1. Predictors of ventriculostomy infection in a large single-center cohort
- Author
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Erica Mann, Robert H. Rosenwasser, Christine Wamsley, James S. Harrop, Nohra Chalouhi, Jeffery Head, Ahmad Sweid, Stavropoula Tjoumakaris, Julie Hauge, Nabeel Herial, Symeon Missios, Christopher Neely, Hekmat Zarzour, Pascal Jabbour, Kareem El Naamani, Rawad Abbas, David Nauheim, M. Reid Gooch, Tyler D Alexander, David Hasan, and Joshua H. Weinberg
- Subjects
Adult ,Male ,Reoperation ,Ventriculostomy ,medicine.medical_specialty ,medicine.medical_treatment ,Single Center ,Logistic regression ,Neurosurgical Procedures ,Cohort Studies ,03 medical and health sciences ,Sex Factors ,0302 clinical medicine ,Predictive Value of Tests ,Risk Factors ,Chart review ,Internal medicine ,medicine ,Humans ,Surgical Wound Infection ,Cerebrospinal Fluid Leak ,business.industry ,Female sex ,General Medicine ,Length of Stay ,Middle Aged ,medicine.disease ,Hydrocephalus ,030220 oncology & carcinogenesis ,Cohort ,Drainage ,Female ,business ,030217 neurology & neurosurgery ,External ventricular drain - Abstract
OBJECTIVE External ventricular drain (EVD) placement is a common neurosurgical procedure. While this procedure is simple and effective, infection is a major limiting factor. Factors predictive of infection reported in the literature are not conclusive. The aim of this retrospective, single-center large series was to assess the rate and independent predictors of ventriculostomy-associated infection (VAI). METHODS The authors performed a retrospective chart review of consecutive patients who underwent EVD placement between January 2012 and January 2018. RESULTS A total of 389 patients were included in the study. The infection rate was 3.1% (n = 12). Variables that were significantly associated with VAI were EVD replacement (OR 10, p = 0.001), bilateral EVDs (OR 9.2, p = 0.009), duration of EVD placement (OR 1.1, p = 0.011), increased CSF output/day (OR 1.0, p = 0.001), CSF leak (OR 12.9, p = 0.001), and increased length of hospital stay (OR 1.1, p = 0.002). Using multivariate logistic regression, independent predictors of VAI were female sex (OR 7.1, 95% CI 1.1–47.4; p = 0.043), EVD replacement (OR 8.5, 95% CI 1.44–50.72; p = 0.027), increased CSF output/day (OR 1.01, 95% CI 1.0–1.02; p = 0.023), and CSF leak (OR 15.1, 95% CI 2.6–87.1; p = 0.003). CONCLUSIONS The rate of VAI was 3.1%. Routine CSF collection (every other day or every 3 days) and CSF collection when needed were not associated with VAI. The authors recommend CSF collection when clinically needed rather than routinely.
- Published
- 2021