5 results on '"Jun Yang Zhao"'
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2. Efficacy and Side Effects in HER2-Positive Advanced Breast Cancer Patients Treated with Pyrrotinib: A Real-World Study in China
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Jun Yang Zhao, Xiaolei Wang, Fanfan Li, Jingjing Li, Yu Su, and Chen Xu Meng
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Oncology ,medicine.medical_specialty ,business.industry ,Advanced breast ,Internal medicine ,medicine ,Cancer ,General Medicine ,China ,medicine.disease ,business - Abstract
Background: Pyrotinib is a molecular and irreversible tyrosine kinase inhibitor independently developed in China, and its efficacy against HER2- positive breast cancer in the real world is not clear. In this study, we evaluated the efficacy and safety of pyrotinib in the treatment of HER2-positive advanced breast cancer based on real-world evidence. Materials and Methods: We designed a prospective observational study. Thirty-six patients with HER2-positive advanced breast cancer from a single medical center were included in the study from December 2018 to February 2021. All patients received the oral HER2 receptor inhibitor pyrotinib and received concurrent chemotherapy or endocrinotherapy. The follow-up endpoint is set as April 1, 2021. The primary endpoint is Objective Response Rate (ORR) and Disease Control Rate (DCR), and the secondary endpoint is Progression- Free Survival (PFS) and related side effects. Results: By the end point of follow-up, a total of 17 patients had progressed (including 6 deaths), and the progression-free survival rate was 52.78%. The median PFS was 13months (PFS range: 3-22 months). As the best response, 4 patients achieved CR, 20 patients achieved PR, 9 patients achieved SD, and 3 patient developed PD. The ORR was 66.67% and DCR was 91.67%. In the analysis, first-line pyrotinib treatment appeared to have higher ORR (88.88% vs 59.26%), but there was no significant difference. In addition, pyrotinib showed significant efficacy in patients with brain metastases, with an ORR of 42.85%. In terms of safety, the incidence of diarrhea was 80.55%, but only 4 patients had grade 3 diarrhea, which was tolerable after the drug dose was reduced; 1 patient had grade 4 neutropenia and grade 3 and thrombocytopenia, which were considered to be related to the chemotherapy drugs. The incidence of other adverse reactions was low, and all were grade 1 to 2. Conclusion: Pyrotinib combined with chemotherapy has a significant effect on HER2-positive breast cancer, and there is still a high ORR in patients who fail multiple lines of treatment. Side effects are overall controllable and safe.
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- 2021
3. Full-Term Neonatal Ophthalmic Screening in China: A Review of 4-Year Outcomes
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Jun Yang Zhao, Guo Ming Zhang, Li Hong Li, Yan Ma, Jun Lu, Wei Chi Wu, and Na Li
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Male ,China ,Pediatrics ,medicine.medical_specialty ,Time Factors ,Visual acuity ,Visual Acuity ,MEDLINE ,03 medical and health sciences ,Neonatal Screening ,Vision Screening ,0302 clinical medicine ,030225 pediatrics ,medicine ,Humans ,Eye Abnormalities ,Retrospective Studies ,Full Term ,Child care ,business.industry ,Incidence ,Incidence (epidemiology) ,Infant, Newborn ,Retrospective cohort study ,030221 ophthalmology & optometry ,Female ,Observational study ,medicine.symptom ,business ,Follow-Up Studies ,Case series - Abstract
BACKGROUND AND OBJECTIVE: To report the 4-year outcomes of a neonatal ophthalmic screening program in the Kunming Maternity and Child Care Hospital of Kunming City, Kunming, China. PATIENTS AND METHODS: This was a retrospective, observational case series study. Newborns who underwent neonatal eye screening using the RetCam system (Clarity Medical Systems, Pleasanton, CA) at the authors' hospital from March 2010 to February 2014 were included. RESULTS: Of the 15,284 full-term infants who participated in the program, 21% (3,171 of 15,284) had some ocular abnormalities. Among these abnormalities, retinal hemorrhage was the most frequent finding, accounting for 19% (2,899 of 15,284) of all cases. Other anomalies were found in 2% (272 of 15,284) of the cases. No major ocular or systemic complications were found to be associated with the screening process. CONCLUSION: Overall, 21% of the newborns who underwent the eye screening program were found to have an abnormality. The use of the RetCam for the screening program was both efficient and safe in identifying ocular anomalies. [ Ophthalmic Surg Lasers Imaging Retina . 2017;48:983โ992.]
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- 2017
4. Clinical presentation and group classification of newly diagnosed intraocular retinoblastoma in China
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Jitong Shi, Jun-Yang Zhao, Ningli Wang, and Songfeng Li
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Male ,China ,medicine.medical_specialty ,Pediatrics ,Time Factors ,Retinal Neoplasms ,Disease ,Newly diagnosed ,Fundus (eye) ,Intraocular Retinoblastoma ,Cellular and Molecular Neuroscience ,medicine ,Humans ,Stage (cooking) ,Child ,Retrospective Studies ,Retinoblastoma ,business.industry ,Infant, Newborn ,Infant ,medicine.disease ,eye diseases ,Sensory Systems ,Surgery ,Ophthalmology ,Child, Preschool ,Female ,Presentation (obstetrics) ,business ,Unilateral Retinoblastoma - Abstract
Aim To describe the clinical presentation and group classification of newly diagnosed retinoblastoma patients in China, and to identify future priorities for improving the medical care of this disease. Methods The retrospective review included all patients who presented with previously untreated intraocular retinoblastoma at Beijing Tongren Hospital between August 2006 and August 2009. The clinical charts were reviewed and fundus images taken for all patients were analysed. The tumours were classified according to the International Intraocular Retinoblastoma Classification. Results The study included 595 eyes (470 patients) with untreated retinoblastoma. The mean age at diagnosis was 23 months, with 84% of the patients being younger than 3 years at the time of diagnosis. Bilateral retinoblastoma was present in 150 (32%) of the patients. Bilateral retinoblastoma as compared with unilateral retinoblastoma was diagnosed at a significantly (p0.001) younger mean age (15 months vs 27 months). Leucocoria was the most common leading sign (73% of patients). The vast majority of eyes (501/595 or 84%) presented with an advanced stage of the tumour (Group D or E of International Intraocular Retinoblastoma Classification). Conclusion In China, diagnosis of retinoblastoma occurs at a relatively advanced clinical stage of the disease. An intensified programme for earlier detection of retinoblastoma including educating parents and physicians may be warranted to improve clinical outcome with fewer enucleations.
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- 2011
5. Findings of perinatal ocular examination performed on 3573, healthy full-term newborns
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Guo-ming Zhang, Lihong Li, Paul J. Rychwalski, Ping Fei, Na Li, Jun-Yang Zhao, and Jian-bo Mao
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Male ,medicine.medical_specialty ,China ,genetic structures ,Eye Diseases ,Light ,Term Birth ,Ocular Pathology ,Physical examination ,Gestational Age ,Child Health (Paediatrics) ,Reflex, Pupillary ,Retina ,Cellular and Molecular Neuroscience ,Red reflex ,Neonatal Screening ,Vision Screening ,Ophthalmology ,medicine ,Humans ,Pupillary light reflex ,Eye Abnormalities ,Synechia ,Physical Examination ,Persistent pupillary membrane ,medicine.diagnostic_test ,business.industry ,Infant, Newborn ,Clinical Science ,medicine.disease ,eye diseases ,Sensory Systems ,Cross-Sectional Studies ,Eye examination ,Female ,Public Health ,sense organs ,business ,Retinal haemorrhage ,Retinoscopy - Abstract
Objective To document the findings of a newborn eye examination programme for detecting ocular pathology in the healthy full-term newborn. Methods This is a cross-sectional study of the majority of newborns born in the Kunming Maternal and Child Healthcare Hospital, China, between May 2010 and June 2011. Infants underwent ocular examination within 42 days after birth using a flashlight, retinoscope, hand-held slit lamp microscope and wide-angle digital retinal image acquisition system. The retinal fundus examination utilised the RetCam wide-field digital imaging system (Clarity Medical Systems, Pleasanton, California, USA). The external eye, pupillary light reflex, red reflex, opacity of refractive media, anterior chamber and posterior segments were also examined. Results A total of 3573 healthy full-term newborns were enrolled and examined in the programme. There was detection of 871 abnormal cases (24.4%). The majority of abnormal exams were 769 (21.52%) retinal haemorrhages. Of these, there were 215 cases of significant retinal haemorrhage, possible sight threatening or amblyogenic, representing 6.02% of the total. In addition, 67 cases (1.88%) involved macular haemorrhage. The other 107 cases (2.99%) with abnormal ocular findings included subconjunctival haemorrhage, congenital microphthalmos, congenital corneal leukoma, posterior synechia, persistent pupillary membrane, congenital cataract, enlarged C/D ratio, retinal hamartoma versus retinoblastoma, optic nerve defects, macular pigment disorder and non-specific peripheral retinopathy. Conclusion Ocular examination of healthy newborns leads to the detection of a significant number of ocular pathologies. The most commonly discovered ocular abnormality during examination of the newborns in this study is retinal haemorrhage. The long-term impact of these findings is unknown. Although presumed by some to benign, neonatal retinal haemorrhages due to birth trauma could be involved in altering visual development. Further work, including prospective examination of newborns with long-term follow-up, is needed and supported by our findings.
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- 2013
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