15 results on '"Martin Masek"'
Search Results
2. Utility of cardiac CT for evaluating delayed contrast enhancement in dilated cardiomyopathy
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David Ambroz, Jan Daneš, Lukas Lambert, Josef Marek, Petr Kuchynka, Martin Masek, Tomas Palecek, Aleš Linhart, and Vladimir Cerny
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Adult ,Cardiomyopathy, Dilated ,Male ,medicine.medical_specialty ,Endomyocardial fibrosis ,Contrast Media ,030204 cardiovascular system & hematology ,Sensitivity and Specificity ,030218 nuclear medicine & medical imaging ,Cohort Studies ,Ventricular Dysfunction, Left ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Myocardial scarring ,Humans ,Medicine ,Prospective Studies ,cardiovascular diseases ,Prospective cohort study ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Dilated cardiomyopathy ,Gold standard (test) ,Middle Aged ,Endomyocardial Fibrosis ,Image Enhancement ,musculoskeletal system ,medicine.disease ,Magnetic Resonance Imaging ,Heart failure ,cardiovascular system ,Cardiology ,Female ,Myocardial fibrosis ,Radiology ,medicine.symptom ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business - Abstract
The presence of myocardial fibrosis is associated with adverse outcome in dilated cardiomyopathy (DCM). Delayed contrast-enhanced cardiac magnetic resonance (DE-CMR) currently represents the gold standard in noninvasive evaluation of myocardial scarring. However, a significant number of patients are unable to undergo DE-CMR study for various reasons. We sought to determine the diagnostic accuracy of cardiac CT (CCT) compared with CMR in the investigation of the presence of delayed contrast enhancement (DCE) in subjects with DCM. We prospectively enrolled 17 consecutive patients with DCM, who were initially referred to our institution because of recently manifested heart failure due to unexplained left ventricular systolic dysfunction. In all subjects, CCT and DE-CMR were performed within 1 week. CCT and DE-CMR showed satisfactory agreement in detecting DCE (agreement in 82% cases, κ = 0.56) with 50% sensitivity, 100% specificity, and a positive predictive value of 100%. CCT may be a valuable method for detecting DCE in patients with DCM. CCT thus might be considered as an alternative method to DE-CMR in the assessment of the presence and extent of myocardial fibrosis in subjects who are not suitable for DE-CMR examination.
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- 2016
3. Comparison of routine contrast‑enhanced computed tomography with late gadolinium enhancement cardiac magnetic resonance imaging in the detection of myocardial pathology
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David Ambroz, Martin Masek, Tomáš Paleček, Lukas Lambert, Jan Habasko, Josef Marek, Vladimir Cerny, Andrea Burgetova, Petr Kuchynka, and Barbara A. Danek
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Adult ,Male ,Pathology ,medicine.medical_specialty ,Heart Diseases ,media_common.quotation_subject ,Contrast Media ,Computed tomography ,Gadolinium ,Sensitivity and Specificity ,Cardiac magnetic resonance imaging ,Medicine ,Late gadolinium enhancement ,Contrast (vision) ,Humans ,media_common ,Aged ,medicine.diagnostic_test ,Hypoattenuation ,Myocardial tissue ,business.industry ,Myocardium ,Magnetic resonance imaging ,Heart ,Gold standard (test) ,Middle Aged ,Magnetic Resonance Imaging ,Female ,Cardiology and Cardiovascular Medicine ,business ,Tomography, X-Ray Computed - Abstract
Bacground: Cardiac magnetic resonance imaging (MRI) represents the gold standard in noninvasive evaluation of myocardial tissue. However, some patients are unable to undergo cardiac MRI due to a variety of reasons. Aims: We sought to determine the diagnostic accuracy of routinely performed contrast‑enhanced computed tomography (CECT) compared with cardiac MRI in the evaluation of myocardial tissue. Methods: We retrospectively evaluated 96 consecutive patients (mean [SD] age, 51 [15] years; 41 women) who underwent both CECT and cardiac MRI within 30 days. All CECT scans that visualized the entire heart were analyzed, regardless of the indication for and protocol of the procedure. The presence of late gadolinium enhancement on cardiac MRI was compared with the finding of myocardial hypoattenuation on computed tomography scans. Results: With cardiac MRI as the gold standard, CECT revealed a per‑patient sensitivity of 66%, specificity of 89%, positive predictive value of 75%, negative predictive value of 84%, and accuracy of 81%. Per‑segment sensitivity was 54%; specificity, 98%; positive predictive value, 76%; negative predictive value, 94%; and accuracy, 92%. Conclusions: Our study suggests that routinely performed CECT has high specificity, but only moderate sensitivity, compared with cardiac MRI in the evaluation of myocardial tissue. This result supports the recommendation that all CECT scans that visualize the entire heart should be analyzed for myocardial tissue pathology.
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- 2019
4. A rare case of regressively changed lipomatous hypertrophy of the interatrial septum presenting with anemia and recurrent fever
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David Zogala, Aleš Linhart, Tomas Palecek, Vladimir Cerny, Martin Masek, Eduard Nemecek, Ivana Vitkova, Zuzana Rucklova, Daniel Rob, and Petr Kuchynka
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Pathology ,medicine.medical_specialty ,Fever ,Heart Diseases ,Anemia ,030204 cardiovascular system & hematology ,Pathology and Forensic Medicine ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,medicine.artery ,Ascending aorta ,Biopsy ,medicine ,Humans ,Lipomatosis ,Pathological ,Aged ,Atrial Septum ,medicine.diagnostic_test ,business.industry ,Hypertrophy ,General Medicine ,medicine.disease ,Lipomatous hypertrophy ,medicine.anatomical_structure ,Recurrent fever ,030220 oncology & carcinogenesis ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Interatrial septum - Abstract
Lipomatous hypertrophy of the interatrial septum (LHIS) is characterized by excessive accumulation of adipose tissue within some segments of the interatrial septum. Only one published case so far describes fever as a presenting feature of LHIS. On the other hand, systemic symptoms including anemia and fever are well-known clinical presentations of cardiac myxomas. We report an unusual case of a 79-year-old woman who was thoroughly but unsuccessfully investigated for recurrent fever and anemia in several specialized departments over the course of 4 years. Computed tomography scan showed a pathological mass localized in the interatrial septum and spreading to ascending aorta. Histological analysis of the biopsy samples from surgery revealed the unexpected diagnosis of regressively changed LHIS. We discuss the clinical and pathologic features of this lesion suggesting that its regressive changes may be associated with inflammation and can cause systemic symptoms such as fever and anemia.
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- 2016
5. Dystrophic calcification of the interventricular septum mimicking cardiac tumour and role of multimodality imaging
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Petr Kuchynka, Iveta Sotolova, Martin Masek, Lukas Lambert, and Tomas Palecek
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Pathology ,medicine.medical_specialty ,business.industry ,Calcinosis ,Ventricular Septum ,General Medicine ,medicine.disease ,Multimodal Imaging ,Heart Neoplasms ,Heart neoplasms ,medicine.anatomical_structure ,Text mining ,Dystrophic calcification ,medicine ,Medical imaging ,Humans ,Radiology, Nuclear Medicine and imaging ,Interventricular septum ,Cardiology and Cardiovascular Medicine ,business - Published
- 2020
6. Submilisievert ultralow-dose CT colonography using iterative reconstruction technique: a feasibility study
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Martin Masek, Jiri Jahoda, Jiri Lisy, Lukas Lambert, Petr Ourednicek, and Jan Daneš
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Male ,medicine.medical_specialty ,Supine position ,Image quality ,Ultralow dose ,Contrast Media ,Pilot Projects ,Iterative reconstruction ,Radiation Dosage ,Triiodobenzoic Acids ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Aged ,Radiological and Ultrasound Technology ,Radon transform ,business.industry ,Distortion (optics) ,General Medicine ,Radiographic Image Enhancement ,Intestinal Diseases ,Prone position ,Feasibility Studies ,Radiographic Image Interpretation, Computer-Assisted ,Female ,Tomography ,Radiology ,business ,Colonography, Computed Tomographic - Abstract
Background Computed tomography (CT) colonography is a well established modality for the examination of symptomatic patients as well as in screening. Recent technical advances in improving image quality by iterative reconstruction contribute to the reduction of the radiation dose which is a major concern in CT imaging. Purpose To evaluate image quality of ultralow-dose submilisievert CT colonography using hybrid iterative reconstruction technique. Material and Methods Sixteen patients underwent contrast-enhanced CT colonography with standard protocol in supine position and ultralow-dose protocol in prone position. Ultralow-dose datasets were reconstructed with filtered back projection and an advanced hybrid iterative reconstruction technique. Two radiologists independently evaluated 96 colonic segments for image quality in the endoluminal view and axial thin sections. Colonic distension, smoothness of colonic wall and distortion of folds in the endoluminal view, sharpness of colonic wall delineation, perceived image noise, and presence of photon starvation artifact were rated on a five-point scale. Intraluminal noise expressed as standard deviation of Hounsfield density was measured in all segments. Results The mean radiation dose was 0.42 mSv and 5.48 mSv in prone and supine scans, respectively. All distended segments were rated evaluable in standard dose and ultralow-dose series reconstructed with the iterative reconstruction technique, whereas in 61% segments image quality was rated poor or unacceptable in ultralow-dose series where filtered back projection was used with worst ratings in the rectum and the sigmoid colon. Conclusion This pilot study shows that iterative reconstruction technique is a feasible method to decrease the radiation dose from CT colonography for both positions below 1mSv. Further investigations of larger scale need to be done to clarify, whether such a low radiation dose would influence the detection of polyps.
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- 2015
7. Thalamic Iron Differentiates Primary-Progressive and Relapsing-Remitting Multiple Sclerosis
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Martin Masek, Jan Krasensky, Petr Dusek, Dana Horakova, Manuela Vaneckova, Lukas Sobisek, C. Langkammer, P. Matras, Z. Seidl, and Andrea Burgetova
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Adult ,Male ,Pathology ,medicine.medical_specialty ,Iron ,Caudate nucleus ,Corpus callosum ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Atrophy ,Multiple Sclerosis, Relapsing-Remitting ,Thalamus ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Expanded Disability Status Scale ,business.industry ,Multiple sclerosis ,Putamen ,Adult Brain ,Quantitative susceptibility mapping ,Middle Aged ,Multiple Sclerosis, Chronic Progressive ,medicine.disease ,Magnetic Resonance Imaging ,Hyperintensity ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
BACKGROUND AND PURPOSE: Potential differences between primary progressive and relapsing remitting multiple sclerosis are the subject of ongoing controversial discussions. The aim of this work was to determine whether and how primary-progressive and relapsing-remitting multiple sclerosis subtypes differ regarding conventional MR imaging parameters, cerebral iron deposits, and their association with clinical status. MATERIALS AND METHODS: We analyzed 24 patients with primary-progressive MS, 80 with relapsing-remitting MS, and 20 healthy controls with 1.5T MR imaging for assessment of the conventional quantitative parameters: T2 lesion load, T1 lesion load, brain parenchymal fraction, and corpus callosum volume. Quantitative susceptibility mapping was performed to estimate iron concentration in the deep gray matter. RESULTS: Decreased susceptibility within the thalamus in relapsing-remitting MS compared with primary-progressive MS was the only significant MR imaging difference between these MS subtypes. In the relapsing-remitting MS subgroup, the Expanded Disability Status Scale score was positively associated with conventional parameters reflecting white matter lesions and brain atrophy and with iron in the putamen and caudate nucleus. A positive association with putaminal iron and the Expanded Disability Status Scale score was found in primary-progressive MS. CONCLUSIONS: Susceptibility in the thalamus might provide additional support for the differentiation between primary-progressive and relapsing-remitting MS. That the Expanded Disability Status Scale score was associated with conventional MR imaging parameters and iron concentrations in several deep gray matter regions in relapsing-remitting MS, while only a weak association with putaminal iron was observed in primary-progressive MS suggests different driving forces of disability in these MS subtypes.
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- 2017
8. A congenital diverticulum of the left ventricular apex manifested by stroke and recurrent ventricular tachycardia
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Martin Masek, Jaroslav Lindner, Štěpán Havránek, Aleš Linhart, Debora Karetová, Zuzana Hlubocká, Petr Kuchynka, Tomas Palecek, D. Wichterle, Jaroslava Dušková, and Gabriela Dostálová
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Heart Defects, Congenital ,medicine.medical_specialty ,Heart Ventricles ,030204 cardiovascular system & hematology ,Ventricular tachycardia ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Congenital diverticulum ,Cardiac magnetic resonance imaging ,Predictive Value of Tests ,Recurrence ,Internal medicine ,Medicine ,Humans ,cardiovascular diseases ,030212 general & internal medicine ,Stroke ,Echocardiography, Doppler, Pulsed ,medicine.diagnostic_test ,business.industry ,Recurrent ventricular tachycardia ,General Medicine ,medicine.disease ,Fibrosis ,Magnetic Resonance Imaging ,Diverticulum ,medicine.anatomical_structure ,Treatment Outcome ,Ventricle ,cardiovascular system ,Cardiology ,Tachycardia, Ventricular ,Radiology ,Differential diagnosis ,Cardiology and Cardiovascular Medicine ,business ,Electrophysiologic Techniques, Cardiac - Abstract
Ventricular outpouchings include acquired abnormalities (aneurysms and pseudoaneurysms) and congenital ventricular diverticula (CVD). CVD represent rare cardiac pathologies. Although CVD is often associated with other cardiac and extracardiac congenital anomalies, it can also be incidentally observed in otherwise healthy subjects. CVD may lead to significant morbidity and even have lethal consequences. We describe a case of arrhythmogenic left ventricle (LV) apical CVD revealed by cardiac magnetic resonance imaging (CMRI) after being initially overlooked by echocardiography. The paper includes the review of the literature also. This clinical case highlights the possible association of this pathology with recurrent ventricular tachycardia and stroke, and illustrates the importance of multimodal imaging approach in differential diagnosis.
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- 2016
9. Large metastatic involvement of pericardium, myocardium and andocardium of both heart ventricles in pulmonary adenocarcinoma
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Dalibor Kašík, Anna Korcová, Dana Matoušková, Martin Masek, Tomáš Paleček, and Pavel Franc
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Pathology ,medicine.medical_specialty ,medicine.anatomical_structure ,business.industry ,Pulmonary adenocarcinoma ,Medicine ,Pericardium ,Cardiology and Cardiovascular Medicine ,business - Abstract
Kasuistika dokumentuje klinický průběh, výsledky zobrazovacich vysetřeni a pitevni nalez nemocneho s metastatickým postiženim vsech srdecnich struktur jako prvni manifestaci plicniho adenokarcinomu.
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- 2011
10. Cardiac involvement in lymphoma mimicking hypertrophic cardiomyopathy
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Martin Masek, Lukas Lambert, Valerie Knotkova, Tomas Palecek, and Petr Kuchynka
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Adult ,Male ,Pathology ,medicine.medical_specialty ,business.industry ,Lymphoma, Non-Hodgkin ,Myocardium ,05 social sciences ,Cardiomyopathy ,Hypertrophic cardiomyopathy ,Cardiomyopathy, Hypertrophic ,030204 cardiovascular system & hematology ,medicine.disease ,Lymphoma ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Leukemic Infiltration ,0502 economics and business ,medicine ,Humans ,050211 marketing ,Cardiac Surgical Procedures ,Cardiology and Cardiovascular Medicine ,business - Published
- 2018
11. Multimodality imaging in endomyocardial fibrosis associated with Hodgkin lymphoma
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Lukas Lambert, Václav Ptáčník, Tomas Palecek, Petr Kuchynka, and Martin Masek
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Male ,medicine.medical_specialty ,Endomyocardial fibrosis ,Treatment outcome ,MEDLINE ,Multimodal Imaging ,Risk Assessment ,Medical imaging ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Heart Failure ,business.industry ,Follow up studies ,General Medicine ,Middle Aged ,Endomyocardial Fibrosis ,Hodgkin Disease ,Treatment Outcome ,Echocardiography ,Positron-Emission Tomography ,Hodgkin lymphoma ,Lymph Nodes ,Radiology ,Cardiology and Cardiovascular Medicine ,Risk assessment ,business ,Follow-Up Studies - Published
- 2018
12. Computed Tomographic Angiography in Proximal Femoral Focal Deficiency
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Pavel Dungl, Monika Frydrychová, Martin Masek, Jiří Chomiak, and Martin Horák
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Male ,medicine.medical_specialty ,Adolescent ,Femoral artery ,Young Adult ,medicine.artery ,Inferior gluteal artery ,Deep Femoral Artery ,medicine ,Humans ,Orthopedics and Sports Medicine ,Femur ,Child ,medicine.diagnostic_test ,business.industry ,Angiography ,Infant ,External iliac artery ,General Medicine ,Anatomy ,medicine.disease ,Internal iliac artery ,Popliteal artery ,Musculoskeletal Abnormalities ,Femoral Artery ,Lower Extremity ,Child, Preschool ,Proximal femoral focal deficiency ,Female ,Surgery ,Radiology ,Tomography, X-Ray Computed ,business - Abstract
Background Because there is limited information concerning the vascular pattern and the role of vessels in patients with proximal femoral focal deficiency, the vascular supply of the lower extremities was studied systematically with use of computed tomographic angiography in order to identify vascular changes, relate any vascular changes to the classification of the deficiency, and establish that there are no major changes in the topographical anatomy of the vessels. Methods Standardized computed tomographic techniques were used in twenty-one patients (thirteen boys and eight girls who ranged from one to nineteen years old) with proximal femoral focal deficiency types I through IV and VII, VIII, and IX, according to the Pappas classification. Results A common anatomical vascular pattern, in which the hypoplastic extremity was supplied through the femoral artery, was detected in nineteen patients. In patients with Pappas type-I through IV disease, the external iliac, femoral, and deep femoral arteries were substantially reduced in length and diameter and the deep femoral artery arose more proximally in comparison with that in the contralateral extremity; however, in the patients with Pappas type-VII, VIII, or IX disease, the diameters of the arteries and the origin of the deep femoral artery were similar to those of the contralateral extremity. In two patients with Pappas type-III disease, atypical anatomy of the vessels was found. The anterior part of the thigh and the pseudarthrosis were supplied through the femoral artery (the external iliac artery) as a terminal branch, while the remainder of the extremity was supplied from the internal iliac artery, which entered the thigh posterior to the hip as the inferior gluteal artery and continued as the artery to the sciatic nerve to the popliteal artery. No substantial anastomoses were found between the femoral and the posterior arteries in these vascular patterns. Conclusions Computed tomographic-angiographic reconstruction can be used to depict the spatial configuration of the pseudarthrosis and the vascular pattern of the extremity in patients with proximal femoral focal deficiency. We found distinct vascular changes in the majority of the involved thighs, but there were no typical changes related to the Pappas classification. Because we found atypical vascular patterns in two patients, evaluation of the vessels with use of various diagnostic methods is recommended in patients with severe types of proximal femoral focal deficiency.
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- 2009
13. The Role of Magnetic Resonance Imaging and Cardiac Computed Tomography in the Assessment of Left Atrial Anatomy, Size, and Function
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Martin Masek, Barbara A. Danek, Lukas Lambert, Jana Podzimkova, Petr Kuchynka, Tomas Palecek, and Vladimir Cerny
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medicine.medical_specialty ,Cardiac computed tomography ,medicine.medical_treatment ,lcsh:Medicine ,Catheter ablation ,Review Article ,General Biochemistry, Genetics and Molecular Biology ,Left atrial ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,cardiovascular diseases ,Heart Atria ,General Immunology and Microbiology ,medicine.diagnostic_test ,business.industry ,lcsh:R ,Magnetic resonance imaging ,Atrial fibrillation ,General Medicine ,medicine.disease ,Ablation ,Magnetic Resonance Imaging ,Review article ,Cardiology ,cardiovascular system ,Catheter Ablation ,Atrial Function, Left ,Tomography ,Radiology ,business ,Tomography, X-Ray Computed - Abstract
In the last decade, there has been increasing evidence that comprehensive evaluation of the left atrium is of utmost importance. Numerous studies have clearly demonstrated the prognostic value of left atrial volume for long-term outcome. Furthermore, advances in catheter ablation procedures used for the treatment of drug-refractory atrial fibrillation require the need for detailed knowledge of left atrial and pulmonary venous morphology as well of atrial wall characteristics. This review article discusses the role of cardiac magnetic resonance and computed tomography in assessment of left atrial size, its normal and abnormal morphology, and function. Special interest is paid to the utility of these rapidly involving noninvasive imaging methods before and after atrial fibrillation ablation.
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- 2014
14. The diagnostic performance of cardiac magnetic resonance in detection of myocardial involvement in AL amyloidosis
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Romana Rysava, Michal Fikrle, Ivan Spicka, Petr Kuchynka, Jan Straub, Tomáš Paleček, Martin Masek, and Aleš Linhart
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Male ,medicine.medical_specialty ,Physiology ,Population ,Cardiomyopathy ,Magnetic Resonance Imaging, Cine ,030204 cardiovascular system & hematology ,Sensitivity and Specificity ,03 medical and health sciences ,Ventricular Dysfunction, Left ,0302 clinical medicine ,Physiology (medical) ,Internal medicine ,AL amyloidosis ,medicine ,Late gadolinium enhancement ,Humans ,cardiovascular diseases ,030212 general & internal medicine ,education ,Aged ,education.field_of_study ,Ejection fraction ,business.industry ,Reproducibility of Results ,General Medicine ,Amyloidosis ,medicine.disease ,Amyloid heart disease ,Echocardiography ,cardiovascular system ,Cardiology ,Female ,Amyloid cardiomyopathy ,Cardiac magnetic resonance ,business ,Cardiomyopathies - Abstract
Summary Background The non-invasive assessment of amyloid heart disease may be challenging. Cardiac magnetic resonance (CMR) represents a method of choice for assessment of left ventricular (LV) morphology and function, and it also provides a unique possibility to evaluate the presence of amyloid deposition by the late gadolinium enhancement (LGE) technique. However, so far, published studies have not been consistent in terms of described LGE patterns associated with amyloid cardiomyopathy. Aims To compare echocardiographic and CMR assessment of LV morphology and function and to evaluate the presence and pattern of LGE in a population of patients with AL amyloid cardiomyopathy. Methods Twenty-two consecutive patients with newly diagnosed AL amyloid cardiomyopathy and without contraindications to CMR were comprehensively examined by echocardiography and CMR. Results Echocardiography and CMR did not differ in the evaluation of interventricular septal thickness, LV end-diastolic diameter and ejection fraction. Significant differences were found between echocardiographic and CMR estimates of LV end-diastolic volume (P
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- 2014
15. Patients' stratification and correlation of brain magnetic resonance imaging parameters with disability progression in multiple sclerosis
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Ondrej Dolezal, Andrea Burgetova, Martin Masek, Eva Havrdova, Jan Krasensky, Dana Horakova, Manuela Vaneckova, and Zdenek Seidl
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Adult ,Male ,Pathology ,medicine.medical_specialty ,Adolescent ,Severity of Illness Index ,Lesion load ,Correlation ,Young Adult ,Atrophy ,Multiple Sclerosis, Relapsing-Remitting ,medicine ,Humans ,Disability progression ,Brain magnetic resonance imaging ,In patient ,skin and connective tissue diseases ,medicine.diagnostic_test ,business.industry ,Multiple sclerosis ,Brain ,Magnetic resonance imaging ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Neurology ,Disease Progression ,Female ,sense organs ,Neurology (clinical) ,Radiology ,business ,Follow-Up Studies - Abstract
Aims: The objective was to correlate the change in the lesion load (LL) and brain atrophy in patients with multiple sclerosis (MS) with progression of clinical disability, represented by the Expanded Disability Status Scale (EDSS), and to test if stratification of patients according to magnetic resonance imaging (MRI) criteria can increase the predictive ability of MRI for MS clinical development. Methods: 181 patients with clinically definite relapsing-remitting MS underwent MRI for a period of up to 5 years. Grouping of patients according to the LL value at the study entry revealed a substantial increase in the Spearman rank correlation coefficient R. Results: For the low LL cohort of patients, we found a statistically significant correlation (R up to –0.71 with p < 0.01) of a later increase in the EDSS score (years 4 and 5) with increased brain atrophy in the first 2 years. For the high LL group, we found a statistically significant correlation (R up to 0.72 with p < 0.01) of a later increase in the EDSS score (years 4 and 5) with an increase in the LL value in the first year. Conclusions: We conclude that stratification of patients according to the MRI criterion (LL) can increase the predictive ability of MRI.
- Published
- 2008
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