamo F., Gori A., Cuicchi D., D'Alessio R., Benvenuto D., Podda F., Cappellacci F., Salaris C., Sanna S., Marcialis J., Mosino L., Peddis M., Melis S., De Donno G., Aru A. C., Falsetti E., Lanari J., D'Errico U., Bianchini S., Figa F., Caiazzo A., Selvaggi L., Capozzolo A., Cerra C., Pirillo M., Cravano S., Libri I., Laquatra N., Isabello A., Truskovs A., Bartnick A., Malcevs E., Machatschek M. J., Alm J., Lapsa S., Delorme M., Zeynalov F., Larnovskis J., Sauka J., Bodrov D., Gailumsis R., Wiemann A. M., Muller N. L., Jelovskis I., Deksnis D., Bauermeister Potts O., Slimbajevs T., Samalavicius N. E., Nutautiene V., Zeromskas P., Jurgaitis J., Aliosin O., Slepavicius A., Eismontas V., Kybransiene M., Dulskas A., Kuliavas J., Kavaliauskas P., Kavaliauskaite R., Poskus E., Danys D., Kryzauskas M., Mikalauskas S., Rackauskas R., Drungilas M., Jotautas V., Strupas K., Cachia C., Cefai C., Youssef Y., Degaetano D., Debono S., Sammut M., Cassar J., Sammut K., Looijen R. C., Becker M. A. J., Comert D., te Molder L., Tromp J., Matthee E., Tissen Y. M., Brinkhuis E., de Vries H. S., 't Hart E., Beckers K., Bekker Y., Kakar S., van Smaalen T. C., Veen O. C., Dingemans S. A., van den Brink L. C., Vijgen G. H. E. J., van de Voort E. M. F., van der Pool A., van Rest K. L. C., Haak T., Sluijpers N. R. F., Molenaar C. J. L., Gordinou de Gouberville M. C., Saleh S., Mens M. A., Hoeks E. M., Nieuwenhuizen S., van Praag E. M., Westerduin E., Smit M. P. C. M., van der Lely S. J., Nasimi B., Gerdsen M., Stijns R. C. H., Leow T. Y. S., Penningnieuwland G., de Ruiter A., Ribbers T., Aarts C. A. M., Tulek M. S., de Jonge J., Kocak S., Alqethami H. J., Constansia R., van Elst P. C., Tissink M. W., Gruter A., Vroom Y., Voeten D. M., Feenstra T., Azzahhafi J., Bofarid S., Kip M., Saleh W., Franssen S., Boon C. L., Franssen R. J. M., Romaen I., Jense M. T. F., D'Souza J., Pascoe R., Scott A., Stark E., Mulholland K., Lau W. K., Smith B., Adams S. I. B., Shah N., Ling E., Young J., Jacobson A., Macfater H., Chen S. Y., Kilpatrick K., Kim D. H., Dixon S., Yassaie S., Welman D., Coulter J., Morreau M., Li E., Rankin A., Winders J., Skipworth C., Stanfield B., Henderson N., Chuang A., Maskill L., Ker H., McLaughlin S. J. P., Kearney J., Sprosen H., Kerckhoffs P., Alsadat R., Cherry R., Chapman D. A., Singh N., Clucas A., Gatenby G., Kelly B., Ruppeldt P., McIntosh N. D., Koh S., Wilms H., Dalzell F., Tewhaiti-Smith J., Kader T., Yam S. 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F., Parreira R., Faustino A., Medeiros N., Castro R., Soares B., Resendes M., Almeida P., Cruz A., Vaz Pinto G., Sousa D., Costa Santos D., Silva F., Fialho G., Reia M., Pratas N., Costa C., Costa J., Morais S., Machado A., Horta V., Rocha-Melo M., Patricio J., Pereira M., Lima R., Cinza A. M., Oliveira J., Velez C., Borges F., Simoes J., Botelho P., Cismasiu B., Alves D., Dias B., Goncalves J. P., Valente P., Freire L., Saraiva R., Moreira M., Fragoso M., Guimaraes J., Cruz G., Ribeiro J., Borges da Ponte I., Almeida S., Martins A. R., Louro T., Morgado M., Ferreira A. S., Alves M., Oliveira N., Lerias R., Estalagem I., Botelho C., Bartolo J., Fidalgo Antunes C., Cabral F., Brito Silva F., Dias Matos A., Santos M., Cunha R., Sousa M., Canotilho R., Correia A. M., Martins P. C., Jardim J. A. M., Domingos S. P., Baiao J. M., Rocha B. S., Lopes N. M. R. O., Jordao D. M., Angelo M. D., Caroco T., Gomes J. R., Monteiro R. G., Varghese S., Boyle E., Aljohmani L., Alexander J., Graziadei V., McCaughey C., Jain A., Ramanayake H., Sabnani R., Colon L. F., Bansal N., Stephens I., Tan R., Sharma S., Doherty G., Fenn S., Mulhare E., Walsh M., Leavey C., Costigan O., Griffin S., Dockry E., Khogali E., Aly A. K., McPhedran R., O'Gorman D., Vermeulen D., Dervan L., Kang S. J., Dixon O., Morrissey E., Compton M., Pentony A. R., Piong C. L., Nossier R., Hanna J., Sabir K., Eow S. Y., Ladak N., Boersma D., Kamath P. J., Soh T. B. W., Dyer A. H., Chee S. Y., Tan I. X. H., Kelliher A., Adeusi L., Howarth N., McCawley N., O'Neill A., Jones M. R., Saleh R., Singh A., Senaratne R., Kakodkar P., Balasubramanian I., Al-Salihi A., Vyas V., Vedadi A., Popescu S. S., Piras K., Ciubotaru C. I., Romanova E., Ponomarev N., Savchenko A., Luzan R., Lutovinova E., Gavrilina A., Barkovskaya A., Kudelkina N., Topchubaev D., Radulovic R., Milosevic K., Bojicic J., Gencic M., Jankovic U., Zubowicz M., Suchan P. K., Gerstmeier J., Brazitikou E., Fytrou E., Celik M., Dubovsky M., Schmalenbeck J., Sautter S. C., Ceyran H., Fitchat N., Mathebula S., Chauke J., Mculu W., Ngwenya Z., Withey K., Piperidis A., Toyi Y., Nicolaides A., Jaffer T., Sparke A., Van Staden N., McDuling C. R., Claassen L., Kruger C., Weyers J., Lecler J., Yebes A., Mana O. C., Gomez H., Riba L., Perez J., Casaval Cornejo L., Vicente Rodriguez I., Jimenez Escovar F., Calvo Fernandez M., Portugal Martinez A., Badiola Bergara I., Landaluce Olavarria A., del Pozo Andres E., Samartin Toimil C., Primo Alvarez J. C., Rodriguez Fernandez L., Ortega C., Ossola M. E., Camarero E., Martinez Illan M., Aranda Garcia L., Lazaro Cardona M., Montalvo Olmedo C., Livianos Arias-Camison P., Nieto Arranz J. M., Mateos Sexmero M. J., Diego Alonso E., Izquierdo Moreno A., Margarida A., Pando B., Liquete Marin L., Perez Calle M., Ramos Cordero M. J., Sagredo Cuartango A., Sanchez E., Marcos Rodrigo A., Martinez Diaz J. M., Ruiz Manzanera J. J., Navarro Barrios A., Rodriguez Pedreno L., Garcia Moreno P., Garcia Gomez M., Rodrigues K., Platero Diago J., Veras Lista M., Rifa Terricabras S., Butler Sanz L., Alberch Camprubi E., Rico Ferrandez M., Puig Lao E., De Pablo Miro M., Alberca-Paramo A., Alia Verdejo T., Canete-Manzanares J., Molina-Florez M., Garcia Hernandez L. C., Orozco Nunez S., Suarez-Sanchez M., Martin-Fernandez J., Soriano Liebana M. M., Campo Betancourth C. F., Sevila Mico S., Fernandez A., Curtis C., Bosch M., Triguero D., Bosch Ramirez M., Ramayo Diaz N., Gonzalez Caraballo I., Pascual Vicente T., Orue-Echebarria M. I., Sanchez-Calvo L., Wang D., Trueba-Collado C., Morales Bernaldo de Quiros J. T., Lima Pinto F., Nunez OSullivan S., Ramos Jimenez F. A., Perez Ortega A., Trujillo Barbadillo A., Romero Pujana E., Fernandez Illera M. V., De La Llave Serralvo A., Mestres N., Cuello E., Merichal M., Sierra J. E., Escoll J., Rufas M., Pinillos A. I., Ortega J., Vivas Angeles P., Vives Figueras R., Baena Sanfeliu E., Campillo Alonso B., Alberich Prats M., Duran Arrocha J., Cornella Garceso N., Uribe Galeano C., Delisau Puig O., Castro A., Codony Bassols C., Fernandes N., Garcia Adamez J., Caula Freixa C., Sanchez M. J., Martin-Borregon P., Quevedo A., Martinez J., Marin J. M., Rodriguez P., Garcia Orozco J. J., Ferrusola Diaz D. A., Garcia Jimenez M. L., Castro Diez L., Mosquera Fernandez C., Alonso Batanero E., Cifrian Canales I., Calzada M. G., Recuenco C. B., Martin M. C., Esteban Avendano I., Jimenez Relimpio C., Lancho Lavilla P., Blanco Bartolome I., Gomez Cano I., Blasco Andres C., Alonso-Poza A., Dieguez B., Losada M., Gilsanz C., Garcia-Vico A., Roman-Rando A., Sanchez-Galvez M. A., Bersabe-Alonso I. M., Vadillo-Bohorquez A., Gutierrez Rios R. D., Eizaguirre Ubegun M., Novo Sukia I., Uribe Isado M., Ibanez Alda M., Pastor Idoate C., Abad-Motos A., Marinez-Hurtado E., Salvachua-Fernandez R., Padilla Zegarra E. D., Franco M., Martinez A., Ramos Martin P., Mate Mate P., Marcano Chavez C., Ayllon H., Jeri-McFarlane S., Soldevila-Verdeguer C., Pineno-Flores C., Ambrona-Zafra D., Fernandez-Vega L., Gil-Catalan A., Craus-Miguel A., Pujol-Cano N., Sena-Ruiz F., Gomez Jurado M. J., Alberti Delgado P., Bordanova Reverter A., Belzunce-Capo J. F., Verdaguer Tremolosa M., Lin Q., Muniesa C., Avelino L., Cholewa H., Sancho-Muriel J., Navasquillo M., Navio A., Abello D., De Jesus M., Alvarez E., Garcia J. M., Gil A., Giordano H. E., Mignon G., Vanoni A., Henkens A., Jarrar G., Odovic M., Willemin M., Milliet O., Hahnloser D., Demartines N., Teixeira H., Pittet O., Haller M. L., Huot A., Kefleyesus A., Bugmann A., Piotet L. M., Meijers L., Kurtoglu G. K., Sel E. K., Isler V. C., Yilmaz B. S., Adiyaman C., Kara M., Demirkaya H. C., Korkmaz H. K., Pektas A. M., Guner B., Islek E. C., Tombul H. B., Boztug C. Y., Tinaz A., Yilmaz M., Karaman Y., Akin F. A., Dansuk S., Bascavus M., Kaya M., Kutlu B., Seker M. C., Erten V., Memis U., Kocak Z. B., Karapinar Y. E., Fakirullahoglu M., Koseoglu E., Yeni M., Aykun N., Agca M. H., Bilen C., Kilinc I., Atar C., Kilic V., Aktuna C., Aba M., Alim Y. E., Binbuga M., Kurklu O., Ceylan C., Yilmaz S., Calar S. N., Yildirim N., Yavuz G., Can B., Cesmeli E., Kus D., Kavar R. C., Cevlik A. D., Cengiz U., Turk E. G., Yilmaz I., Erdonmez H., Gursoy F., Kara H., Onsal U., Ozbek M., Kasar P. A., Ipor A., Ozen D., Olmez M., Altintas E., Toklu R., Saricicek T., Tipi O. U., Benli G. E., Tasdelen I., Tura A., Ucar A., Ekci B., Bilgili A. C., Kiraz I. N., Aksoy H., Basak A., Erdem M., Kayacan S., Sahin C., Uysal M., Karakus K., Altiner S., Demirci Z. S., Eren E., Yavas M., Aksoy A. B., Karagoz E., Sabanci R., Tumer S. S., Kargici K., Banaz T., Abdulrahman S. M. F., Yesilsancak M., Yanikoglu E., Karabulut A., Yilmaz D., Kuyumcu O. F., Kutluk F., Emiroglu B., Mollavelioglu B., Gereklioglu D., Guler M., Toprak S., Afsar H. B., Guler S. E., Alizade E., Alemdag G., Ulusahin M., Gul E. B., Yildirim R., Semiz A., Bektur G., Tomas K., Yarenci E., Demiroglu Y., Sunal A., Baykan B., Abbasguliyev H., Mutlu V., Mahmoudi Y., Dossa S. A. A., Mizan S. R., Demirtas B., Cavus T., Yuksek A., Mazlum S. S., Yelkenci C., Baran T., Satilmisoglu M., Sahin A. Z., Kilinc A., Isik K., Yumurtaci O., Emin A., Girit C., Yildirak M. K., Senyigit E., Guldag A., Soyleyici B., Aytin Y. E., Akay F. E., Iskan N. G., Mutlu B., Sunay A. O., Tie-Gill T., Ramsay G., De Paola L., McGuckin S., Alshakhs A., Ahmeidat A., Goergen N., Ali Z., Mullarkey L., Walshe R., Lewis E., Berry B., Moneim J., Mookerjee S., Christy S., Ojofeitimi O., Carroll L., Hylands A., Delaugere L. P., Reveendran D., Coulter C., Ralston C., Laverty L., Gallagher P., Ahmed A., Yeo Y. Q., Elliott D., Bennett J., Mcnamara M., Sivarajah S., Dunmore C., Aitken G., Nair M., Aly M. 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L., McCusker C., Hlukha L., Pike G., Kamel F., Thakkar R., Donaldson C., Sequeira Campos M., Armitage M. N., Hussain A. S., Hardy B., Hassan Serry M. Y., Bradbury M., Osunronbi T., Tam L. Y. C., Khanan Kaabneh A., Lawther J., Fisher P., Tribedi T., Moosa A., Ramdin A., Goble M., Downs E., Wheldon L., Baggus E., Mandal A., Nayeem A., Ahmed S., Fradley W., Wilson C., Gallagher S., Criswell T., Ward J., Mukkavilli A., Stubbs B., Fordyce W., Suchdev N., Wei Lim S., Sookramanien S. R., Chan A., Bointas G., Paul M., Ward K. L., Bagnall M., Pherwani S. A., Wang K., Mitchell L., Heyworth J., Ayyar S., Polson R., Mackenzie E., Doyle N., Habib Z., Zardab M., Sartaj F., Farooq H., Tabibi M., Drury D. J., James S. J., Barnett R., Teasdale A. B., Richardson E. T. J., Thomas D. A., Williams R. L., Najabat-Lattif H. F., Cahya E., Lou G., Coyle M., Homyer K., Zhu L. Y., Woods M., Chang J., O'Callaghan H., Suchett-Kaye I., Mihailidis T. H., Alawattegama H., Seite E., Barrett A., Riordan E., Lam W., Dowdeswell M., Mulvenna C., Awokoya O., Gurowich L., Dhera K., Hayat S., Tincknell L., Spazzapan M., Teeling F., Sysum K., Latter J., Latter M., Khan S., Guruswamy M., Beedham W., Brazier E., Elghobashy M., Bajaj M., Mann H., Etel E., Woodmass M., Hayden H., Ali Y., Husain S., Arnold A., Pedersen A. C., Cunha P., Ahmed M., Al Zawawi S., Kudva V., Theodoropoulou K., Miscampbell M., Robinson A. V., Johnston J., Dharni A., Lamb S., Westerman T., Evans E., Campbell L., Gillespie M., Cheong C. M., Kulathevanayagam K., Varghese A., Ike S. I., Chu T. S. M., Baljer B., Mogg J. A. W., Rai P., Claireaux H. A., Williams M., Smillie R., Goetz J., Appleby E., Fadipe T., Vaughan-Burleigh S., Puri G., Hussain P., Flather R., Cutler A., Pathak S., Sheldon J., Collicott T., al-Ausi M., Jovaisaite A., Shah S. M., Khalid N., Gutmann D., Davison S., Alame Y. J., Syed L., Owen W. J., Ahsan S. D., Anthony-Uzoeto U., Macleod Hall C., Zheng S., Wynter K., James C., Sapre D., Ghosh R., Baird J., Cockburn L., Blackwood O., Simpson W., Jeong S., Bishop S., Bate R., Hobson C., Adam A. H., Redclift C., Do J., Adeleye O., Poli F., Batterham A., Brown S., Parekh J. N., Clay W., Pieri K., Jackson A., Saxena A., Gurung B., Oyebola T., O'Brien F., Djeugam B., Gardezi S., Ul-Hasan S., Martin-Hernandez M. P., Sisley M., Modi S., Antakia R., Elbayouk A., Soh Y. J., Mather J., Yusuf Z., Al-Sarraf Z., Naja M., Rassool S. B., Convill J., Nikookam Y., Warsame A., Pace C., Kiandee M., Ridwan R., Carey C., Hirri F., McMillan M. J. A., Ling J. J., Pendelbury L., Kerimzade K., Tang A., Howard E. O., Humayun S., Wadsworth O. J., Tan K., Abdelhameed F., Haglund C., Radnaeva I., Hu N., Rambhatla S., Waldron D., Madahar P., Malik S., Meney L. C., Ibrahim I., Kang C. K., Chiu J. Z. J., Livie V., Ibrahim B., Khalil M., Pooley G., Shishkin B., Docherty J., Southgate A., Coomes A., McGee F., Flanagan S., Tan Q. J., Anwar H., Clough R., Chrisp B., Cassels J., Cross G. W. V., Mercer L., Mercer C., Refalo A., Hadley R., McTighe A., Farrow F., Brodie A., Davis G., Shah D. R., Bowers C., Patel S., Morice O., Burzic A., Cheung J., Shashidhara A., Theodoraki G., Birk J., Ong A., Ng M. P. E., Wong R. T. W., Maese S., Yeap B., Iqbal Z., Rojoa D. M., Cabaleiro Barciela C., Ruddy C. M., Lindwe S., Qamar Y., Chuita S., Melaugh T., Hall J. D., Kouli O., Hassane A. S. I., Azhar A. W., Tan T. K., Perchard W., Scurr T., Campbell E., Kelk L., Ghosh A., Gibbins A., Mala D., Loizidou A., Hall O., Mecia L., Hew C., Varathan K., Tong L., Chandrasekar B., Buchanan E., O'Connell M., Kwak S. Y., Ong E. 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T., Wynell-Mayow W., Udayachandran V., Alsoof D., Ekert J., Joseph N., Zulkefley N., Hunt G., Christodoulou T., Wright O., Soman S., Jamal M., Beqiri S., Borgas P., Christie S., Pereira F., Browne S., Yiu J., Dworkin A., Brayley J., Palmer A., Charalambos M., Jones C. S., Toner S., Cowden R., Lee L., Nicol P., Holman O., Imtiaz M., Albert V., Leung S. P., Erotocritou M., Stroud R., Wilkin R., Thomson W., Mackee L., G N., Bei Y., Mckenna Favier S., Ibrahim A., Kler A., Reynolds L., Mohamed S. H., Majeed Y., Fakim B., Jones A., Liversedge G., Carrington Z., Windebank J., Izzarina A., Akbani U., Craven J., Aldarragi A., Harding S., Millward A., Bedford M., Gopalan V., Midgen A., Khadka P., Cheng O., Taneja S., Manobharath N., Kok J. Y., Lim D. W. E., Buick T., Boland M., Piya S., Devlin R., Fairfield C. J., George R. J., Rahi M., Zaman S., Hajiev S., Ross T., Crisp E., Thompson C., Charalambous A., Hollywood J. L., Hammond R. F. L., Matthews J., Mendonca V., Spinty J., Khan K., Cheng J., Glynn N., Muhammad U., Khan M., Anderson L., Mccormack K., Mak J., Patrawala S., Milinkovic N., Schofield R., Chauhan M., Hartley L., Hind J., Nelson L., Ratnasingham D., Whitehead T., Dimitriadis S., Marshall K., Flint E. J., Horner C., Heybourne A., Morgan H., Wickstone C., Panagiotou D., O'Connell E., Dean K., Iqbal R., Walsh L., Yu N., Rana N., Massie E., Ng J., Jung M., Lee Y. D., Harris M., White S., Boev B., Tonchev P., Prochazka V., Skalicky A., Ravn S., Ojakaar A., Dorr-Harim C., Koutserimpas C., Giraudo G., Armellini A., Ruzzenente A., Mazzeo C., De Padua C., Realis Luc A., Maroli A., Giani I., Cufari M. E., Vitali M., Gusai G. P., Quattromani R., Virgilio E., Berti S., Di Mola Ospedale SS Annunziata F. F., Papagni V., Tuminello F., Vittori L., Longheu A., Loche G. A., Braccio B., De Luca E., Resta G., Ancans G., Tamosiunas A., Petrulionis M., Andrejevic P., Stellingwerf M. E., Abdulrahman N., van de Pas K. G. H., Thomas G., Brandsma A. M., Davids J., Rottier S. J., de Roy van Zuidewijn D., Hawkins R., Ong H. I., Li Y., Desmond B., Winstanley J., Martins M., Americano M., Frade S., Senhorinho R., Peixoto R., Alves-Vale C., Lamas M., O'Connor D. B., Hoo M., Gopaul A., Scanlon K., O'Dwyer N., Jovanovic M., Panyko A., Van Vuuren S., Centeno A., Bernado I. R., Paniagua Garcia Senorans M., Gonzalez Amor L., Cuenca Ramirez A., Abrisqueta J., Estaire Gomez M., Arroyo A., Cerdan C., Gomez Romeu N., Enriquez-Navascues J. M., Collado-Roura F., Curchod P., Gaspar S., Imadalou L., Mutlu D., Akyol C., Uygur F. A., Eray I. C., Biyiklioglu O., Cetin M. F., Isik A. E., Karip B., Dogan H., Sarigul L., Tunc E., Aydin T., Bodur S., Karabulut K., Francis A. A., Al-hadithi A., To N., Lau I. S. F., Smith E., Mahapatra S., McAuliffe O., Imam L., Akram B., Hossaini S., Davies R., Ko M., Collins J., Pandya A., Reilly S., Archer J., Auty C., Roche C. D., Livie J., Chaudhry F. A., Ntakomyti E., Diallo R., Bylinski T., Wright J., Masiha E., Tung J., Shirazi B., Neilson A., Epton S., Patel N., Trussell S., Couldrey A., Donnelly C., Eftychiou S., Glasbey J.C., Bibi S., Pata F., Ozkan B.B., Van Straten S., Hodson J., Chapman S.J., Blanco-Colino R., Pellino G., Sgro A., Soares A., van Elst T., Nepogodiev D., Borakati A., Bath M.F., Yasin I.H., Mclean K., Arthur T., Kovacevic M., Delibegovic S., Karamanliev M., Swamad M., Zebrak R., Paramasivam R., Martensen A., Larsen H.M., Radeker L., Frey P.E., Kechagias A., Venara A., Duchalais E., Ioannidis A., Pasquali S., Simioni A., Farina V., Podda M., Lorenzon L., ItSURG I., Schaeff V., Otto A., Jakubauskas M., van Elst T.R., Chu M., Fagan P.V.B., Wells C.I., Alagoa Joao A., Juloski J., Perez-Ajates S., Anabitarte Bautista O., El Kasmy Y., Espin-Basany E., Clerc D., Ciubotaru C., Popescu S., Yanishev A., Lee S., Yagiz Sen A., Aktas M.K., Baki B.E., Yuksek B., Kamarajah S., Khaw R.A., Mills E., Goodson R., Thakral N., Collaborative S., Ablett A.D., Adra M., Kwek I., Khan S.M., Quinn P., Manley L.R., Badran A., Ramjeeawon A., Campbell A., Tan H.L., Rye D.S., Rajaraman N., Norman J.G., Vutipongsatorn K., Solomou G., Akhbari M., Ali A., Murray V., Baker D.M., Brandao B.D., Stainer B., Thavayogan R., Jones D., Onafowokan O.O., Gharooni A., Dabab N., Carlton-Carew S., Kungwengwe G., Gabriel M., Sewart E., Shortland T.C., Lawday S., Pockney P., Dawson A., Brumfitt C.D., Stewart P., Ng B., Luong J.K., Ivanov V., Borisova A., Neykov V., Kuncarova K., Kolosova B., Antonova T., Farkasova M., Harbjerg J.L., Brandsborg S., Brinck S., Kjaer M.D., Mark-Christensen A., Unbehaun K.P., Dalsgaard P., Lycke K.D., LeNaoures P., Brigand C., Dumange E., Gout M., Moehwald C., Prem M., Alhalabi O., Sliwinski S., Krupp J., Gablenz E., Schmitzer L., Kopp A., Steinle J., Gsenger J., Pohl L.J., Riccardi M., Christodoulou I.M., Konstantinidis M., Machairas N., Zoikas A., Balalis D., Manatakis D.K., Aguilera M.L., Marano L., Fleres F., Lovisetto F., Sasia D., Segalini E., Pata G., Lucchi A., Sagnotta A., Campagnaro T., Petrelli F., Gallo G., Papandrea M., Testa V., Sinibaldi G., Di Candido F., Colombo F., Perrone G., Biancafarina A., Canonico G., Pagnanelli M., Curletti G., Bini R., de Manzoni Garberini A., Impellizzeri H., Cillara N., Tutino R., Picciariello A., Coletta D., Savino G., Ferrara F., Tamini N., Talamo G., Parini D., Giamundo P., lo Conte A., Pagano G., Ripetti V., Pesce A., Menduni N., Giudicissi R., Goldin E., Rega D., Belli A., Andriola V., Gordini L., Foppa C., Piccolo G., Birindelli A., Ferrari C., Ballarini Z., Tirelli F., Milone M., De Rosa M., Pipitone Federico N.S., Molteni B., Tilocca P.L., Sancini G., Piozzi G.N., Lauretta A., Poillucci G., Mulas S., Simcikas D., Portelli L., van Wijnbergen J.W.M., Dinger T.L., ten Doesschate S.F.H., van Dalen A.S.H.M., van den Bos D.D., Hansmann M., Medina Feliz J., Kuiper S.Z., Abdulrahman Z., Pruijssers S.R., Farik S., Elliott B.M., Geneta V.P., Wilton S., Kandelaki H., Peng S.L., Campbell S., Lim Y.K., Yassaie S.S., Murray M., Haran C., Tan J., Castro J., Laranjeira A., Catarino S., Neves-Marques C., Correia J.G., Vieira B.N., Quintela A.C., Serra M.L., Maciel J., Cunha M., Aparicio D.J., Neves J., Azevedo J., Romano M., Eiro F., Romano J., Monteiro C., Claro M., Almeida M.R., Peyroteo M., Machado N.D., Capote H., Ferreira M., Sousa X., Devesa H., Cavadas D., Guerreiro I., Costa M., Rosete M., Salman M., English C., Mohammed N., Litvin A., Cuk V.V., Meszarosova K., Jaich R., De Lima H., Brooks S., Marx M., Nshalati Salvation M., Garcia Cardo J., Mora-Guzman I., Sancho Muriel J., de Andres Olabarria U., Muriel P., Jimenez Vinas C., Alconchel F., Esteban Sinovas O., Gomez del Pulgar A., Fairen Oro C., Lopez Otero M., Figueroa Jimenez S., Claramonte Bellmunt O., Martinez Caballero J., Rubio-Perez I., Aguilar-Martinez M.M., Segura-Sampedro J.J., Olmedo Moreno C., Negre Parra D., Estevez Diz A.M., Martin-Balbuena R., Bustamante Recuenco C., Licardie Bolanos R.E., Fernandez P., Diaz Padillo A., Forero-Torres A., Alberdi San Roman I., Salvador Roses H., Merayo Alvarez M., Villarejo Campos P., Lopes Moreira C.C., Uriol Peralta P., Serrano Navidad M., Ripolles-Melchor J., Garcea A., Gomez Facundo H., Troncoso Pereira P., V Perez Guarinos C., Blaser B., Piazza G., Gagliardi B., Serin H., Yurdaor S.S., Arslan E., Kopac O., Uyanik A., Ozmen B.B., Tiftik E., Aksoy B., Yalcinkaya A., Ozoglu F., Kocer M.D., Bilicen G., Cinar E.N., Uslu O., Kaya Y., Demirci K., Wong J., Farhan-Alanie M.M.H., Suresh G., Asif A., Finch B.J., Bhahirathan Y., Herron J., Yi Tew Z., Obukofe R., Russell C., Suchett-Kay I., Netke T., Williams L., Kisiel A., Liu F.Y., Claireaux H., James P., Mondal A., Kalderon R., Nadama H.H., Al-Saraff Z., Tam J.P.H., Powell-Chandler A., Wood F., Gorgievska R., Ragavoodoo A., Thakrar C., Rojoa D., Palmer C., Davidson K., Giacci L., Hale J., Gan F.W., Makin-Taylor R., Hey C.Y., Toh C., Findlay J.M., Griffiths N., Ganesananthan S., Jasionowska S., Poustie M., Wong C., Turner T., Pyc W., Sloper W., Warner C., Coey J., Mason D., Sait S., Kowal M., Owen M., Saiyed A., Ashworth I., Akbari K., Curran M., Martin P., Parker D., Kwok K., Lye C., Ghaly M., Sammour T., Lewis D., Mundasad R., Wilkes A., Ctercteko G., Maslyankov S., Dimov R., Iliev S., Dimitrov D., Marek F., Orhalmi J., Skalicky P., Skalicky T., Chrz K., Christensen P., Worsoe J., Kristensen E.S., Emmertsen K.J., Loeve U.S., Mihaljevic A.L., Herrle F., Konstantinidis K.M., Korkolis D., Karanikas I., Vincenti L., Anania G., Borghi F., Agresta F., Maretto I., Parisi A., Bucci L., De Palma G., Guglielmi A., Cucinotta E., La Torre F., Cianchi F., Guerrieri M., Trompetto M., Persiani R., Micheletto G., Delrio P., Cantafio S., Ronconi M., Bisagni P.A.G., De Prizio M., Franceschi A., Galleano R., Cavallini M., Brescia A., D'Ambra L., Benevento A., Niolu P., Calgaro M., Colangelo E., Grottola T., Altomare D.F., Puleo S., Salamone G., Pietrabissa A., Poggioli G., Erdas E., Ottonello R., Tonini V., Selvaggi F., Sammarco G., Ceccarelli G., De Nisco C., Surgo D., Taglietti L., Ozolins A., Sivins A., Poskus T., Psaila J., Bemelman W.A., Graat L.J., Langenhoff B., Wijnhoven B.P.L., van de Ven A.H.W., Poelman M., Stassen L.P.S., Slooter G., Acherman Y.I.Z., Hoff C., Gerhards M.F., Stommel M.W.J., Hazebroek E.J., van Geloven A.A.W., Schasfoort R.A., van Leeuwen B.L., Tuynman J.B., van Tilburg M.W.A., Boerma E.G., Sharma P., Jenkins B., Bissett I.P., Herd A., Gordon A., Vernon D., Omundsen M., Ly J., Reddy A., Bonnet G., Harmston C., Morales M., Francisco V., Costa S., Manso A., Amorim E., Pereira J., Cardoso J., Ouro S., Caratao M., Nascimento C., Ribeiro da Silva B., Taranu V., Dias R., Mendes J., Allen M., Silva A., Carlos S., Barbosa E., Carneiro C., Ramos L., Lencastre L., Martins R., Silva-Vaz P., Ridgway P.F., McNamara D.A., Cahill R., Hogan A., Larkin J., O'Connell P.R., Negoi I., Abelevich A., Cuk V.M., Vician M., Ede C., Sardiwalla I., Mulira S., Montwedi D., Oyomno M., Sabia D., Portugal Porras V., Vigorita V., Sanz Ortega G., Garcia J., Espi Macias A., Blanco Antona F., Lujan Mompean J.A., Salvans Ruiz S., Villarejo-Campos P., Romero Simo M., Sanchez-Guillen L., Jimenez-Gomez L.M., Sanchez Lopez A., Golda T., Julia Bergkvist D., Nevado C., Noguera Aguilar J.F., cRicardo Felipe B., Septiem J., Rodriguez Sanchez A., Canete-Gomez J., Ruiz Montesinos I., Millan-Scheiding M., Prieto-Nieto I., Frasson M., Garcia Olmo D., Hubner M., Petermann D., Sauvain M.O., Ozben V., Gecim I.E., Disci E., Rencuzogullari A., Kurt A., Bisgin T., Pehlivan M., Isik A., Onur E., Leventoglu S., Haksal M.C., Erturk M.S., Keskin M., Guner A., Tutcu Sahin S., Ozbalci G.S., Pergel A., Albayrak D., Bruce D., Fearnhead N., Arthur J., Harron M., Beattie G., Titu L., Saunders M., Phillips J., Dindyal S., Cresswell B., Gercek Y., Lee J., Linn T., Faulkner G., Lockwood S., Rees J., Charalabopoulos A., Campbell B., Kontovounisios C., Amarnath T., Johnson M., Epanomeritakis E., Vigs S., Nastro P., Gilliam A., Smolarek S., Wilson T., Orbell J., McIntyre R., Agarwal T., Hainsworth P., Patel P., Vijay J., Liu B., Dhruva Rao P., Roxburgh C., Vipond M., Youssef H., Thorn C., Schizas A., Denley S., Bowley D., Das K., Cuming T., Saha A., Chung L., Pitt J., Davis P., Jones O., Taylor M., Bhargava A., Haji A., Watson N., Bloom I., Singh B., Norwood M., Gurjar S., Stylianides N., Mirza S., Evans M., Williams G., Patil P., Hernon J., Finch G., Green S., Chapple K., Fafemi O., Warusavitarne J., Samee A., Carden C., Ong L., Verma K., Joseph A., Rawat N., Pinkney T., Oke O., Glen P., Maxwell-Armstrong C., Oliphant R., Garner J., Moug S.J., Middleton S., Lund J.N., Smart N.J., Osborn G., Moore T., Raymond T., Knowles C.H., Hany T.S., Clarke R., Khera G., Brady R., Sellahewa C., Mason C., Torrance A., Lasithiotakis K., Knight J., Pullybank A., Ainsworth P., Reid F., Ramwell A., Maslekar S., George R., Skull A., Holtham S., 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E., Ciccioli E., Galgano A., Zuin M., Bettella A., Barina A., Vendramin E., Palano G., Schiavone D., Di Cintio A., Gemini A., Trastulli S., De Luca M., Desiderio J., Gubbiotti F., Cigognini M., Zaffaroni G., Maffioli A., Colombo S., Bondurri A., Sampietro G., Foschi D., Manigrasso M., Danzi M., Amato R., Anastasio L., Mastella F., Basile R., Peltrini R., Marra E., Luglio G., Giglio M., Anoldo P., Vertaldi S., Grimaldi L., Tammaro N., Pedrazzani C., Turri G., Lazzarini E., Conti C., Vulcano I., Bertilone E., Pintabona G., Viscosi F., Cerasari S., Galiffa G., Lapolla P., Del Basso C., Cirillo B., De Toma G., Fazzi K., Bini S., Coratti F., Montanelli P., Grandi S., Nelli T., Ben Khaled N., Cammelli F., Ferrini E., Billo M.E., Marrosu A.G., Scognamillo F., Pala C., Attene F., Carboni L., Ruggiu M.W., Gabbas G., Marziali I., Mazzocato S., Vergari R., Piazzai F., Kubolli I., Aggiusti A., Paolucci A., Ortenzi M., Olivieri M., Belluco C., Antona A.D., Basso S., Morino M., Mistrangelo M., 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F., Sysum K., Latter J., Latter M., Khan S., Guruswamy M., Beedham W., Brazier E., Elghobashy M., Bajaj M., Mann H., Etel E., Woodmass M., Hayden H., Ali Y., Husain S., Arnold A., Pedersen A.C., Cunha P., Ahmed M., Al Zawawi S., Kudva V., Theodoropoulou K., Miscampbell M., Robinson A.V., Johnston J., Dharni A., Lamb S., Westerman T., Evans E., Campbell L., Gillespie M., Cheong C.M., Kulathevanayagam K., Varghese A., Ike S.I., Chu T.S.M., Baljer B., Mogg J.A.W., Rai P., Claireaux H.A., Williams M., Smillie R., Goetz J., Appleby E., Fadipe T., Vaughan-Burleigh S., Puri G., Hussain P., Flather R., Cutler A., Pathak S., Sheldon J., Collicott T., al-Ausi M., Jovaisaite A., Shah S.M., Khalid N., Gutmann D., Davison S., Alame Y.J., Syed L., Owen W.J., Ahsan S.D., Anthony-Uzoeto U., Macleod Hall C., Zheng S., Wynter K., James C., Sapre D., Ghosh R., Baird J., Cockburn L., Blackwood O., Simpson W., Jeong S., Bishop S., Bate R., Hobson C., Adam A.H., Redclift C., Do J., Adeleye O., Poli F., Batterham A., Brown S., Parekh J.N., Clay W., Pieri K., Jackson A., Saxena A., Gurung B., Oyebola T., O'Brien F., Djeugam B., Gardezi S., Ul-Hasan S., Martin-Hernandez M.P., Sisley M., Modi S., Antakia R., Elbayouk A., Soh Y.J., Mather J., Yusuf Z., Al-Sarraf Z., Naja M., Rassool S.B., Convill J., Nikookam Y., Warsame A., Pace C., Kiandee M., Ridwan R., Carey C., Hirri F., McMillan M.J.A., Ling J.J., Pendelbury L., Kerimzade K., Tang A., Howard E.O., Humayun S., Wadsworth O.J., Tan K., Abdelhameed F., Haglund C., Radnaeva I., Hu N., Rambhatla S., Waldron D., Madahar P., Malik S., Meney L.C., Ibrahim I., Kang C.K., Chiu J.Z.J., Livie V., Ibrahim B., Khalil M., Pooley G., Shishkin B., Docherty J., Southgate A., Coomes A., McGee F., Flanagan S., Tan Q.J., Anwar H., Clough R., Chrisp B., Cassels J., Cross G.W.V., Mercer L., Mercer C., Refalo A., Hadley R., McTighe A., Farrow F., Brodie A., Davis G., Shah D.R., Bowers C., Patel S., Morice O., Burzic A., Cheung J., Shashidhara A., Theodoraki G., Birk J., Ong A., Ng M.P.E., Wong R.T.W., Maese S., Yeap B., Iqbal Z., Rojoa D.M., Cabaleiro Barciela C., Ruddy C.M., Lindwe S., Qamar Y., Chuita S., Melaugh T., Hall J.D., Kouli O., Hassane A.S.I., Azhar A.W., Tan T.K., Perchard W., Scurr T., Campbell E., Kelk L., Ghosh A., Gibbins A., Mala D., Loizidou A., Hall O., Mecia L., Hew C., Varathan K., Tong L., Chandrasekar B., Buchanan E., O'Connell M., Kwak S.Y., Ong E.H., Gardner S., Lim J., Maden C., Illahi M., Xuan Tan Z., Stahl R., Stahl J., Hickman A., Collett D., Goolam-Mahomed Z., Allen B., Atiyah A., Ahmad H., Jones J., McGregor O., Ogundiya E., Boulbadaoui A., Kirnon-Jackman O., Lim Q.X., Peckham H., Yeoh T., Yong S.Q., Chen J.Y., Siva S., Sam Z.H., Gilani M., Goh Y.N., Muthukumar M.G., Phillips S., Tjoakarfa J., Giri A., Suresan S., Thomas P., Johnson T.A., Williams R.I., Rashid A., Kushairi A., Rais A., James A., Bugelli M., Chechelnitskaya Y., Sandhu N., Tandon R., Gray M., Kumar A., Ciurleo C., Nyamali I., Hiremath S., Sinha S., Chowdhary M., Bradley E., McTiernan M., Macdonald S., Sharkey S., McLaughlin N., Amey C., Kraria L., Skan O., Kind C., Tupper P., Van Rhee C., Honeyman S.I., Menon G., Jegatheeswaran L., Madhavan A., Warne M., Malcolm F.L., Lessware T., Wilkerson H.T., Chatterjee-Woolman S., Yoong A., Ahmed W.U.R., Longshaw A., Flannery O., Green R., Leaning M., Cragg J., Sharriff H., Doherty C., Kwan K.W.L., Sanders-Crook L., Bhatia S., Eames S., Lewis F., Kirupananthan P., Boh Z.Y., Dass S., Soma A., Newton A., Hill M., Shafiq Y., Brkljac M., Boyce L., English W.J., Lam S., Chipeta C., Jain C., Garofalidou T., Novotny S.A., Locke S., Bowman C., Begaj A., Murphy C., Radcliffe K., Chong J.T., Jeffrey E., Chaudhury N., Rajendran K., Akbar Z., Walters B., Kulendrarajah B., Tran N., Shrestha S., Parmar S., Gallagher C., Hennessy L., Pentti E., Badhrinarayanan S., Fung A., Mansoor M., Kenny R., Kan P., Lee D.E., Khosla S., Samake M., Shaban F., Aftab R., Gough M., Woodburn B., Vayalapra S., McMurrugh K., Jimulia D., Deol S., Pike S., Embury-Young Y., Patel M., Kilgallon E., Keating R., Walsh A., Khan H., Logue G., Orekoya M., Alasmar M., Charalambides M., Clave Llavall A., Williamson E., Bharwada Y., Zearmal S., Evans H., Panikkar M., de la Cruz G., Caplan J., Ruparelia A., Tanvir T., Soare C., Pang Y.L., Trotter J., Zaidi A., Thakrar V., Pulickal P., Ahmed H., Parnell J., Lennock S., Ford V., Brignall R., O'Neill D., Hanna R., Kane R., Nicola M., Rajput K., Xiao Y., Michael S., Wright E., Juniper S., Thompson E., Hoskyns L., Kanitkar A., Ross C., Unsworth A., Rshaidat H., Demarre K., Chiang A., Bareh A., van Dellen J., Faqihinejad C., Gadhvi A., Grant R., Lewsey J., Morris A., Martin H., McClarty C., Sanyal S., Alsaif A., Palkhi A., Bhopal S., Vishnu K S., Papanikolaou A., Mitra A., Nur A., Ali F., Burford C., Huq T., Irwin E., Matthews L., Ngu W.S., Hosfield T., Muneeb F., Page O., Zeb E., Al-Azzawi A., McIntosh J., Vucicevic A., Hughes M., Brooks L., Fanibi B., Dixon M., Njoku P., Morris D., Jobson J., Chowdhury H., Alawode D.O.T., Wynell-Mayow W., Udayachandran V., Alsoof D., Ekert J., Joseph N., Zulkefley N., Hunt G., Christodoulou T., Wright O., Soman S., Jamal M., Beqiri S., Borgas P., Christie S., Pereira F., Browne S., Yiu J., Dworkin A., Brayley J., Palmer A., Charalambos M., Jones C.S., Toner S., Cowden R., Lee L., Nicol P., Holman O., Imtiaz M., Albert V., Leung S.P., Erotocritou M., Stroud R., Wilkin R., Thomson W., Mackee L., G N., Bei Y., Mckenna Favier S., Ibrahim A., Kler A., Reynolds L., Mohamed S.H., Majeed Y., Fakim B., Jones A., Liversedge G., Carrington Z., Windebank J., Izzarina A., Akbani U., Craven J., Aldarragi A., Harding S., Millward A., Bedford M., Gopalan V., Midgen A., Khadka P., Cheng O., Taneja S., Manobharath N., Kok J.Y., Lim D.W.E., Buick T., Boland M., Piya S., Devlin R., Fairfield C.J., George R.J., Rahi M., Zaman S., Hajiev S., Ross T., Crisp E., Thompson C., Charalambous A., Hollywood J.L., Hammond R.F.L., 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Brandsma A.M., Davids J., Rottier S.J., de Roy van Zuidewijn D., Hawkins R., Ong H.I., Li Y., Desmond B., Winstanley J., Martins M., Americano M., Frade S., Senhorinho R., Peixoto R., Alves-Vale C., Lamas M., O'Connor D.B., Hoo M., Gopaul A., Scanlon K., O'Dwyer N., Jovanovic M., Panyko A., Van Vuuren S., Centeno A., Bernado I.R., Paniagua Garcia Senorans M., Gonzalez Amor L., Cuenca Ramirez A., Abrisqueta J., Estaire Gomez M., Arroyo A., Cerdan C., Gomez Romeu N., Enriquez-Navascues J.M., Collado-Roura F., Curchod P., Gaspar S., Imadalou L., Mutlu D., Akyol C., Uygur F.A., Eray I.C., Biyiklioglu O., Cetin M.F., Isik A.E., Karip B., Dogan H., Sarigul L., Tunc E., Aydin T., Bodur S., Karabulut K., Francis A.A., Al-hadithi A., To N., Lau I.S.F., Smith E., Mahapatra S., McAuliffe O., Imam L., Akram B., Hossaini S., Davies R., Ko M., Collins J., Pandya A., Reilly S., Archer J., Auty C., Roche C.D., Livie J., Chaudhry F.A., Ntakomyti E., Diallo R., Bylinski T., Wright J., Masiha E., Tung 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D., Hansmann, M., Medina Feliz, J., Kuiper, S. Z., Abdulrahman, Z., Pruijssers, S. R., Farik, S., Elliott, B. M., Geneta, V. P., Wilton, S., Kandelaki, H., Peng, S. L., Campbell, S., Lim, Y. K., Yassaie, S. S., Murray, M., Haran, C., Tan, J., Castro, J., Laranjeira, A., Catarino, S., Neves-Marques, C., Correia, J. G., Vieira, B. N., Quintela, A. C., Serra, M. L., Maciel, J., Cunha, M., Aparicio, D. J., Neves, J., Azevedo, J., Romano, M., Eiro, F., Romano, J., Monteiro, C., Claro, M., Almeida, M. R., Peyroteo, M., Machado, N. D., Capote, H., Ferreira, M., Sousa, X., Devesa, H., Cavadas, D., Guerreiro, I., Costa, M., Rosete, M., Salman, M., English, C., Mohammed, N., Litvin, A., Cuk, V. 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Hlaváčová, L., Tomanová, D., Novický, R., Sobotková, K., Šuta Kimle, K., Paclík, A., Jürgens-Lahnstein, J., Kristensen, F.P., Bønnerup, K., Højgaard Pedersen, J., Jepsen, B.N., Hillgaard, T.K., Erichsen, S.B., Nielsen, C.V., Madsen, C.P., Skejø, C.D., Aabling, R.R., Sørensen, J.S., Schöning, L., Cs Simon, S., Thäwel, T., Seckler, A.M., Athanasopoulos, P.G., Giuffrida, M.C., Billo, M.E., Marrosu, A.G., Ruggiu, M.W., Antona, A.D., Bitonti, M.F., Romano, F.M., Pellicanò, G.A., Murru, M.L., Angelucci, G.P., Tenconi, S.M., Mura, F.A., Ruggiu, G.V., Mura, G.A., Perrone, B.A., Esposito, L.M., Marcianò, M., Milani, M.S., Aru, A.C., Figà, F., Truškovs, A., Machatschek, M.J., Wiemann, A.M., Müller, N.L., Samalavicius, N.E., Poškus, E., Kryžauskas, M., Poškus, T., Looijen, R.C., Becker, M., Te Molder, L., Tissen, Y.M., de Vries, H.S., van Smaalen, T.C., Veen, O.C., Dingemans, S.A., van den Brink, L.C., Vijgen, G., van de Voort, E., van Rest, K., Sluijpers, N., Molenaar, C., Gordinou de Gouberville, M.C., Mens, M.A., Hoeks, E.M., van Praag, E.M., Smit, M., van der Lely, S.J., Stijns, R., Leow, T., Aarts, C., Tulek, M.S., Alqethami, H.J., van Elst, P.C., Tissink, M.W., Grüter, A., Voeten, D.M., Boon, C.L., Franssen, R., Jense, M., Lau, W.K., Adams, S., Chen, S.Y., Kim, D.H., McLaughlin, S., Chapman, D.A., McIntosh, N.D., Yam, S.T., Tomé, M., Santos, T.C., Lages, R.R., Sá, T.C., Bernardes, F.M., Cunha, M.F., Veiga, D.N., Loureiro, A.R., Torre, A.P., Paixão, I., Rocha, A.F., Jervis, M.J., Paixão, V., Silva, A.G., Galvão, D., Mónica, I., Guimarães, N., Martins, S.F., Patrício, J., Cinza, A.M., Simões, J., Gonçalves, J.P., Guimarães, J., Martins, A.R., Ferreira, A.S., Lérias, R., Bártolo, J., Correia, A.M., Martins, P.C., Jardim, J., Domingos, S.P., Baião, J.M., Rocha, B.S., Lopes, N., Jordão, D.M., Ângelo, M.D., Caroço, T., Gomes, J.R., Monteiro, R.G., McCaughey, C., Colon, L.F., Dockry, É., Aly, A.K., McPhedran, R., Kang, S.J., Pentony, A.R., Piong, C.L., Eow, S.Y., Kamath, P.J., Soh, T., Dyer, A.H., Chee, S.Y., Tan, I., McCawley, N., Jones, M.R., Popescu, S.S., Ciubotaru, C.I., Radulović, R., Miloševic, K., Bojičić, J., Genčić, M., Janković, U., Sucháň, P.K., Dubovský, M., Sautter, S.C., McDuling, C.R., Mana, O.C., Vicente Rodríguez, I., Jiménez Escovar, F., Calvo Fernández, M., Portugal Martínez, A., Del Pozo Andrés, E., Samartín Toimil, C., Primo Álvarez, J.C., Ossola, M.E., Martínez Illán, M., Aranda García, L., Lázaro Cardona, M., Livianos Arias-Camisón, P., Nieto Arranz, J.M., Mateos Sexmero, M.J., Liquete Marín, L., Pérez Calle, M., Ramos Cordero, M.J., Sánchez, E., Martínez Díaz, J.M., Ruiz Manzanera, J.J., Navarro Barrios, Á., Rodríguez Pedreño, L., García Moreno, P., García Gómez, M., Rifà Terricabras, S., Alberch Camprubí, E., Rico Ferrández, M., De Pablo Miró, M., Cañete-Manzanares, J., García Hernández, L.C., Orozco Nuñez, S., Soriano Liébana, M.M., Campo Betancourth, C.F., Bosch Ramírez, M., Ramayo Díaz, N., González Caraballo, I., Orue-Echebarria, M.I., Sánchez-Calvo, L., Morales Bernaldo de Quirós, J.T., Núñez O Sullivan, S., Ramos Jiménez, F.A., Pérez Ortega, A., Fernandez Illera, M.V., Sierra, J.E., Pinillos, A.I., Cornellà Garceso, N., García Ádamez, J., Sánchez, M.J., Martín-Borregón, P., Martínez, J., Marín, J.M., Rodríguez, P., Garcia Orozco, J.J., Ferrusola Diaz, D.A., Garcia Jimenez, M.L., Cifrián Canales, I., Calzada, M.G., Recuenco, C.B., Martin, M.C., Esteban Avendaño, I., Jiménez Relimpio, C., Blanco Bartolomé, I., Gómez Cano, I., Blasco Andrés, C., García-Vico, A., Sánchez-Gálvez, M.Á., Bersabe-Alonso, I.M., Gutierrez Rios, R.D., Ibañez Alda, M., Marínez-Hurtado, E., Salvachua-Fernández, R., Padilla Zegarra, E.D., Jerí-McFarlane, S., Pineño-Flores, C., Fernández-Vega, L., Gil-Catalán, A., Gómez Jurado, M.J., Belzunce-Capó, J.F., Navío, A., Abelló, D., Garcia, J.M., Giordano, H.E., Haller, M.L., Piotet, L.M., Kurtoglu, G.K., Sel, E.K., Isler, V.C., Yilmaz, B.S., Demirkaya, H.C., Korkmaz, H.K., Pektas, A.M., Güner, B., İşlek, E.C., Tombul, H.B., Boztuğ, C.Y., Tınaz, A., Yılmaz, M., Akın, F.A., Başçavuş, M., Seker, M.C., Koçak, Z.B., Karapinar, Y.E., Köseoglu, E., Agca, M.H., Alim, Y.E., Kürklü, Ö., Çalar, S.N., Kavar, R.C., Cevlik, A.D., Turk, E.G., Erdönmez, H., Gürsoy, F., Önsal, U., Özbek, M., Kasar, P.A., Özen, D., Ölmez, M., Sariçiçek, T., Tipi, O.U., Benli, G.E., Bilgili, A.C., Kiraz, I.N., Demirci, Z.S., Aksoy, A.B., Karagöz, E., Tümer, S.S., Abdulrahman, S., Kuyumcu, O.F., Afsar, H.B., Guler, S.E., Gul, E.B., Dossa, S., Mizan, S.R., Mazlum, S.S., Sahin, A.Z., Kilinç, A., Yumurtaci, Ö., Girit, Ç., Yildirak, M.K., Güldag, A., Söyleyici, B., Aytin, Y.E., Akay, F.E., Iskan, N.G., Sunay, A.O., McGuckin, S., Delaugere, L.P., Yeo, Y.Q., Aly, M.H., Bin Amran, M.A., Kyaw, H.A., Clements, J.M., Wong, H.L., McCusker, C., Armitage, M.N., Hussain, A.S., Hassan Serry, M.Y., Tam, L., Sookramanien, S.R., Ward, K.L., Pherwani, S.A., Drury, D.J., James, S.J., Teasdale, A.B., Richardson, E., Thomas, D.A., Williams, R.L., Najabat-Lattif, H.F., Zhu, L.Y., Mihailidis, T.H., Pedersen, A.C., Robinson, A.V., Cheong, C.M., Ike, S.I., Chu, T., Mogg, J., Claireaux, H.A., Al-Ausi, M., Shah, S.M., Alame, Y.J., Owen, W.J., Ahsan, S.D., Adam, A.H., Parekh, J.N., Martin-Hernandez, M.P., Soh, Y.J., Rassool, S.B., McMillan, M., Ling, J.J., Howard, E.O., Wadsworth, O.J., Meney, L.C., Kang, C.K., Chiu, J., McGee, F., Tan, Q.J., Cross, G., McTighe, A., Shah, D.R., Ng, M., Wong, R., Rojoa, D.M., Ruddy, C.M., Hall, J.D., Hassane, A., Azhar, A.W., Tan, T.K., Kwak, S.Y., Ong, E.H., McGregor, O., Lim, Q.X., Yong, S.Q., Chen, J.Y., Sam, Z.H., Goh, Y.N., Muthukumar, M.G., Johnson, T.A., Williams, R.I., McTiernan, M., McLaughlin, N., Honeyman, S.I., Malcolm, F.L., Wilkerson, H.T., Ahmed, W., Kwan, K., Boh, Z.Y., English, W.J., Novotny, S.A., Chong, J.T., Lee, D.E., McMurrugh, K., Clavé Llavall, A., Pang, Y.L., McClarty, C., Ngu, W.S., McIntosh, J., Alawode, D., Jones, C.S., Leung, S.P., Mohamed, S.H., Kok, J.Y., Lim, D., Fairfield, C.J., George, R.J., Hollywood, J.L., Hammond, R., Flint, E.J., Lee, Y.D., Skalický, A., Ojakäär, A., Dörr-Harim, C., Cufari, M.E., Gusai, G.P., Di Mola Ospedale Ss Annunziata, F.F., Loche, G.A., Stellingwerf, M.E., van de Pas, K., Brandsma, A.M., Rottier, S.J., Ong, H.I., O'Connor, D.B., Jovanović, M., Bernado, I.R., Paniagua Garcia Señorans, M., González Amor, L., Cuenca Ramírez, A., Cerdán, C., Gómez Romeu, N., Enriquez-Navascues, J.M., Uygur, F.A., Eray, I.C., Çetin, M.F., Isik, A.E., Sarıgül, L., Francis, A.A., Al-Hadithi, A., Lau, I., McAuliffe, O., Roche, C.D., Chaudhry, F.A., Amsterdam Gastroenterology Endocrinology Metabolism, Other Research, Graduate School, Surgery, Oncology, AII - Infectious diseases, and ACS - Microcirculation
Subjects: medicine.medical_specialty, endocrine system, general surgery, Gastrointestinal, endocrine system diseases, Settore MED/18 - CHIRURGIA GENERALE, pulmonary complications, 03 medical and health sciences, 0302 clinical medicine, Ileus, Nasogastric tube insertion, Medicine, pulmonary complication, pneumonia, EPIDEMIOLOGY, Humans, Prospective Studies, colorectal surgery, nasogastric tube, Prospective cohort study, Intubation, Gastrointestinal, OUTCOMES, VENTILATOR-ASSOCIATED PNEUMONIA, business.industry, Elective Surgical Procedures, Pneumonia, Confounding, Gastroenterology, nutritional and metabolic diseases, Odds ratio, Postoperative pneumonia, medicine.disease, Colorectal surgery, Surgery, body regions, Intubation, Gastrointestinal/adverse effects, Pneumonia/epidemiology, Pneumonia/etiology, Pneumonia/prevention & control, 030220 oncology & carcinogenesis, Vomiting, 030211 gastroenterology & hepatology, medicine.symptom, business, Intubation, hormones, hormone substitutes, and hormone antagonists
Abstract: © 2020 The Association of Coloproctology of Great Britain and IrelandAim: Aspiration is a common cause of pneumonia in patients with postoperative ileus. Insertion of a nasogastric tube (NGT) is often performed, but this can be distressing. The aim of this study was to determine whether the timing of NGT insertion after surgery (before versus after vomiting) was associated with reduced rates of pneumonia in patients undergoing elective colorectal surgery. Method: This was a preplanned secondary analysis of a multicentre, prospective cohort study. Patients undergoing elective colorectal surgery between January 2018 and April 2018 were eligible. Those receiving a NGT were divided into three groups, based on the timing of the insertion: routine NGT (inserted at the time of surgery), prophylactic NGT (inserted after surgery but before vomiting) and reactive NGT (inserted after surgery and after vomiting). The primary outcome was the development of pneumonia within 30 days of surgery, which was compared between the prophylactic and reactive NGT groups using multivariable regression analysis. Results: A total of 4715 patients were included in the analysis and 1536 (32.6%) received a NGT. These were classified as routine in 926 (60.3%), reactive in 461 (30.0%) and prophylactic in 149 (9.7%). Two hundred patients (4.2%) developed pneumonia (no NGT 2.7%; routine NGT 5.2%; reactive NGT 10.6%; prophylactic NGT 11.4%). After adjustment for confounding factors, no significant difference in pneumonia rates was detected between the prophylactic and reactive NGT groups (odds ratio 1.03, 95% CI 0.56–1.87, P = 0.932). Conclusion: In patients who required the insertion of a NGT after surgery, prophylactic insertion was not associated with fewer cases of pneumonia within 30 days of surgery compared with reactive insertion.
Published: 2020
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17. Transanal total mesorectal excision and adverse conditions for laparoscopic total mesorectal excision

Author: María Labalde Martínez, Francisco Javier García Borda, Juan Alcalde Escribano, Eduardo Ferrero Herrero, Felipe de la Cruz Vigo, Eduardo Rubio González, Pablo Peláez Torres, Oscar García Villar, and Cristina Nevado García
Subjects: medicine.medical_specialty, Colorectal cancer, business.industry, medicine.medical_treatment, Rectum, Vascular surgery, medicine.disease, Total mesorectal excision, Surgery, Cardiac surgery, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, 030220 oncology & carcinogenesis, medicine, 030211 gastroenterology & hepatology, business, Pathological, Neoadjuvant therapy, Abdominal surgery
Abstract: Transanal total mesorectal excision (TaTME) is an alternative technique for rectal surgery that could facilitate the mobilization and the distal transection of the rectum. Our objective was to analyze whether the presence of factors affecting the difficulty of laparoscopic total mesorectal excision (TME) could affect surgical and oncological outcomes of TaTME for mid and low rectal cancer. 20 patients (13 male, 7 female) with a mean age of 66.5 years (range 55.5–75.7) and mid–low rectal cancer were prospectively submitted to TaTME. Every TaTME procedure was performed by two teams of experienced surgeons working simultaneously. Adverse conditions for laparoscopic TME were considered to be male gender, obesity, benign prostatic hypertrophy, low rectal cancer, pT3-T4, tumor size >5 cm, and neoadjuvant therapy. These factors were matched to surgical (morbidity, operative time, conversion rate) and pathological (quality of mesorectum, circumferential resection margin) outcomes. Male gender was associated with longer operative time (285 vs. 240 min, p = 0.031). There were no significant associations among the rest of the analyzed factors complicating laparoscopic TME and pathological and surgical outcomes of TaTME. Multivariate analysis showed that male gender was independently associated with operative time (β = 0.18 OR 1.019 CI95%:1.001–1.037; p = 0.042). TaTME seems to be more difficult in males but not in obesity, benign prostatic hypertrophy, low rectal cancer, pT3-T4, tumor size >5 cm, or neoadjuvant therapy. TaTME could be considered an alternative surgery for low rectal cancer in the presence of these factors affecting laparoscopic TME.
Published: 2020
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18. Palliative Sedation in Patients Hospitalized in Internal Medicine Departments

Author: Jesús Díez-Manglano, Soledad Isasi de Isasmendi Pérez, Rosa García Fenoll, Luis Ángel Sánchez, Françesc Formiga, Vicente Giner Galvañ, Carlos Dueñas, Bernardino Roca, Cristina Estrada Díaz, Emilio Casariego Vales, Marta Rubio Gómez, Magdalena Martín Pérez, Luis Felipe Díez García, Ignacio Vallejo Maroto, Cristina Ocaña Losada, Susana Moya Roldán, Catalina Díaz Pérez, Javier Caballero Granado, Resfa María García Font, Francisco J. Jódar Lorente, Gloria Pérez Vázquez, Ana belén Ferro Expósito, María Luisa Amaya González, Fernando Gamboa Antiñolo, Álvaro González Molina, Mercedes Gómez Hernández, Marcos Guzmán García, Lola Benítez León, Lorena Montero Rivas, María Ruiz Mariscal, Noelia Gómez Aguirre, María Pilar González García, Isabel Martín Algora, María Carmen Bueno Castel, Fernando Ruiz Laiglesia, Esperanza Bejarano Tello, José Luis Cabrerizo García, Nuria Guiral Fernández, Luis Camera, Carla Gauna, Pedro Abad Requejo, Rocío Martínez Gutiérrez, Rebeca Fernández Regueiro, María Teresa Sánchez Vidal, Joaquín Alfonso Mejido, Enrique García Carús, Carmen Elena Calvo Rodríguez, Paula Martínez García, Sixto Ruiz Olivares, María Isabel Fullana Barcelo, Carmen González Arencibia, Rosa Ros Vilamajó, María José Monedero Prieto, Concepción González Becerra, Sofía Pérez, Andrea Martín Plata, Raquel Portilla Chocarro, Carlos Dueñas Gutiérrez, Francisco Estrada Álvarez, Sonia Peña Balbuena, Raúl Rodríguez Galindo, Marta María Cobos Siles, Luis Ángel Sánchez Muñoz, Ana Castañón López, Celia Sanz Lobo, María Montserrat Chimeno Viñas, María Ángeles Contreras Uriel, Judit Gil Domínguez, Francisco Medrano González, José Manuel Machín Lázaro, Jeffrey Magallanes Gamboa, Mónica Rodríguez Galdeano, Joaquín Castro Giménez, José Ramón Barberá Farré, Raquel Núñez Aragón, Ferrán Masanés Torán, José Barbé, Elena Güell Farré, Olga Torres Bonafonte, Ana lozano Miñana, Desirée Moras Sarabia, Rosa Pérez, Dolors Arnau i Fernández, Francesc Formiga, Javier Fernández Fernández, Antoni Castro Salomó, Rami Qanneta, María Victoria Pardo Ortega, Yasmina Monterroso Pintado, Montserrat García Cors, María Cruz Almendros Rivas, Dolors Domingo Albin, Jaume Roig Morera, Nuria Galofré Álvaro, Aythami Toro Parodi, Mario Loureiro Sánchez, Carla de la Guerra Acebal, Javier Zubizarreta García, Iasone Benavente Claveras, Juan Martí Cabanes, Ignacio Sanz Lázaro, José Barquero Romero, Leticia Nevado López-Alegría, José Carlos Arévalo Lorido, Ana María Lorenzo Vizcaya, Cristina Macía Rodríguez, Silvia Pérez Fernández, Pascual Sesma Sánchez, María Dolores Jiménez-Beatty, Laura González Vázquez, Ángel Brea Hernando, Jesús Castiella Herrero, María Isabel González Anglada, Virginia M. Gracia Lorenzo, Alejandro Pérez Martín, Gerardo García Melcón, María Gómez Antúnez, María Angustias Quesada Simón, Fuensanta Gil Gil, María Asenjo Martínez, Lourdes Mancebo Aragoneses, Jorge Calderón Parra, María del Carmen Romero Pérez, José Curbelo García, Fernando Laguna Cuesta, María Eugenia Segovia Abad, María Fontecha Ortega, Guillermina Lara Martínez, Ana Pinos Blanco, Raquel Rodil Fraile, Elisabel Martínez Litago, Aitziber Echeverría Echeverría, Manuel Priego Valladares, Carlos Trescoli Serrano, Josep Vicente Mas, Óscar Torregrosa Suau, Eva Gil Tomás, Rafael Castillo Rubio, José Manuel Murcia Zaragoza, Pilar Román Sánchez, Ana García Herola, Pedro Pablo Tenllado Doblas, Julio César Blázquez Encinar, Enrique Castellano Vela, Néstor Carrizo, Bernardino Manuel Roca Villanueva, Francisco Pasquau Liaño, and José María Pascual Izuel
Subjects: Clinical audit, medicine.medical_specialty, Palliative care, Argentina, Context (language use), Palliative sedation, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, Internal medicine, Terminal care, Humans, Hypnotics and Sedatives, Medicine, In patient, 030212 general & internal medicine, General Nursing, Retrospective Studies, Terminal Care, business.industry, Palliative Care, Odds ratio, Cross-Sectional Studies, Anesthesiology and Pain Medicine, Spain, 030220 oncology & carcinogenesis, Observational study, Neurology (clinical), business
Abstract: Palliative sedation is used to relieve end-of-life refractory symptoms.The objective of this study was to describe the use of palliative sedation in patients who die in internal medicine departments.An observational, cross-sectional, retrospective, and multicenter clinical audit study was conducted in 145 hospitals in Spain and Argentina. Each hospital included the first 10 patients who died in the internal medicine department, starting on December 1, 2015.We included 1447 patients, and palliative sedation was administered to 701 patients (48.4%). Having a terminal illness (odds ratio [OR] 2.469, 95% CI 1.971-3.093, P 0.001) and the length of hospital stay (OR 1.011, 95% CI 1.002-1.021, P = 0.017) were independently associated with the use of palliative sedation. Consent was granted by the families of 582 (83%) patients. The most common refractory symptom was dyspnea, and the most commonly used drugs for sedation were midazolam (77%) and morphine (89.7%). An induction dose was administered in 25.7% of the patients. Rescue doses were scheduled for 70% of the patients, and hydration was maintained in 49.5%. Pain was more common in patients with cancer, whereas dyspnea was more common in those without cancer. Rescue doses were used more often for the patients with cancer (77.8% vs. 67.7%, P = 0.015). Monitoring the palliative sedation with a scale was more frequent in the patients with cancer (23.7% vs. 14.3%, P = 0.008).Palliative sedation is used more often for terminal patients. There are differences in the administration of palliative sedation between patients with and without cancer.
Published: 2020
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19. Targeting Galectin-1 by Aflibercept Strongly Enhances Its Antitumor Effect in Neuroendocrine Carcinomas

Author: Marlid Cruz-Ramos, María Jesús Fernández-Aceñero, María Rodríguez-Remírez, Sonia Solanes, Jesús García-Foncillas, Laura García-García, Elena Molina-Roldán, Laura del Puerto-Nevado, and Arancha Cebrián
Subjects: medicine.medical_specialty, Epithelial-Mesenchymal Transition, Stromal cell, Galectin 1, Recombinant Fusion Proteins, Endocrinology, Diabetes and Metabolism, Mice, Nude, Angiogenesis Inhibitors, 030209 endocrinology & metabolism, 030218 nuclear medicine & medical imaging, Extracellular matrix, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Endocrinology, Cell Movement, Cell Line, Tumor, Internal medicine, medicine, Extracellular, Animals, Humans, Fibroblast, Aflibercept, Lung, Endocrine and Autonomic Systems, business.industry, Cancer, medicine.disease, Vascular Endothelial Growth Factor Receptor-2, digestive system diseases, Carcinoma, Neuroendocrine, Receptors, Vascular Endothelial Growth Factor, medicine.anatomical_structure, Galectin-1, Cancer research, business, medicine.drug
Abstract: Background: Galectin-1 (Gal-1) plays major roles in cancer by modulating different processes leading to tumor development and progression. In the last years, it has been suggested as a promising target for anticancer therapy. Recently, aflibercept has shown high affinity for Gal-1. Here, we investigated how aflibercept could exert its antitumor activity via Gal-1-driven pathways in neuroendocrine carcinomas (NECs). Methods and Results: NEC tumor xenografts were used to assess the effect of aflibercept on Gal-1 functions. Aflibercept induced a significant reduction of Gal-1 at epithelial, stromal, and extracellular localizations in lung NEC, whereas this was not observed in colon NECs, which displayed low expression of Gal-1. Additionally, aflibercept significantly reduced p-VEGFR2 protein, extracellular matrix remodeling, epithelial-mesenchymal transition, and activation of cancer-associated fibroblast hampering cell invasion in lung NEC but not in colon NEC. Gal-1 screening in human NECs confirmed that pulmonary and pancreatic tumors displayed higher levels of Gal-1 than colon NECs, becoming good candidates to benefit from aflibercept treatment. Conclusions: The lack of validated predictive markers of aflibercept is a weakness for guaranteeing the best treatment management with this drug. This work provides new mechanistic insight of aflibercept depending on Gal-1. Thus, in tumors overexpressing Gal-1, aflibercept has not only an antiangiogenic effect but also prevents Gal-1-mediated tumor-stroma cross talk. The stronger aflibercept effect in tumors with high levels of Gal-1 points out this protein as a molecular marker to predict the efficacy of this agent not only for NECs but also for other tumors with high levels of this protein.
Published: 2020
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20. Genetic variants in dopamine pathways affect personality dimensions displayed by patients with eating disorders

Author: Luz M. González, Guillermo Gervasini, Estefanía López-Nevado, Sonia Mota-Zamorano, and Angustias García-Herráiz
Subjects: medicine.medical_specialty, Anorexia Nervosa, Dopamine, Feeding and Eating Disorders, Dopamine receptor D3, Binge-eating disorder, Internal medicine, medicine, Humans, Bulimia Nervosa, Dopamine transporter, biology, Bulimia nervosa, business.industry, Receptors, Dopamine D3, medicine.disease, Psychiatry and Mental health, Clinical Psychology, Eating disorders, Anorexia nervosa (differential diagnoses), Dopamine receptor, Cohort, biology.protein, Female, business, Personality
Abstract: We aimed to analyze the association between common polymorphisms in dopamine pathways with personality dimensions frequently present in patients with eating disorders (ED). A total of 324 patients [210 with anorexia nervosa (AN), 80 with bulimia nervosa (BN) and 34 with binge-eating disorder (BED)] were diagnosed according to DSM-5 criteria and interviewed using the EDI 2 and SCL-90R questionnaires at the eating disorders unit. Blood samples were drawn and the DNA screened for polymorphisms in dopamine receptor genes (DRD2 A2/A1 and DRD3 Ser9Gly) and in the dopamine transporter DAT1 10R/9R. AN patients who carried the DRD3 Gly9Gly genotype displayed significantly higher EDI-2 total scores than patients with the Ser9 allele (118.09 ± 8.75 vs. 97.23 ± 2.73, p = 0.010). In these patients, Gly9Gly carriers also showed higher scores in all the individuals’ EDI-2 scales. Differences were especially relevant for bulimia (p = 0.004), ineffectiveness (p = 0.044), interpersonal distrust (p = 0.037), interoceptive awareness (p = 0.006) and maturity fears (p = 0.038). Epistasis analyses showed a strong effect of the interaction between DRD3 Ser9Gly and DRD2 A2A1 on the bulimia (p
Published: 2019
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21. International meeting on Wolf‐Hirschhorn syndrome: Update on the nosology and new insights on the pathogenic mechanisms for seizures and growth delay

Author: Nevado, J., K. S., Ho, Zollino, Marcella, Blanco, R., Cobaleda, C., Golzio, C., Beaudry-Bellefeuille, I., Berrocoso, S., Limeres, J., Barruz, P., Serrano-Martin, C., Cafiero, C., Malaga, I., Marangi, Giuseppe, Campos-Sanchez, E., Moriyon-Iglesias, T., Marquez, S., Markham, L., Twede, H., Lortz, A., Olson, L., Sheng, X., Weng, C., Wassman, E. R., Newcomb, T., Carey, J. C., Battaglia, A., Lopez-Granados, E., Douglas, D., and Lapunzina, P.
Subjects: 0301 basic medicine, Nosology, medicine.medical_specialty, hepatoadenomas, 030105 genetics & heredity, 4p, Settore MED/03 - GENETICA MEDICA, medicine.disease, University hospital, 03 medical and health sciences, 030104 developmental biology, antiepileptic drugs, seizures, WHS, Family medicine, Genetics, medicine, Psychology, Wolf–Hirschhorn syndrome, Genetics (clinical), Panel discussion, Theme (narrative)
Abstract: "An International Meeting on Wolf-Hirschhorn Syndrome (WHS)" was held at The University Hospital La Paz in Madrid, Spain (October 13-14, 2017). One hundred and twenty-five people, including physicians, scientists and affected families, attended the meeting. Parent and patient advocates from the Spanish Association of WHS opened the meeting with a panel discussion to set the stage regarding their hopes and expectations for therapeutic advances. In keeping with the theme on therapeutic development, the sessions followed a progression from description of the phenotype and definition of therapeutic endpoints, to definition of genomic changes. These proceedings will review the major points of discussion.
Published: 2019
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22. Further delineation of neuropsychiatric findings in Tatton-Brown-Rahman syndrome due to disease-causing variants in DNMT3A: seven new patients

Author: Mario Solís, Bardón Rivera Mb, Jair Tenorio, Salvador Climent, Pablo Lapunzina, Pablo Alarcón, Gisela Teixido-Tura, Fermina López Grondona, Victor L. Ruiz-Perez, Antonio Martinez Monseny, Juan C. Cigudosa, Mercedes Serrano, Eduardo F. Tizzano, Sara Alvarez, Irene Valenzuela, Gema Gordo, Sergio Ramos, Fernando Santos-Simarro, Fernández Jaén A, Julián Nevado, Palomares Bralo M, Sixto García-Miñaur, Irene Dapía, Jaime Campistol, Alicia Hernández, Pedro Arias, Javier Botet, Instituto de Salud Carlos III, and European Commission
Subjects: Adult, Male, medicine.medical_specialty, Adolescent, Disease, Bioinformatics, Article, DNA Methyltransferase 3A, 03 medical and health sciences, Intellectual Disability, Genetics research, Intellectual disability, Genetics, medicine, Humans, DNA (Cytosine-5-)-Methyltransferases, Child, Growth Disorders, Genetics (clinical), Cerebral atrophy, 0303 health sciences, business.industry, Medical genetics, 030305 genetics & heredity, Macrocephaly, Syndrome, Middle Aged, medicine.disease, Phenotype, Psychotic Disorders, Schizophrenia, Overgrowth syndrome, Mutation, Female, Differential diagnosis, medicine.symptom, business
Abstract: Tatton-Brown-Rahman (TBRS) syndrome is a recently described overgrowth syndrome caused by loss of function variants in the DNMT3A gene. This gene encodes for a DNA methyltransferase 3 alpha, which is involved in epigenetic regulation, especially during embryonic development. Somatic variants in DNMT3A have been widely studied in different types of tumors, including acute myeloid leukemia, hematopoietic, and lymphoid cancers. Germline gain-of-function variants in this gene have been recently implicated in microcephalic dwarfism. Common clinical features of patients with TBRS include tall stature, macrocephaly, intellectual disability (ID), and a distinctive facial appearance. Differential diagnosis of TBRS comprises Sotos, Weaver, and Malan Syndromes. The majority of these disorders present other clinical features with a high clinical overlap, making necessary a molecular confirmation of the clinical diagnosis. We here describe seven new patients with variants in DNMT3A, four of them with neuropsychiatric disorders, including schizophrenia and psychotic behavior. In addition, one of the patients has developed a brain tumor in adulthood. This patient has also cerebral atrophy, aggressive behavior, ID, and abnormal facial features. Clinical evaluation of this group of patients should include a complete neuropsychiatric assessment together with psychological support in order to detect and manage abnormal behaviors such as aggressiveness, impulsivity, and attention deficit-hyperactivity disorder. TBRS should be suspected in patients with overgrowth, ID, tall stature, and macrocephaly, who also have some neuropsychiatric disorders without any genetic defects in the commonest overgrowth disorders. Molecular confirmation in these patients is mandatory., This project was supported by ISCII, FEDER funds grant: FIS-PI15/01481.
Published: 2019
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23. A homozygous mutation in the highly conserved Tyr60 of the mature IGF1 peptide broadens the spectrum of IGF1 deficiency

Author: Pablo Lapunzina-Badía, Sabina Domene, Angel Campos Barros, Hector Jasper, Julia F Castro, Laura Ramirez, Ayelen Martin, Claudia Arberas, Barbara Casali, Julián Nevado Blanco, María Gabriela Ropelato, Estefania Landi, Debora Braslavsky, Ignacio Bergadá, Patricia Pennisi, Romina Armando, Ana Keselman, María Gabriela Ballerini, Mariana Gutierrez, Rodolfo Rey, Paula Scaglia, Graciela Del Rey, Horacio M. Domené, Nora Sanguineti, and Hamilton Cassinelli
Subjects: endocrine system, medicine.medical_specialty, Microcephaly, Endocrinology, Diabetes and Metabolism, IGFBP3, Intrauterine growth restriction, 030209 endocrinology & metabolism, General Medicine, Gene mutation, Biology, medicine.disease, Short stature, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, 030220 oncology & carcinogenesis, Internal medicine, medicine, Small for gestational age, Missense mutation, medicine.symptom, hormones, hormone substitutes, and hormone antagonists, SNP array
Abstract: Background IGF1 is a key factor in fetal and postnatal growth. To date, only three homozygous IGF1 gene defects leading to complete or partial loss of IGF1 activity have been reported in three short patients born small for gestational age. We describe the fourth patient with severe short stature presenting a novel homozygous IGF1 gene mutation. Results We report a boy born from consanguineous parents at 40 weeks of gestational age with intrauterine growth restriction and severe postnatal growth failure. Physical examination revealed proportionate short stature, microcephaly, facial dysmorphism, bilateral sensorineural deafness and mild global developmental delay. Basal growth hormone (GH) fluctuated from 0.2 to 29 ng/mL, while IGF1 levels ranged from −1.15 to 2.95 SDS. IGFBP3 was normal-high. SNP array delimited chromosomal regions of homozygosity, including 12q23.2 where IGF1 is located. IGF1 screening by HRM revealed a homozygous missense variant NM_000618.4(IGF1):c.322T>C, p.(Tyr108His). The change of the highly conserved Tyr60 in the mature IGF1 peptide was consistently predicted as pathogenic by multiple bioinformatic tools. Tyr60 has been described to be critical for IGF1 interaction with type 1 IGF receptor (IGF1R). In vitro, HEK293T cells showed a marked reduction of IGF1R phosphorylation after stimulation with serum from the patient as compared to sera from age-matched controls. Mutant IGF1 was also less efficient in inducing cell growth. Conclusion The present report broadens the spectrum of clinical and biochemical presentation of homozygous IGF1 defects and underscores the variability these patients may present depending on the IGF/IGF1R pathway activity.
Published: 2019
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24. Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay

Author: Isabelle Bos, Henrik Zetterberg, Daniel Alcolea, Gwendoline Peyratout, B. Paul Morgan, Susan Baker, Simon Lovestone, Liu Shi, Fabian Kilpert, Lars Bertram, Shengjun Hong, Ellen Elisa De Roeck, Alberto Lleó, Mikel Tainta, Pablo Martinez-Lage, Kaj Blennow, Alison L. Baird, Olivier Blin, Lorena Rami, José Luis Molinuevo, Kristel Sleegers, Yvonne Freund-Levi, Lutz Frölich, Angharad R. Morgan, Pieter Jelle Visser, Rik Vandenberghe, Philip Scheltens, Silvy Gabel, Charlotte E. Teunissen, Petronella Kettunen, Julius Popp, Jill C. Richardson, Noel J. Buckley, Stephanie J. B. Vos, Abdul Hye, Johannes Streffer, Sarah Westwood, Nicholas J. Ashton, Valerija Dobricic, Alejo J. Nevado-Holgado, Magda Tsolaki, Giovanni B. Frisoni, Andre Franke, Frans R.J. Verhey, Sebastiaan Engelborghs, Mara ten Kate, Régis Bordet, Cristina Legido-Quigley, Laura Winchester, Anders Wallin, Karen Meersmans, Frederik Barkhof, Peter Johannsen, University of Oxford, Universität zu Lübeck = University of Lübeck [Lübeck], Christian-Albrechts University of Kiel, King‘s College London, University of Gothenburg (GU), Cardiff University, Maastricht University [Maastricht], VU University Medical Center [Amsterdam], University Hospitals Leuven [Leuven], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Vrije Universiteit Brussel (VUB), University of Antwerp (UA), Université de Genève = University of Geneva (UNIGE), Istituto Centro San Giovanni di Dio Fatebenefratelli, Partenaires INRAE, Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance Publique - Hôpitaux de Marseille (APHM), GlaxoSmithKline [Stevenage, UK] (GSK), GlaxoSmithKline [Headquarters, London, UK] (GSK), CHU Lille, Université de Lille, Hospital Clinic (IDIBAPS), Universitat Pompeu Fabra [Barcelona] (UPF), Sahlgrenska Academy at University of Gothenburg [Göteborg], AHEPA University General Hospital [Thessaloniki], Hospital de la Santa Creu i Sant Pau, Lausanne University Hospital, Geneva University Hospital (HUG), Center for Research and Advanced Therapies CITA-Alzheimer Foundation [San Sebastián], Copenhagen University Hospital, Amsterdam UMC - Amsterdam University Medical Center, Vrije Universiteit Amsterdam [Amsterdam] (VU), Karolinska Institutet [Stockholm], Örebro University, Universität Heidelberg [Heidelberg] = Heidelberg University, Institutes of Neurology and Healthcare Engineering, UCL, London, Sahlgrenska University Hospital [Gothenburg], UCL, Institute of Neurology [London], Janssen Research & Development, University of Oslo (UiO), Neurology, Radiology and nuclear medicine, Amsterdam Neuroscience - Neurodegeneration, Clinical chemistry, Faculty of Arts and Philosophy, Clinical sciences, Educational Science, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Psychiatrie & Neuropsychologie, Promovendi MHN, and MUMC+: MA Med Staf Spec Psychiatrie (9)
Subjects: 0301 basic medicine, Apolipoprotein E, Male, Proteomics, Neurology, Epidemiology, Apolipoprotein E4, Disease, SOMAscan assay, ddc:616.89, BLOOD-BASED BIOMARKERS, 0302 clinical medicine, CASCADE HYPOTHESIS, MARKERS, Tau, Medicine, Biomarker discovery, DRUG, Medicine(all), Health Policy, Age Factors, Brain, Middle Aged, Blood proteins, 3. Good health, Europe, ALZHEIMERS-DISEASE, Psychiatry and Mental health, MENDELIAN RANDOMIZATION, Biomarker (medicine), Female, Life Sciences & Biomedicine, medicine.medical_specialty, Amyloid, MODELS, Clinical Neurology, Replication, Plasma proteomics, Computational biology, Article, SIGNALING PATHWAYS, 03 medical and health sciences, Cellular and Molecular Neuroscience, AGE, Developmental Neuroscience, Alzheimer Disease, Amyloid β, Causal relationship, Mendelian randomization, Humans, Biology, Aged, Science & Technology, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, Amyloid beta, 030104 developmental biology, Neurology (clinical), Human medicine, Neurosciences & Neurology, Geriatrics and Gerontology, TAU, business, 030217 neurology & neurosurgery, Biomarkers
Abstract: Plasma proteins have been widely studied as candidate biomarkers to predict brain amyloid deposition to increase recruitment efficiency in secondary prevention clinical trials for Alzheimer's disease. Most such biomarker studies are targeted to specific proteins or are biased toward high abundant proteins. 4001 plasma proteins were measured in two groups of participants (discovery group = 516, replication group = 365) selected from the European Medical Information Framework for Alzheimer's disease Multimodal Biomarker Discovery study, all of whom had measures of amyloid. A panel of proteins (n = 44), along with age and apolipoprotein E (APOE) ε4, predicted brain amyloid deposition with good performance in both the discovery group (area under the curve = 0.78) and the replication group (area under the curve = 0.68). Furthermore, a causal relationship between amyloid and tau was confirmed by Mendelian randomization. The results suggest that high-dimensional plasma protein testing could be a useful and reproducible approach for measuring brain amyloid deposition. This research was conducted as part of the EMIF-AD project, which has received support from the Innovative Medicines Initiative Joint Undertaking under EMIF grant agreement no. 115372, resources of which are composed of financial contribution from the European Union’s Seventh Framework Program (FP7/2007-2013), and EFPIA companies’ in-kind contribution. The DESCRIPA study was funded by the European Commission within the 5th framework program (QLRT-2001-2455). The EDAR study was funded by the European Commission within the 5th framework program (contract # 37670). The Leuven cohort was funded by the Stichting voor Alzheimer Onderzoek (grant numbers #11020, #13007, and #15005). R.V. is a senior clinical investigator of the Flemish Research Foundation (FWO). J.S. is currently an employee of UCB, Braine-l’Alleud, Belgium. The San Sebastian GAP study is partially funded by the Department of Health of the Basque Government (allocation 17.0.1.08.12.0000.2.454.01.41142.001.H). The authors acknowledge the contribution of the personnel of the Genomic Service Facility at the VIB-U Antwerp Center for Molecular Neurology. The research at VIBCMN is funded in part by the University of Antwerp Research Fund. F.B. is supported by the NIHR biomedical research centre at UCLH. L.S. is funded by DPUK through MRC (grant no. MR/L023784/2) and the UK Medical Research Council Award to the University of Oxford (grant no. MC_PC_17215).
Published: 2019
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25. Strong Antitumor Activity of Bevacizumab and Aflibercept in Neuroendocrine Carcinomas: In-Depth Preclinical Study

Author: Laura del Puerto-Nevado, María Jesús Fernández Aceñero, María Rodríguez-Remírez, Jesús García-Foncillas, Marlid Cruz-Ramos, Natalia Baños, Sonia Solanes, Arancha Cebrián, Laura García-García, Hakimeh Ebrahimi-Nik, and Elena Molina-Roldán
Subjects: Oncology, medicine.medical_specialty, Bevacizumab, Recombinant Fusion Proteins, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Angiogenesis Inhibitors, 030209 endocrinology & metabolism, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Endocrinology, Western blot, In vivo, Cell Line, Tumor, Internal medicine, medicine, Humans, Aflibercept, Chemotherapy, medicine.diagnostic_test, Vascular Endothelial Growth Factors, Endocrine and Autonomic Systems, business.industry, Growth factor, Carcinoma, Neuroendocrine, Clinical trial, Receptors, Vascular Endothelial Growth Factor, Immunohistochemistry, business, medicine.drug
Abstract: Background: Neuroendocrine carcinoma (NEC) is a rare and very aggressive tumor. It has been greatly understudied, and very little is known about optimal treatment strategy for patients with this disease. The purpose of this study was to evaluate in vivo whether anti-vascular endothelial growth factor (VEGF) drugs could be a therapeutic alternative for these tumors with a poor prognosis. Methods: We have developed 2 xenograft models using either human cell line derived from lung (H460) or from colon (COLO320) NEC to assess the effect of 2 antiangiogenic drugs, aflibercept and bevacizumab, on tumor growth and their pathological characteristics. Additionally, tumors were subjected to immunohistochemistry staining and proteins were measured with Western blot and ELISA. Results: Both aflibercept and bevacizumab showed significant antitumor activity (p < 0.001). In the H460 model, aflibercept resulted in 94% tumor growth inhibition (TGI) and bevacizumab treatment resulted in 72.2% TGI. Similarly, in the COLO320 model, aflibercept and bevacizumab resulted in 89.3 and 84% TGI, respectively. Moreover, antitumor activity occurs early after treatment initiation. Using Tumor Control Index score, which address the kinetics of tumor growth in a way comparable to the methods used in human clinical studies, we confirmed that both drugs inhibit significantly tumor growth. When tumor stabilization was evaluated, aflibercept shows higher ability to stabilize NEC tumors than bevacizumab. Conclusion: Results derived from this study strongly support anti-VEGF therapies, especially aflibercept, as a novel therapeutic option in NECs. Further studies are necessary, but our observations encourage the evaluation of antiangiogenics in clinical trials combined with standard chemotherapy.
Published: 2019
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26. Traumatismo hepático penetrante como causa de fístula arteriovenosa

Author: Laura Romacho López, María Pérez Reyes, Mariana Neuhaus Nevado, and Tatiana Priego-Puga Arjona
Subjects: Gynecology, medicine.medical_specialty, business.industry, Medicine, Surgery, business
Published: 2022
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27. Plasma Proteomic Biomarkers Relating to Alzheimer's Disease

Author: Liu Shi, Noel J. Buckley, Isabelle Bos, Sebastiaan Engelborghs, Kristel Sleegers, Giovanni B. Frisoni, Anders Wallin, Alberto Lléo, Julius Popp, Pablo Martinez-Lage, Cristina Legido-Quigley, Frederik Barkhof, Henrik Zetterberg, Pieter Jelle Visser, Lars Bertram, Simon Lovestone, Alejo J. Nevado-Holgado, Clinical sciences, Neuroprotection & Neuromodulation, Neurology, Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Neuroinfection & -inflammation, Amsterdam Neuroscience - Neurodegeneration, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, and Psychiatrie & Neuropsychologie
Subjects: 0301 basic medicine, Oncology, Fibrinogen-gamma chain, Aging, medicine.medical_specialty, diagnosis, Cognitive Neuroscience, Neuroscience(all), Alzheimer’s disease (AD), Neurosciences. Biological psychiatry. Neuropsychiatry, Disease, 03 medical and health sciences, blood biomarkers, meta-analysis, proteomic, 0302 clinical medicine, Internal medicine, medicine, Dementia, Biology, Original Research, Medicine(all), Complement component 4, business.industry, medicine.disease, CTL, 030104 developmental biology, Meta-analysis, Alzheimer's disease (AD), Biomarker (medicine), Human medicine, business, 030217 neurology & neurosurgery, Neuroscience, RC321-571, Frontotemporal dementia
Abstract: Altres ajuts: Innovative Medicines Initiative Joint Undertaking (EMIF grant agreement no. 115372); Department of Health of the Basque Government (allocation 17.0.1.08.12.0000.2.454.01.41142.001.H); University of Antwerp Research Fund. European Comission. Seventh Framework Programme FP7/2007-2013 and European Comission. Fifth Framework Programme QLRT2001-2455 Background and Objective: Plasma biomarkers for the diagnosis and stratification of Alzheimer's disease (AD) are intensively sought. However, no plasma markers are well established so far for AD diagnosis. Our group has identified and validated various blood-based proteomic biomarkers relating to AD pathology in multiple cohorts. The study aims to conduct a meta-analysis based on our own studies to systematically assess the diagnostic performance of our previously identified blood biomarkers. Methods: To do this, we included seven studies that our group has conducted during the last decade. These studies used either Luminex xMAP or ELISA to measure proteomic biomarkers. As proteins measured in these studies differed, we selected protein based on the criteria that it must be measured in at least four studies. We then examined biomarker performance using random-effect meta-analyses based on the mean difference between biomarker concentrations in AD and controls (CTL), AD and mild cognitive impairment (MCI), MCI, and CTL as well as MCI converted to dementia (MCIc) and non-converted (MCInc) individuals. Results: An overall of 2,879 subjects were retrieved for meta-analysis including 1,053 CTL, 895 MCI, 882 AD, and 49 frontotemporal dementia (FTD) patients. Six proteins were measured in at least four studies and were chosen for meta-analyses for AD diagnosis. Of them, three proteins had significant difference between AD and controls, among which alpha-2-macroglobulin (A2M) and ficolin-2 (FCN2) increased in AD while fibrinogen gamma chain (FGG) decreased in AD compared to CTL. Furthermore, FGG significantly increased in FTD compared to AD. None of the proteins passed the significance between AD and MCI, or MCI and CTL, or MCIc and MCInc, although complement component 4 (CC4) tended to increase in MCIc individuals compared to MCInc. Conclusions: The results suggest that A2M, FCN2, and FGG are promising biomarkers to discriminate AD patients from controls, which are worthy of further validation.
Published: 2021
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28. Effect of trazodone on cognitive decline in people with dementia: Cohort study using UK routinely collected data

Author: Robert Stewart, Gayan Perera, Nomi Werbeloff, Andrew Sommerlad, Simon Lovestone, Matthew Broadbent, Harry Costello, Tanya Smith, Andrey Kormilitzin, Gill Livingston, Alejo J. Nevado-Holgado, and Christoph Mueller
Subjects: medicine.medical_specialty, business.industry, Mirtazapine, Trazodone, Cognition, Pharmacoepidemiology, Citalopram, medicine.disease, Psychiatry and Mental health, mental disorders, medicine, Dementia, Geriatrics and Gerontology, Cognitive decline, business, Psychiatry, Cohort study, medicine.drug
Abstract: OBJECTIVES Evidence in mouse models has found that the antidepressant trazodone may be protective against neurodegeneration. We therefore aimed to compare cognitive decline of people with dementia taking trazodone with those taking other antidepressants. METHODS Three identical naturalistic cohort studies using UK clinical registers. We included all people with dementia assessed during 2008-16 who were recorded taking trazodone, citalopram or mirtazapine for at least 6 weeks. Linear mixed models examined age, time and sex-adjusted Mini-mental state examination (MMSE) change in people with all-cause dementia taking trazodone compared with those taking citalopram and mirtazapine. In secondary analyses, we examined those with non-vascular dementia; mild dementia; and adjusted results for neuropsychiatric symptoms. We combined results from the three study sites using random-effects meta-analysis. RESULTS We included 2,199 people with dementia, including 406 taking trazodone, with mean 2.2 years follow-up. There was no difference in adjusted cognitive decline in people with all-cause or non-vascular dementia taking trazodone, citalopram or mirtazapine in any of the three study sites. When data from the three sites were combined in meta-analysis, we found greater mean MMSE decline in people with all-cause dementia taking trazodone compared to those taking citalopram (0·26 points per successive MMSE measurement, 95% CI 0·03-0·49; p = 0·03). Results in sensitivity analyses were consistent with primary analyses. CONCLUSIONS There was no evidence of cognitive benefit from trazodone compared to other antidepressants in people with dementia in three naturalistic cohort studies. Despite preclinical evidence, trazodone should not be advocated for cognition in dementia.
Published: 2021

29. Drinking only when thirsty or when eating solids can normalize serum sodium levels in most patients with SIADH and a high fluid intake, regardless of Urine Osmolarity

Author: Gabriel Ruiz Sánchez Jorge, Alfonso Calle, Pérez Candel Xavier, Mario Pazos, Espinosa De Los Monteros Patricia, Hernández Olmeda Fernando, Celia Lopez Nevado, Cuesta Hernández Martín, Isabel Runkle, and Pallarés Raquel
Subjects: medicine.medical_specialty, Fluid intake, Endocrinology, chemistry, business.industry, Internal medicine, Sodium, medicine, Urine osmolality, chemistry.chemical_element, business
Published: 2021
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30. Importance of lymph extranodal extension to therapy outcomes in patients with thyroid follicular epithelial cell-derived carcinoma evaluated at one year

Author: Nevado Celia Lopez, Pallarés Raquel, Pérez Candel Xavier, Espinosa De Los Monteros Patricia, Hernández Olmeda Fernando, Jiménez Inés, and Cristina Familiar Casado Maria
Subjects: Follicular epithelial cell, Pathology, medicine.medical_specialty, medicine.anatomical_structure, business.industry, Extranodal Extension, Thyroid, medicine, Carcinoma, In patient, Lymph, business, medicine.disease
Published: 2021
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31. LONG-TERM OUTCOMES OF TRANSANAL TOTAL MESORECTAL EXCISION FOR RECTAL CANCER

Author: C Narvaez Chavez, E. Ferrero Herrero, J Ocaña Jimenez, O. García Villar, C. Nevado García, M. Labalde Martínez, A. Vivas López, and F.J. García Borda
Subjects: medicine.medical_specialty, medicine.diagnostic_test, business.industry, Colorectal cancer, Rectum, medicine.disease, Total mesorectal excision, Surgery, Rectosigmoidectomy, Sexual dysfunction, medicine.anatomical_structure, medicine, Fecal incontinence, medicine.symptom, Laparoscopy, business, Survival rate
Abstract: INTRODUCTION Transanal total mesorectal excision (TaTME) for rectal cancer offers a better vision of the dissection planes and facilitates the distal transection of the rectum. The aim of this study was to compare functional outcomes, local recurrence rate y 2-years overall survival and disease free survival rates of TaTME and laparoscopic total mesorectal excision (LPC TME). MATERIAL AND METHODS From December 2016 to October 2018, 50 patients (36 males and 14 females) with low rectal cancer and an age of 67 (55.7-75.2) years underwent TME (20 TaTME and 30 LPCTME). RESULTS Clinical features and quality indicators for rectal cancer surgery were similar in both groups. After a median follow-up of 35 (30-40) months, low anterior resection syndrome rate was 14% (15% vs 13%, p = 0.043), fecal incontinence rate was 8% (15% vs 3%, p = 0.017) and sexual dysfunction was 8% (15% vs 3%, p = 0.017). Systemic recurrence rate was 10% (15% vs 6%, p = 0.377). One patient presented local recurrence 2 years after TATME. 2-years overall survival rate was 98% (95% vs 100%, p = 0.400) and 2-years disease free survival rate was 90 % (85% vs 93%, p = 0.377). CONCLUSION Although 2-years overall survival and disease free survival rates were similar in TaTME and LPC TME group, functional outcomes were worse after TATME in our study.
Published: 2021
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32. Impact of the covid pandemic on admission for acute heart disease in a level II coronary unit

Author: M Frutos Lopez, M Villa Gil Ortega, L. García Riesco, J Nevado Portero, and A Campos Pareja
Subjects: medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Cardiac arrhythmia, General Medicine, Acute heart disease, 18.2 - Epidemiology, Prognosis, Outcome, Critical Care and Intensive Care Medicine, medicine.disease, Unit (housing), AcademicSubjects/MED00170, Diabetes mellitus, Intensive care, Emergency medicine, Pandemic, medicine, AcademicSubjects/MED00200, Level ii, Cardiology and Cardiovascular Medicine, business, AcademicSubjects/MED00460
Abstract: Funding Acknowledgements Type of funding sources: None. Purpose and Methods The Covid-19 pandemic has led to an increase in demand for Critical Patient Care Units. For this reason, level III Coronary Units have become a very valuable resource in the care of seriously ill patients, especially those due to covid. Level II Coronary Units could have assumed a greater number of acute heart patients, especially coronary, during the pandemic in hospitals that have coronary units of different levels. Our objective has been to compare the profile of patients who have been admitted to our level II Coronary Unit, retrospectively analyzing and comparing the demographic data and the reason for admission of the patients who were admitted between March and November 2019 (group I) with those who did so between the same months of 2020 (group II). Results Group I patients were 518 patients compared to 625 in group II. There was no difference between the age of the patients admitted (65.2 + 13 vs 65.1 + 13.8 years old). In the covid period, there were no significant differences between the classic risk factors, such as hypertension, diabetes or dyslipidemia. There was a higher percentage of smoking among the patients. During the pandemic, the patients admitted had significantly less history of previous heart disease (40.2% vs 78%). There has been a significant increase in admissions for acute ischemic heart disease in our unit (60% vs 13.8% the previous year), at the expense of Acute coronary syndrome with ST elevation (STEMI), with a downward trend in pathologies such as arrhythmias (13.5% in 2020 vs 20.6% in 2019) and acute heart failure (11.1% in 2020 vs 12.1% in 2019). The average length of stay during the Covid-19 period was significantly shorter, 2.7 days, compared to 3.3 days in the 2019 period, at the expense of a higher turnover rate in the Unit (79.42 vs 74, 09). During the covid period, there were 36.67% more discharge. Conclusions During the Covid-19 pandemic, a significant increase in acute ischemic heart disease (STEMI) has been observed in our level II Coronary unit, which is responsible for the greater number of discharges and the decrease in our average length of stay. This has allowed level III Coronary Units the ability to assume the excess of patients in need of intensive care that has been significantly increased by the Covid-19 pandemic
Published: 2021

33. Epigenetic age acceleration changes 2 years after antiretroviral therapy initiation in adults with HIV: a substudy of the NEAT001/ANRS143 randomised trial

Author: Rosa de Miguel, Eric Florence, François Raffi, Beatriz Mena-Garay, Pilar Barruz, Belén Alejos, Neat, Julen Cadiñanos, Andrea Antinori, Fiona Mulcahy, Jose R. Arribas, Anton Pozniak, Cédrick Wallet, Julián Nevado, Rocío Montejano, Gabriel Saiz-Medrano, Andrés Esteban-Cantos, Jose I Bernardino, Dénes Bánhegyi, Artur Martin, Berta Rodés, Javier Rodriguez-Centeno, Francisco Gayá, Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Adult, Male, 0301 basic medicine, Oncology, Aging, medicine.medical_specialty, Anti-HIV Agents, Epidemiology, Immunology, HIV Infections, Emtricitabine, Epigenesis, Genetic, 03 medical and health sciences, 0302 clinical medicine, Virology, Internal medicine, medicine, Humans, Clinical significance, 030212 general & internal medicine, Epigenetics, Darunavir, Randomized Controlled Trials as Topic, business.industry, DNA Methylation, Middle Aged, Viral Load, Raltegravir, 030112 virology, CD4 Lymphocyte Count, 3. Good health, Clinical trial, Infectious Diseases, Ageing, DNA methylation, Drug Therapy, Combination, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Biomarkers, medicine.drug
Abstract: BACKGROUND: DNA methylation-based estimators of biological age are reliable biomarkers of the ageing process. We aimed to investigate a range of epigenetic ageing biomarkers in a substudy of the NEAT001/ANRS143 clinical trial, which compared ritonavir-boosted darunavir with either raltegravir or tenofovir disoproxil fumarate and emtricitabine in antiretroviral therapy (ART)-naive adults. METHODS: We analysed frozen whole blood samples from 168 ART-naive participants with HIV from the NEAT001/ANRS143 trial, before ART initiation and after 2 years of ART (84 participants on ritonavir-boosted darunavir with raltegravir and 84 participants on ritonavir-boosted darunavir with tenofovir disoproxil fumarate and emtricitabine). We also included 44 participants without HIV with a similar age and sex distribution. We analysed DNA methylation. Epigenetic age estimators (Horvath's clock, Hannum's clock, GrimAge, and PhenoAge) and estimated leucocyte compositions were generated using Horvath's New Online Methylation Age Calculator and Houseman's method. We calculated epigenetic age acceleration measures for each estimator of epigenetic age. The NEAT001/ANRS143 trial is registered with ClinicalTrials.gov, NCT01066962. FINDINGS: Compared with the HIV-uninfected group, ART-naive participants with HIV showed higher epigenetic age acceleration (EAA) according to all EAA estimators (mean 2·5 years, 95% CI 1·89-3·22 for Horvath-EAA; 1·4 years, 0·74-1·99 for Hannum-EAA; 2·8 years, 1·97-3·68 for GrimAge-EAA; and 7·3 years, 6·40-8·13 for PhenoAge-EAA), with all differences being statistically significant except for Hannum-EAA (Horvath-EAA p=0·0008; Hannum-EAA p=0·059; GrimAge-EAA p=0·0021; and PhenoAge-EAA p
Published: 2021
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34. Prenatal ultrasound findings in Koolen‐de Vries foetuses: Central nervous system anomalies are frequent markers of this syndrome

Author: Fe Amalia García-Santiago, Jair Tenorio, Fernando Santos-Simarro, María Ángeles Mori, Y. Nieto, Miguel Ruiz de Azua Ballesteros, Eugenia Antolín Alvarado, Julián Nevado, Elena Mansilla, Pablo Lapunzina, Isabel Vallcorba, and C. Martínez-Payo
Subjects: Adult, Male, 0301 basic medicine, prenatal ultrasound, medicine.medical_specialty, Koolen De Vries syndrome, Genetic counseling, Central nervous system, Prenatal diagnosis, QH426-470, 030105 genetics & heredity, Corpus callosum, Ultrasonography, Prenatal, Cerebral Ventricles, Corpus Callosum, 03 medical and health sciences, Pregnancy, Intellectual Disability, Genetics, Humans, Medicine, Abnormalities, Multiple, Genetic Testing, Molecular Biology, Koolen‐de Vries syndrome, ventriculomegaly, Genetics (clinical), prenatal diagnosis, business.industry, Obstetrics, Ultrasound, Infant, Newborn, Original Articles, medicine.disease, 17q21.31 microdeletion, genomic imbalance, 030104 developmental biology, medicine.anatomical_structure, Female, Original Article, Chromosome Deletion, business, Chromosomes, Human, Pair 17, Ventriculomegaly
Abstract: Objective Prenatal diagnoses of microdeletion syndromes without ultrasound findings in the first and second trimester are always difficult. The objective of this study is to report the prenatal ultrasound findings in four foetuses diagnosed with 17q21.31 microdeletions (Koolen‐de Vries syndrome) using chromosomal microarrays (CMA). Patients and Methods We present four foetuses with 17q21.31 microdeletion. All showed CNS anomalies in the third trimester, three had ventriculomegaly, and one hypogenesis of corpus callosum at 31 weeks of pregnancy. Results Array‐SNPs and CGH‐array were performed on uncultured amniocytes and peripheral blood revealing a 17q21.31 microdeletion. Conclusions Prenatal CNS anomalies (mainly ventriculomegaly) at third trimester, in spite of isolate, should be considered a prenatal ultrasound marker of this syndrome. This kind of malformations raise the possibility of an underlying genetic conditions including 17q21.31 microdeletion; thus, CMA should be taken into consideration when offering prenatal genetic counselling., Prenatal CNS anomalies (mainly ventriculomegaly) at third trimester, should be considered a prenatal ultrasound marker of this syndrome. This kind of malformations raise the possibility of an underlying genetic condition including 17q21.31 microdeletion. Thus CMA should be taken into consideration when offering prenatal genetic counselling.
Published: 2021
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35. Next-generation Sequencing in Bone Marrow Failure Syndromes and Isolated Cytopenias: Experience of the Spanish Network on Bone Marrow Failure Syndromes

Author: Albert Català, Cristina Beléndez, Elena Vallespín, Carmen Sánchez-Valdepeñas, Elena Sebastián, Rosario Perona, Yari Giménez, Elena G Arias-Salgado, Luis Madero, Jordi Surrallés, Ana Galera, Susana Navarro, Julián Nevado, Leandro Sastre, Cristina Díaz de Heredia, Julián Sevilla, Eva M. Galvez, Roser Pujol, Juan A. Bueren, Isabel Badell, Paula Río, Massimo Bogliolo, Josune Zubicaray, Pablo Lapunzina, Montserrat Peiró, Institut Català de la Salut, [Gálvez E] Servicio de Hematología y Oncología Pediátrica, Fundación de Investigación Biomédica, Hospital Infantil Universitario Niño Jesús, Madrid, Spain. Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid, Spain. [Vallespín E] Institute of Medical and Molecular Genetics (INGEMM), Hospital Universitario La Paz, IDIPAZ, Madrid, Spain. Instituto de Investigaciones Biomédicas CSIC/UAM, IDIPaz, Madrid. [Arias-Salgado EG] Instituto de Investigaciones Biomédicas CSIC/UAM, IDIPaz, Madrid, Spain. [Sánchez-Valdepeñas C] Servicio de Hematología y Oncología Pediátrica, Fundación de Investigación Biomédica, Hospital Infantil Universitario Niño Jesús, Madrid, Spain. [Giménez Y, Navarro S] Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid, Spain. Hematopoietic Innovative Therapies Division, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid, Spain. [Díaz de Heredia C] Grupo insuficiencias medulares de la SEHOP, Spain. Servei d’Oncologia i Hematologia Pediàtriques, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
Subjects: Oncology, medicine.medical_specialty, Article, DNA sequencing, Medul·la òssia - Malalties, Investigative Techniques::Genetic Techniques::Sequence Analysis::High-Throughput Nucleotide Sequencing [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Internal medicine, Medicine, Gene, Hemic and Lymphatic Diseases::Hematologic Diseases::Bone Marrow Diseases [DISEASES], Seqüència de nucleòtids, enfermedades hematológicas y linfáticas::enfermedades hematológicas::enfermedades de la médula ósea [ENFERMEDADES], lcsh:RC633-647.5, business.industry, Genetic heterogeneity, Network on, Bone marrow failure, Cancer, lcsh:Diseases of the blood and blood-forming organs, Hematology, medicine.disease, Bone Marrow failure syndromes, Cohort, técnicas de investigación::técnicas genéticas::análisis de secuencias::secuenciación de nucleótidos de alto rendimiento [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], business
Abstract: © 2021 the Author(s)., Inherited bone marrow failure syndromes (IBMFSs) are a group of congenital rare diseases characterized by bone marrow failure, congenital anomalies, high genetic heterogeneity, and predisposition to cancer. Appropriate treatment and cancer surveillance ideally depend on the identification of the mutated gene. A next-generation sequencing (NGS) panel of genes could be 1 initial genetic screening test to be carried out in a comprehensive study of IBMFSs, allowing molecular detection in affected patients. We designed 2 NGS panels of IBMFS genes: version 1 included 129 genes and version 2 involved 145 genes. The cohort included a total of 204 patients with suspected IBMFSs without molecular diagnosis. Capture-based targeted sequencing covered > 99% of the target regions of 145 genes, with more than 20 independent reads. No differences were seen between the 2 versions of the panel. The NGS tool allowed a total of 91 patients to be diagnosed, with an overall molecular diagnostic rate of 44%. Among the 167 patients with classified IBMFSs, 81 patients (48%) were diagnosed. Unclassified IBMFSs involved a total of 37 patients, of whom 9 patients (24%) were diagnosed. The preexisting diagnosis of 6 clinically classified patients (6%) was amended, implying a change of therapy for some of them. Our NGS IBMFS gene panel assay is a useful tool in the molecular diagnosis of IBMFSs and a reasonable option as the first tier genetic test in these disorders.
Published: 2021

36. Improving selection of patients with metastatic colorectal cancer to benefit from cetuximab based on KIR genotypes

Author: Sonia Solanes, Enrique Aranda, Arancha Cebrián Aranda, Maria Auxiliadora Gómez-España, Jesús García-Foncillas, Barbara Manzanares-Martin, Laura del Puerto-Nevado, and Rafael González
Subjects: 0301 basic medicine, Oncology, Male, Cancer Research, Colorectal cancer, Cetuximab, medicine.disease_cause, 0302 clinical medicine, Antineoplastic Agents, Immunological, Receptors, KIR, Risk Factors, Genotype, Immunotherapy Biomarkers, Immunology and Allergy, Neoplasm, antibodies, Neoplasm Metastasis, Child, RC254-282, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Middle Aged, Progression-Free Survival, Phenotype, 030220 oncology & carcinogenesis, Child, Preschool, translational medical research, Molecular Medicine, Female, KRAS, Colorectal Neoplasms, medicine.drug, Adult, medicine.medical_specialty, tumor, Adolescent, Immunology, Clinical Decision-Making, Risk Assessment, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, Young Adult, Predictive Value of Tests, Internal medicine, medicine, Biomarkers, Tumor, Humans, Genetic Predisposition to Disease, Genotyping, neoplasms, Aged, Pharmacology, business.industry, Patient Selection, Haplotype, biomarkers, medicine.disease, digestive system diseases, Clinical trial, 030104 developmental biology, Haplotypes, Spain, Mutation, natural killer t-cells, business, neoplasm
Abstract: AimCetuximab is a standard-of-care treatment for KRAS wild-type metastatic colorectal cancer (mCRC), but it may also be effective in a subgroup of KRAS mutant patients by its immunomodulatory activity. Here, we explore if KIR (killer cell immunoglobulin-like receptor) genotyping can provide a significant added value in the clinical outcome of patients with KRAS mutant mCRC based on cetuximab treatment.MethodsWe included 69 patients with histologically confirmed mCRC and KRAS mutation, positive EGFR expression, and Eastern Cooperative Oncology Group performance status ≤2. Based on KIR gene content, haplotype (A or B) was defined and genotypes (AA or Bx) were grouped for each patient.ResultsWe demonstrated with new evidence the immunomodulatory activity of cetuximab in patients with KRAS mutant mCRC. Patients with homozygous genotypes (AA or BB) showed shorter 12-month progression-free survival (PFS12) and poorer overall survival (OS) than those with heterozygotes (AB). Moreover, multivariate analysis confirmed stratification of patients based on genotype was an independent marker of PFS12 (HR 2.16) and the centromeric and telomeric distribution of KIRs was an independent predictor of both PFS12 (HR 2.26) and OS (HR 1.93) in patients with mCRC with KRAS mutation treated with cetuximab.ConclusionsSelection of patients with mCRC based on their KIR genotypes opens a therapeutic opportunity for patients with KRAS mutation, and it should be tested in clinical trials in comparison with other alternatives with scarce benefit.Trial registration numberNCT01450319, EudraCT 2010-023580-18.
Published: 2021

37. Effects of an eccentric overload and small-side games training in match accelerations and decelerations performance in female under-23 soccer players

Author: Víctor Torreblanca-Martínez, Carlos Balsalobre-Fernández, Víctor Paredes-Hernández, Juan del Campo-Vecino, and Fabio Nevado-Garrosa
Subjects: Male, medicine.medical_specialty, High intensity, Deceleration, Acceleration, Physical Therapy, Sports Therapy and Rehabilitation, 030229 sport sciences, Athletic Performance, Control Groups, Running, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Internal medicine, Soccer, medicine, Cardiology, Eccentric, Humans, Orthopedics and Sports Medicine, Female, 030217 neurology & neurosurgery, Mathematics
Abstract: Background The aims of this study were: 1) to investigate the impacts that an eccentric overload training (EOT) and a small-side game training (SSGT) have on the characteristics of the accelerations (ACC) and decelerations (DCC) of the players in a soccer match; and 2) to determine if EOT and SSGT could affect the ACC and DCC reduction over time in a soccer match. Methods Twenty-three female soccer players from a Spanish professional club were split into three groups: a small-sided game training group (SGG), an eccentric overload training group (EOG) and a control group (CG). Results The SSG improved the high intensity distance performed (ES [CI]=0.72 [0.22; 1.22]), the number of high intensity actions (ES [CI]=0.65 [0.01; 1.29]), the percentage of repeated high intensity actions (ES [CI]=0.54 [-0.17; 1.25]), the initial velocity of the ACC (ES [CI]=0.55 [-0.08; 1.17]) and the percentage of repeated accelerations (ES [CI]=0.87 [-0.18; 1.91]) with respect to the control group. The EOG obtained better results in distance travelling accelerating (ES [CI]=0.84 [0.09; 1.60]) and decelerating (ES [CI]=0.87 [0.23; 1.51]) above 3 m/s2, maximum ACC (ES [CI]=1.92 [0.90; 2.94]) and DCC (ES [CI]=1.29 [0.44; 2.14]) and the average of maximum ACC (ES [CI]=0.89 [0.23; 1.54]) and DCC (ES [CI]=1.08 [0.62; 1.55]) with respect to the CG. A decrement in the ACC and DCC performance was observed between the first and last 15 minutes of the competition, except for the EOG. Conclusions The SSG obtained mainly improvements in variables related with efforts repetitions and the capacity of maintaining the ACC and the DCC over time, while improvements in the EOG were related to intensity in the ACC and DCC.
Published: 2021

38. Comorbidity between Alzheimer's disease and major depression: a behavioural and transcriptomic characterization study in mice

Author: Lara Nonell, Elena M. Ribe, Janet Piñero, Olga Valverde, Laura I. Furlong, Simon Lovestone, Alejo J. Nevado-Holgado, Ana Martín-Sánchez, Ferran Sanz, and Magdalena Arnal
Subjects: medicine.medical_specialty, Neurology, Cognitive Neuroscience, Population, Hippocampus, Mice, Transgenic, Disease, Comorbidity, Gene Set Enrichment Analysis, Biology, Amygdala, lcsh:RC346-429, lcsh:RC321-571, Transcriptome, Amyloid beta-Protein Precursor, Mice, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, medicine, Animals, Major depression, Behaviour, education, Prefrontal cortex, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, lcsh:Neurology. Diseases of the nervous system, 030304 developmental biology, Depressive Disorder, Major, 0303 health sciences, education.field_of_study, Amyloid beta-Peptides, Depression, Research, medicine.disease, 3. Good health, Disease Models, Animal, medicine.anatomical_structure, Neurology (clinical), Neuroscience, Alzheimer’s disease, 030217 neurology & neurosurgery
Abstract: Background: Major depression (MD) is the most prevalent psychiatric disease in the population and is considered a prodromal stage of the Alzheimer's disease (AD). Despite both diseases having a robust genetic component, the common transcriptomic signature remains unknown. Methods: We investigated the cognitive and emotional behavioural responses in 3- and 6-month-old APP/PSEN1-Tg mice, before β-amyloid plaques were detected. We studied the genetic and pathway deregulation in the prefrontal cortex, striatum, hippocampus and amygdala of mice at both ages, using transcriptomic and functional data analysis. Results: We found that depressive-like and anxiety-like behaviours, as well as memory impairments, are already present at 3-month-old APP/PSEN1-Tg mutant mice together with the deregulation of several genes, such as Ciart, Grin3b, Nr1d1 and Mc4r, and other genes including components of the circadian rhythms, electron transport chain and neurotransmission in all brain areas. Extending these results to human data performing GSEA analysis using DisGeNET database, it provides translational support for common deregulated gene sets related to MD and AD. Conclusions: The present study sheds light on the shared genetic bases between MD and AD, based on a comprehensive characterization from the behavioural to transcriptomic level. These findings suggest that late MD could be an early manifestation of AD. This study was funded by the EU Medbioinformatic project (grant number 634143), Ministerio de Economia y Competitividad (grant number SAF2016-75966-R-FEDER and PID2019-104077-RB-100) and Ministerio de Sanidad (Retic-ISCIII, RD16/017/010 and Plan Nacional sobre Drogas 2018/007). The Department of Experimental and Health Sciences (UPF) is a “Unidad de Excelencia María de Maeztu” funded by the AEI (CEX2018-000792-M). The Research Programme on Biomedical Informatics (GRIB) is a member of the Spanish National Bioinformatics Institute (INB), funded by ISCIII and FEDER (PT17/0009/0014). The GRIB is also supported by the Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR), Generalitat de Catalunya (2017 SGR 00519).
Published: 2021

39. Variants Near CETP, MTTP and BUD13-ZPR1-APOA5 may be Nominally Associated with Poor Statin Response Among Filipinos

Author: Charlene F. Agustin, Eva Maria C. Cutiongco de la Paz, Lauro L. Abrahan, Rody G. Sy, Lourdes Ella G. Santos, Jose B. Nevado, Elmer Jasper B. Llanes, Deborah Ignacia D. Ona, Aimee Yvonne Criselle L. Aman, Felix Eduardo R. Punzalan, Jaime Alfonso M. Aherrera, Paul Ferdinand M. Reganit, Adrian John P. Bejarin, Richard Henry P. Tiongco, and Jose Donato A. Magno
Subjects: Oncology, education.field_of_study, medicine.medical_specialty, Statin, business.industry, medicine.drug_class, Poor responder, Population, Genetic variants, General Medicine, Logistic regression, External validity, Internal medicine, Medicine, lipids (amino acids, peptides, and proteins), business, education
Abstract: Objective. Several studies showed that genetic factors affect responsiveness to statins among different populations. This study investigated the associations of candidate genetic variants with poor response to statins among Filipinos. Methods. In this unmatched case-control study, dyslipidemic participants were grouped into statin responders and poor responders based on the degree of reduction in LDL-c from baseline. DNA from blood samples were genotyped and analyzed. The association of candidate variants with statin response was determined using chi-square and logistic regression analysis. Results. We included 162 adults on statins (30 poor responders as cases, 132 good responders as controls). The following variants are nominally associated with poor response to statin among Filipinos at a per-comparison error rate of 0.05: rs173539 near CETP (OR=3.05, p=0.015), rs1800591 in MTTP (OR=3.07, p=0.021), and rs1558861 near the BUD13-ZPR1-APOA5 region (OR=5.08, p=0.004). Conclusion. Genetic variants near CETP, MTTP and the BUD13-ZPR1-APOA5 region are associated with poor response to statins among Filipinos. Further study is recommended to test the external validity of the study in the general Filipino population.
Published: 2021
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40. Sex-specific metabolic pathways associate with Alzheimer’s Disease (AD) endophenotypes in the European Medical Information Framework for AD Multimodal Biomarker Discovery cohort

Author: Min Kim, Charlotte E. Teunissen, Alison L. Baird, Petronella Kettunen, José Luis Molinuevo, Isabelle Bos, Frans R.J. Verhey, Mikel Tainta, Julius Popp, Philip Scheltens, Sarah Westwood, Pieter Jelle Visser, Lutz Frölich, Simon Lovestone, Daniel Alcolea, Cristina Legido-Quigley, Alejo J. Nevado-Holgado, Jin Xu, Lars Bertram, Mara ten Kate, Gwendoline Peyratout, Sebastiaan Engelborghs, Magda Tsolaki, Rebecca Green, Yvonne Freund-Levi, Alberto Lleó, Peter Johannsen, Pablo Martinez-Lage, Karen Meersmans, Valerija Dobricic, Olivier Blin, Amera A. Ebshiana, Jodie Lord, Giovanni B. Frisoni, Silvy Gabel, Rik Vandenberghe, Henrik Zetterberg, Stuart G. Snowden, Kaj Blennow, Régis Bordet, Johannes Streffer, Anders Wallin, Liu Shi, Jill C. Richardson, Petroula Proitsi, Ellen Elisa De Roeck, Lorena Rami, Abdul Hye, Kristel Sleegers, and Stephanie J.B. Vos
Subjects: Oncology, medicine.medical_specialty, business.industry, Disease, Kynurenate, Metabolic pathway, Dopamine, Endophenotype, Internal medicine, Cohort, medicine, Serotonin, Biomarker discovery, business, medicine.drug
Abstract: BACKGROUNDPhysiological differences between males and females could contribute to the development of AD. Here, we examined metabolic pathways that may lead to precision medicine initiatives.METHODSWe explored whether sex modifies the association of 540 plasma metabolites with AD endophenotypes including diagnosis, CSF biomarkers, brain imaging, and cognition using regression analyses for 695 participants (377 females), followed by sex-specific pathway overrepresentation analyses, APOE ε4 stratification and assessment of metabolites’ discriminatory performance in AD.RESULTSIn females with AD, vanillylmandelate (tyrosine pathway) was increased and tryptophan betaine (tryptophan pathway) was decreased. The inclusion of these two metabolites (AUC = 0.83, SE = 0.029) to a baseline model (covariates + CSF biomarkers, AUC = 0.92, SE = 0.019) resulted in a significantly higher AUC of 0.96 (SE = 0.012). Kynurenate was decreased in males with AD (AUC = 0.679, SE = 0.046).CONCLUSIONSMetabolic sex-specific differences were reported, covering neurotransmission and inflammation pathways with AD endophenotypes. Two metabolites, in pathways related to dopamine and serotonin, associated to females, paving the way to personalised treatment.
Published: 2021

41. A Modest Increase in 11C-PK11195-Positron Emission Tomography TSPO Binding in Depression Is Not Associated With Serum C-Reactive Protein or Body Mass Index

Author: Julia J. Schubert, Mattia Veronese, Tim D. Fryer, Roido Manavaki, Manfred G. Kitzbichler, Maria A. Nettis, Valeria Mondelli, Carmine M. Pariante, Edward T. Bullmore, Federico E. Turkheimer, Dominika Wlazly, Amber Dickinson, Andy Foster, Clare Knight, Claire Leckey, Paul Morgan, Angharad Morgan, Caroline O'Hagan, Samuel Touchard, Shahid Khan, Phil Murphy, Christine Parker, Jai Patel, Jill Richardson, Paul Acton, Nigel Austin, Anindya Bhattacharya, Nick Carruthers, Peter de Boer, Wayne Drevets, John Isaac, Declan Jones, John Kemp, Hartmuth Kolb, Jeff Nye, Gayle Wittenberg, Gareth Barker, Anna Bogdanova, Heidi Byrom, Diana Cash, Annamaria Cattaneo, Daniela Enache, Tony Gee, Caitlin Hastings, Melisa Kose, Giulia Lombardo, Nicole Mariani, Anna McLaughlin, Maria Nettis, Naghmeh Nikkheslat, Carmine Pariante, Karen Randall, Julia Schubert, Luca Sforzini, Hannah Sheridan, Camilla Simmons, Nisha Singh, Federico Turkheimer, Vicky Van Loo, Marta Vicente Rodriguez, Toby Wood, Courtney Worrell, Zuzanna Zajkowska, Brian Campbell, Jan Egebjerg, Hans Eriksson, Francois Gastambide, Karen Husted Adams, Ross Jeggo, Thomas Moeller, Bob Nelson, Niels Plath, Christian Thomsen, Jan Torleif Pederson, Stevin Zorn, Catherine Deith, Scott Farmer, John McClean, Andrew McPherson, Nagore Penandes, Paul Scouller, Murray Sutherland, Mary Jane Attenburrow, Jithen Benjamin, Helen Jones, Fran Mada, Akintayo Oladejo, Katy Smith, Rita Balice-Gordon, Brendon Binneman, James Duerr, Terence Fullerton, Veeru Goli, Zoe Hughes, Justin Piro, Tarek Samad, Jonathan Sporn, Liz Hoskins, Charmaine Kohn, Lauren Wilcock, Franklin Aigbirhio, Junaid Bhatti, Ed Bullmore, Sam Chamberlain, Marta Correia, Anna Crofts, Tim Fryer, Martin Graves, Alex Hatton, Manfred Kitzbichler, Mary-Ellen Lynall, Christina Maurice, Ciara O'Donnell, Linda Pointon, Peter St George Hyslop, Lorinda Turner, Petra Vertes, Barry Widmer, Guy Williams, Jonathan Cavanagh, Alison McColl, Robin Shaw, Erik Boddeke, Alison Baird, Stuart Clare, Phil Cowen, I-Shu (Dante) Huang, Sam Hurley, Simon Lovestone, Alejo Nevado-Holgado, Elena Ribe, Anviti Vyas, Laura Winchester, Madeleine Cleal, Diego Gomez-Nicola, Renzo Mancuso, Hugh Perry, Mara Cercignani, Charlotte Clarke, Alessandro Colasanti, Neil Harrison, Rosemary Murray, Jason O'Connor, and Howard Mount
Subjects: medicine.medical_specialty, Cognitive Neuroscience, 050105 experimental psychology, Body Mass Index, C-reactive protein, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Receptors, GABA, Interquartile range, Internal medicine, medicine, Translocator protein, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, Prefrontal cortex, Biological Psychiatry, Anterior cingulate cortex, Inflammation, Depressive Disorder, Major, biology, business.industry, Depression, 05 social sciences, Microglia, PET, TSPO, medicine.disease, Isoquinolines, Archival Report, Endocrinology, medicine.anatomical_structure, Positron-Emission Tomography, biology.protein, Major depressive disorder, Neurology (clinical), business, Body mass index, 030217 neurology & neurosurgery
Abstract: Background: Immune mechanisms have been implicated in the pathogenesis of depression. Translocator protein (TSPO)–targeted positron emission tomography (PET) has been used to assess neuroinflammation in major depressive disorder. We aimed to 1) test the hypothesis of significant case-control differences in TSPO binding in the anterior cingulate cortex, prefrontal cortex, and insula regions; and 2) explore the relationship between cerebral TSPO binding and peripheral blood C-reactive protein (CRP) concentration. Methods: A total of 51 depressed subjects with Hamilton Depression Rating Scale score >13 (median 17; interquartile range, 16–22) and 25 healthy control subjects underwent dynamic brain 11C-PK11195 PET and peripheral blood immune marker characterization. Depressed subjects were divided into high CRP (>3 mg/L; n = 20) and low CRP (2 p = .09; F 1,71 = 6.97, p = .01), which was not influenced by body mass index. The case-control difference was greatest in the anterior cingulate cortex (d = 0.49; t 74 = 2.00, p = .03) and not significant in the prefrontal cortex or insula (d = 0.27 and d = 0.36, respectively). Following CRP stratification, significantly higher TSPO binding was observed in low-CRP depression compared with controls (d = 0.53; t 54 = 1.96, p = .03). These effect sizes are comparable to prior major depressive disorder case-control TSPO PET data. No significant correlations were observed between TSPO and CRP measures. Conclusions: Consistent with previous findings, there is a modest increase in TSPO binding in depressed patients compared with healthy control subjects. The lack of a significant correlation between brain TSPO binding and blood CRP concentration or body mass index poses questions about the interactions between central and peripheral immune responses in the pathogenesis of depression.
Published: 2021

42. Effect of trazodone on cognitive function in people with dementia: Cohort study using UK routinely collected data

Author: Gayan Perera, Robert Stewart, Matthew Broadbent, Nomi Werbeloff, Andrey Kormilitzin, Alejo J. Nevado-Holgado, Gill Livingston, Christoph Mueller, Andrew Sommerlad, Simon Lovestone, Tanya Smith, and Harry Costello
Subjects: Gerontology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Trazodone, Cognition, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Assessment methods, medicine, Dementia, Neurology (clinical), Geriatrics and Gerontology, business, medicine.drug, Cohort study
Published: 2020
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43. Teaching old drugs new tricks: Do cardiovascular medications effect cognitive decline?

Author: William Sproviero, Danielle Newby, Laura Winchester, Alejo J. Nevado-Holgado, Marco Fernandes, Lenore J. Launer, and Simon Lovestone
Subjects: Gerontology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, CARDIOVASCULAR MEDICATIONS, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Medicine, Dementia, Neurology (clinical), Geriatrics and Gerontology, Cognitive decline, business
Published: 2020
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44. Oral Manifestations of Wolf-Hirschhorn Syndrome: Genotype-Phenotype Correlation Analysis

Author: Márcio Diniz-Freitas, Pedro Diz, Isabel Maura, Candela Serrano, Jacobo Limeres, Guillermo Machuca, Jose Cruz Ruiz-Villandiego, Raquel Blanco-Lago, Julián Nevado, Javier Silvestre-Rangil, Joaquín De Nova, and Universidade de Santiago de Compostela. Departamento de Cirurxía e Especialidades Médico-Cirúrxicas
Subjects: Candidate gene, Pediatrics, medicine.medical_specialty, Genotype, genotype, lcsh:Medicine, Oligodontia, Disease, Contiguous gene syndrome, Odontologia, Article, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, medicine, Oral manifestations, Wolf–Hirschhorn syndrome, 0303 health sciences, Wolf-Hirschhorn syndrome, business.industry, 030305 genetics & heredity, lcsh:R, General Medicine, Stomatognathic diseases, medicine.disease, 4p, Patologia, oral manifestations, stomatognathic diseases, business, 030217 neurology & neurosurgery, Rare disease
Abstract: Background: Wolf-Hirschhorn syndrome (WHS) is a rare disease caused by deletion in the distal moiety of the short arm of chromosome 4. The objectives of this study were to report the most representative oral findings of WHS, relate them with other clinical characteristics of the disease, and establish possible phenotype-genotype correlation. Methods: The study was conducted at 6 reference centers distributed throughout Spain during 2018&ndash, 2019. The study group consisted of 31 patients with WHS who underwent a standardized oral examination. Due to behavioral reasons, imaging studies were performed on only 11 of the children 6 years of age or older. All participants had previously undergone a specific medical examination for WHS, during which anatomical, functional, epilepsy-related, and genetic variables were recorded. Results: The most prevalent oral manifestations were delayed tooth eruption (74.1%), bruxism (64.5%), dental agenesis (63.6%), micrognathia (60.0%), oligodontia (45.5%), and downturned corners of the mouth (32.3%). We detected strong correlation between psychomotor delay and oligodontia (p = 0.008, Cram&eacute, r&rsquo, s V coefficient, 0.75). The size of the deletion was correlated in a statistically significant manner with the presence of oligodontia (p = 0.009, point-biserial correlation coefficient, 0.75). Conclusion: Certain oral manifestations prevalent in WHS can form part of the syndrome&rsquo, s phenotypic variability. A number of the characteristics of WHS, such as psychomotor delay and epilepsy, are correlated with oral findings such as oligodontia and bruxism. Although most genotype-phenotype correlations are currently unknown, most of them seem to be associated with larger deletions, suggesting that some oral-facial candidate genes might be outside the critical WHS region, indicating that WHS is a contiguous gene syndrome.
Published: 2020
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45. Concurrent comorbidities substantially alter long-term health behaviours and outcomes of headache patients

Author: M. Zameel Cader, Anthony Nash, Sarah M. Goodday, Clare Bankhead, Alejo J. Nevado-Holgado, Alice Fuller, Qiang Liu, and Caleb Webber
Subjects: Pediatrics, medicine.medical_specialty, business.industry, Primary care, Health outcomes, medicine.disease, Comorbidity, Social deprivation, Migraine, Health care, medicine, business, Survival analysis, Cohort study
Abstract: ObjectivesTo investigate factors affecting the long-term health behaviours and outcomes of headache patients and to design a risk-stratification tool.MethodsA population based observational-longitudinal cohort study using primary care electronic healthcare records from the UK Clinical Practice Research Datalink. 550,103 participants with a headache or migraine diagnosis of which 170,336 patients were identified as having recurrent headache-related events. Univariate and multivariable survival analysis was performed to determine factors influencing remission and a neural network classifier was developed.ResultsThere were almost twice as many female patients (352,330) as males (197,802). The median age at which a patient first saw their GP in males was 38 years, and in females was 37 years. Whilst age, gender and social deprivation significantly influenced the likelihood of seeing a GP, these factors had little effect on likelihood of remission from a period of recurrent headache-related events. In contrast, a comorbidity during the recurrent headache period reduced the risk of remission and increased median survival time from approximately 400-days up 1600. Increasing numbers of comorbidities progressively reduced the hazard risks for remission. The prediction models on remission within two and five years, demonstrated high precision and recall, with an F1 score of 0.795 and 0.887, respectively.InterpretationHeadache patients who suffer comorbidities have a substantively reduced likelihood of remission, highlighting an opportunity to considerably improve health outcomes in recurrent headache patients through addressing multi-morbidity more effectively. The prediction model could be used to help stratify patients most at risk of poor long-term outcomes.
Published: 2020
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46. Chronicity and primary care in times of pandemic☆

Author: Dolores Corrales Nevado and Luis Palomo Cobos
Subjects: medicine.medical_specialty, Editorial, business.industry, Emergency medicine, Pandemic, medicine, Primary care, business, General Economics, Econometrics and Finance
Published: 2020

47. Doses of tolvaptan needed in chronic therapy of SIADH-induced euvolemic hyponatremia vary according to the etiology of SIADH

Author: Candel Xavier Perez, Hoyos Emilia Gomez, Nevado Celia Lopez, Pascual Alfonso Calle, Isabel Runkle, Virginina Puebla, Teresa Ruiz, Rodriguez Cabezas Miguel Angel, Martin Cuesta, and Miguel Paz de
Subjects: medicine.medical_specialty, business.industry, Internal medicine, Etiology, medicine, Tolvaptan, Hyponatremia, medicine.disease, business, Gastroenterology, medicine.drug
Published: 2020
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48. Inspection of the internal jugular vein pulse appears to be superior to impedance analysis for determination of volemia in a Hyponatremia outpatient clinic

Author: Sandra Vadillo, Pascual Alfonso Calle, Angelica Larrad, Elvira Barrio, Nevado Celia Lopez, Martin Cuesta, Candel Xavier Perez, Isabel Runkle, Jorge Ruiz, and Adriana Villareal
Subjects: medicine.medical_specialty, Pulse (signal processing), business.industry, medicine, Outpatient clinic, Radiology, business, Hyponatremia, medicine.disease, Internal jugular vein
Published: 2020
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49. Prospective evaluation of an anti-cancer drugs management programme in a dedicated oral therapy center (DICTO programme)

Author: Gaelle Maillan, Evelyne Caille, Sabine Chaput, Julie Querrioux, Jeremy Jost, Geraldine Bayard, Elise Deluche, Tiffany Darbas, L. Venat, Elodie Nevado, Valérie Le Brun-Ly, J. Pestre, Frédéric Thuillier, Chantal Suchaud, Sandrine Lavau-Denes, Sonia Zabaleta, Kevin Bourcier, Sophie Leobon, Nicole Tubiana-Mathieu, and Loic Montangon
Subjects: Adult, Male, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Administration, Oral, Management programme, Antineoplastic Agents, Nurse's Role, Targeted therapy, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, Multidisciplinary management, Global health, Medicine, Humans, 030212 general & internal medicine, Prospective Studies, Stage (cooking), Neoplasm Metastasis, Oral therapy, Co-ordination, Cancer, Aged, Retrospective Studies, Aged, 80 and over, Chemotherapy, Original Paper, business.industry, Oral therapies, Hematology, General Medicine, Middle Aged, medicine.disease, Hospitalization, Oncology, 030220 oncology & carcinogenesis, Anti cancer drugs, Emergency medicine, Patient Compliance, Female, business
Abstract: Oral therapies have highly modified cancer patient management and changed hospital practises. We introduce a specific Oral Therapy Centre and retrospectively review information prospectively recorded by co-ordination nurses (CNs) (the DICTO programme). We describe the roles played by CNs in the management of oral cancer therapies at Limoges Dupuytren Hospital between May 2015 and June 2018. All cancers, irrespective of stage or whether oral general chemotherapy or targeted therapy was prescribed, are included. We followed up 287 patients of median age 67 years (range 26–89 years). Of these, 76% had metastases and 44% were on first-line therapy. The vast majority (88%) of their first CN contacts occurred just after physician consultation and lasted an average of 60 min. As part of follow-up, the CNs made 2719 calls (average 10 min) to patients to educate them and to verify compliance and drug tolerance. They also received 833 calls from patients (70%) or their relatives or health professionals (30%) seeking advice on management of side effects. In addition to the initial appointments, 1069 non-scheduled follow-up visits were made to assess side effects (49.2%). The CNs devoted 5 h to each patient over 3 months of treatment (i.e. 25 min/day) and, also organised scheduled hospitalisations in the department of oncology for 51% of patients. We show the interest and real-life work in a specific oral therapy centre within oncology department with the role of CNs to facilitate the global health care of the patients. Electronic supplementary material The online version of this article (10.1007/s12032-020-01393-7) contains supplementary material, which is available to authorized users.
Published: 2020

50. Síndrome de osteoporosis-pseudoglioma: a propósito de un caso pediátrico de osteoporosis primaria

Author: Hamilton Cassinelli, Miriam Aza-Carmona, Pablo Daniel Lapunzina Badía, Paula Scaglia, Debora Braslavsky, Marina Szlago, Julián Nevado Blanco, Karen E. Heath, Olivia Ruiz, Claudia Arberas, Ignacio Bergadá, Alejandra Carmona, Nora Sanguineti, Maria del Carmen Fernandez, and Rodolfo Rey
Subjects: 0301 basic medicine, Pediatrics, medicine.medical_specialty, business.industry, Osteoporosis Pseudoglioma Syndrome, Osteoporosis, Wnt signaling pathway, 030209 endocrinology & metabolism, LRP5, medicine.disease, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Pediatrics, Perinatology and Child Health, medicine, Primary osteoporosis, Multiple fractures, business, Loss function, Rare disease
Abstract: Osteoporosis should be considered in children with severe chronic diseases or in association with some genetic diseases that bear an increased risk of bone fragility. Primary osteoporosis is an entity in which emerging aetiologies are being recognized. Its association with congenital retinal folds should guide the diagnosis to the Osteoporosis-Pseudoglioma syndrome (OMIM 259770), a rare disease (prevalence of 1/2 000 000), caused by the loss of function of the protein LRP5 (low-density lipoprotein receptor-related protein 5) resulting in the alteration of the Wnt/β-catenin signalling pathway. We report the case of a child with congenital retinal folds, progressive loss of vision and multiple fractures whose clinical, biochemical and genetic studies confirmed the diagnosis of primary osteoporosis due to a novel homozygous inactivating variant in LRP5.
Published: 2020
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