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Die Lobomykose, verursacht durch Lacazia loboi, ist eine chronisch verlaufende tiefe Mykose und kommt ausschlieslich in Mittel- und Sudamerika vor. Klinisch ist die Erkrankung durch konfluierende, braunlich glanzende Knoten gekennzeichnet, die an Keloide erinnern. Die Lasionen befinden sich bevorzugt an den Extremitaten und im Gesicht. Als Erfolg versprechende Behandlungsmethode galt bisher nur die chirurgische Exzision. Wir berichten uber einen erfolgreichen Behandlungsversuch nach einer 1-jahrigen Kombinationstherapie mit Clofazimin (100 mg/Tag) und Itrakonazol (100 mg/Tag). Klinisch und histologisch konnte eine Vollremission beobachtet werden.

The Melkersson-Rosenthal Syndrome is composed of the Triad: linqua plicata, intermittent facial palsy and orofacial swelling. Usually, the dominant and earliest finding of the syndrome is the orofacial swelling. Therefore, it’s frequently the dermatologist the first professional to have contact with the patient. Yet, the condition has been few times described in dermatological literature. We present a classical case of the complete triad.

Clofazimine and clarithromycin are used to treat leprosy and infections caused by Mycobacterium avium complex. Little data on the toxicity of co-administration of these two drugs are available. Here we evaluated the potential adverse effects of polytherapy with these two drugs in male Wistar rats by determining WBCs counts and other blood cell counts, neutrophilic phagocytosis, and burst oxidative, by flow cytometry. We observed an increase in WBCs, in multiple-dose regimens, and in polymorphonuclear cells, in both single- clarithromycin only and multiple dose regimens. We also observed a reduction in mononuclear cell counts in single and multiple doses. The drugs seem to reverse the mononuclear and polymorphonuclear cell ratio. An increase in oxidative burst was observed in animals treated with the drugs administered either individually or combined. In conclusion, clofazimine and clarithromycin change WBCs counts. Our results may contribute for a better understanding of the mechanisms related to the effects of co-administrating the two drugs.Clofazimina e laritromicina são utilizadas no tratamento da hanseníase e em infecções causadas pelo complexo Mycobacterium avium. Devido à escassez de dados sobre a toxicidade de esquemas terapêuticos que associam estes fármacos, este estudo teve por objetivo avaliar os efeitos adversos desta terapia, em ratos machos Wistar, por meio da determinação da contagem global e específica de leucócitos e ensaios de fagocitose e burst oxidativo de neutrófilos por citometria de fluxo. Houve aumento do número de leucócitos (dose múltipla) e de células polimorfonucleares (doses única e múltipla) nos grupos tratados com claritromicina em monoterapia ou associada à clofazimina e redução das células mononucleares, em doses única e múltipla, nos mesmos grupos. Os fármacos parecem inverter a proporção entre células mono e polimorfonucleares. Observou-se aumento do burst oxidativo nos animais tratados com os fármacos isolados ou associados. Concluindo, clofazimina e claritromicina provocam alterações leucocitárias e os resultados podem contribuir para melhor entendimento dos mecanismos relacionados aos efeitos da administração dos fármacos em associação.

Cheilitis granulomatosa Miescher is a rare condition of unknown cause characterized by intermittent lip swelling that gradually persists and causes cosmetic deformity. We report the case of a young woman with cheilitis granulomatosa as a monosymptomatic manifestation of Melkersson-Rosenthal syndrome successfully treated by the antileprosy agent clofazimine, and propose clofazimine as an alternative treatment in cases refractory to corticosteroids. The differential diagnosis and current methods of treatment are summarized, and the literature is reviewed and discussed.

Ashy dermatosis, or erythema dyschromicum perstans, is a rare dermatosis of unknown etiology. The au- thors report the case of a 46-year-old healthy man that presented with a 1-year history of asymptomatic gray macules on the trunk. The constellation of clinical features, laboratory studies and histopathology allowed the diagnosis of Ashy dermatosis. Treatment with oral clofazimine was started, with complete resolution of the cutaneous lesions and without relapses after 6 months of follow-up. Therapeutic options for Ashy dermatosis are numerous, but none with consistent efficacy. Treatment with clofazimine has been attempted not only for its cosmetic effect, producing a uniform colouring of the skin that masks the pigmented areas, but also because its beneficial effect may be mediated by anti-inflammatory and immunomodulatory actions. This report supports the therapeutic efficacy of clofazimine in a patient with Ashy der- matosis.KEYWORDS – Clofazimine; Erythema; Pigmentation disorders; Skin diseases.