1. Placental oxygen transfer reduces hypoxia-reoxygenation swings in fetal blood in a sheep model of gestational sleep apnea
- Author
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Joaquín J. Sopena-Juncosa, Mónica Rubio-Zaragoza, Antonio Gonzalez-Bulnes, Ramon Farré, Marta Torres, Álvaro J. Gutiérrez-Bautista, Isaac Almendros, David Gozal, José M. Carrillo-Poveda, Paula Martinez-Ros, Núria Farré, UCH. Departamento de Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos, and Producción Científica UCH 2019
- Subjects
0301 basic medicine ,Fetal blood ,medicine.medical_specialty ,Pregnancy apnea ,Oxygen transfer ,Physiology ,Placenta ,Sleep disorders ,Sangre fetal ,03 medical and health sciences ,0302 clinical medicine ,Fetal oxygenation ,Pregnancy ,Physiology (medical) ,Internal medicine ,medicine ,Animals ,Sleep Apnea, Obstructive ,Fetus ,Sheep ,Intermittent hypoxia ,business.industry ,Sleep apnea ,General Medicine ,respiratory system ,Airway obstruction ,Fetal Blood ,Sueño - Trastornos ,medicine.disease ,respiratory tract diseases ,Oxygen ,Pregnancy Complications ,Fetal anoxia ,body regions ,Disease Models, Animal ,030104 developmental biology ,Cardiology ,Embarazo - Complicaciones y secuelas ,Gestation ,Female ,Anoxia fetal ,Hypoxia reoxygenation ,Pregnancy - Complications ,business ,Oxygen in the body ,Oxígeno en el organismo ,030217 neurology & neurosurgery - Abstract
Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://journals.physiology.org/doi/full/10.1152/japplphysiol.00303.2019?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org This is the pre-peer reviewed version of the following article: Almendros, I., Martínez-Ros, P., Farré, N., Rubio-Zaragoza, M., Torres, M., Gutiérrez-Bautista, A.J. et al. (2019). Placental oxygen transfer reduces hypoxia-reoxygenation swings in fetal blood in a sheep model of gestational sleep apnea. Journal of Applied Physiology, vol. 127, i. 3 (13 sep.), pp. 745-752, which has been published in final form at https://doi.org/10.1152/japplphysiol.00303.2019. Este es el pre-print del siguiente artículo: Almendros, I., Martínez-Ros, P., Farré, N., Rubio-Zaragoza, M., Torres, M., Gutiérrez-Bautista, A.J. et al. (2019). Placental oxygen transfer reduces hypoxia-reoxygenation swings in fetal blood in a sheep model of gestational sleep apnea. Journal of Applied Physiology, vol. 127, i. 3 (13 sep.), pp. 745-752, que se ha publicado de forma definitiva en https://doi.org/10.1152/japplphysiol.00303.2019. AIM: Obstructive sleep apnea (OSA), characterized by events of hypoxia reoxygenation, is highly prevalent in pregnancy, negatively affecting the gestation process and particularly the fetus. Whether the consequences of OSA on the fetus and offspring are mainly caused by systemic alterations in the mother or by direct effect of intermittent hypoxia in the fetus is unknown. In fact, how apnea-induced hypoxemic swings in OSA are transmitted across the placenta remains to be investigated. The aim of this study was to test the hypothesis, based on a theoretical background on the dampening effect of oxygen transfer in the placenta, that oxygen partial pressure (PO2) swings resulting from obstructive apneas mimicking OSA are mitigated in the fetal circulation. METHODS: To this end, 4 anesthetized ewes close to term pregnancy were subjected to obstructive apneas consisting of 25-s airway obstructions. Real time PO2 was measured in the maternal carotid artery and in the umbilical vein using fast-response fiberoptic oxygen sensors. RESULTS: The amplitude of PO2 swings in the umbilical vein were considerably smaller (3.1±1.0 vs. 21.0±6.1 mmHg (m±SE); p
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- 2019