21 results on '"N. S. Track"'
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2. Pathomorphologic, biochemical, and diagnostic aspects of gastrinomas (Zollinger-Ellison syndrome)
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Werner Creutzfeldt, Corn Creutzfeldt, N. S. Track, and Rudolf Arnold
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endocrine system ,Pathology ,medicine.medical_specialty ,Radioimmunoassay ,Pathology and Forensic Medicine ,Secretin ,Zollinger-Ellison Syndrome ,Eating ,Islets of Langerhans ,03 medical and health sciences ,0302 clinical medicine ,Antigens, Neoplasm ,Duodenal Neoplasms ,Gastrins ,medicine ,Humans ,Insulin ,Intestinal Mucosa ,Neoplasm Metastasis ,Gastrin ,Gastrinoma ,Staining and Labeling ,business.industry ,Immune Sera ,Pancreatic islets ,digestive, oral, and skin physiology ,Hyperplasia ,Glucagon ,medicine.disease ,digestive system diseases ,Zollinger-Ellison syndrome ,3. Good health ,Pancreatic Neoplasms ,Microscopy, Electron ,medicine.anatomical_structure ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Chromatography, Gel ,Duodenum ,Calcium ,030211 gastroenterology & hepatology ,Pancreas ,business ,hormones, hormone substitutes, and hormone antagonists - Abstract
The clinical symptomatology of the Zollinger-Ellison syndrome and the pathologic anatomy of gastrinomas are reviewed. Experience with 17 patients with the Zollinger-Ellison syndrome is presented with special reference to stimulation tests (secretin, glucagon, calcium infusion, test meal) and to localization and immunohistologic, ultrastructural, and biochemical findings in gastrinomas. Multiple hormone production by the tumors is frequent. The ultrastructure and the Sephadex G-50 gel filtration patterns of immunoreactive gastrin in sera and tumors are not uniform and are not related to localization of the tumors in the pancreas or duodenum or to the gastrin concentration. Hyperplasia of the pancreatic islets is a frequent finding in gastrinoma patients, suggesting that hypergastrinemia may stimulate islet growth.
- Published
- 1975
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3. Human pancreatic polypeptide: studies of fasting and postprandial plasma concentrations
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R. S. McLeod, A. V. Mee, and N. S. Track
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Adult ,Male ,medicine.medical_specialty ,Physiology ,Pancreatic Polypeptide ,Propantheline ,Parasympathetic Nervous System ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,Circadian rhythm ,Pharmacology ,Meal ,Chemistry ,Parasympatholytics ,Fasting ,General Medicine ,Human pancreatic polypeptide ,Circadian Rhythm ,Endocrinology ,Postprandial ,Food ,Plasma concentration ,Female - Abstract
Circulating human pancreatic polypeptide (HPP) was studied in 16 human subjects during two 24-h test periods, one fasting and another eating meals at 0830, 1230, and 1730. In six subjects the tests were repeated with propantheline administration. Blood was sampled every 30 min; additional blood samples were drawn 15 and 45 min postprandially. Mean HPP concentrations increased gradually during the day in 13 out of 16 fasting subjects, reaching an average peak at 2100. By 0200 mean HPP concentrations returned to initial fasting concentration. Propantheline eliminated this circadian rhythm. Biphasic plasma HPP responses were recorded after each of the three meals during the test. Calculation of integrated HPP outputs revealed similar outputs to the three meals; the percentage contribution of the first release phase increased with successive meals. Propantheline caused a 60% decrease in integrated HPP outputs. The first release phase was practically absent after the 0830 meal; however, distinct biphasic responses were present after the 1230 and 1730 meals. These studies demonstrate that fasting plasma HPP displays a cholinergic-dependent circadian rhythm, that postprandial plasma HPP responses are quantitatively similar throughout the day, and that different cholinergic activities are involved in the maintenance of these fasting and postprandial plasma HPP patterns.
- Published
- 1980
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4. Diets rich in natural fibre improve carbohydrate tolerance in maturity-onset, non-insulin dependent diabetics
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Ruth M. Kay, N. S. Track, and W. Grobin
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Blood Glucose ,Dietary Fiber ,Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Carbohydrates ,Gastric Inhibitory Polypeptide ,Gastric inhibitory polypeptide ,Animal science ,Internal medicine ,Diabetes mellitus ,Diabetes Mellitus ,Internal Medicine ,medicine ,Humans ,Cellulose ,Aged ,Plasma glucose ,Chemistry ,Insulin ,Non insulin dependent diabetes mellitus ,Dietary management ,Glucose Tolerance Test ,medicine.disease ,Carbohydrate tolerance ,Endocrinology ,Basal (medicine) ,Female - Abstract
The influence of low and high fibre diets upon carbohydrate tolerance was examined in five maturity-onset, non-insulin dependent diabetics. After 14 days on a diet rich in natural fibre (30 g/day), the subjects consumed a high fibre (13 g) test meal. They then ate a low fibre diet (10 g/day) followed by a low fibre (1 g) test meal. Mean basal plasma glucose concentrations were similar after both fibre diets; however, both mean basal plasma insulin and gastric inhibitory polypeptide (GIP) were significantly lower after the high fibre diet. After the high fibre test meal, significantly lower mean plasma glucose, insulin and GIP concentrations were measured. This study is the first study to demonstrate the ability of an institutionally supervised diet of natural foodstuffs rich in fibre to improve carbohydrate tolerance in maturity-onset, non-insulin dependent diabetics. This findings is relevant to the dietary management of diabetics.
- Published
- 1981
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5. The antrat gastrin-producing G-cell: Biochemical and ultrastructural responses to feeding
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N. S. Track, W Creutzfeldt, R. Arnold, and C. Creutzfeldt
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Male ,medicine.medical_specialty ,Histology ,Cell ,Biology ,Cytoplasmic Granules ,digestive system ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Gastrins ,Pyloric Antrum ,medicine ,Animals ,Cycloheximide ,Antrum ,030304 developmental biology ,Gastrin ,0303 health sciences ,digestive, oral, and skin physiology ,Fasting ,Cell Biology ,Diet ,Rats ,Subcellular distribution ,medicine.anatomical_structure ,Endocrinology ,Cytoplasm ,Ultrastructure ,030211 gastroenterology & hepatology - Abstract
The effect of feeding on serum and antral immunoreactive gastrin (IRG) concentrations and on the ultrastructural appearance of antral G-cell granules has been examined. Serum and tissue IRG concentrations were dependent upon the length of time (12 or 48 h) the rats had been fasted before receiving food; IRG release was biphasic; the first peak was more pronounced in rats fasted 12 h. Antral tissue IRG content increased significantly postprandially. An initial depletion of antral IRG was seen in rats fasted 48 h. Examination of the subcellular distribution of antral IRG revealed more of the 5-15 min postprandal total IRG in the cytoplasm and less in the secretory granules. Ultrastructurally, G-cells from fasting rats contained mainly electron-dense granules. Five minutes postprandially numerous electron-lucent granules were observed. More electron dense granules were apparent 60 and 120 min postprandially. Fasting rats had the highest G-cell granule density index; a significantly lower index was observed 5 min postprandially. Indices at 60 and 120 min postprandially increased but were still lower than the fasting index. These studies indicate that gastrin biosynthesis is necessary for food stimulated gastrin release and that the electron density of the G-cells granules is not an accurate reflection of the G-cell gastrin content.
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- 1978
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6. Enzymatic and ultrastructural development of the bovine exocrine pancreas
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N. S. Track, C. Creutzfeldt, W Creutzfeldt, M. Bokermann, and H. Schmidt
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medicine.medical_specialty ,Physiology ,Population ,Gestational Age ,Biology ,Cytoplasmic Granules ,Endoplasmic Reticulum ,Biochemistry ,Leucyl Aminopeptidase ,Fetus ,Internal medicine ,medicine ,Animals ,Chymotrypsin ,Trypsin ,Lipase ,education ,Pancreas ,Molecular Biology ,education.field_of_study ,Endoplasmic reticulum ,General Medicine ,Zymogen granule ,Microscopy, Electron ,Endocrinology ,Phospholipases ,Cytoplasm ,Amylases ,biology.protein ,Cattle ,Ribosomes ,Reticulum ,medicine.drug - Abstract
1. Enzymes were detected in the smallest fetuses (8·5 cm). Generally, in the fetal samples, α-amylase and chymotrypsin activities were low, trypsin, phospholipase A and leucine amino peptidase showed a gradual increase and lipase remained nearly constant over the gestation period. 2. Enzyme activities of 12-week-old calves were higher than the fetal ones. 3. Sixteen-week-old calf activities (except lipase) showed a decrease approaching the lower adult levels. 4. Ultrastructurally, the smallest fetuses (< 19 cm) contained zymogen granules of a wide variety of shapes and sizes, scarce profiles of rough endoplasmic r reticulum and free ribosomes. 5. In larger fetuses, a more homogeneous population of zymogen granules was present with a progressively more organized cytoplasm with prominent rough endoplasmic reticulum. Sixteen-week-old calf and adult samples showed highly organized cytoplasm in a very active state. 6. These biochemical and ultrastructural results reflect the nutritional environment of the animals.
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- 1972
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7. In Vitro Studies of the Rate of Proinsulin and Insulin Turnover in Seven Human Insulinomas
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C. Creutzfeldt, Werner Creutzfeldt, and N. S. Track
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endocrine system ,medicine.medical_specialty ,endocrine system diseases ,medicine.medical_treatment ,Clinical Biochemistry ,In Vitro Techniques ,Biology ,Cytoplasmic Granules ,Tritium ,Biochemistry ,Iodine Radioisotopes ,03 medical and health sciences ,0302 clinical medicine ,Leucine ,Internal medicine ,Centrifugation, Density Gradient ,medicine ,Animals ,Humans ,Insulin ,Centrifugation ,Incubation ,Insulinoma ,030304 developmental biology ,Proinsulin ,0303 health sciences ,geography ,geography.geographical_feature_category ,Staining and Labeling ,Pancreatic islets ,Granule (cell biology) ,General Medicine ,Adenoma, Islet Cell ,Islet ,medicine.disease ,Mitochondria ,Rats ,Pancreatic Neoplasms ,Microscopy, Electron ,Endocrinology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Chromatography, Gel ,Cattle ,Subcellular Fractions - Abstract
Summary. Human insulinoma tissue excised from seven patients was incubated with glucose (3.0 mg/ml) and 3H-leucine (100 μCi/ml) for a 15 min. pulse period. One third of the tissue was homogenized immediately in 0.3 M sucrose (pH 6.0), one third was homogenized after a 20 min. chase (with L-leueine 37S μg/ml) and the remaining third after an 80 min. chase. Subcellular fractions (cell debris, mitochondria, secretory granules, microsomes and S-100) were prepared by centrifugation. Their identity was confirmed by ultrastructural examination. Since only tumours revealing typical β-granules were investigated the secretory granule fractions contained the same types of granules as found in the normal human B-cell.—The S-100 contained approximately 40% of the immuno-reactive insulin (IRI). The secretory granule samples from five tumours were fractionated by sucrose gradient ultracentrifugation. At the three time intervals examined, a peak of radioactivity and IRI was located at 1.60 M sucrose in three of the tumours. The different granule types were not separable in the sucrose gradients. Endogenous proinsulin-like components (proinsulin) and insulin were released throughout the incubation. During incubation of tumour tissue the ratio of IRI release to content was significantly higher than that from isolated human pancreatic islets. Newly synthesized proinsulin was detected in the medium after the 15 min. pulse in five of the tumours; radioactive proinsulin and insulin were present in all the media after the 20 and 80 min. chase periods. Islets isolated from the pancreatic tissue of two insulinoma patients showed a much slower proinsulin and insulin turnover.—These data support the conjecture that human insulinomas have a more rapid turnover of proinsulin and insulin than normal pancreatic islet tissue, apparently as the consequence of defective IRI storage and release mechanisms.
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- 1973
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8. Fourth Annual Meeting of the European Association for the study of diabetes
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M. E. Abrams, D. R. Boyns, J. R. Crossley, R. J. Jarrett, H. Keen, D. Andreani, G. Menzinger, F. Fallucca, A. Alibebti, G. Tamburrane, D. Andreev, S. Ditzov, G. Dashev, D. Strashimirov, A. Appels, B. Willms, H. D. Söling, V. H. Asfeldt, Gh. Bacanu, B. Bakker, F. H. Roerdink, P. R. Bouman, A. Coert, N. M. V. Jaspers, L. Barta, R. Beckmann, W. Berger, A. Beringer, G. Geyer, H. Mösslacher, K. H. Tragl, W. Waldhäusl, J. Beyer, K. Schöffling, H. Ditschuneit, S. Raptis, E. Wolf, E. Güntert, E. F. Pfeiffer, N. Bilic, J. P. Felber, K. Bojanowicz, A. Zubowski, Z. Rybarczyk, C. Bonessa, L. Cremonini, B. Borrebaek, Ø. Spydevold, P. Botterman, P. Dieterle, P. C. Scriba, K. Schwarz, B. J. Boucher, K. Mashiter, L. Stimmler, F. Vince, P. Walters, T. R. Csorba, W. J. H. Butterfield, M. J. Whichelow, A. R. Boyns, R. Mahler, N. Pearce, B. Bruni, V. Büber, J. -P. Felber, A. Vannotti, K. D. Buchanan, J. E. Vance, K. Dinstl, R. H. Williams, B. D. Cox, N. M. Cohen, D. P. Alexander, H. G. Britton, D. A. Nixon, R. A. Parker, L. Cegrell, G. W. Chance, E. C. Albutt, C. Chlouverakis, P. White, N. Juel Christensen, G. Contesse, G. Pathé, J. Crabbé, J. Scarlata, G. Crepaldi, M. Muggeo, A. Tiengo, G. Enzi, G. Federspil, A. Trisotto, A. Czyżyk, A. Gregor, A. Dawidowicz, M. de Gasparo, Che. Malherbe, K. Thomas, J. J. Hoet, I. De Leeuw, M. Dérot, M. Rathery, G. Rosselin, James G. Devlin, Marion Duggan, U. C. Dubach, I. Forgò, R. Fellin, H. Muggeo, S. B. Fagerberg, A. Axelsson, S. Fankhauser, B. Morell, K. Federlin, H. -D. Flad, D. Kriegbaum, D. A. Rivier, E. Fellmann, D. Glaubitt, U. Hönlinger, I. Ulrich, K. Wulff, H. Förster, K. Brauch, H. Mehnert, F. Dittmar, H. Frerichs, W. Creutzfeldt, G. Fbeytag, W. Schabschmidt, G. Klöppel, Denise Friedler, J. P. Benhamou, J. Lubetzki, E. Azerad, A. Gnudi, C. Coscelli, V. Palmari, G. Valenti, U. Btttturini, F. Gomez, L. Guidoux-Grassi, J. Maerki, R. Guidoux, J. J. Groen, D. Grüneklee, H. Liebermeister, W. H. Schilling, H. G. Solbach, L. Herberg, H. Daweke, B. Guy-Grand, M. Tutin, H. Bour, D. R. Hadden, J. M. G. Harley, D. A. D. Montgomery, J. S. Mackay, Lise G. Heding, C. Hellerström, H. Stork, S. Westman, F. H. Schmidt, C. F. Boehringer, Söhne GmbH, Dieter Hepp, David R. Challoner, Robert H. Williams, M. Berger, F. A. Gries, H. Preiss, K. Jahnke, J. B. Herman, A. Keynam, D. M. Hill, A. D. Munro-Faure, J. Anderson, Z. Horn, A. Jakob, R. E. Humbel, U. Buxtorf, E. R. Froesch, N. S. Track, A. Kaeding, H. Karmann, P. Mialhe, H. Kasemir, U. Paulus, S. Steinhilber, L. Kerp, E. M. Kohner, N. W. Oakley, T. Russell Fraser, and J. Kühnau
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0303 health sciences ,medicine.medical_specialty ,business.industry ,Endocrinology, Diabetes and Metabolism ,Association (object-oriented programming) ,030209 endocrinology & metabolism ,Human physiology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,Family medicine ,Internal Medicine ,Medicine ,business ,030304 developmental biology - Published
- 1968
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9. British Diabetic Association Abstracts
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R. E. Humbel, S. J. H. Ashcroft, P. Baker, F. Malaisse-Lagae, A. M. Scott, I. Tamir, J. K. Lloyd, J. D. Baird, D. Turner, P. E. Lacy, C. N. Hales, J. R. Henderson, H. Zahn, G. M. Grodsky, P. J. Watkins, N. M. Cohen, W. J. H. Butterfield, R. J. Jarret, S. L. Howell, H. Cohen, G. J. Knight, A. J. Moody, E. Coll-Garcia, W. Danho, T. J. Merimee, N. S. Track, Aa. V. Nielsen, W. T. Strauss, J. K. Nelson, M. E. Abrams, W. J. Malaisse, A. Hart, G. A. Stewart, T. R. Csorba, C. Hellerstrm, P. C. Farrant, M. M. Segall, D. Rabinowitz, S. Falkmer, F. C. Greenwood, L. L. Bennett, D. M. Hill, J. Gliemann, M. J. Whichelow, K. W. Taylor, P. J. Randle, M. Kellock, F. L. Mitchell, J. B. Gill, R. W. J. Neville, T. H. Whittington, J. S. Smith, H. Keen, A. D. Munro-Faure, R. F. Mottram, J. Anderson, G. Schmidt, D. Cameron, and R. J. Jarrett
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medicine.medical_specialty ,business.industry ,Endocrinology, Diabetes and Metabolism ,Ophthalmology ,Family medicine ,Section (typography) ,Internal Medicine ,Medicine ,business - Published
- 1968
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10. Eighth annual meeting of the European Association for the Study of Diabetes
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K. G. M. M. Alberti, J. Darley, Pauline M. Emerson, T. D. R. Hockaday, M. Amherdt, A. A. Like, B. Blondel, B. Marliss, C. Wollheim, L. Orci, O. Ortved Andersen, Arne Andersson, F. M. Antonini, C. Fumagalli, E. Petruzzi, G. Bertini, S. Mori, P. Tinti, S. J. H. Ashcroft, L. C. C. Weerasinghe, P. J. Randle, R. Assan, N. Slusher, B. Guy-Grand, F. Girard, E. Soufflet, J. R. Attali, G. Ballerio, J. Boillot, T. Atkins, A. J. Matty, C. J. Bailey, A. Aynsley-Green, S. R. Bloom, R. A. Bacchus, L. G. Meade, D. R. London, L. Balant, G. Zahnd, B. Petitpierre, J. Fabre, E. O. Balasse, M. A. Neef, L. Barta, G. Brooser, Maria Molnar, D. P. Bataille, P. Freychet, P. Kitabgi, G. E. Rosselin, Christian Berne, J. Beyer, U. Cordes, G. Sell, C. Rosak, K. Schöffling, B. Birkner, J. Henner, P. Wagner, F. Erhardt, P. Dieterle, N. J. A. Vaughan, A. V. Edwards, L. Boquist, I. Brand, H. D. Söling, D. Brandenburg, J. Gliemann, H. A. Ooms, W. Puls, A. Wollmer, R. A. Camerini-Davalos, J. M. B. Bloodworth, B. Limburg, W. Oppermann, A. K. Campbell, K. Siddle, J. M. Cañadell, J. Barraquer, A. Muiños, C. D. Heredia, J. Castillo-Olivares, J. Guijo, L. F. Pallardo, E. Cerasi, S. Efendić, R. Luft, J. Wahren, P. Felig, Niels Juel Christensen, A. H. Christiansen, A. Vølund, J. J. Connon, E. Trimble, G. Copinschi, R. Leclercq, O. D. Bruno, E. Haupt, C. Creutzfeldt, N. S. Track, G. S. Cuendet, C. B. Wollheim, D. P. Cameron, W. Stauffacher, E. B. Marliss, A. Czyzyk, B. Lao, W. Bartosiewicz, Z. Szczepanik, E. De Nobel, A. Van't Laar, R. A. P. Koene, Th. J. Benraad, G. Dietze, K. D. Hepp, M. Wickmayr, H. Mehnert, K. Dixon, P. D. Exon, H. R. Hughes, D. W. Jones, R. S. Elkeles, M. G. FitzGerald, J. M. Malins, A. Falorni, F. Massi-Benedetti, G. Gallo, S. Maffei, D. Fedele, A. Tiengo, M. Muggeo, P. Fabris, G. Crepaldi, K. Federlin, K. Helmke, M. Slijepčević, E. F. Pfeiffer, J. P. Felber, J. Oulès, Ch. Schindler, V. Chabot, A. Fernandez-Cruz, E. Catalán, M. Luque Otero, O. Garcia Hermida, J. P. Flatt, G. Blackburn, G. Randers, H. Förster, I Hoos, D. Lerche, I. Hoos, M. Matthäus, J. R. M. Franckson, H. Frerichs, H. Daweke, F. Gries, D. Grüneklee, J. Hessing, K. Jahnke, U. Keup, H. Miss, H. Otto, D. Schmidt, C. Zumfelde, H. v. Funcke, G. Löffler, O. Wieland, D. J. Galton, R. Guttman, G. C. Gazzola, R. Franchi, P. Ronchi, V. Saibene, G. G. Guidotti, V. Gligore, N. Hîncu, Rodica Tecuceanu, R. Goberna, F. Garcia-Albertos, J. Tamarit-Rodriguez, E. del Rio, R. Roca, José Gomez-Acebo, A. V. Creco, G. Fedeli, G. Ghirlanda, R. Fenici, M. Lucente, A. Gutman, G. Agam, N. Nahas, P. Cazalis, E. Gylfe, B. Hellman, D. R. Hadden, J. H. Connolly, D. A. D. Montgomery, J. A. Weaver, Claes Hellerström, Simon Howell, John Edwards, J. Sehlin, I. -B. Täljedal, W. Heptner, H. B. Neubauer, A. Herchuelz, D. G. Pipeleers, W. J. Malaisse, E. Herrera, Eladio Montoya, H. Hommel, IT. Fischer, B. Schmid, H. Fiedler, H. Bibergeil, J. Iversen, P. B. Iynedjian, G. Peters, C. Jacquemin, B. Lambert, B. Ch. J. Sutter, A. Jakob, J. Zapf, E. R. Froesch, F. K. Jansen, G. Freytag, L. Herberg, R. J. Jarrett, I. A. Baker, C. Jarrousse, F. Rancon, D. Job, G. Tchobroutsky, E. Eschwege, C. Guyot-Argenton, J. P. Aubry, M. Déret, H. Karman, P. Mialhe, A. Kissebah, B. Tulloch, Russell Fraser, N. Vydelingum, J. Kissing, S. Raptis, H. Dollinger, J. Faulhaber, G. Rothenbuchner, J. Kleineke, H. Sauer, J. Kloeze, Eva M. Kohner, Barbara A. Sutcliffe, M. Tudball, C. T. Dollery, W. Korp, J. Neubert, H. Bruneder, A. Lenhardt, R. E. Levett, T. Koschinsky, F. A. Gries, M. M. C. Landgraf-Leurs, R. Landgraf, R. Hörl, D. R. Langslow, H. Laube, R. Fussgänger, R. Mayer, H. Klör, E. Lázaro, V. Leclercq-Meyer, J. J. Marchand, W. Malaisse, Thomas Ledet, P. J. Lefébvre, A. S. Luyckx, Y. Le Marchand, F. Assimacopoulos, A. Singh, Ch. Rouiller, B. Jeanrenaud, G. Lenti, R. Frezzotti, G. Angotzi, A. M. Bardelli, G. Pagano, A. Basetti-Sani, M. Galli, Å. Lernmark, G. Fex, D. G. Lindsay, O. Loge, C. Lopez-Quijada, L. Chiva, M. Rodriguez-Lopez, E. G. Loten, A. L. Loubatières, M. M. Loubatières-Mariani, G. Ribes, J. Chapal, J. Lubetzki, J. Duprey, Cl. Sambourg, P. J. Lefebvre, V. Maier, M. Hinz, H. Schatz, C. Nierle, F. Malaisse-Lagae, M. Ravazzola, A. E. Renold, P. Manzano, E. Rojas-Hidalgo, J. Marco, D. Diaz-Fierros, C. Calle, D. Roman, M. L. Villanueva, I. Valverde, A. Like, A. L. Luycks, F. Fracassini, R. Menzel, D. Michaelis, I. Neumann, B. Schulz, W. Wilke, P. Wulfert, K. Krämer, G. Menzinger, F. Fallucca, F. Tamburrano, R. Carratu', D. Andreani, P. Metzger, P. Franken, R. Michael, W. Hildmann, E. Jutzi, J. Michl, S. Fankhauser, J. Schlichtkrull, J. Mirouze, A. Orsetti, Y. Vierne, N. Arnoux, L. Mølsted-Pederson, Inge Tygstrup, Åge L. Villumsen, Jørgen Pedersen, W. Montague, S. L. Howell, A. J. Moody, G. S. Agerbak, F. Sundby, A. Baritussio, Peter Naeser, R. Navalesi, A. Pilo, S. Lenzi, P. Cecchetti, G. Corsini, L. Donato, J. Nerup, G. Bendixen, J. Egeberg, J. E. Poulsen, J. Høiriis Nielsen, F. Mølgaard Hansen, A. Niki, H. Niki, T. Koide, B. J. Lin, R. E. Nikkels, J. Terpstra, A. Gay, R. H. Oakman, Norman R. Lazarus, C. Rouiller, J. Ostman, L. Backman, D. Hallberg, K. Ostrowski, U. Panten, J. Christians, H. -H. Parving, S. Munkgaard Rasmussen, M. Marichal, H. Platilovà, M. Dufek, E. Konopàsek, V. Pozuelo, J. Tamarit, A. Suner, C. Castell, E. D. R. Pruett, S. Maehlum, B. Grebe, M. Chrissiku, R. Müller, H. J. Hinze, H. Reinauer, E. R. Müller-Ruchholtz, X. Rietzler, P. Passa, J. Canivet, J. Otto, G. Behrens, T. Bücher, U. Schlumpf, B. Morell, A. Zingg, J. Schönborn, P. Westphal, G. D. Bloom, L. -A. Idahl, A. Lernmark, M. Söderberg, M. Serrano Rios, F. G. Hawkins, F. Escobar, J. M. Mato, L. Larrodera, M. de Oya, J. L. Rodriguez-Miñon, E. Shafrir, G. Sitbon, Z. Skrabalo, N. Panajatović, Z. Papić, J. Posinovec, A. Stavljenić, V. Lipovac, I. Aganović, N. G. Soler, M. A. Bennett, H. Peters, G. Janson, P. H. Sönksen, M. C. Srivastava, C. V. Tompkins, J. D. N. Nabarro, N. Schwartz Sørensen, K. Ladefoged, K. E. Wildenhoff, F. Sorge, H. -J. Diehl, H. Hoffmann, W. Schwartzkopff, E. Standl, H. Kolb, A. Standl, H. W. Sutherland, J. M. Stowers, J. C. G. Whetham, B. C. J. Sutter, B. Billaudel, M. T. Sutter-Dub, R. Jacquot, I. B. Täljedal, R. Gobema, Gy. Tamás, Éva Baranyi, A. Baranyi, A. Radvanyi, J. Tatoń, A. Hinek, A. Wiśniewska, R. B. Tattersall, D. A. Pyke, J. Bruins Slot, P. L. M. v. d. Sande, J. K. Radder, K. J. J. Waldeok, R. C. P. A. v. Muijden, W. Creutzfeldt, D. S. Turner, R. W. Baker, W. G. L. Gent, A. Shabaan, V. Marks, D. A. B. Young, Ph. Vague, H. Heim, C. Martin Laval, M. Vegezzi, C.Di Campo, G. Rahamandridona, D. Garron, B. Heyraud, J. Vague, I. Lozano, M. Diaz-Fierros, F. A. Van Assche, W. Gepts, E. Van Obberghen, G. Somers, G. Devis, G. D. Vaughan, J. Veleminsky, E. Spirova, W. Waldhäusl, H. Frisch, H. Haydl, L. Weiss, B. Willms, U. Deuticke, M. Zrůstová, and J. Roštlapil
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0303 health sciences ,medicine.medical_specialty ,business.industry ,Endocrinology, Diabetes and Metabolism ,Association (object-oriented programming) ,030209 endocrinology & metabolism ,Human physiology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,Family medicine ,Internal Medicine ,medicine ,business ,030304 developmental biology - Published
- 1973
- Full Text
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11. Seventh Annual Meeting of the European Association for the Study Of Diabetes Southampton, England, September 15–17, 1971 Abstacts, Part 1
- Author
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H. Bibergeil, W. J. H. Butterfield, F. Fallucca, H. Brunengraber, M. J. Munday, Eveline Eschwège, M. Hinz, J. Rogers, O. Richter, J. Hanoune, B. Jeanrenaud, Kjell Asplund, H. Laube, G. Stirati, G. Ghirlanda, C. Dumitrescu, Aa. Hein Christiansen, I. Pencev, L. Nye, S. Ditzov, Claes Hellerström, L. Bodic, V. Gligore, G. Brooser, I. Mastrogiacomo, K. W. Taylor, R. Franchi, R. Fussgänger, L. Stoichescu, Y. Vierne, B. Charbonnel, L. Sjöström, J. Girard, E. Jéquier, U. Fischer, George E, O. Alpi, G. C. Gazzola, M. Austoni, G. Ballerio, F. K. Jansen, G. Chiumello, G. G. Guidotti, J. G. Mills, L. Baldet, Elizabeth Mayne, S. Munkgaard Rasmussen, G. Tamburrano, P. Zöfel, A. Luyckx, M. Carnelutti, U. Cordes, H. Hommel, J. P. Felber, R. Luft, Aa. Vø und, F. Mira, V. Chabot, I. Calusera, S. Frezzato, J. Guillon, J. Terpstra, R. Michael, Brigitte Ziegler, L. Anghelescu, Ernst-Friedrich Pfeiffer, Aa. Vølund, S. Nistrup Madsen, M. Miclutia, S. E. Brolin, G. Freytag, J. Linde, W. D. Gassel, A. Fernandez-CruzJr., M. Ionesou, W. Creutzfeldt, A. Hegedüs, U. Deuticke, J. B. Attali, J. F. Biebuyck, L. Kerp, Gh. Bacanu, J. J. Connon, H. Fiedler, K. E. Schröder, G. Fedeli, N. Katsilambros, S. K. Varma, K. G. M. M. Alberti, Günter Klöppel, E. Napoli, Margaret J. Whichelow, G. A. Cinotti, B. Bierens de Haan, M. J. del Guercio, B. Bruni, G. Tchobroutsky, G. Perry, N. Mosora, L. Papoz, M. Bolea-Feldman, K. D. Hepp, N. Sicolo, F. A. Gries, G. Cavazzini, A. Fernandes-CruzJr., D. Bal, A. C. Asmal, M. Ziegler, Beyer J, J. Lawecki, D. Grüneklee, H. Daweke, Barbara Rudas, J. J. Turner, B. Schröder, K. D. Buchanan, G. Sell, K. Mylarch, T. Holan, E. Capra, S. Fankhauser, E. O. Baiasse, E. Bruck, C. Creutzfeldt, F. Belfiore, J. M. Warnet, S. Campeami, G. Menzinger, L. Olteanu, K. Bojanowicz, J. A. Weaver, T. Fekete, L. Herberg, O. Wieland, M. Varma, V. Turcanu, John Edwards, F. Gomez, M. Rathery, Y. Abdel Rahman, S. J. H. Ashcroft, C. J. Vardey, T. Deckert, P. Lefebvre, D. Andreani, M. Zaccaria, N. Sieolo, Raimundo Goberna, D. P. M. Howells, D. Andreev, B. Karamanos, F. Nistor, S. W. Cushman, Hung Cheng, J. J. Heindel, G. Piemonte, Jean Franckson, R. R. de Mowbray, W. Guder, B. D. Cox, Etienne Brachet, L. Boquist, W. Stauffacher, T. Beraru, M. Luque Otero, N. Krall, J. Hahn, Ch. Rouiller, L. Sirskov, V. Maier, L. Orci, C. Lopiz-Quijada, C. Coscelli, W. G. Whyte, W. Rippel, V. Büber, J. Fövenyi, A. Gnudi, V. Palmari, R. K. Blach, P. W. Adams, J. Iversen, A. J. Valleron, P. Ronchi, H. Rogala, E. Goth, Niels Juel Christensen, J. G. Devlin, U. Keller, H. Keen, R. Leclercq, D. P. Cameron, C. Geldermans, J. Kuti, F. Assimacopoulos, R. A. Jackson, Åke Lernmark, E. Jutzi, N. W. Oakley, H. Schatz, J. P. Aboulker, J. L. Richard, L. Campeanu, R. A. Bacchus, R. Assan, A. Serban, S. J. Heaney, I. De Leeuw, R. Fenici, R. S. Walker, M. Amherdt, A. Z. Middelheim, D. Casara, L. Lo Vecchio, H. M. J. Krans, J. M. Bassett, L. B. Martin, N. S. Track, J. Sehlin, J. Mirouze, E. Cerasi, George Gross, T. Clausen, R. M. Buckle, A. Aynsley-Green, B. Hellman, U. Advani, D. Pometta, L. Barta, V. V. Pipilian, U. Heink, E. Rattenhuber, R. Arnold, S. Efendic, H. Kaffarnik, Christian Berne, A. Kaeding, S. R. Bloom, S. D. Garner, V. Wynn, C. A. Geser, A. V. Greco, S. Triggs, G. C. Reffo, C. Jafflol, W. J. H. Butterfieid, D. R. Hadden, H. J. Hahn, R. Vanroux, C. De Palo, G. Federspil, L. G. Meade, Henri Ooms, D. Ancreev, Mária Judit Molnár, U. Birk Lauridsen, I. B. Täljedal, P. Björntorp, J. Michl, B. Petersson, A. Czyzyk, R. J. Jarrett, S. Steinhilber, D. R. London, J. R. Scherrer, O. Förster, G. Gambassi, Schöffling K, H. Frerichs, D. A. D. Montgomery, E. Saibene, M. Javicoli, J. Hessing, M. Szadkowski, W. H. Davies, N. Tarkolev, P. J. Randle, C. Scandellari, and E. R. Froesch
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0303 health sciences ,medicine.medical_specialty ,business.industry ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Human physiology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Family medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Optometry ,business ,030304 developmental biology - Published
- 1971
- Full Text
- View/download PDF
12. Seventh Annual Meeting of the European Association for the Study of Diabetes
- Author
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Bo Hellman, G. C. Palmieri, N. Mihalache, P. Siltanen, G. Bagnariol, W. K. Waldhäusl, M. Javicoli, U. Klör, F.A. Van Assche, M. Rathery, O. Melogli, D. Fedele, E. F. Pfeiffer, G. K. Rastogi, M. Bretán, R. R. de Mowbray, Poul Ebbe Nielsen, A. E. Lambert, Aa. Prange Hansen, Guido Tamburrano, J. C. Sodovez, B. Riveline, J. Canivet, Bartelt Km, S. Efendic, Franco Camanni, J. P. Bali, J. R. Claude, C. Rouiller, B. Schulz, M. Hinz, E. Eschwege, M. M. Mariani, M. Vigas, L. Kammerer, G. Enzi, M. Prud'homme, F. Massi-Benedetti, P. P. Foà, A. Ghidoni, I. M. Burr, L. Niklas, L. Nye, Sotirios Raptis, U. Brinck, B. Meyer, Hamish W. Sutherland, H. Laube, W. R. Drucker, B. Lesobre, H. J. Quabbe, M. A. Page, Åke Lernmark, Raimundo Goberna, M. Muggio, A. van't Laar, R. F. Murphy, Jens F. Rehfeld, Rolf Luft, C. E. Østerby, H. Karmann, K. E. Schröder, Ch. Thum, K. A. Munday, N. Mosora, Y. Kanazawa, D. P. Cameron, C. V. Tompkins, R. E. Levett, P. H. Sönksen, Domenico Andreani, R. D. M. Scott, P. J. Reeds, R. Fellin, A. Loubatières, M. J. Smith, J. Samsel, H. Iwatsuka, A. J. Valleron, S. Persson, K. Pyörälä, Victor Conard, J. M. Warnet, P. Polosa, R. Sparthe, A. Gordon, Y. Abdel Rahman, E. Fusco, Felix P. N. Schennetten, M. C. Srivastava, K. Johansen, D. Wübbens, F. Dauchy, Keith D. Buchanan, J. Marco, W. Teller, W. Poser, J. D. N. Nabarro, M. Rousselet, A. Hasselblatt, G. Rothenbuchner, H. Ørskov, G. M. Molinatti, J. Schönborn, A. Vitelli, A. M. McCarroll, Inge Bert Täljedal, M. Amherdt, R. Knussman, F. A. Gries, L. Orci, Beyer J, F. Jallet, J. Schlichtkrull, Z. Skrabalo, J. Vincze, W. Korp, Schöffling K, Ev. Kriedstein, E. B. Möller, J. Landon, S. Frezzato, H. Wingstrand, F. Massara, G. E. Rosselin, G. J. A. I. Snodgrass, H. L. Fehm, D. Michaelis, S. Le Guilcher, K. Seyer-Hansen, C. Kruger, D. M. Kipnis, J. Mirouze, María L. Villanueva, O. Oelz, P. J. Lefèbvre, V. Duma, Per Westermark, E. Giangrandi, M. R. Turner, H. Bibergeil, G. R. Brisson, J. Birk, T. Mincu, I. M. Baroja, M. R. P. Hall, G. Wick, Patricia Metzger, Werner Oppermann, E. Jutzi, Guido Pozza, P. Jacquet, A. Kopf, J Ostman, N. Conte, R. Fuchs, Theodore Ehrenreich, I. Mincu, Barbara Rudas, A. S. Luyckx, A. E. Renold, A. Schirmann, U. Klemens, R. E. Haist, V. Nuteanu, L. Papoz, R. Spaethe, G. Tohobroutsky, W. Hildmann, V. Gligore, B. Morell, G. Tchobroutsky, Willy Malaisse, J. Sterne, G. Löffler, N. S. Track, E. B. Marliss, EskoA. Nikkilä, C. R. C. Heard, Tr. Baciu, F. Fallucca, E. Krug, J. Trap-Jensen, Isabel Valverde, Rafael A. Camerini-Davalos, S. Klahr, L. Stimmler, C. Rosak, M. Motocou, K. W. Taylor, H. Otto, O. Wieland, K. Lundbak, Th. Koschinsky, R. Assan, E. Cerasi, M. Toeller, S. Triggs, W. Stauffacher, Haupt E, R. J. Dash, C. Scandellari, E. R. Froesch, F. J. Woodroffe, L. Balant, M. Verry, M. Lunetta, A. Tiengo, D. G. Parry, L. Weiss, M. Kikuchi, Uwe Panten, G. C. Viberti, B. Blondel, J. D. Teale, J. C. Dunbar, N. S. Bricker, C. E. Ruth, M. K. Sinha, W. Braun, M.R. Taskinen, D. H. Williamson, U. Loos, O. Steingaszner, Giovanni Federspil, L. Herberg, S. Georgescu, R. Fussgänger, J. Hewitt, A. L. Bergström, S. Levin Nielsen, H. Schatz, E. Lehtovirta, Jurgen Steinke, I. Lozano, F. Sodovez-Goffaux, D. R. Langslow, E. Speich, I. Neumann, G. Menzinger, A. Tinant, S. Munkgaard Rasmussen, Janove Sehlin, C. Dumitrescu, N. Katsilambros, A. Tognetti, Ligia Simionesco, C. Oliver, C. E. Mogensen, A. E. Pappalettera, P. Vague, K. Sträub, L. Motta, J. Vague, A. Orsetti, Mme A. Serre, B. M. Freeman, A. Trisotto, R. Korec, M. Diaz-Fierros, F. Stadil, S. Campeanu, J. Sabin, H. P. T. Ammon, P. Mialhe, F. Legros, C. Rogister, R. Schröder, V. Maier, Risto Pelkonen, F. Scaroina, M. Parvulescu, and K. E. Schenk
- Subjects
medicine.medical_specialty ,business.industry ,Endocrinology, Diabetes and Metabolism ,Association (object-oriented programming) ,Family medicine ,Ophthalmology ,Diabetes mellitus ,Internal Medicine ,medicine ,Human physiology ,business ,medicine.disease - Published
- 1972
- Full Text
- View/download PDF
13. Biochemical and morphological investigations of 30 human insulinomas
- Author
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U. Deuticke, N. S. Track, Rudolf Arnold, C. Creutzfeldt, H. Frerichs, and Werner Creutzfeldt
- Subjects
endocrine system ,medicine.medical_specialty ,Pathology ,Adenoma ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Internal Medicine ,medicine ,Diazoxide ,Insulinoma ,030304 developmental biology ,Proinsulin ,0303 health sciences ,geography ,geography.geographical_feature_category ,business.industry ,Insulin ,medicine.disease ,Islet ,3. Good health ,Endocrinology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Ultrastructure ,Pancreas ,business ,medicine.drug - Abstract
Thirty human insulinomas have been investigated histologically and their immunoreactive insulin (IRI) content estimated. In most cases immunohistological and ultrastructural studies were also performed and the percentage of proinsulin-like components (PLC) in the tumour determined. Except for 1 case the IRI concentration in the tumours was lower (0.01–89.0 U/g) than in the islet tissue. Histologically, immunohistologically and ultrastructurally a variable number of tumour cells contained few and often no beta-granules, indicating a decreased storage capacity for insulin. This defective storage capacity seems to be the major functional abnormality of insulinoma cells. Ultrastructurally four types of insulinoma can be distinguished. The ultra-structural diagnosis of an insulinoma can only be made in type I (typical beta-granules, 13 cases) and type II (typical and atypical granules, 7 cases) but not in type III (atypical granules only, 4 cases) and type IV (virtually agranular, 4 cases). The type IV tumours had the lowest IRI concentration and did not respond to diazoxide treatment. The IRI concentration of the uninvolved pancreas of 19 patients was 2.0±0.2 U/g and in the range of non-diabetic adults. — The percentage PLC in 19 insulinomas was higher (5.3–22%) than in the pancreas of human adults with and without insulinoma (1.7–4.8%). The percentage of PLC in the serum of patients with insulinoma was always higher than in their tumours (33–61%). It is suggested that the higher PLC levels found in the tumour and serum of insulinoma patients are the consequence of the reduced storage capacity of the tumour cells resulting in a rapid passage through the granular route or even a non-granular release of newly synthesized insulin.
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- 1973
- Full Text
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14. Increased serum immunoreactive gastrin levels in idiopathic hypertrophic pyloric stenosis
- Author
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B Shandling, W Zingg, N S Track, H W Karl, and M A Bleicher
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Vomiting ,medicine.medical_treatment ,Pyloromyotomy ,Pyloric stenosis ,Pyloric Stenosis ,Muscle hypertrophy ,Gastrin levels ,Internal medicine ,Gastrins ,Medicine ,Humans ,Antigens ,Gastrin ,business.industry ,Gastroenterology ,Infant, Newborn ,Infant ,Hypertrophy ,medicine.disease ,Infant newborn ,Idiopathic Hypertrophic Pyloric Stenosis ,Endocrinology ,Female ,medicine.symptom ,business ,Research Article - Abstract
The serum immunoreactive gastrin (IRG) level in infants with confirmed idiopathic hypertrophic pyloric stenosis (IHPS) has been determined and compared to that found in vomiting infants without IHPS, in normal infants, and in normal adults. The mean serum IRG level of normal infants (103 +/- 9 pg/ml (mean +/- SEM) exceeded that of normal adults (28 +/- 5 pg/ml). The preoperative mean serum IRG level in IHPS infants (256 +/- 26 pg/ml) was significantly higher than that of both normal infants and vomiting infants without IHPS (93 +/- 9 pg/ml). Twenty-five per cent (5/20) of the IHPS infants had serum IRG levels within the upper range of normal infants. Fasting serum IRG levels in IHPS infants were not altered immediately by pyloromyotomy. The results from this study suggest a relationship between gastrin and idiopathic hypertrophic pyloric stenosis.
- Published
- 1978
15. Appearance of gastrin and somatostatin in the human fetal stomach, duodenum and pancreas
- Author
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Werner Creutzfeldt, C. Neuhoff, N. S. Track, C. Creutzfeldt, J. Litzenberger, and Rudolf Arnold
- Subjects
endocrine system ,medicine.medical_specialty ,Duodenum ,Regulation of gastric function ,digestive system ,Internal medicine ,Gastrins ,medicine ,Humans ,Antrum ,Pancreas ,Gastrin ,business.industry ,Stomach ,digestive, oral, and skin physiology ,Gastroenterology ,medicine.anatomical_structure ,Endocrinology ,Somatostatin ,Gastric Mucosa ,Chromatography, Gel ,Immunologic Techniques ,G cell ,business ,hormones, hormone substitutes, and hormone antagonists - Abstract
The gestational time of appearance of gastrin and somatostatin in the human fetal stomach, duodenum and pancreas was examined. Immunoreactive gastrin (IRG) is detected in antral, duodenal and pancreatic extracts of a 7.0-cm (crown-heel length) fetus. More IRG is extracted from the duodenum than the antrum. Duodenal IRG concentration from fetuses of 16.0--26.0 cm are higher than younger fetal and adult concentrations. Antral IRG concentrations are one tenth of the adult contents. Very small IRG concentrations are present in the human fetal pancreas. Gastrin immunohistochemical staining is positive first in duodenal (6.5-cm fetus) and later in antral (12.5-cm fetus) mucosa; pancreatic tissue is negative for gastrin immunohistochemistry. Type IV cells are encountered in antral and duodenal mucosa of 4.0-cm fetuses; other endocrine cells appear with fetal growth. Not until much later in gestation (21.0 cm) do typical G cells appear. These results suggest that early in fetal life gastrin is produced by the type IV cell. Somatostatin immunohistochemical staining is positive in stomach, duodenum and pancreas in 6.5-cm fetuses. Immature D cells are found in antral and duodenal mucosa of 5.0-cm fetuses and mature D cells in 11.0-cm fetuses.
- Published
- 1979
16. Mucosal gastrin concentration, molecular forms of gastrin, number and ultrastructure of G-cells in patients with duodenal ulcer
- Author
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Rudolf Arnold, N. S. Track, W Creutzfeldt, and C Creutzfeldt
- Subjects
Adult ,Male ,medicine.medical_specialty ,Duodenum ,Radioimmunoassay ,Cell Count ,Cytoplasmic Granules ,Gastroenterology ,Internal medicine ,Gastrins ,Gastric mucosa ,Pyloric Antrum ,Medicine ,Humans ,Antrum ,Gastrin ,Aged ,Clinical Trials as Topic ,business.industry ,Middle Aged ,Microscopy, Electron ,medicine.anatomical_structure ,Endocrinology ,Gastric Mucosa ,Duodenal Ulcer ,Ultrastructure ,Female ,G cell ,business ,Research Article - Abstract
The mean antral immunoreactive gastrin (IRG) concentration of 38 duodenal ulcer (DU) patients was significantly higher (35-9+/-5-2 mug/g) than that of 21 controls (15-9+/-2-6 mug/g). Also the mean IRG concentration in the proximal duodenal mucosa of 15 DU patients (3-2+/-0-8 mug/g) was higher (but not significantly) than that of 10 controls (1-8+/-0-5 mug/g). The number of G-cells in the antral mucosa of 58 DU patients and in the duodenal mucosa of 29 DU patients was not larger than that of controls. The distribution of immunoreactivity in gastrin components has been investigated in the antral and duodenal mucosa of six DU patients and six controls. In the antral mucosa the mean percentage of G-17 was 93-3% in DU patients and 92-0% in controls. G-34 amounted to 4-0% in DU patients and to 5-0% in controls. The G-34 percentage in the duodenal mucosa was higher (however not significantly) in the DU patients than in the controls (50-1% versus 35-8%). Ultrastructurally, the antral G-cells of DU patients had a significantly lower density index of their secretory granules suggesting higher functional activity. It is concluded that the exaggerated serum IRG response of DU patients to different stimuli is not a consequence of an increased G-cell mass.
- Published
- 1976
17. Bombesin, calcitonin and leu-enkephalin immunoreactivity in endocrine cells of human lung
- Author
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E. Cutz, N. S. Track, and Wilson Chan
- Subjects
Adult ,Calcitonin ,medicine.medical_specialty ,Adolescent ,Peptide ,Enteroendocrine cell ,Biology ,Human lung ,Immunoenzyme Techniques ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,Age groups ,Internal medicine ,medicine ,Humans ,Child ,Molecular Biology ,Lung ,Pharmacology ,chemistry.chemical_classification ,Histocytochemistry ,Bombesin ,Infant ,Cell Biology ,Enkephalins ,respiratory system ,Leu-enkephalin ,respiratory tract diseases ,medicine.anatomical_structure ,Endocrinology ,chemistry ,Child, Preschool ,Molecular Medicine ,Immunohistochemistry ,Endorphins ,Peptides ,hormones, hormone substitutes, and hormone antagonists ,Enkephalin, Leucine - Abstract
By immunohistochemistry, bombesin, calcitonin and leu-enkephalin was localized in endocrine cells of human lungs from various age groups. It is suggested that at least 3 different peptide containing endocrine cells may be present in human lung.
- Published
- 1981
18. The Different Forms of Immunoreactive Gastrin in Blood and Tissue
- Author
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Creutzfeldt W, Arnold R, Creutzfeldt C, and N. S. Track
- Subjects
chemistry.chemical_classification ,medicine.medical_specialty ,Chemistry ,digestive, oral, and skin physiology ,digestive system ,Gastrin II ,Amino acid ,Residue (chemistry) ,Endocrinology ,Internal medicine ,medicine ,Tyrosine ,hormones, hormone substitutes, and hormone antagonists ,Gastrin - Abstract
Immunoreactive gastrin (IRG) is found in both tissues and blood. Gastrin was isolated as a polypeptide of seventeen amino acids (G-17) which is present in two forms designated gastrin I and gastrin.II. Gastrin II contains a sulphate group on the tyrosine residue at position 12; gastrin I is sulphate-free. Studies in recent years have established the heterogeneity of IRG in both tissue and blood [1, 2].
- Published
- 1974
- Full Text
- View/download PDF
19. Age of onset and inheritance of diabetes: the importance of examining relatives
- Author
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N. S. Track and Harry Keen
- Subjects
Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Endocrinology, Diabetes and Metabolism ,media_common.quotation_subject ,Internal medicine ,Diabetes mellitus ,Good evidence ,Internal Medicine ,medicine ,Diabetes Mellitus ,Humans ,Child ,media_common ,Aged ,Glucose tolerance test ,medicine.diagnostic_test ,business.industry ,Age Factors ,Infant, Newborn ,Diabetes prevalence ,Infant ,Human physiology ,Glucose Tolerance Test ,Middle Aged ,medicine.disease ,Endocrinology ,Diabetes Mellitus, Type 1 ,Child, Preschool ,Female ,Age of onset ,Abnormality ,Inheritance ,business - Abstract
Suggestions that diabetes of younger- and older-onset are inherited differently have been examined in a family study which compares the first-degree relatives of 735 diabetic patients with those of 514 ‘control’ patients. Verbally reported histories from the propositi indicated an excess prevalence of known diabetes among the siblings of younger-onset diabetics; however, when the ostensibly normal, first-degree relatives were examined a high frequency of unsuspected glucose tolerance test abnormality was found. When the diabetes prevalence in relatives of diabetics was compared with that in relatives of controls (K ratio), a method at present widely used to determine the mode of inheritance, a number of problems arose suggesting that this means of genetic analysis may be misleading in diseases such as diabetes. It is concluded, for reasons which are discussed, that differences in prevalence ratios cannot be accepted as good evidence for different modes of inheritance of younger- and older-onset diabetes in man.
- Published
- 1968
20. Evolutionary aspects of the gastrointestinal hormones
- Author
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N. S. Track
- Subjects
endocrine system ,medicine.medical_specialty ,Physiology ,Swine ,medicine.medical_treatment ,Secretin receptor family ,Secretin family ,Biology ,digestive system ,Biochemistry ,Glucagon ,Frameshift mutation ,Secretin ,Gastrointestinal Hormones ,Internal medicine ,Gastrins ,medicine ,Animals ,Insulin ,Amino Acid Sequence ,Molecular Biology ,Gastrin ,digestive, oral, and skin physiology ,General Medicine ,Biological Evolution ,Endocrinology ,Mutation ,hormones, hormone substitutes, and hormone antagonists ,Hormone ,Proinsulin - Abstract
It is proposed that a proinsulin-like molecule formed the ancestral protein from which insulin, glucagon, gastrin and secretin evolved by an evolutionary pathway involving codon frameshift mutation.
- Published
- 1973
21. LOWERING OF BASAL AND STIMULATED SERUM IMMUNOREACTIVE GASTRIN AND GASTRIC SECRETION IN PATIENTS WITH ZOLLINGER-ELLISON SYNDROME BY SOMATOSTATIN
- Author
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R. Arnold, W Creutzfeldt, N. S. Track, and J Köbberling
- Subjects
medicine.medical_specialty ,business.industry ,Endocrinology, Diabetes and Metabolism ,Regulation of gastric function ,General Medicine ,medicine.disease ,Gastric secretion ,Zollinger-Ellison syndrome ,Basal (phylogenetics) ,Endocrinology ,Somatostatin ,Internal medicine ,Medicine ,In patient ,business ,Gastrin - Published
- 1975
- Full Text
- View/download PDF
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