1. Full-thickness skin reconstruction with basic fibroblast growth factor-impregnated collagen-gelatin sponge
- Author
-
Satoko Mori, Mika Takagi, Hajime Matsumine, Masaki Takeuchi, Tomohiro Iwata, Mari Shimizu, and Hiroshi Fujimaki
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Reconstructive surgery ,medicine.medical_treatment ,Basic fibroblast growth factor ,Drug delivery system ,Biomedical Engineering ,Scars ,Biomaterials ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,bFGF, basic fibroblast growth factor ,Dermis ,medicine ,lcsh:QH573-671 ,lcsh:R5-920 ,Debridement ,integumentary system ,business.industry ,lcsh:Cytology ,Cartilage ,bFGF-CGS, basic fibroblast growth factor-impregnated collagen gelatin sponge ,Artificial dermis ,Tendon ,Surgery ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,Skin grafting ,Original Article ,medicine.symptom ,business ,lcsh:Medicine (General) ,030217 neurology & neurosurgery ,Developmental Biology - Abstract
Introduction This study examined the usefulness of basic fibroblast growth factor impregnated collagen-gelatin sponge (bFGF-CGS) in reconstructive surgery for various acute skin defects including deep dermal burns, facial full-thickness skin defects, and finger amputations as the first clinical application. Methods Reconstructive surgery was performed in two stages with bFGF-CGS in 8 male subjects, ranging in age from 6 to 84 years, with acute full-thickness skin defects. Following the adequate debridement of the defect, surgeons prepared a bFGF-CGS with bFGF solution at a dose of 7–14 mg/cm2 approximately 10 min just before application and then secured the bFGF-CGS in place with non-absorbable sutures. Second-stage wound closure was performed with autologous skin grafting following adequate dermis-like tissue regeneration at the site postoperatively. Follow-up was continued for 6 months. Results Of the 8 subjects, the mean duration from the adequate vascularization of the dermis-like tissue until the second-stage autologous skin graft was 22 ± 4 days. Wound closure was achieved in all cases; the mean duration until wound closure was 32 ± 8 days. During the 6-month follow-up period, no wound infection, recurrent skin ulceration, and no exposure of tendon, bone, and cartilage were observed, and there were no cases of indirectly restricted range of motion from postoperative scar contracture and none with disfiguring scars. Conclusion The authors achieved favorable outcomes following reconstructive surgery with a hybrid artificial dermis impregnated with bFGF for treating acute full-thickness skin defects. bFGF-CGS serves as a convenient regenerative device requiring no specialized medical facilities., Highlights • This study examined the usefulness of bFGF-impregnated collagen gelatin sponge for skin defects. • bFGF-CGS achieved wound closure with acute full-thickness skin defects in a short period of time. • bFGF-CGS is a convenient device without requiring specialized medical facilities.
- Published
- 2019