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Sarcomatoid carcinoma of the urinary bladder is rare and presented as a high grade and an advanced stage tumor. A 79-year old man presented with macroscopic hematuria was carried out transurethral resection. Pathological examination revealed a tumor composed of epitelial and mesenchimal areas which were showed strong positivity with pancytokeratin and vimentin, respectively. We want to present this rare neoplasm of the bladder with clinic and pathologic findings.

Introduction TPOG-NBL 2003 national protocol was designed to improve treatment results of the high risk patients by adjunction of stem cell rescue with intensive multimodal therapy. Material and Methods High risk stratification was made according to COG criteria. Just before the third cycle of chemotherapy, patients without progression were allocated into two treatment groups non-randomly by physicians’ and/or parent’s choices guided to the center’s facility, toxicity and social-economical facility to attain the megatherapy. After an induction of 6 chemotherapy cycles, the protocol was divided into two arms which were designed to continue the intensive conventional chemotherapy (CCT), or initiate myeloablative therapy with autologous stem-cell rescue (ASCR). All patients were also given 13-cis-retinoic acid as maintenance therapy. Results Fifty-six percent (272 patients) of all neuroblastoma patients was evaluated as high risk. Response rate to induction chemotherapy was 81% (CR/VGPR: 32%, PR: 49%) in patients at the end of induction chemotherapy. Overall EFS and OS at 3-years were 36% and 45%, respectively. Intention-to-treat analysis documented post-induction (after the six cycles of induction chemotherapy) EFS of 46% in CCT arm (137 patients) and 37% in ASCR group (55 patients) (p= 0.037); whereas, OS was 59% and 43%, respectively (p=0.052). Thirty-one patients (11%) died of treatment-related complications. Conclusion Survival rates of high-risk neuroblastoma have improved over the last decade in Turkey. The main problems when managing these patients were an effective local control, early progression and death. Megatherapy has not augmented the therapeutic end point in our country’s circumstances. However; the better the supportive care and the higher the patients’ compliance is attained, the higher the survival rates might be obtained in Turkish neuroblastoma patients. Disclosures: No relevant conflicts of interest to declare.

Mezenterik lipomalar matür yağ hücrelerinin iyi huylu tümörleridir. Genellikle asemptomatik olmalarına rağmen, lokalizasyonlarına ve büyüklüğüne bağlı olarak klinik tablo oluştururlar. Çok nadir görülmelerine rağmen, çok büyümüş dev mezenterik lipomalar kısmi veya tam barsak tıkanıklığına neden olabilirler. Kısmı barsak tıkanıklığı oluşturan lipomalar aralıklı karın ağrısı ve karın şişliği gibi şikayetlere neden olurken, tam barsak tıkanıklığı gelişen olgular akut batın tab- losuyla karşımıza çıkarlar. Tedavileri etkilenmiş barsak bölümüyle bir- likte kitlenin eksize edilmesidir. Bu çalışmada dev mezenterik lipom nedeniyle barsak tıkanıklığı gelişmiş 2 yaşında bir kız olgu ve şu ana kadar ingilizce literatürde yayınlanmış 16 olgunun klinik özellikleri sunulmuştur., Mesenteric lipomas are benign tumors of mature fat cells. They are usually asymptomatic and create a clinical picture that depends on the localization and size of the lipoma. Although rare, unusually large mesenteric giant lipomas can cause partial or complete bowel obstruction. Lipomas resulting in partial bowel obstruction can present with symptoms such as intermittent abdominal pain and abdominal distention. With complete obstruction, a child can present with an acute abdomen. Treatment is the excision of the mass along with the affected portion of bowel. in this case study, a 2-year-old female presented with a bowel obstruction due to the presence of a giant mesenteric lipoma. Clinical features of 16 cases published in the English literature to date are presented.

Angioleiomyoma is an uncommon type of leiomyoma of the uterus that originates from smooth muscle cells and contains thick-walled vessels. A 45-year-old woman with the complaint of lower abdominal pain was admitted to the hospital. In the operation a ruptured, bleeding uterine tumor was seen. She underwent total hysterectomy and bilateral salpingo-oophorectomy. On pathologic examination of the specimen, the tumor was diagnosed as angioleiomyoma. Here, an unusual clinical presentation of uterine angioleiomyoma was reported.